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Hepatitis B viral infection and role of alcohol

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World Journal of Gastroenterology 2022年第35期28卷 5233-5236页

作者： Manuel Muro Aurelia Collados-Ros isabel Legaz Department of Immunology Clinical University HospitaĺVirgen de la Arrixaca-IMIB(Murcian Institute of Biomedical Investigation)Murcia 30120Spain Department of Legal and Forensic Medicine Biomedical Research Institute(IMIB)Regional Campus of International Excellence"Campus Mare Nostrum"Faculty of MedicineUniversity of Murcia(Spain)Universidad de MurciaEspinardo 30100MurciaSpain

End-stage liver disease is frequently caused by hepatitis B virus (HBV) andalcohol consumption. Notably, the mechanism by which alcohol affects the courseof HBV-associated liver disease is unknown, and additional research is needed inthis area. A reduced immunological response, oxidative stress, endoplasmicreticulum stress, Golgi apparatus stress, and enhanced HBV replication are a fewpotential causes.

关键词： Hepatitis B virus Alcohol Hepatocarcinoma Immunity Liver disease

Onto the sense of smell in macaws, amazons and toucans: can they use volatile cues of fruits to make foraging decisions?

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Integrative Zoology 2023年第4期18卷 762-771页

作者： M.Carmen HERNÁNDEZ Ana María VILLADA isabel BARJA Unidad Zoología Departamento de BiologíaUniversidad Autónoma de MadridCampus Universitario de CantoblancoMadridSpain Toucan Rescue Ranch HerediaCosta Rica Centro de Investigación en Biodiversidad y Cambio Global(CIBC-UAM)Universidad Autónoma de Madrid MadridSpain

Over the past decades,empirical evidence has been accumulated indicating that olfactory information plays a fundamental role in bird life ***,many aspects of avian olfaction remain poorly *** purpose was to broaden the knowledge about the importance of the sense of smell in some neglected bird groups:psittaciformes and ramphastids,and to compare how the response varied between the *** of the lack of information about the use of chemical cues for locating food in fruit-eating species,we also aimed to delve into this *** conducted a 3-choice(water/vinegar/papaya and banana juice)scent test in 5 Costa Rican native species:scarlet macaw(Ara macao),red-lored amazon(Amazona autumnalis),yellow-naped amazon(Amazona auropalliata),keel-billed toucan(Ramphastos sulfuratus),and yellow-throated toucan(Ramphastos ambiguus).Results revealed that macaws and toucans allocated signiﬁcantly more time to interacting with the fruit scent container,indicating that these species can perceive the volatile chemicals emitted by ripe fruits and that they can use this information to make foraging ***,amazons did not dedicate more time to interact with the fruit *** research provides theﬁrst evidence of the ability to exploit chemical volatile cues in macaws and toucans.

关键词： avian olfaction bird senses frugivorous birds psittaciformes ramphastids scent test

Origin and evolution of the genera Lonsdaleia and Actinocyathus:Insights for the Mississippian palaeogeography from the western Palaeotethys

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Journal of Palaeogeography 2023年第2期12卷 296-310页

作者： isabel Rodríguez-Castro Ian D.Somerville Sergio Rodríguez Departamento de Geodinamica Estratigrafía y PaleontologíaUniversidad Complutense de Madrid28040MadridSpain UCD School of Earth Sciences University College DublinBelfieldDublin 4Ireland Instituto de Geociencias(CSIC UCM)Ciudad Universitaria28040MadridSpain

Representatives of the subfamily Lonsdaleiinae Chapman,1893 are common in the Mississippian of the western Palaeotethys.A general analysis of the origin,distribution and evolution of that subfamily has been *** most probable hypothesis for the origin of the genus Lonsdaleia McCoy,1849 is to acquire colonialism via the genus Axophyllum Milne Edwards and Haime,*** d'Orbigny,1849 would be a descendant of Lonsdaleia by increasing integration in the *** first occurrences of Lonsdaleia have been recorded in the lower Visean from northern Britain and northern Tianshan Mountains of northwestern China,but the diversification and migration to the whole Palaeotethys only happened in the late *** hypotheses are proposed on that *** Serpukhovian was also a period of migrations and diversification for these *** Lonsdaleia and Actinocyathus have been recorded in Bashkirian refuges,the Sverdrup Basin in northern Laurasia and the Tindouf Basin in northern Africa,*** division of the western Palaeotethys into six subprovinces based on the distribution of corals is proposed.

