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PTEN encoding product:a marker for tumorigenesis and progression of gastric carcinoma

World Journal of Gastroenterology 2003年第1期9卷 35-39页

作者： Lin Yang Li-Ge Kuang Hua-Chuan Zheng Jin-Yi Li Dong-Ying Wu Su-Min Zhang Yan Xin No.4 Lab,Cancer Institute,The first affiliated hospital,china medical university,shenyang 110001,china Ying Chen Shen Yang Gynecology & Obstetrics hospital,shenyang 110014,china No.4 Lab Cancer Institute The First Affiliated Hospital China Medical University Shenyang 110001 China. yxin@***

AIM: To detect the expression of PTEN encoding productin normal mucosa, intestinal metaplasia (IM), dysplasia andcarcinoma of the stomach, and to investigate its clinicalimplication in tumorigenesis and progression of ***: Formalin-fixed paraffin embedded specimens from184 cases of gastric carcinoma, their adjacent normal mucosa,IM and dysplasia were evaluated for PTEN protein expressionby SABC immunohistochemistry. PTEN expression wascompared with tumor stage, lymph node metastasis, Lauren'sand WHO's histological classification of gastric *** of VEGF was also detected in 60 cases of gastriccarcinoma and its correlation with PTEN was ***: The positive rates of PTEN protein were 100 %(102/102), 98.5 %(65/66), 66.7 % (4/6) and 47.8 %(88/184)in normal mucosa, IM, dysplasia and carcinoma of the stomach,respectively. The positive rates in dysplasia and carcinomawere lower than in normal mucosa and IM (P＜0.01).Advanced gastric cancers expressed less frequent PTEN thanearly gastric cancer (42.9 % v567.6 %, P＜0.01). The positiverate of PTEN protein was lower in gastric cancer with thanwithout lymph node metastasis (40.3 % v563.3 %, P＜0.01).PTEN was less expressed in diffuse-type than in intestinal-type gastric cancer (41.5 % v557.8 %,P＜0.05). Signet ringcell carcinoma showed the expression of PTEN at the lowestlevel (25.0 %, 7/28); less than well and moderatelydifferentiated ones (P＜0.01). Expression of PTEN was notcorrelated with expression of VEGF (P＞0.05).CONCLUSION: Loss or reduced expression of PTEN proteinoccures commonly in tumorigenesis and progression of gastriccarcinoma. It is suggested that PTEN can be an objective markerfor pathologically biological behaviors of gastric carcinoma.

关键词： PTEN 肠化生胃癌肿瘤发生肿瘤病理学细胞因子免疫组织化学

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Volumetric lattice Boltzmann method for pore-scale mass diffusionadvection process in geopolymer porous structures

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第6期16卷 2126-2136页

作者： Xiaoyu Zhang Zirui Mao Floyd W.Hilty Yulan Li Agnes Grandjean Robert Montgomery Hans-Conrad zur Loye Huidan Yu shenyang Hu Purdue university IndianapolisIN46202USA Pacific Northwest National Laboratory RichlandWA99352USA CEA DESISECDMRCUniv.MontpellierMarcouleFrance Department of Chemistry and Biochemistry University of South CarolinaColumbiaSC29208USA

Porous materials present significant advantages for absorbing radioactive isotopes in nuclear waste *** improve absorption efficiency in nuclear waste treatment,a thorough understanding of the diffusion-advection process within porous structures is essential for material *** this study,we present advancements in the volumetric lattice Boltzmann method(VLBM)for modeling and simulating pore-scale diffusion-advection of radioactive isotopes within geopolymer porous *** structures are created using the phase field method(PFM)to precisely control pore *** our VLBM approach,we introduce a concentration field of an isotope seamlessly coupled with the velocity field and solve it by the time evolution of its particle population *** address the computational intensity inherent in the coupled lattice Boltzmann equations for velocity and concentration fields,we implement graphics processing unit(GPU)*** of the developed model involves examining the flow and diffusion fields in porous ***,good agreement is observed for both the velocity field from VLBM and multiphysics object-oriented simulation environment(MOOSE),and the concentration field from VLBM and the finite difference method(FDM).Furthermore,we investigate the effects of background flow,species diffusivity,and porosity on the diffusion-advection behavior by varying the background flow velocity,diffusion coefficient,and pore volume fraction,***,all three parameters exert an influence on the diffusion-advection *** background flow and diffusivity markedly accelerate the process due to increased advection intensity and enhanced diffusion capability,***,increasing the porosity has a less significant effect,causing a slight slowdown of the diffusion-advection process due to the expanded pore *** comprehensive parametric study provides valuable insights into the kinetics of isotope

关键词： Volumetric lattice Boltzmann method(VLBM) Phase field method(PFM) Pore-scale diffusion-advection Nuclear waste treatment Porous media flow Graphics processing unit(GPU) parallelization

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CCL_（229）细胞经诱导后蛋白激酶C及抑制剂活性的变化

