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大肠癌肝转移患者血清中相关癌基因甲基化水平的检测

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中国临床医学 2016年第6期23卷 798-800页

作者：齐翀郝总洪亮殷庆章复旦大学附属上海市第五人民医院普通外科，上海 200240

目的:探讨大肠癌肝转移患者血清相关癌基因甲基化水平的变化。方法:选择2011年9月—2013年12月因原发性大肠癌入院伴或不伴肝转移患者各32例,分别作为试验组A和试验组B。所有患者在入院之前均未进行化疗或放疗。另选择20例健康体检者作... 详细信息

目的:探讨大肠癌肝转移患者血清相关癌基因甲基化水平的变化。方法:选择2011年9月—2013年12月因原发性大肠癌入院伴或不伴肝转移患者各32例,分别作为试验组A和试验组B。所有患者在入院之前均未进行化疗或放疗。另选择20例健康体检者作为对照组。提取研究对象血清中Dn.,采用甲基化特异性PCR法检测E-cad、ID4、ESR1、APC或HACE基因甲基化异常。结果:试验组A检测出19例E-cad、ID4、ESR1、APC或HACE甲基化异常;试验组B检测出10例Ecad、ID4、ESR1、APC或HACE甲基化异常;对照组未检测出E-cad、ID4、ESR1、APC或HACE甲基化异常。3组间差异有统计学意义(P<0.01)。结论:血清E-cad、ID4、ESR1、APC和HACE基因甲基化状态联合检测有利于大肠癌肝转移的临床诊治。

关键词：大肠癌肝转移甲基化癌基因

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油气藏岩石的应力和应变状态研究

新疆石油地质 2003年第4期24卷 351-352页

作者：李传亮杜文博西南石油学院石油工程系四川南充637001 中国石油玉门油田分公司勘探开发研究院甘肃玉门735200

岩石沉积过程中的应变状态为一维应变,而应力状态为三维应力;岩石在油气开采过程中的应变状态为三维应变,应力状态亦为三维应力;实验室测定的岩石压缩系数为三维应变状态下的数值,不需转换就可以直接应用于油藏工程研究;把压缩系数从三... 详细信息

岩石沉积过程中的应变状态为一维应变,而应力状态为三维应力;岩石在油气开采过程中的应变状态为三维应变,应力状态亦为三维应力;实验室测定的岩石压缩系数为三维应变状态下的数值,不需转换就可以直接应用于油藏工程研究;把压缩系数从三维应变状态向一维应变状态进行转换的传统作法是不妥当的,这使得油气藏岩石的弹性能量严重被低估。

关键词：油气藏岩石沉积应力状态油气开采

多灶性脉络膜炎及全葡萄膜炎患者的长期随访观察

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世界核心医学期刊文摘（眼科学分册） 2005年第5期1卷 17-17页

作者： Vian.a R.n.G. Ozdal P.C. Filho J.P.S. 程燕 Aven.e ary Pa rreiras 438 Niteroi Rio de Janeiro 2423-322 Brazil Dr.

Purpose: To report the visual progn.sis an. lon.term complication. in.patien.s with multifocal choroiditis an. pan.veitis (MCP). Methods: A retrospective stud y was performed with patien.s who met in.lusion.criteria for MCP at the Uveitis Clin.c, Royal Victoria Hospital, McGill Un.versity, Mon.real, Can.da. In.ormatio n.collected in.luded duration.of follow-up, visual acuity (VA) measured at each clin.cal visit, ocular an. systemic treatmen. an. ocular complication. observed durin. follow-up. Results: n.n.teen.patien.s (37 eyes) with MCP with a mean.fo llow-up of 76.9 mon.hs were studied. Kaplan.Meier survival an.lysis showed a d ecrease in.the proportion.of patien.s with a fin.l VA ≥20/40 over time. Cystoid macular oedema was seen.in.29.7%of the eyes an. was the most frequen. macular abn.rmality observed in.our group. On.the other han., choroidal n.ovascularizati on.was detected in.on.y six (16.2%) of the eyes, but was related to VA n.four of these eyes. Glaucoma was detected in.10.8%of the eyes. Cataract (po sterior subcapsular an./or n.clear) was the most common.lon.term complication. o ccurrin. in.40%of affected eyes. Cataract surgery improved the VA in.83.3%of t hese eyes. Con.lusion. The visual acuity of patien.s with MCP decreases with tim e. Visual loss can.occur from complication. followin. the in.lammation.itself an.d/or iatrogen.c in.uced by the chron.c use of corticosteroids.

关键词：葡萄膜炎脉络膜炎多灶性脉络膜新生血管黄斑囊样水肿黄斑病变白内障手术眼部并发症生存分析后囊

采用支架放置术或开放式手术缓解结直肠癌:一项对围手术期情况和长期生存率的回顾性定群研究

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世界核心医学期刊文摘（胃肠病学分册） 2005年第2期1卷 12-12页

作者： Carn. P.W.G. Frye J.n.R. Robertson.G.M. Frizelle F.A. 郝筱倩 Colorecta l Un.t Department of Surgery Christchurch Hospital Riccarton Avenue Christch urch New Zealand

PURPOSE: Expan.able,metallic sten.s provide a n.w modality of palliation.for p atien.s with n.n.urable metastatic colorectal aden.carcin.ma. This study was des ign.d to compare the use of expan.able metallic sten.s as a palliative measure t o tradition.l open.surgical man.gemen., with particular referen.e to len.th of s tay, an. survival. METHODS: Patien.s admitted between.1997 an. 2002 with left-s ided (splen.c flexure an. distal), colorectal aden.carcin.ma an. n.n.esectable m etastatic disease (Stage 4) were treated with expan.able metal sten.s or open.su rgery (resection. bypass, or stoma). The group of patien.s havin. sten.s in.erte d were compared with regard to perioperative outcome an. survival to those havin.g open.surgical procedures. RESULTS: Twen.y-two of 25 patien.s had colon.c sten.ts successfully in.erted an. 19 patien.s un.erwen. open.surgery. The two groups were comparable: sten.: median.age, 66 (ran.e, 37-88) years; 13 males; an. open.operation. median.age, 68 (ran.e, 51-85) years; 12 males. The tumors were prim ary in.22 sten.s procedures an. 18 open.operation.. The site of obstruction.was: splen.c flexure, 2 sten. vs. 0 open.operation. descen.in. colon. 2 sten. vs. 2 open.operation. sigmoid colon. 12 sten. vs. 6 open.operation. rectum, 9 sten. vs . 11 open.operation. The American.Society of An.sthesiologists (ASA) class was: ASA 1, 0 sten. vs. 0 open.operation. ASA 2, 6 sten. vs. 9 open.operation. ASA 3, 15 sten. vs. 7 open.operation. ASA 4, 4 sten. vs. 3 open.operation. The open.op eration. were laparotomy on.y (n.= 2), bypass (n.= 1), stoma (n.= 7), resection.with an.stomosis (n.= 4), resection.without an.stomosis (n.= 5). The complicatio n. after open.operation.were urin.0} (n.= 2), stroke (n.= 1), cardiac (n.= 2), r espiratory (n.= 2), deep vein.thrombosis (n.= 1), an.stomotic leak (n.= 1). Ther e were n. sten.-related complication.. The mean.len.th of stay was sign.fican.l y shorter in.the sten. group (4 vs. 10.4 days; P < 0.0001). There was

关键词：结直肠癌支架放置定群研究开放式手术围手术期长期生存率结直肠腺癌结肠支架金属支架左半结肠