关键词： Carboniferous Palaeotethys Biogeography Evolution Rugosa

Analysis of hepatitis C virus-positive organs in liver transplantation

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World Journal of Hepatology 2022年第9期14卷 1840-1843页

作者： isabel Legaz Manuel Muro Department of Legal and Forensic Medicine Biomedical Research InstituteRegional Campus of International Excellence"Campus Mare Nostrum"Faculty of MedicineUniversity of MurciaMurcia 30100Spain Department of Immunology Service Instituto Murciano de Investigación BiosanitariaHospital Clínico Universitario Virgen de la ArrixacaMurcia 30120Spain

The authors of this study note that in liver transplantation(LT),the survival rates of hepatitis C virus(HCV)-positive donors and HCV-negative receivers are compa-rable to those of HCV-negative donors and ***-acting antiviral(DAA)therapies have nearly 100%effectiveness in treating *** 2006 and 2016,the percentages of HCV-positive patients on the waiting list and HCVpositive LT recipients fell by 8.2 percent and 7.6 percent,*** from April 1,2014,in which the donor and receiver were both at least 18 years old and had a positive HCV status,were the only ones eligible for the *** analysis for this study was restricted to the first transplant recorded for each patient using a data element that documented the number of prior transplants for each recipient,although some recipients appeared multiple times in the data ***-positive recipients or people with fulminant hepatic failure were the main beneficiaries of primary biliary cirrhosis among HCV-positive ***,there is still a reticence to use HCV-positive donor organs in HCV recipients due to clinical and ethical *** survival rates between HCV-positive donors and recipients and HCV-negative donors and receivers illustrate the efficacy of these DAA regimens.

关键词： Hepatitis C virus Liver transplant Graft survival United network for organ sharing Direct-acting antiviral

Relation of COVID-19 with liver diseases and their impact on healthcare systems:The Portuguese case

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World Journal of Gastroenterology 2023年第6期29卷 1109-1122页

作者： Sara Fernandes Milaydis Sosa-Napolskij Graça Lobo isabel Silva Instituto de Ciências Biomédicas Abel Salazar da Universidade do Porto(ICBAS-UP) Porto 4050-313Portugal CINTESIS@RISE Center for Health Technology and Services Research at The Associate Laboratory RISE–Health Research NetworkFaculty of Medicine of The University of PortoPorto 4200-219Portugal Laboratory of Pharmacology and Neurobiology–Department of Immuno-physiology and Pharmacology Instituto de Ciências Biomédicas Abel Salazar da Universidade do Porto(ICBAS-UP)Porto 4050-313Portugal Center for Drug Discovery and Innovative Medicines(MedInUP) Instituto de Ciências Biomédicas Abel Salazar da Universidade do Porto(ICBAS-UP)Porto 4050-313Portugal

BACKGROUND The impact caused by the coronavirus disease 2019(COVID-19)on the Portuguese population has been addressed in areas such as clinical manifestations,frequent comorbidities,and alterations in consumption ***,comorbidities like liver conditions and changes concerning the Portuguese population's access to healthcare-related services have received less *** To(1)Review the impact of COVID-19 on the healthcare system;(2)examine the relationship between liver diseases and COVID-19 in infected individuals;and(3)investigate the situation in the Portuguese population concerning these *** For our purposes,we conducted a literature review using specific *** COVID-19 is frequently associated with liver ***,liver injury in COVID-19 individuals is a multifactor-mediated ***,it remains unclear whether changes in liver laboratory tests are associated with a worse prognosis in Portuguese individuals with *** COVID-19 has impacted healthcare systems in Portugal and other countries;the combination of COVID-19 with liver injury is *** liver damage may represent a risk factor that worsens the prognosis in individuals with COVID-19.

