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Interaction between tumor stage and age on survival outcomes of patients with anaplastic thyroid cancer

World Journal of Experimental Medicine 2024年第3期14卷 90-100页

作者： Ayrton I Bangolo Auda Auda John Bukasa-Kakamba Nayan Bhakta Shraboni Dey Anupriya lilhori Gowry Reddy Budoor Alqinai Aman Sidiqui Imranjot Sekhon Barbare Khatiashvili Iqra Abbas Sandra Kunnel Amer Jarri Emelyn Martinez Deborah Daoud ishita gupta Harshini Gompa Silvanna Pender Dana Aljaberi Hamed Aljanaahi Sandra S Kunnel Yingxia Xiao Yoontae Jung Sneha Nagpaul Afshan Naz Tejaswee Mallela Phyo Maung Maung Ibtihal Y Khalaf Soobee Kim Roua Alrestom Aditya Gajera Hiba Alkealy Deepti Kansal Sonam Dhall Sanya Satheesha Simcha Weissman Pierre Fwelo Department of Internal Medicine Palisades Medical CenterNorth BergenNJ 07047United States Department of Medicine Palisades Medical CenterNorth BergenNJ 07047United States Department of Endocrine and Metabolic Disorders University of KinshasaKinshasa KinshasaCongo Department of Epidemiology Human Geneticsand Environmental SciencesUTHealth School of Public HealthHoustonTX 77030United States

BACKGROUND Anaplastic thyroid cancer(ATC)is an aggressive,rare malignancy associated with rapid growth and metastasis,and a very poor *** investigated the clinical characteristics,survival outcomes and independent prognostic factors associated with anaplastic thyroid *** To assess to what extent the interaction between age and tumor stage affects *** A total of 622 patients diagnosed with anaplastic thyroid cancer,between 2010 and 2017 were enrolled in our study by retrieving data from the Surveillance,Epidemiology and End Results(SEER)*** analyzed demographics,clinical characteristics,overall mortality(OM)and cancer specific mortality(CSM)of *** with a P value<0.1 were incorporated into the multivariate cox model to determine the independent prognostic ***,we analyzed the interaction between age and tumor stage on *** In the multivariate analyses,the divorced/separated population had a lower OM[hazard ratio(HR)=0.63,95%CI:0.42-0.94,P<0.05]and CSM(HR=0.61,95%CI:0.40-0.92,P<0.05).OM was higher in tumors with direct extension only(HR=6.26,95%CI:1.29-30.42,P<0.05)and tumors with distant spread(HR=5.73,95%CI:1.34-24.51,P<0.05).CSM was also higher in tumors with direct extension(HR=5.05,95%CI:1.05-24.19,P<0.05)and tumors with distant spread(HR=4.57,95%CI:1.08-19.29,P<0.05).Mortality was not adversely affected by lymph node *** was lower in patients who received radiation(HR=0.66,95%CI:0.53-0.83,P<0.01),chemotherapy(HR=0.63,95%CI:0.50-0.79,P<0.01)or surgery(HR=0.53,95%CI:0.43-0.66,P<0.01).CSM was also lower in patient who received radiation(HR=0.64,95%CI:0.51-0.81,P<0.01),chemotherapy(HR=0.62,95%CI:0.50-0.78,P<0.01)or surgery(HR=0.51,95%CI:0.41-0.63,P<0.01).There was no significant interaction between age and tumor stage that affected *** In this large US SEER database retrospective study,we found the mortality to be higher in advanced stage tumors with direct extensi

关键词： Undifferentiated thyroid cancer Survival outcome Prognosis Metastasis Clinical trials Interaction

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Visualizing traumatic brain injury:ocular clues for diagnosis and assessment

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Neural Regeneration Research 2025年第5期20卷 1399-1400页

作者： Morteza Abyadeh Vivek gupta Yuyi You Joao A.Paulo Mehdi Mirzaei ProGene Technologies Pty Ltd SydneyNSWAustralia Department of Clinical Medicine Faculty of MedicineHealth and Human SciencesMacquarie Medical SchoolMacquarie UniversityMacquarie ParkNorth RydeSydneyNSWAustralia Department of Cell Biology Harvard Medical SchoolBostonMAUSA

Traumatic brain injury (TBI) is defined as damage to the brain resulting from an external sudden physical force or shock to the *** is considered a silent public health epidemic causing significant death and disability *** were 64,000 TBI related deaths reported in the USA in 2020,with about US$76 billion in direct and indirect medical costs annually.

