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Prevalence and risk factors associated with metabolic dysfunctionassociated steatohepatitis in patients with Helicobacter pylori infection: A population-based study

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World Journal of Hepatology 2024年第10期16卷 1169-1176页

作者： Rashid Abdel-Razeq Lynn Bitar Elio R Bitar Chidera Onwuzo Mohamad-Noor Abu-Hammour Barish Eren islam mohamed Adejoke Johnson Antoine Boustany Somtochukwu Onwuzo Imad Asaad Department of Internal Medicine Cleveland Clinic FoundationClevelandOH 44111United States Faculty of Medicine Saint Joseph University of BeirutBeirut 11042020Lebanon Faculty of Medicine American University of BeirutBeirut 11072020Lebanon Department of Medicine&Surgery General Hospital Lagos IslandLagos Island 101223LagosNigeria Department of Internal Medicine Jacobi Medical Center/North Central Bronx HospitalBronxNY 10461United States Division of Gastroenterology Department of Internal MedicineUniversity of Florida College of MedicineJacksonvilleFL 32209United States Department of Gastroenterology Allegheny General HospitalPittsburghPA 15212United States Department of Gastroenterology Firelands HealthSanduskyOH 44870United States

BACKGROUND Helicobacter pylori(***)is associated with the development of gastrointestinal disorders ranging from gastritis to gastric *** evidence of the association between metabolic dysfunction-associated steatohepatitis(MASH)and *** infection in the literature is ***,we aim to evaluate the risk of developing MASH in patients who have had a diagnosis of *** infection independently of any confounding *** To evaluate the risk of developing MASH in patients who have had a diagnosis of *** *** This study used a validated multicenter research database of over 360 hospitals across 26 healthcare systems across the United States from 1999 to *** regression analysis assessed the risk of developing MASH,adjusting for confounders including *** infection,obesity,type 2 diabetes,hypertension,dyslipidemia,and male gender.A two-sided P value<0.05 was considered as statistically significant,and all statistical analyses were performed using R version 4.0.2(R Foundation for Statistical Computing,Vienna,Austria,2008).RESULTS A total of 79476132 individuals were screened in the database and 69232620 were selected in the final analysis after accounting for inclusion and exclusion ***(14.30%),patients with hyperlipidemia(70.35%),hypertension(73.86%),diabetes mellitus type 2(56.46%),and obese patients(58.15%)were more common in patients with MASH compared to *** a multivariate regression analysis,the risk of MASH was increased in diabetics[odds ratio(OR):3.55;95%CI:3.48-3.62],obese(OR:5.93;95%CI:5.81-6.04),males(OR:1.49;95%CI:1.46-1.52),individuals with hyperlipidemia(OR:2.43;95%CI:2.38-2.49)and *** infection(OR:2.51;95%CI:2.31-2.73).CONCLUSION This is the largest population-based study in the United States illustrating an increased prevalence and odds of developing MASH in patients with *** infection after adjusting for risk factors.

关键词： Metabolic dysfunction-associated steatohepatitis Metabolic dysfunction-associated steatotic liver disease Helicobacter Pylori Cirrhosis Liver

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Hepatocellular carcinoma national burden across different geographical regions in the United States between 2001 and 2020

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World Journal of Methodology 2024年第4期14卷 110-120页

作者： Yazan Abboud Raj Malhotra Muhammad Hassaan Arif Maan Anna Mathew Ibrahim Abboud Chun-Wei Pan Saqr Alsakarneh Fouad Jaber islam mohamed David Kim Nikolaos T Pyrsopoulos Department of Internal Medicine Rutgers New Jersey Medical SchoolNewarkNJ 07103United States University of California Riverside School of Medicine RiversideCA 92521United States Department of Internal Medicine John H Stroger Hospital of Cook CountyChicagoIL 60612United States Department of Internal Medicine University of Missouri-Kansas CityKansasMO 64108United States Division of Gastroenterology and Hepatology Rutgers New Jersey Medical SchoolNewarkNJ 07101United States