关键词： COVID-19 Healthcare systems Liver Portuguese individuals Comorbidities Clinical outcomes

Impact of socioeconomic and health-related factors on consumption of homeopathic and natural remedies in Spain in 2006, 2011 and 2017

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Journal of Integrative Medicine 2022年第1期20卷 52-56页

作者： Jose Antonio Castilla-Jimena isabel Ruiz-Perez Jesus Henares-Montiel Andalusian School of Public Health 1801J GranadaSpain Unit of Clinical Management of Preventive Medicine and Public Health and Occupational Medicine Puerto del Mar University Hospital11009 CadizSpain Consortium for Networked Biomedical Research in Epidemiology and Public Health 28029 MadridSpain Institute for Biosanitary Research(ibs.GRANADA) 18012 GranadaSpain

Objective: Complementary and alternative medicine use and type of use may be influenced by sociodemographic and economic determinants through which we could identify characteristics of patients with greater trend to use it. This paper aims to describe the changes in the consumption of homeopathic and natural remedies in Spain for three time points in order to discern changes in rate of consumption, associated factors and whether their use has been affected by a period of economic ***: This study utilized 2006, 2011 and 2017 cross-sectional data from the Spanish National Health Survey, a nationally representative survey of the population aged more than 15 years old and resident in Spain. Independent bivariate and multivariate descriptive analyses for each of the 3 years studied were ***: The rate of consumption of both homeopathic and natural remedies has decreased over the periods studied. In spite of this decrease, the consumer profile appears to remain stable over the three periods. The sociodemographic factors associated with their consumption were being female, being 30–64 years old, being separated/divorced, having higher education qualifications, being employed and belonging to a higher social class. Psychiatric morbidity, chronic health problems such as pain, mental health problems or malignant tumors, and absence of major cardiovascular events were the clinical factors ***: It can be concluded that beyond the economic situation, the use of homeopathic and natural remedies obeys to the needs of the patients related to their state of health and the response they receive from the health system. It may be that women have different needs and expectations of the healthcare system and, given this breach of expectations, seek remedy to alleviate their needs outside the system and conventional medicine.

关键词： Complementary and alternative medicine Homeopathic remedies Natural remedies Economic recession Gender differences

The brain as a source and a target of prolactin in mammals

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Neural Regeneration Research 2022年第8期17卷 1695-1702页

作者： Ana R.Costa-Brito isabel Gonçalves Cecília R.A.Santos CICS-UBI-Health Sciences Research Centre Universidade da Beira InteriorCovilhãPortugal C4-UBI-Cloud Computing Competence Centre Universidade da Beira InteriorCovilhãPortugal

Prolactin is a polypeptide hormone associated with an extensive variety of biological *** the roles of prolactin in vertebrates,some were preserved throughout *** is the case of its function in the brain,where prolactin receptors,are expressed in different structures of the central nervous *** the brain,prolactin actions are principally associated with reproduction and parental behavior,and involves the modulation of adult neurogenesis,neuroprotection,and neuroplasticity,especially during pregnancy,thereby preparing the brain to *** is mainly produced by specialized cells in the anterior pituitary ***,during vertebrate evolution many other extrapituitary tissues do also produce prolactin,like the immune system,endothelial cells,reproductive structures and in several regions of the *** review summarizes the relevance of prolactin for brain function,the sources of prolactin in the central nervous system,as well as its local production and secretion.A highlight on the impact of prolactin in human neurological diseases is also provided.

关键词： brain brain disease choroid plexus neurogenesis neuroplasticity neuroprotection prolactin prolactin receptor

Contribution of the Open Access Modality to the Impact of Hybrid Journals Controlling by Field and Time Effects

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Journal of Data and Information Science 2022年第2期7卷 57-83页

作者： Pablo Dorta-González María isabel Dorta-González University of Las Palmas de Gran Canaria TiDES Research Institute35017 Las Palmas de Gran CanariaSpain University of La Laguna 38271 La LagunaSpain