关键词： diagnosis ocular injury

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A Comprehensive Survey on Federated Learning Applications in Computational Mental Healthcare

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Computer Modeling in Engineering & Sciences 2025年第1期142卷 49-90页

作者： Vajratiya Vajrobol Geetika Jain Saxena Amit Pundir Sanjeev Singh Akshat Gaurav Savi Bansal Razaz Waheeb Attar Mosiur Rahman Brij B.gupta Institute of Informatics and Communication University of DelhiDelhi110021India Maharaja Agrasen College University of DelhiDelhi110096India Computer Engineering Ronin InstituteMontclairNJ 07043USA Department of Research and Innovation Insights2TechinfoJaipur302001India University Centre for Research and Development(UCRD) Chandigarh UniversityChandigarh140413India Management Department College of Business AdministrationPrincess Nourah bint Abdulrahman UniversityRiyadh11671Saudi Arabia CCRI&Department of Computer Science and Information Engineering Asia UniversityTaichung413Taiwan Symbiosis Centre for Information Technology(SCIT) Symbiosis International UniversityPune411057India Center for Interdisciplinary Research University of Petroleum and Energy Studies(UPES)Dehradun248007India

Mental health is a significant issue worldwide,and the utilization of technology to assist mental health has seen a growing *** aims to alleviate the workload on healthcare professionals and aid *** applications have been developed to support the challenges in intelligent healthcare ***,because mental health data is sensitive,privacy concerns have *** learning has gotten some *** research reviews the studies on federated learning and mental health related to solving the issue of intelligent healthcare *** explores various dimensions of federated learning in mental health,such as datasets(their types and sources),applications categorized based on mental health symptoms,federated mental health frameworks,federated machine learning,federated deep learning,and the benefits of federated learning in mental health *** research conducts surveys to evaluate the current state of mental health applications,mainly focusing on the role of Federated Learning(FL)and related privacy and data security *** survey provides valuable insights into how these applications are emerging and evolving,specifically emphasizing FL’s impact.

关键词： Depression emotional recognition intelligent healthcare systems mental health federated learning stress detection sleep behaviour

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Intricacies during pregnancy with gestational diabetes mellitus

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World Journal of Clinical Cases 2025年第1期13卷 62-64页

作者： Richa Rattan Rimesh Pal Parul Chawla gupta Arvind Kumar Morya Ripunjay Prasad Department of Endocrinology Post Graduate Institute of Medical Education and ResearchChandigarh 160012India Department of Ophthalmology Post Graduate Institute of Medical Education and ResearchChandigarh 160012PunjabIndia Department of Ophthalmology All India Institute of Medical SciencesHyderabad 508126TelanganaIndia Department of Ophthalmology RP Eye InstituteDelhi 110001India

The study by Cao et al aimed to identify early second-trimester biomarkers that could predict gestational diabetes mellitus(GDM)development using advanced proteomic techniques,such as Isobaric tags for relative and absolute quantitation isobaric tags for relative and absolute quantitation and liquid chromatography-mass spectrometry liquid chromatography-mass *** analysis revealed 47 differentially expressed proteins in the GDM group,with retinol-binding protein 4 and angiopoietin-like 8 showing significantly elevated serum levels compared to *** these findings are promising,the study is limited by its small sample size(n=4 per group)and lacks essential details on the reproducibility and reliability of the protein quantification methods ***,the absence of experimental validation weakens the interpretation of the protein-protein interaction network identified through bioinformatics *** study's focus on second-trimester biomarkers raises concerns about whether this is a sufficiently early period to implement preventive interventions for *** GDM risk during the first trimester or pre-conceptional period may offer more clinical *** its limitations,the study presents valuable insights into potential GDM biomarkers,but larger,well-validated studies are needed to establish their predictive utility and generalizability.