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生物化学与生物物理进展 1996年第1期23卷 52-56页

作者：王红梅于秉治王芸庆宋今丹中国医科大学细胞生物学卫生部重点实验室中国医科大学生物化学教研室

检测以维甲酸（ＲＡ）、１，２５－二羟基维生素Ｄ３（１，２５（ＯＨ）２ＶＤ３）诱导２ｄ、佛波酯（ＰＭＡ）诱导６ｈ的人大肠癌细胞ＣＣＬ（２２９）的蛋白激酶Ｃ（ＰＫＣ）及其抑制剂活性．结果显示：诱导后ＰＫＣ总活性升高（Ｐ＜... 详细信息

检测以维甲酸（ＲＡ）、１，２５－二羟基维生素Ｄ３（１，２５（ＯＨ）２ＶＤ３）诱导２ｄ、佛波酯（ＰＭＡ）诱导６ｈ的人大肠癌细胞ＣＣＬ（２２９）的蛋白激酶Ｃ（ＰＫＣ）及其抑制剂活性．结果显示：诱导后ＰＫＣ总活性升高（Ｐ＜０．０５）；ＲＡ、１，２５（ＯＨ）２ＶＤ３诱导引起细胞质ＰＫＣ活性增加，ＰＭＡ诱导后细胞膜ＰＫＣ比率（细胞膜活性／总活性）显著升高（Ｐ＜０．０１）；诱导后ＰＫＣ抑制剂活性均降低，其中１，２５（ＯＨ）２ＶＤ３组与对照组有显著差异（Ｐ＜０．０５）；提示ＰＭＡ引起ＰＫＣ从细胞质向细胞膜转移，不同药物诱导后ＰＫＣ及其抑制剂活性出现不同的相对均衡关系．

关键词：大肠肿瘤癌细胞蛋白激酶C 抑制剂

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Pharmacological treatment of Pulmonary Hypertension: mechanism relevance to 5-Hydroxytraptamine, Receptors and Transporters

Pharmacological treatment of Pulmonary Hypertension: mechani...

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第十五届国际药理学大会

作者： Wang Huai-Liang china medical university, shenyang 110001, china

＜正＞ There is critical relevance between 5-HT and pulmonary hypertension （PH）. Further investigation of receptor and transporter mechanism using chronic " monocro-taline" rats, cultured pulmonary artery smooth muscle cells （PASMC） and liposo-mal transfection to introduce ERK1/2 ODNs into cultured rat PASMCs shown that selective serotonin reuptake inhibitor fluoxetine and sertraline concentration-depen-dently inhibited MCT-induced PH in rats and the proliferation of PASMCs induced by 5-HT. 5-HT1B antagonist rather than 5-HT1D antagonist inhibited 5-HT- and 5-HT1B/1D-induced proliferation of PASMC. Meanwhile, antisense ODN to ERK1/ 2 inhibited 5-HT-induced proliferation of PASMCs. 5-HT1B receptor and 5-HTT mediated mitogenesis of PASMCs by 5-HT and the intracellular signal transduction of 5-HT in PASMCs is dependent on ERKs signal pathway. PH compromised complicated pathology i.e. pulmonary vasoconstriction, vascular remodeling, inflammation and micro-thrombosis, in which multiple factors was involved. 5-HT1B receptor and 5-HTT mechanism are of importance induce PH and both might be novel therapeutic targets.

关键词： Pulmonary Hypertension

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Approach for mechanism of BH3 domain counterpart BH3I-2' inducing colorectal cancer cell apoptosis

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沈阳药科大学学报 2008年第S1期25卷 15-15页

作者： FENG Wan-yu,LIU Yang,ZHANG Zhi-cheng(The first affiliated hospital,china medical university,shenyang 110001,china)

Objective To discuss mechanism of BH3 domain counterpart BH3I-2' inducing colorectal cancer cell *** Detected inhibition ratio and apoptosis of colorectal cancer cells HCT-116,which were treated by BH3I-2',with microplate reader and flow *** Inhibition ratio of colorectal cancer cells,which were treated by BH3I-2',could reach about 50%.Ratio of viable apoptotic cell decreased and that of non-viable apoptotic cell increased as time *** BH3I-2' can induce colorectal cancer cell apoptosis.

关键词： BH3I-2’ apoptosis colorectal cancer cells flow cytometry

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Clinical characteristics of triple negative breast cancer in northeast Chinese patients

Clinical characteristics of triple negative breast cancer in...