Purpose:Researchers are more likely to read and cite papers to which they have access than those that they cannot ***,the objective of this work is to analyze the contribution of the Open Access(OA)modality to the impact of hybrid ***/methodology/approach:The“research articles”in the year 2017 from 200 hybrid journals in four subject areas,and the citations received by such articles in the period 2017-2020 in the Scopus database,were *** hybrid OA papers were compared with the paywalled *** journals were randomly selected from those with share of OA papers higher than some minimal *** than 60 thousand research articles were analyzed in the sample,of which 24%under the OA ***:We obtain at journal level that cites per article in both hybrid modalities(OA and paywalled)strongly ***,there is no correlation between the OA prevalence and cites per *** is OA citation advantage in 80%of hybrid ***,the OA citation advantage is consistent across fields and held in *** obtain an OA citation advantage of 50%in average,and higher than 37%in half of the hybrid ***,the OA citation advantage is higher in Humanities than in Science and Social *** limitations:Some of the citation advantage is likely due to more access allows more people to read and hence cite articles they otherwise would ***,causation is difficult to establish and there are many possible *** factors can affect the observed differences in citation *** mandates can be one of *** are likely to have OA requirement,and well-funded studies are more likely to receive more citations than poorly funded *** discussed factor is the selection bias postulate,which suggests that authors choose only their most impactful studies to be open *** implications:For hybrid journals,the open access modality is positive,in the sense that it provides a greater

关键词： Open access Open science Scholarly communication Hybrid journals Citation advantage

Systemic epigallocatechin gallate protects against retinal degeneration and hepatic oxidative stress in the P23H-1 rat

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Neural Regeneration Research 2022年第3期17卷 625-631页

作者： Lorena Perdices Lorena Fuentes-Broto Francisco Segura Ana Cavero Elvira Orduna-Hospital Gema Insa-Sánchez Ana isabel Sánchez-Cano Laura Fernández-Sánchez Nicolás Cuenca isabel Pinilla Aragón Institute for Health Research(IIS Aragón) ZaragozaSpain Pharmacology Physiology&Legal and Forensic MedicineUniversity of ZaragozaZaragozaSpain Department of Applied Physics University of ZaragozaZaragozaSpain Health Sciences Faculty San Jorge UniversityVillanueva de GállegoSpain Department of Ophthalmology Miguel Servet University HospitalZaragozaSpain Department of Physiology Genetics and MicrobiologyUniversity of AlicanteAlicanteSpain Department of Surgery Gynecology and ObstetricsUniversity of ZaragozaZaragozaSpain/Department of OphthalmologyLozano Blesa University HospitalZaragozaSpain

Retinitis pigmentosa(RP) is a group of inherited retinal disorders that lead to photoreceptor *** has been reported to be related to oxidative stress,autophagy,and inflammation.(-)-Epigallocatechin gallate(EGCG),the most abundant catechin-based flavonoid in green tea leaves,has significant antioxidant,anti-carcinogenic,antimicrobial,and neuroprotective ***,given its low molecular weight and hydrophilic properties,can cross the blood-retinal barrier and is able to reach different ocular tissues such as the lens,cornea,and *** has been shown to provide retinal protection against ischemia;sodium nitroprusside-,N-methyl-D-aspartate-,lipopolysaccharide-,light-,sodium iodate-,or H2 O2-induced damage and diabetic *** suggests that systemic EGCG administration has the potential to protect against retinal degenerative or neurodegenerative diseases such as *** aim of this work was to investigate whether EGCG can protect against RP progression in the animal P23 H line 1,the model of *** P23 H rats were crossed with pigmented Long Evans rats to produce offspring exhibiting the clinical features of *** P23 H rats were treated via intraperitoneal injection with saline or EGCG at a dose of 25 mg/kg every week from P100 to P160 and then compared to wild-type Long Evans *** treated with EGCG showed better visual and retinal electrical function with increased contrast sensitivity and b-wave values compared with those observed in P23 H rats treated with *** reduced lipid peroxidation and increased total antioxidant capacity and catalase and superoxide dismutase *** differences were observed in visual acuity,nitrate levels,nitrite levels or glutathione S-transferase *** conclusion,EGCG not only reduced the loss of visual function in P23 H rats but also improved the levels of antioxidant enzymes and reduced oxidative *** study was approved by the Institutional Animal Care and Use Committee(CE

关键词： antioxidants contrast sensitivity electroretinogram green tea neurodegeneration oxidative stress retinal degeneration retinitis pigmentosa systemic visual acuity