关键词： Gestational diabetes mellitus Biomarkers Differentially expressed proteins Retinol-binding protein 4 Angiopoietin-like 8 Proteomics Lifestyle interventions Early prediction

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COVID-19 status quo:Emphasis on gastrointestinal and liver manifestations

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World Journal of Gastroenterology 2021年第46期27卷 7969-7981页

作者： Abhishek Bhurwal Carlos D Minacapelli Evan Orosz Kapil gupta Christopher Tait ishita Dalal Clark Zhang Eric Zhao Vinod K Rustgi Department of Medicine Division of Gastroenterology and HepatologyRutgers Robert Wood Johnson Medical SchoolNew BrunswickNJ 08901United States Center for Liver Diseases and Masses Rutgers Robert Wood Johnson School of MedicineNew BrunswickNJ 08901United States Department of Internal Medicine Rutgers Robert Wood Johnson Medical SchoolNew BrunswickNJ 08901United States

The coronavirus disease 2019(COVID-19)has caused one of the worst public health crises in modern *** though severe acute respiratory syndrome coronavirus 2 primarily affects the respiratory tract,gastrointestinal manifestations are well described in *** review will discuss the epidemiology,virology,manifestations,immunosuppressant states,and lessons learned from ***:At the time of writing,COVID-19 had infected more than 111 million people and caused over 2.5 million deaths *** medical comorbidities including obesity,pre-existing liver condition and the use of proton pump inhibitor have been described as risk factor for severe ***-19 most frequently causes diarrhea(12.4%),nausea/vomiting(9%)and elevation in liver enzymes(15%-20%).The current data does not suggest that patients on immunomodulators have a significantly increased risk of mortality from *** current guidelines from American Gastroenterological Association and American Association for the Study of Liver Diseases do not recommend pre-emptive changes in patients on immunosuppression if the patients have not been infected with *** and relevance:The COVID-19 pandemic has prompted a change in structure and shape of gastroenterology departmental *** should be performed only when necessary and with strict protective *** consultations in the form of telehealth services and home drug deliveries have revolutionized the field.

关键词： COVID-19 Status quo Epidemiology Virology Gastrointestinal manifestations Liver manifestations Immunosuppressed states

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Evaluation of graphite depressants in a poly-metallic sulfide flotation circuit

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International Journal of Mining Science and Technology 2017年第2期27卷 285-292页

作者： Nikhil gupta Department of Mining and Minerals Engineering Virginia Polytechnic Institute and State UniversityBlacksburgVA 24061USA

Synthetic dyes are commonly used for graphite depression in poly-metallic flotation circuits; however,these dyes can be very expensive. The aim of this study is to evaluate performance of certain low-cost alternative depressants for a complex lead-zinc(Pb-Zn) ore rich in graphite(Gr-C) on a conventional mini pilot-scale flotation circuit. The reagents used were commercial and industrial grade starch; agro-based waste-sugarcane bagasse and charred(burnt) bagasse powder. The primary evaluation criteria were quality(grades) of lead and zinc concentrates, their recoveries(%), and graphite rejection(%) in the *** tests using nigrosine as graphite depressant showed 94.3% rejection of Gr-C. The results with commercial starch were found as effective with 93.8% graphite rejection. Furthermore, bagasse powder showed potential in improving product quality(36.4% and 65.6% Pb grade and recovery) with an intermediate effectiveness in graphite rejection(85.6%). The order of effectiveness in Gr-C rejection follows nigrosine % commercial starch > bagasse > industrial starch > charred bagasse. In addition, the effect these depressants on silver(byproduct) grade and recovery was also investigated.

