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Exposure of Phosphatidylserine to the Cell Surface

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Exposure of Phosphatidylserine to the Cell Surface

Initial testing of ohmic heating through double flux swing during electron cyclotron start-up in the QUEST spherical tokamak

第十一届全国免疫学学术大会

作者： Shigekazu nagata Biochemistry & Immunology Immunology Frontier Research Center Osaka University

Phosphatidylserine(Ptd Ser),one of most abundant phospholipids in eukaryotic plasma membranes,is usually kept at the inner leaflets of plasma membranes by the action of ATP-dependent enzyme called"flippase".Ptd Ser is scrambled by a scramblase(s)between the inner and outer leaflets of the plasma membranes in various biological processes such as apoptosis and activation of *** Ptd Ser,thus exposed to the cell surface,works

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Plasma Science and Technology 2023年第5期25卷 31-36页

作者：张逸凡 Takumi ONCHI Kazuo NAKAMURA 岳其霖 Takahiro nagata Shoji KAWASAKI Kengoh KURODA Makoto HASEGAWA Ryuya IKEZOE Takeshi IDO Kazuaki HANADA Hiroshi IDEI Interdisciplinary Graduate School of Engineering Sciences Kyushu UniversityKasuga 816-8580Japan Research Institute for Applied Mechanics Kyushu UniversityKasuga 816-8580Japan

A power-supply system was developed for Ohmic heating(OH)to double×10^(18)the amount of change magnetic flux in the primary central solenoid(CS)on the QUEST spherical *** power supplies are connected with stacks of insulated-gate bipolar transistors,and sequentially operated to generate positive and negative CS *** bipolar power-supply system is controlled via a field-programmable gate array,which guarantees the safety of the entire system *** new OH system,assisted by electron cyclotron heating,enables the stable generation of plasma currents exceeding 100 k ***,the achieved electron density over the wide range in the major radial direction exceeds the cut-off density for one of the highpower microwave sources in *** strategy yields target plasmas for future experiments with the electron Bernstein wave.

关键词： spherical tokamak ohmic heating electron cyclotron heating FPGA

An Explanatory Study Approach,Using Machine Learning to Forecast Solar Energy Outcome

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Journal of Energy and Power Engineering 2022年第2期16卷 81-89页

作者： Agada Ihuoma Nkechi nagata Yasunori Department of Electrical and Electronics Engineering University of the RyukyusOkinawa 903-0213Japan

AI(artificial intelligence)techniques play a crucially important role in predicting the expected energy outcome and its performance,analysis,modeling and control of renewable *** energy usage has grown exponentially over the *** the face of global energy consumption and increased depletion of most fossil fuel,the world is faced with the challenges of meeting the ever-increasing energy demands,also utility companies who provide solar energy have a challenge of unstable input of solar energy to the grid due to its intermittent nature,unlike other sources,hence the difference between expected generation and actual generation,demand and supply can lead to an unbalanced ***,incorporating accurately machine learning technology to predict the expected outcome of solar energy from the intermittent solar radiation will be crucial to keep a balance grid operation between supply and demand,production planning and energy management especially during installations of a photovoltaic power ***,one of the major problems of forecasting is the algorithms used to control,model,and predict performances of the energy systems which are complicated and involve large computer power,differential equations,and time *** having unreliable data(poor quality)for solar radiation over a geographical location as well as insufficient long series can be a bottleneck to *** overcome these problems,we employ the Anaconda Navigator(Jupyter Notebook)for machine learning which can combine large amounts of data with fast,iterative processing and intelligent algorithms allowing the software to learn automatically from patterns or features to predict the performance and outcome of Solar Energy which in turn enables the balance between supply and demand on loads,efficient operation of the utility company as well as enhances power production planning and management.

关键词： AI backward elimination data mining machine learning linear regression solar energy.

