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A monocenter retrospective study of serological,histological and genetic characteristics of celiac disease in Northern Central Italy

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Open Journal of Clinical Diagnostics 2013年第3期3卷 122-127页

作者： Stefania Lombardi Gloria Bertacca isabella giannelli Elena Bonomi Daniela Tornaboni Marco Culli Andrea Cavazzana Antonella Puccini Paolo Franceschini Marco Friggeri SSD Immunologia Allergologia e Patologia Molecolare Azienda USL1 Massa e Carrara Massa Italy UO Anatomia Patologia Azienda USL1 Massa e Carrara Carrara Italy

Objective: To examine the seroprevalence, correlates and characteristics of Celiac disease (CD) in a population sample of a Northern Central Area of Italy, by a monocenter retrospective study. Methods: Between 2006 and 2010, serum samples of 9371 subjects (age range 6 months to 91 years) were screened for tissue transglutaminase IgA antibodies (IgA-tTG) by the Immunologia-Allergologia Unit of AUSL1 Massa-Carrara, an area with a population of approximately 150,000. Endomysial IgA antibodies (EMA), HLA typing and small-bowel biopsy were also performed when indicated. Results: Of the 9371 subjects, 269 (2.87%) had positive antibody tests. The population was divided into several age groups and the highest prevalence (5.63%) was found in the 6 months-3 years group. The prevalence of IgA-tTG positivity was double in females compared to males. All IgA-tTG positive patients that were genotyped carried HLA-DQ2 or DQ8, none was a5 positive only. In positive IgA-tTG sera, levels of IgA-tTG were significantly higher in EMA positive than in EMA negative sera (p in children and in adults. Ninety-five/269 IgA-tTG positive subjects underwent biopsy. IgA-tTG levels were different according to the histological degree of the lesion. When EMA were evaluated in IgA-tTG positive subjects the number of EMA negative sera was significantly higher in adults than in children. Conclusions: In summary, this study provides a monocenter retrospective analysis of serological, histological and genetic parameters of subjects with suspicion of CD in an area of Northern Central Italy from 2006 to 2010.

关键词： Celiac Disease Anti-Endomysium Antibodies Anti-Transglutaminase Antibodies Epidemiology HLA-DR

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Changes in nutritional status after liver transplantation

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World Journal of Gastroenterology 2014年第31期20卷 10682-10690页

作者： Michela Giusto Barbara Lattanzi Vincenza Di Gregorio Valerio giannelli Cristina Lucidi Manuela Merli Ⅱ Gastroenterologia Dipartimento di Medicina Clinica "Sapienza" Università di Roma00185 Roma Italy

Chronic liver disease has an important effect on nutritional status, and malnourishment is almost universally present in patients with end-stage liver disease who undergo liver transplantation. During recent decades,a trend has been reported that shows an increase in number of patients with end-stage liver disease and obesity in developed countries. The importance of carefully assessing the nutritional status during the workup of patients who are candidates for liver replacement is widely recognised. Cirrhotic patients with depleted lean body mass(sarcopenia) and fat deposits have an increased surgical risk; malnutrition may further impact morbidity, mortality and costs in the post-transplantation setting. After transplantation and liver function is restored, many metabolic alterations are corrected,dietary intake is progressively normalised, and lifestyle changes may improve physical activity. Few studies have examined the modifications in body composition that occur in liver recipients. During the first 12 mo, the fat mass progressively increases in those patients who had previously depleted body mass, and the muscle mass recovery is subtle and non-significant by the end of the first year. In some patients, unregulated weight gain may lead to obesity and may promote metabolicdisorders in the long term. Careful monitoring of nutritional changes will help identify the patients who are at risk for malnutrition or over-weight after liver transplantation. Physical and nutritional interventions must be investigated to evaluate their potential beneficial effect on body composition and muscle function after liver transplantation.

关键词： Liver transplantation Sarcopenia Malnutrition Obesity Metabolic syndrome Outcome Survival

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Role of the tissue microenvironment as a therapeutic target in hepatocellular carcinoma

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World Journal of Gastroenterology 2014年第15期20卷 4128-4140页

作者： Bhavna Rani Yuan Cao Andrea Malfettone Ciprian Tomuleasa Isabel Fabregat Gianluigi giannelli Department of Medical Biosciences and Human Oncology Padiglione Semeiotica Medica70124 BariItaly Bellvitge Biomedical Research Institute (IDIBELL) 08028 BarcelonaSpain Department of Hematology Center for Genomics and Translational MedicineIuliu Hatieganu University of Medicine and Pharmacy400012 Cluj NapocaRomania Department of Physiological Sciences Ⅱ University of Barcelona08028 BarcelonaSpain

Hepatocellular carcinoma is difficult to treat,primarilybecause the underlying molecular mechanisms drivingclinical outcome are still poorly *** suggests that the tissue microenvironmenthas a role in the biological behavior of the *** clinical issue is to identify the best target fortherapeutic ***,we discuss the hypothesis that the entire tissue microenvironment might beconsidered as a biological ***,the tissuemicroenvironment consists of several cellular and biochemical components,each of which displays a distinctbiological *** discuss the major components ofthis environment and consider how they may interactto promote tumor/host crosstalk.