BACKGROUND While prior data showed an increasing incidence of hepatocellular carcinoma(HCC)in the United States,there are limited comprehensive and comparative data on the geographical variations of HCC trends in different demographicspecific *** To evaluate sex and age-specific incidence rates and time trends in different geographical regions in the United *** Age-adjusted HCC incidence rates were collected from the United States Cancer Statistics(USCS)database which covers approximately 98%of the population in the United *** rates were stratified by sex,age,and geographical *** percentage change(APC)and average APC(AAPC)were estimated using Joinpoint Regression.A pairwise comparison was conducted between sex-specific *** There were 467344 patients diagnosed with HCC in the United States in the USCS database between 2001 and *** rates and trends varied by geographical *** looking at the West region(115336 patients),incidence rates of HCC were overall increasing and also increasing in older ***,when evaluating younger adults,HCC incidence rates decreased in men but not in women with a sex-specific absolute AAPC-difference of 2.15(P=0.005).When evaluating the Midwest region(84612 patients),similar results were *** incidence rates were increasing in the overall population and in older adults as well,they were decreasing in younger men but not in women with a sex-specific absolute AAPC-difference of 1.61(P<0.001).For the Northeast region(87259 patients),the analysis showed similar results with decreasing HCC incidence rates in younger men but not counterpart women(Sex-specific AAPC-difference=3.26,P<0.001).Lastly,when evaluating the south(180137 patients),the results were also decreasing in younger men but not in women(Sex-specific AAPC-difference=2.55,P<0.001).CONCLUSION Nationwide analysis covering around 98%of the United States population shows an increasing incidence of HCC across all

关键词： Hepatocellular carcinoma Incidence Epidemiology Health disparity Geography

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Remimazolam for sedation in gastrointestinal endoscopy:A comprehensive review

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World Journal of Gastrointestinal Endoscopy 2024年第7期16卷 385-395页

作者： Dushyant Singh Dahiya Ganesh Kumar Syeda Parsa Manesh Kumar Gangwani Hassam Ali Amir Humza Sohail Saqr Alsakarneh Umar Hayat Sheza Malik Yash R Shah Bhanu Siva Mohan Pinnam Sahib Singh islam mohamed Adishwar Rao Saurabh Chandan Mohammad Al-Haddad Division of Gastroenterology Hepatology&MotilityThe University of Kansas School of MedicineKansas CityMO 66160United States Department of Internal Medicine Chandka Medical CollegeSindh 77280Pakistan Department of Gastroenterology and Hepatology University of Arkansas For Medical SciencesLittle RockAR 72205United States Division of Gastroenterology Hepatology and NutritionEast Carolina University/Brody School of MedicineGreenvilleNC 27858United States Department of Surgery University of New Mexico School of MedicineAlbuquerqueNM 87106United States Department of Internal Medicine University of Missouri-Kansas CityKansas CityMO 64108United States Department of Internal Medicine Geisinger Wyoming Valley Medical CenterWilkes BarrePA 18711United States Department of Internal Medicine Rochester General HospitalRochesterNY 14621United States Department of Internal Medicine Trinity Health Oakland/Wayne State UniversityPontiacMI 48341United States Department of Internal Medicine John H.Stroger Hospital of Cook CountyChicagoIL 60612United States Department of Internal Medicine Sinai hospitalBaltimoreMD 21215United States Department of Hepatology University of MissouriColumbiaMO 65211United States Department of Internal Medicine Guthrie Robert Packer HospitalSayrePA 18840United States Division of Gastroenterology and Hepatology Creighton University School of MedicineOmahaNE 68131United States Division of Gastroenterology and Hepatology Indiana University School of MedicineIndianapolisIN 46202United States

Worldwide,a majority of routine endoscopic procedures are performed under some form of sedation to maximize patient ***,benzodiazepines and opioids continue to be widely ***,in recent years,Remimazolam is gaining immense popularity for procedural sedation in gastrointestinal(GI)*** is an ultra-short-acting benzodiazepine sedative which was approved by the Food and Drug Administration in July 2020 for use in procedural *** has shown a favorable pharmacokinetic and pharmacodynamic profile in terms of its non-specific metabolism by tissue esterase,volume of distribution,total body clearance,and negligible drug-drug *** also has satisfactory efficacy and has achieved high rates of successful sedation in GI ***,studies have demonstrated that the efficacy of Remimazolam is non-inferior to Propofol,which is currently a gold standard for procedural sedation in most parts of the ***,the use of Propofol is associated with hemodynamic instability and respiratory *** contrast,Remimazolam has lower incidence of these adverse effects intra-procedurally and hence,may provide a safer alternative to Propofol in procedural *** this comprehensive narrative review,highlight the pharmacologic characteristics,efficacy,and safety of Remimazolam for procedural *** also discuss the potential of Remimazolam as a suitable alternative and how it can shape the future of procedural sedation in gastroenterology.