At wavelength coherent scatterometry microscope using high-order harmonics for EUV mask inspection

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International Journal of Extreme Manufacturing 2019年第3期1卷 1-12页

作者： Yutaka nagata Tetsuo Harada Takeo Watanabe Hiroo Kinoshita Katsumi Midorikawa RIKEN Center for Advanced Photonics RIKEN2-1 HirosawaWako Saitama 351-0198Japan Center for EUV Lithography Laboratory of Advanced Science and Technology for IndustryUniversity of HyogoKamigoriHyogo 678-1205Japan

In this review,we describe our research on the development of the 13.5 nm coherent microscope using high-order harmonics for the mask inspection of extreme ultraviolet(EUV)*** lithography is a game-changing piece of technology for high-volume manufacturing of commercial *** top manufacturers apply EUV technology for fabricating the most critical layers of 7 nm *** and inspection of defect-free masks,however,still remain critical issues in EUV ***,in our pursuit for a resolution,we have developed the coherent EUV scatterometry microscope(CSM)system with a synchrotron radiation(SR)source to establish the actinic metrology,along with inspection *** intensity and phase images of patterned EUV masks were reconstructed from diffraction patterns using ptychography *** expedite the practical application of the CSM,we have also developed a standalone CSM,based on high-order harmonic generation,as an alternative to the *** the application of a coherent 13.5 nm harmonic enabled the production of a high contrast diffraction pattern,diffraction patterns of sub-100 ns size defects in a 2D periodic pattern mask could be *** of intensity and phase images from diffraction patterns were also performed for a periodic line-and-space structure,an aperiodic angle edge structure,as well as a cross pattern in an EUV mask.

关键词： high-order harmonics coherent EUV light EUV lithography coherent EUV scatterometry microscope synchrotron radiation EUV mask inspection

Structures of Stoichiometric Sodium Oxide Cluster Cations Studied by Ion Mobility Mass Spectrometry

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Chinese Journal of Chemical Physics 2019年第2期32卷 193-199,I0002页

作者： Motoyoshi Nakano Yudai Ishimura Riki Hotta Daiki Hebiguchi Toshiaki nagata Fuminori Misaizu Institute for Excellence in Higher Education Tohoku University 41 Kawauchi Aoba-ku Sendai 980-8576 Japan Department of Chemistry Graduate School of Science Tohoku University 6-3 Aoba Aramaki Aoba-ku Sendai 980-8578 Japan

Structures of stable compositions of sodium oxide cluster cations (NanOm+,n≤11) have been investigated by ion mobility mass spectrometry. Stoichiometric compositions series, Na(Na2O)(n-1)/2^+(n=3, 5, 7, 9, and 11), were observed as stable composition series, and NaO(Na2O)(n-1)/2^+ series (n=5, 7, 9, and 11) were observed as secondary stable series in the mass spectra. To assign the structures of these cluster ion series, collision cross sections between the ions and helium buffer gas were determined experimentally from the ion mobility measurements. Theoretical collision cross sections were also calculated for optimized structures of these compositions. Finally, the structures of Na(Na2O)(n-1)/2^+ and NaO(Na2O)(n-1)/2^+ were assigned to those having similar structural frames for each n except for n=9. All bonds in the assigned structures of Na(Na2O)(n-1)/2^+ were between sodium and oxygen. On the other hand, there was one O-O bond in addition to Na-O bonds in NaO(Na2O)(n-1)/2^+. This result indicates that NaO(Na2O)(n-1)/2^+ have a peroxide ion (O22-) as a substitute for an oxide ion (O2-) of Na(Na2O)(n-1)/2^+. As a result, both stable series, Na(Na2O)(n-1)/2^+ and NaO(Na2O)(n-1)/2^+, are closed-shell compositions. These closed-shell characteristics have a strong influence on the stability of sodium oxide cluster cations.