关键词： Tissue microenvironment Hepatocellular carcinoma Transforming growth factor-beta Laminin-5 Cancer stem cells Therapy Target therapy

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Microbiota and the gut-liver axis:Bacterial translocation,inflammation and infection in cirrhosis

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World Journal of Gastroenterology 2014年第45期20卷 16795-16810页

作者： Valerio giannelli Vincenza Di Gregorio Valerio Iebba Michela Giusto Serena Schippa Manuela Merli Ulrich Thalheimer Gastroenterology Department of Clinical Medicine Sapienza University of Rome Department of Public Health and Infectious Diseases Sapienza University of Rome The Exeter Liver Unit Royal Devon and Exeter Foundation Trust

Liver disease is associated with qualitative and quantitative changes in the intestinal microbiota. In cirrhotic patients the alteration in gut microbiota is characterized by an overgrowth of potentially pathogenic bacteria (i.e., gram negative species) and a decrease in autochthonous familiae. Here we summarize the available literature on the risk of gut dysbiosis in liver cirrhosis and its clinical consequences. We therefore described the features of the complex interaction between gut microbiota and cirrhotic host, the so called “gut-liver axis”, with a particular attention to the acquired risk of bacterial translocation, systemic inflammation and the relationship with systemic infections in the cirrhotic patient. Such knowledge might help to develop novel and innovative strategies for the prevention and therapy of gut dysbiosis and its complication in liver cirrhosis.

关键词： Dysbiosis Cirrhosis Bacterial translocation Inflammation Infection Bacterial overgrowth Rifaximine Lactulose Liver Gut Portal hypertension

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读·爱

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疯狂英语（阅读版） 2011年第5期 48-50页

作者： Adina giannelli 小肥羊

当我发现自己怀上女儿托亚的时候，我深知三件事。第一，我会生下这个孩子，尽管她的父亲要求我堕胎，尽管这不是怀孕的最佳时机。第二，从我得知自己怀孕那刻起，我就对这个孩子怀有爱意。最后，我知道我会常常兴致勃勃地读故事给孩子听。

关键词：英语教学教学方法阅读《读·爱》

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显性突变异质性疾病的遗传咨询的新对策:血友病B模式

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国外医学（遗传学分册） 1993年第2期16卷 86-90页

作者： giannelli F 孟南奇

许多人类遗传病具有较高的突变异质性,每个家庭都携带特定起源的突变。为了利用现有自然突变资源,有必要研究快速识别基因缺陷的方法,目前已将这种方法用于血友病B的研究。为迅速显示血友病突变的特征,用PCR扩增技术分离了该基因的区域... 详细信息

许多人类遗传病具有较高的突变异质性,每个家庭都携带特定起源的突变。为了利用现有自然突变资源,有必要研究快速识别基因缺陷的方法,目前已将这种方法用于血友病B的研究。为迅速显示血友病突变的特征,用PCR扩增技术分离了该基因的区域,通过直接检测基因缺陷,可做出血友病B的携带者诊断及产前诊断。提高预期诊断成功率60～100%。

关键词：遗传病显性突变异质性血友病

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Acute alcoholic hepatitis, end stage alcoholic liver disease and liver transplantation: An Italian position statement

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World Journal of Gastroenterology 2014年第40期20卷 14642-14651页

作者： Gianni Testino Patrizia Burra Ferruccio Bonino Francesco Piani Alessandro Sumberaz Roberto Peressutti Andrea giannelli Castiglione Valentino Patussi Tiziana Fanucchi Ornella Ancarani Giovanna De Cerce Anna Teresa Iannini Giovanni Greco Antonio Mosti Marilena Durante Paola Babocci Mariano Quartini Davide Mioni Sarino Aricò Aniello Baselice Silvia Leone Fabiola Lozer Emanuele Scafato Paolo Borro Regional Alcohologic Centre Liguria Region Alcohol Unit and Related Diseases Department of Internal and Specialist Medicine IRCCS AOU San Martino-IST National Institute for Cancer Research 16100 Genova Italy Gastroenterology Department of Surgical and Gastroenterological Sciences University Hospital of Padova Veneto Region 35100 Padova Italy Internal Medicine University of Pisa 56100 Pisa Italy Department of DependenceASS4 Medio Friuli Regione Autonoma Friuli Venezia Giulia34100 Trieste Italy Regional Transplantation Centre Autonomous Region of Friuli Venezia Giulia 33100 Udine Italy Regional Transplantation Centre Liguria Region 16100 Genova Italy Regional AlcohologicCentre Toscana Region Alcohol Unit Careggi Hospital University of Firenze 50100 Firenze Italy Department of Dependence Molise Region 86100 Campobasso Italy Alcohol Unit Department of Dependence Molise Region 86100 Campobasso Italy Alcohol Unit ASL di Ravenna Emilia Romagna Region 48100 Ravenna Italy Alcohol Unit ASL 4 di Terni Umbria Region05100 Terni Italy Hepatology Unit Santa Maria Hospital 05100 Terni Italy Gastroenterology Ordine Mauriziano Hospital Piemonte Region 10100 Torino Italy Italian Clubs of Alcoholics in Treatment 84134 Salerno Italy Department of Toxicology University of Genova 16100 Genova Italy World Health Organization Collaborating Centre for Research and Health Promotion on Alcohol and Alcohol-related Health Problems Europe Region Istituto Superiore di Sanità 00100 Roma Italy