关键词： Graphite depressants Sulfide flotation Dyes Starch Bagasse Hydrophobic impurities

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Asymptotic and Partial Asymptotic Hankel Operators on H^2(D^n)

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Acta Mathematica Sinica,English Series 2019年第11期35卷 1729-1740页

作者： Anuradha gupta Bhawna gupta Department of Mathematics Delhi College of Arts and CommerceNetaji NagarUniversity of DelhiDelhiIndia Department of Mathematics University of DelhiDelhiIndia

In this paper,we generalize the concept of asymptotic Hankel operators on H2(D)to the Hardy space H2(Dn)(over polydisk)in terms of asymptotic Hankel and partial asymptotic Hankel operators and investigate some properties in case of its weak and strong ***,we introduce ith-partial Hankel operators on H2(Dn)and obtain a characterization of its compactness for n>*** main results include the containment of Toeplitz algebra in the collection of all strong partial asymptotic Hankel operators on H2(Dn).It is also shown that a Toeplitz operator with symbolφis asymptotic Hankel if and only if φ is holomorphic function in L∞(Tn).

关键词： Hankel operator Asymptotic Hankel operator partial asymptotic Hankel operator i(th)-partial Hankel operator i(th)-partial big Hankel operator

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Stability and weighted sensitivity analysis of robust controller for heat exchanger

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Control Theory and Technology 2020年第1期18卷 56-71页

作者： Sapna gupta Rajeev gupta Subhransu PADHEE Department of Electronics Engineering Rajasthan Technical UniversityKotaRajasthanIndia Department of Electrical and Electronics Engineering Aditya Engineering College{Autonomous)SurampalemAndhra PradeshIndia

This study presents a parametric system identification approach to estimate the dynamics of a chemical plant from experimental data and develops a robust PID controller for the *** system identification of the heat exchanger system has been carried out using experimental data and prediction error *** estimated model of the heat exchanger system is a time-delay model and a robust PID controller for the time-delayed model has been designed considering weighted sensitivity *** mathematical background of parametric system identification,stability analysis,and H∞ weighted sensitivity analysis have been provided in this paper.A graphical plot has been provided to determine the stability region in the(Kp,Ki),(Kp,Kd)and(KuKd)*** stability region is a locus dependent on parameters of the controller and frequency,in the parameter plane.

关键词： Heat exchanger parametric system identification prediction error method PID controller robust stability analysis weighted sensitivity analysis

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Influence of Various Parameters on Collapse Behaviour of Thin Cylinders

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上海交通大学学报 2004年第z2期38卷 1-7页

作者： N K gupta Applied Mechanics Department ⅡT Delhi India - 110016

Axial compression experiments on as received aluminum tubes and tubes with wall thickness eccentricity incorporated by off centre machining showed that the eccentricity caused transition of their collapse mode from axisymmetric to diamond. The numerical simulation of the collapse phenomenon was undertaken using a static non-linear Finite Element Analysis in ANSYS, and results are found to compare well with the experimental load compression and energy absorption responses for axisymmetric concertina and non-axisymmetric diamond modes. Having validated the numerical model with experiments, it has been used to undertake a systematic study of the load - compression characteristics and collapse mode transitions of the tubes with varying eccentricities in wall thickness and boundary conditions, as well as the material properties.

关键词： thin tube collapse thickness eccentricity ANSYS axial compression

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Active Learning Query Strategies for Classification,Regression,and Clustering:A Survey

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Journal of Computer Science & Technology 2020年第4期35卷 913-945页

作者： Punit Kumar Atul gupta Indian Institute of Information Technology Design and ManufacturingJabalpurMadhya Pradesh 482005India

Generally,data is available abundantly in unlabeled form,and its annotation requires some *** labeling,as well as learning cost,can be minimized by learning with the minimum labeled data *** learning(AL),learns from a few labeled data instances with the additional facility of querying the labels of instances from an expert annotator or *** active learner uses an instance selection strategy for selecting those critical query instances,which reduce the generalization error as fast as *** process results in a refined training dataset,which helps in minimizing the overall *** key to the success of AL is query strategies that select the candidate query instances and help the learner in learning a valid *** survey reviews AL query strategies for classification,regression,and clustering under the pool-based AL *** query strategies under classification are further divided into:informative-based,representative-based,informative-and representative-based,and ***,more advanced query strategies based on reinforcement learning and deep learning,along with query strategies under the realistic environment setting,are *** a rigorous mathematical analysis of AL strategies,this work presents a comparative analysis of these ***,implementation guide,applications,and challenges of AL are discussed.

关键词： active learning active learning query strategy active classification active regression active clustering deep active learning

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