关键词： Sodium oxide cluster Structure Ion mobility mass spectrometry

Effect of educational intervention on attitudes toward the concept of criminal responsibility

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World Journal of Psychiatry 2017年第4期7卷 197-206页

作者： Akihiro Shiina Tomihisa Niitsu Aiko Sato Soichiro Omiya Takako nagata Aika Tomoto Hiroyuki Watanabe Yoshito Igarashi Masaomi Iyo Division of Medical Treatment and Rehabilitation Chiba University Center for Forensic Mental Health Department of Psychiatry Graduate School of Medicine Chiba University Social Psychiatry and Mental Health Faculty of Medicine University of Tsukuba Ministry of Health Labour and Welfare Division of Law and Psy-chiatry Chiba University Center for Forensic Mental Health

AIM To evaluate the effect of educational intervention on individuals' knowledge of and attitudes toward forensic mental *** We conducted a questionnaire regarding attitudes toward various ideas about forensic mental health. The respondents attended a 1-h seminar regarding forensic mental health after answering the questionnaire. On completion of the seminar, the respondents answered another questionnaire containing many of the same questions as contained in the pre-seminar *** A total of 86 individuals attended the seminar, and 78 responded to the questionnaire. Only 13(18.8%) participants were supportive of the concept of criminal responsibility initially, and there was a statistically significant increase in those who became more supportive after the seminar, with 22(33%) being supportive after the seminar(Wilcoxon signed-rank test, P < 0.001). Logistic regression analysis revealed that participants who were skeptical about forensic mental systems and those with fewer opportunities to see media reports regarding psychiatry were likely to become supportive of criminal responsibility after the *** These results suggest that public attitudes toward criminal responsibility and mental health can be influenced via educational interventions.

关键词： Forensic psychiatry Criminal responsibility Psychiatry,Law and Ethics Public policy Education in psychiatry Anti-stigma in psychiatry

Ten Years of GIAHS Development in Japan

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Journal of Resources and Ecology 2021年第4期12卷 567-577页

作者： nagata Akira YIU Evonne Institute for the Advanced Study of Sustainability Operating Unit Ishikawa/KanazawaUnited Nations UniversityIshikawa 920-0962Japan Institute for the Advanced Study of Sustainability United Nations UniversityTokyo 150-8925Japan

Approximately ten years have passed since Globally Important Agricultural Heritage Systems(GIAHS)was introduced to Japan in 2011,with 11 GIAHS sites designated so *** Japan Nationally Important Agricultural Heritage Systems(J-NIAHS),which considers resilience,multi-stakeholder participation and sixth industrialization,was subsequently established in 2016,and has designated 15 J-NIAHS *** sites can be classified into three major types:Landscape,farming method,and genetic resource conservation types,and most Japanese GIAHS sites are of the landscape *** there is almost no national subsidy for GIAHS or J-NIAHS,designated sites are expected to secure funding for conservation from their own *** this reason,a voluntary network of the Japanese GIAHS sites has been active in promoting cooperation on GIAHS *** priorities of the Japanese GIAHS have focused on raising public awareness about GIAHS and J-NIAHS,improving livelihoods,as well as fostering the international exchange of experience and knowledge regarding Agricultural Heritage Systems,especially among Japan,China and Korea.

关键词： GIAHS agricultural heritage traditional agriculture sustainability biodiversity landscape

Recurrent colorectal cancer after endoscopic resectionwhen additional surgery was recommended

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World Journal of Gastroenterology 2016年第7期22卷 2336-2341页

作者： Yukiko Takatsu Yosuke Fukunaga Shunsuke Hamasaki Atsushi Ogura Jun nagata Toshiya Nagasaki,Takashi Akiyoshi Tsuyoshi Konishi Yoshiya Fujimoto Satoshi Nagayama Masashi Ueno Department of Gastroenterological Surgery Cancer Institute HospitalJapanese Foundation for Cancer ResearchTokyo 135-8550Japan