Alcoholic liver disease encompasses a broad spectrum of diseases ranging from steatosis steatohepatitis, fibrosis, and cirrhosis to hepatocellular carcinoma. Forty-four per cent of all deaths from cirrhosis are attributed to alcohol. Alcoholic liver disease is the second most common diagnosis among patients undergoing liver transplantation (LT). The vast majority of transplant programmes (85%) require 6 mo of abstinence prior to transplantation; commonly referred to as the “6-mo rule”. Both in the case of progressive end-stage liver disease (ESLD) and in the case of severe acute alcoholic hepatitis (AAH), not responding to medical therapy, there is a lack of evidence to support a 6-mo sobriety period. It is necessary to identify other risk factors that could be associated with the resumption of alcohol drinking. The “Group of Italian Regions” suggests that: in a case of ESLD with model for end-stage liver disease < 19 a 6-mo abstinence period is required; in a case of ESLD, a 3-mo sober period before LT may be more ideal than a 6-mo period, in selected patients; and in a case of severe AAH, not responding to medical therapies (up to 70% of patients die within 6 mo), LT is mandatory, even without achieving abstinence. The multidisciplinary transplant team must include an addiction specialist/hepato-alcohologist. Patients have to participate in self-help groups.

关键词： Alcohol Alcoholic hepatitis Cirrhosis Hepatocellular carcinoma Liver transplantation

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肝细胞癌领域的新概念：从分子研究到临床实践（上）

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传染病网络动态 2007年第4期 15-17页

作者： Gianluigi giannelli Salvatore Antonaci 姚勤伟（编译）杨露绮（审校）

肝细胞癌（HCC）排在世界常见肿瘤的第五位和肿瘤相关死亡原因的第三位，也是目前世界范围内的一个主要健康问题。在美国1975年到1998年间在其它恶性肿瘤的发生率下降的同时，肝细胞癌的发病率却增加了80％。根据数学模型估计，因为丙... 详细信息

肝细胞癌（HCC）排在世界常见肿瘤的第五位和肿瘤相关死亡原因的第三位，也是目前世界范围内的一个主要健康问题。在美国1975年到1998年间在其它恶性肿瘤的发生率下降的同时，肝细胞癌的发病率却增加了80％。根据数学模型估计，因为丙型肝炎病毒的传播和肝硬化患者的存活时间延长，故未来它的发病率会进一步升高。事实上，在西欧和北美国家，HCC通常发生在肝硬化患者中，因此肝硬化是最重要的危险因素。

关键词：肝细胞癌临床实践肝硬化患者分子丙型肝炎病毒肿瘤相关世界范围死亡原因

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肝细胞癌领域的新概念：从分子研究到临床实践（下）

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传染病网络动态 2007年第5期 13-15页

作者： Gianluigi giannelli,MD Salvatore Antonaci,MD 姚勤伟（编译）杨月（审校）

HCC是一种“可塑性”的癌症？癌细胞分化、恶性程度变得更高的能力被称为“可塑性”，并且需要上皮一间叶样表型转化（EMT）——个通常在胚胎发生期和癌症发生中的多步骤过程。经过表型改变之后的细胞变得更加具有侵袭性和浸润性，就像... 详细信息

HCC是一种“可塑性”的癌症？癌细胞分化、恶性程度变得更高的能力被称为“可塑性”，并且需要上皮一间叶样表型转化（EMT）——个通常在胚胎发生期和癌症发生中的多步骤过程。经过表型改变之后的细胞变得更加具有侵袭性和浸润性，就像已经在大肠癌中详细描述的那样。

关键词：肝细胞癌临床实践 “可塑性” 分子癌症发生癌细胞分化恶性程度胚胎发生

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平均扩散系数对局灶性晚期乳腺癌化疗反应预测价值的初步研究结果

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国际医学放射学杂志 2010年第2期 197-198页

作者： C.Iacconi M.giannelli C.Marini A.Cilotti M.Moretti P.Viacava 范丽 Department of Radiology Azienda Ospedaliero-Universitaria PisanaVia Roma 6756100 PisaItaly

目的评价平均扩散系数(MD)对局灶性晚期乳腺癌化疗反应的预测价值。方法21例来本机构就治的局灶性晚期乳腺癌病人分别联合新辅助化疗前后行1.5T MRI检查。MR

关键词：晚期乳腺癌平均扩散系数局灶性预测价值化疗反应

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