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国际药理学术研讨会暨第三届两岸三地药理学学术会议

作者： Jie Ren,Zhao-Jin Yu,Lin Zhao,Feng Jin,Hai-Shan Zhao 1,Wei-Fan Yao, Min-Jie Wei~* Department of Pharmacology,Pharmaceutical College of china medical university, first affiliated hospital of china medical university,shenyang 1100011, china shenyang 110001 china

＜正＞Aim:Triple-negative breast cancer（TNBC）is defined by a lack of expression of estrogen receptor, progesterone receptor,and human epidermal growth factor receptor2（HER2）,which has a relatively aggressive clini... 详细信息

关键词： Triple -Negative Breast Cancer Clinical characteristics BRCA1

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麻醉前应用戊乙奎醚对冠脉搭桥术患者血流动力学和脑电双频指数的影响

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中国新药与临床杂志 2011年第9期30卷 667-669页

作者：方波马虹中国医科大学附属第一医院麻醉科辽宁沈阳110001

目的观察冠脉搭桥术麻醉前应用戊乙奎醚对麻醉诱导前后患者血流动力学和脑电双频指数(BIS)的影响。方法择期全麻下行冠脉搭桥术患者40例,随机分为2组,每组20例。戊乙奎醚组麻醉诱导前肌内注射(肌注)戊乙奎醚0.01 ***-1,东莨菪碱组肌注... 详细信息

目的观察冠脉搭桥术麻醉前应用戊乙奎醚对麻醉诱导前后患者血流动力学和脑电双频指数(BIS)的影响。方法择期全麻下行冠脉搭桥术患者40例,随机分为2组,每组20例。戊乙奎醚组麻醉诱导前肌内注射(肌注)戊乙奎醚0.01 ***-1,东莨菪碱组肌注东莨菪碱0.006 ***-1。观察比较2组麻醉诱导前后心率、血压、心率收缩压乘积(RPP)和BIS值。结果东莨菪碱组用药后收缩压和RPP无明显变化,用药后20 min患者心率有所上升,用药后10、20 min BIS值有所下降,但高于戊乙奎醚组(P<0.05)。戊乙奎醚组用药后10、20 min,患者心率、血压、RPP和BIS值均降低(P<0.05)。气管插管前后戊乙奎醚组心率、收缩压、RPP和BIS值多低于东莨菪碱组。2组均未见明显不良反应。结论应用戊乙奎醚作为冠脉搭桥术前用药,可降低心肌耗氧量,有利于患者血流动力学平稳和镇静。

关键词：戊乙奎醚东莨菪碱冠状动脉分流术血流动力学脑电双频指数

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Bacteriological and electron microscopic examination of primary intrahepatic stones

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Hepatobiliary & Pancreatic Diseases International 2006年第2期5卷 228-231页

作者： Shuo-Dong Wu, Hong Yu and Ji-Mei Sun Department of General Surgery Department of Microbiology Center Second affiliated Hos- pital china medical university, shenyang 110004, china Department of General Surgery Second Affiliated Hospital (Shengjing Hospital) China Medical University Shenyang 110004 China. wushuodong@***

BACKGROUND: Primary intrahepatic cholelithiasis is usually combined with biliary tract infection. This research was undertaken to investigate the relationship between intrahepatic stones and biliary tract infection. METHODS: Thirty-five bile samples and 30 stones specimens were cultured for bacteria and 12 stones specimens were examined with a scan electron microscope (SEM) or a transmission electron microscope (TEM). RESULT: 94.2% bile samples and 96.7% stones specimens were positive in bacteria culture. Bacteria were found in stones under SEM and TEM. CONCLUSION: Bacteria in stones are associated with the infection of the biliary tract.

关键词： cholelithiasis bacteria scan electron microscope transmission electron microscope biofilm

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围手术期支气管哮喘的处理

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中国实用内科杂志 2009年第4期29卷 297-299页

作者：李芹子孔灵菲中国医科大学附属第一医院呼吸疾病研究所沈阳110001

支气管哮喘是一种对多种刺激发生反应的慢性呼吸道炎症性疾病。目前,全世界有约2亿支气管哮喘患者,而且发病率在逐年上升,所以,支气管哮喘患者恰当的围手术期的治疗显得尤为重要。支气管哮喘患者围手术期肺部并发症的发病风险高,这些并... 详细信息

支气管哮喘是一种对多种刺激发生反应的慢性呼吸道炎症性疾病。目前,全世界有约2亿支气管哮喘患者,而且发病率在逐年上升,所以,支气管哮喘患者恰当的围手术期的治疗显得尤为重要。支气管哮喘患者围手术期肺部并发症的发病风险高,这些并发症导致严重的病死率。因此,在围手术期控制好支气管哮喘、防治肺部并发症对提高手术成功率十分重要。

关键词：哮喘围手术期

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Relevance between major depression disorder and respiratory diseases

Relevance between major depression disorder and respiratory ...

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中国药理学会药学监护专业委员会第一届第四次学术研讨会

作者： Huai-Liang Wang (china medical university,shenyang 110001,china)

Objective:there is a link between anxiety and respiratory symptoms,probably mediated by the serotonergic *** has been found that a high proportion of patients with panic disorder suffer from COPD and the prevalence of panic disorder has been shown to be higher in patients with *** selecetive serotonin reuptake inhibitors (SSRIs),such as fluoxetine,sertraline,paroxetine et al,are effective

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