AIM: To evaluate the type of recurrence after endoscopic resection in colorectal cancer patients and whether rescue was possible by salvage ***: Among 4972 patients who underwent surgical resection at our institution for primary or recurrent colorectal cancers from January 2005 to February 2015, we experienced eight recurrent colorectal cancers after endoscopic resection when additional surgical resection was ***: The recurrence patterns were: intramural local recurrence(five cases), regional lymph node recurrence(three cases), and associated with simultaneous distant metastasis(three cases). Among five cases with lymphatic invasion observed histologically in endoscopic resected specimens, four cases recurred with lymph node metastasis or distant metastasis. All cases were treated laparoscopically and curative surgery was achieved in six cases. Among four cases located in the rectum, three cases achieved preservation of the anus. Postoperative complications occurred in two cases(enteritis).CONCLUSION: For high-risk submucosal invasive colorectal cancers after endoscopic resection, additional surgical resection with lymphadenectomy is recommended, particularly in cases with lymphovascular invasion.

关键词： Colorectal neoplasms Colorectal surgery Laparoscopy Endoscopy Recurrence

Diagnostic value of endothelial markers and HHV-8 staining in gastrointestinal Kaposi sarcoma and its difference in endoscopic tumor staging

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World Journal of Gastroenterology 2013年第23期19卷 3608-3614页

作者： Naoyoshi nagata Toru Igari Takuro Shimbo Katsunori Sekine Junichi Akiyama Yohei Hamada Hirohisa Yazaki Norio Ohmagari Katsuji Teruya Shinichi Oka Naomi Uemura Department of Gastroenterology and Hepatology National Center for Global Health and MedicineTokyo 162-8655 Japan Department of Clinical pathology National Center for Global Health and MedicineTokyo 162-8655 Japan Department of Clinical Research and Informatics National Center for Global Health and MedicineTokyo 162-8655 Japan Division of AIDS Clinical Center (ACC) National Center for Global Health and MedicineTokyo 162-8655 Japan Department of Infectious disease National Center for Global Health and MedicineTokyo 162-8655 Japan Department of Gastroenterology and Hepatology National Center for Global Health and Medicine Kohnodai HospitalChiba 272-8516 Japan

AIM: To clarify the diagnostic values of hematoxylin and eosin (HE), D2-40, CD31, CD34, and HHV-8 immunohistochemical (IHC) staining in gastrointestinal Kaposi's sarcoma (GI-KS) in relation to endoscopic tumor staging. METHODS: Biopsy samples (n = 133) from 41 human immunodeficiency virus-infected patients were reviewed. GI-KS was defined as histologically negative for other GI diseases and as a positive clinical response to KS therapy. The receiver operating characteristic area under the curve (ROC-AUC) was compared in relation to lesion size, GI location, and macroscopic appearances on endoscopy. RESULTS: GI-KS was confirmed in 84 lesions (81.6%). Other endoscopic findings were polyps (n = 9), inflammation (n = 4), malignant lymphoma (n = 4), and condyloma (n = 2), which mimicked GI-KS on endoscopy. ROC-AUC of HE, D2-40, blood vessel markers, and HHV-8 showed results of 0.83, 0.89, 0.80, and 0.82, respectively. For IHC staining, the ROC-AUC of D2-40 was significantly higher (P < 0.05) than that of HE staining only. In the analysis of endoscopic appearance, the ROC-AUC of HE and IHC showed a tendency toward an increase in tumor staging (e.g. , small to large, patches, and polypoid to SMT appearance). D2-40 was significantly (P < 0.05) advantageous in the upper GI tract and for polypoid appearance compared with HE staining. CONCLUSION: The diagnostic value of endothelial markers and HHV-8 staining was found to be high, and its accuracy tended to increase with endoscopic tumor staging. D2-40 will be useful for complementing HE staining in the diagnosis of GI-KS, especially in the upper GI tract and for polypoid appearance.

关键词： Gastrointestinal Kaposi’s sarcoma Hematoxylin and eosin CD31 CD34 D2-40 Human herpesvirus-8