关键词： Remimazolam Endoscopy Sedation Outcomes Efficacy Safety Pharmacokinetics

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Digital Watermarking Scheme for Securing Textual Database Using Histogram Shifting Model

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Computers, Materials & Continua 2022年第6期71卷 5253-5270页

作者： Khalid A.El Drandaly Walid Khedr islam S.mohamed Ayman mohamed Mostafa Faculty of Computers and Informatics Zagazig UniversityZagazig44519Egypt College of Computer and Information Sciences Jouf UniversitySakaka72314Saudi Arabia

Information security is one of the most important methods of protecting the confidentiality and privacy of internet *** greater the volume of data,the more the need to increase the security methods for protecting data from *** task can be challenging for researchers in terms of managing enormous data and maintaining their safety and *** of digital content is a major issue in maintaining the privacy and secrecy of *** this end,digital watermarking is based on the concept of information security through the insertion and detection of an embedded watermark in an efficient *** methodologies in the research on digital watermarking result in data distortion after embedding the *** scenario can reduce the efficiency of detecting watermarks as well as violate data *** study adapts a robust reversible histogram shifting(HS)technique for textual data in relational ***,the study presents a digital watermarking scheme intended for document copyright protection and proof of *** major advantage of the proposed watermarking scheme is that it can protect digital data and preserve data *** the best of our knowledge,this research methodology is promising for use in the HS expansion model for watermarking data on nonnumeric *** addition,the results showed that despite exposing the database to an insertion attacks at 50%and 75%of the watermark,the proposed algorithm can recovermore than half of the embedded watermark in all addition and alteration attacks *** a result,the watermark information can be retained and restored completely.

关键词： Information security digital watermarking information hiding histogram shifting technique

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Preparation of ammonium nitrate-based solid composite propellants supplemented with polyurethane/nitrocellulose blends binder and their thermal decomposition behavior

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Defence Technology（防务技术） 2022年第11期18卷 2023-2033页

作者： Sabri Touidjine Moulai Karim Boulkadid Djalal Trache Samir Belkhiri Abderrahmane Mezroua mohamed islam Aleg Afaf Belkebiche Energetic Propulsion Laboratory Teaching and Research Unit of Energetic ProcessesEcole Militaire PolytechniqueBP 17Bordj-El-Bahri16046AlgiersAlgeria Energetic Materials Laboratory Teaching and Research Unit of Energetic ProcessesEcole Militaire PolytechniqueBP 17Bordj-El-Bahri16046AlgiersAlgeria

To improve the performance of solid composite propellants(SCPs)supplemented with ammonium nitrate(AN)as an oxidizer,the incorporation of energetic ingredients such as explosives,energetic binders or catalysts is a common effective *** this purpose,polyurethane(PU),a typical inert binder,was mixed with nitrocellulose(NC)as an energetic *** composite solid propellant compositions based on AN and NC-modified polyurethane binder with different NC ratios were *** prepared formulations were characterized using Fourier transform infrared spectroscopy(FTIR),RAMAN spectroscopy,X-ray diffraction(XRD),electron densimetry,thermogravimetric(TG)analysis,and differential scanning calorimetry(DSC).A kinetic study was then performed using the iterative KissingerAkahira-Sunose(It-KAS),Flynn-Wall-Ozawa(It-FWO),and non-linear Vyazovkin integral with compensation effect(VYA/CE)*** theoretical performances,such as theoretical specific impulse,adiabatic flame temperature,and ideal exhaust gaseous species,were also determined using the NASA Lewis Code,Chemical Equilibrium with Application(CEA).Spectroscopic examinations revealed the existence of NC and full polymerization of PU in the prepared *** to density tests,the density of the propellant increases as the nitrocellulose component *** to the thermal analysis and kinetics study,the increase in NC content catalyzed the thermal decomposition of the AN-based composite solid *** on the theoretical study,increasing the amount of NC in the propellant increased the specific impulse and,as a result,the overall performance.

关键词： Composite propellants Polyurethane Nitrocellulose Ammonium nitrate Decomposition kinetics Thermal decomposition

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