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Evolution and Continuity of Linguistic Systems

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Language and Semiotic Studies 2022年第1期8卷 24-36页

作者： isabel Victoria Galleguillos Jungk Pontifical Catholic University of Sao Paulo University of Sao Paulo Brazil

In the inspiring extract highlighted in this paper,Saussure observes how the relation between the elements of the sign change and evolve over *** his Cours,he also details the elements of the linguistic sign and the principles governing them,defining language as a system of *** the natural resistance to changes in language in order to enable it to continually fulfill its function,that is,despite the necessary immutability of linguistic signs,they change over time,by being in constant contact with the communities of speakers,to whom language actually *** may seem paradoxical because language is composed of arbitrary relations between signified and signifier that seek to represent *** refers to a principle of change in language linked to a principle of *** present study focuses on the semiotic and communicational aspects of the development of linguistic systems in time,understood from a systemic *** is sought to evince how signs perpetuate themselves and evolve through their constant interaction with real communities of language *** approach can offer new insights about the continuity of linguistic systems as systems of signs that present immutable and mutable characters,and whose evolution can be understood based on open systems parameters,such as permanence,autonomy and sensitivity to flows of information,as studied by current theories and authors,showing that,to preserve its semiological life (CGL,1959,p.76),a living language must continuously reflect the purposes of its users.

关键词： linguistic systems linguistic mutability evolution continuity systems parameters

The drama of memory in Shakespeare's history plays

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作者： Karremann isabel

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World Journal of Gastroenterology 2022年第30期28卷 4231-4234页

作者： manuel muro Aurelia Collados-Ros isabel Legaz Immunology Service Instituto Murciano de investigación biosanitaria(IMIB)Hospital Clínico Universitario Virgen de la Arrixaca(HCUVA)Murcia 30120Spain Department of Legal and Forensic medicine Biomedical Research Institute(IMIB)Regional Campus of International Excellence“Campus Mare Nostrum”Faculty of MedicineUniversity of MurciaMurcia 30100Spain

Alcohol intake is a risk factor for cancer development and metastatic disease *** vesicle(EV)-mediated interorgan communication is assumed to be significant in boosting tumorigenic pathways and disease *** research indicates that exosomes have a variety of roles in the development of cancer during pathophysiological *** involvement of EV signaling during cancer progression in the alcohol environment is ***,understanding communication networks and the role of EVs as biomarkers can contribute significantly to developing strategies to address the serious public health problems associated with alcohol consumption and cancer.

关键词： Exosomes Liver metastasis Alcohol-associated liver disease Cancer

Hepatitis B viral infection and role of alcohol

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World Journal of Gastroenterology 2022年第35期28卷 5233-5236页

作者： manuel muro Aurelia Collados-Ros isabel Legaz Department of Immunology Clinical University HospitaĺVirgen de la Arrixaca-IMIB(Murcian Institute of Biomedical Investigation)Murcia 30120Spain Department of Legal and Forensic medicine Biomedical Research Institute(IMIB)Regional Campus of International Excellence"Campus Mare Nostrum"Faculty of MedicineUniversity of Murcia(Spain)Universidad de MurciaEspinardo 30100MurciaSpain

End-stage liver disease is frequently caused by hepatitis B virus (HBV) andalcohol consumption. Notably, the mechanism by which alcohol affects the courseof HBV-associated liver disease is unknown, and additional research is needed inthis area. A reduced immunological response, oxidative stress, endoplasmicreticulum stress, Golgi apparatus stress, and enhanced HBV replication are a fewpotential causes.

关键词： Hepatitis B virus Alcohol Hepatocarcinoma Immunity Liver disease

Changes in demand and supply of ecosystem services under scenarios of future land use in Vorarlberg, Austria

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Journal of mountain Science 2019年第12期16卷 2793-2809页

作者： SAUTER isabel KIENAST Felix BOLLIGER Janine WINTER Benjamin PAZuR Robert Swiss Federal Research Institute WSL Zurcherstrasse 1118903 BirmensdorfSwitzerland ALPS-Centre for Climate Change Adaptation Grabenweg 686020 InnsbruckAustria Institute of Geography University of InnsbruckInnrain 526020 InnsbruckAustria Institute of Geography Slovak Academy of SciencesStefanikova 4981473 BratislavaSlovakia

Ecosystem services(ES)are highly impacted by human-induced land-use *** urbanization and agricultural land abandonment in Western Europe necessitate assessments of future land-change impacts on ES to ensure sustainable service *** present study aims at evaluating future demand and supply of three key services(flood protection,nearby recreation and biodiversity)in the mountainous region of Vorarlberg,*** mapped the ES for the referenced time step 2016 and two scenarios for 2050,assuming the continuation of current land-change trends and pressure on landscape *** for the referenced landscape in 2016 show the highest ES supply for intermediate levels,while ES supply was low in the lowlands and valley bottoms and in high-elevation *** found a high positive correlation of ES with the distribution of forested *** contrast,service demand was highest in lowelevation areas and decreased with increasing *** indicates that densely settled and intensively used agricultural areas currently suffer from ES *** projected future development of land use showed an increase in both supply and demand of the selected *** overall service supply increased more than the respective demand due to some reforestation of open *** forests were found to be important synergistic areas for overall service provision,we expect decreasing demand on related ***,demand was found to exceed the supply of ES,especially in the densely populated Rhine valley-requiring further policy *** ES-related information may contribute to regional policy making and ensure the long-term provision of ESs for future generations.

关键词： Land-use change Future land-use scenarios Regional assessment Ecosystem services Synergies Conflicts

A multi-integrated approach on toxicity effects of engineered TiO2 nanoparticles

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Frontiers of Environmental Science & Engineering 2015年第5期9卷 793-803页

作者： Ana PICADO Susana m. PAIXAO Liliana mOITA Luis SILVA mario S. DINIZ Joana LOURENCO isabel PERES Luisa CASTRO Jose brito CORREIA Joana PEREIRA isabel FERREIRA Antonio Pedro Alves mATOS Pedro BARQUINHA Elsa mENDONCA LNEG-National Laboratory of Energy and Geology I.P. Lisbon 1649-038 Portugal REQUImTE Chemistry Department Fine Chemistry and Biotechnology Center Faculty of Sciences and Technology New University of Lisbon Caparica 2829-516 Portugal ImAR-Ocean Institute Department of Sciences and Environmental Engineering Faculty of Sciences and Technology New University of Lisbon Caparica 2829-516 Portugal CENImAT/I3N and Department of materials Science Faculty of Sciences and Technology New University of Lisbon Caparica 2829-516 Portugal Pathological Anatomy Curry Cabml Hospital Lisbon 1069-166 Portugal CESAm Faculty of Sciences Lisbon University Lisbon 1749-016 Portugal

The new properties of engineered nanoparti- cles drive the need for new knowledge on the safety, fate, behavior and biologic effects of these particles on organisms and ecosystems. Titanium dioxide nanoparticles have been used extensively for a wide range of applica- tions, e.g, self-cleaning surface coatings, solar cells, water treatment agents, topical sunscreens. Within this scenario increased environmental exposure can be expected but data on the ecotoxicological evaluation ofnanoparticles are still scarce. The main purpose of this work was the evaluation of effects of TiO2 nanoparticles in several organisms, covering different trophic levels, using a battery of aquatic assays. Using fish as a vertebrate model organism tissue histological and ultrastructural observations and the stress enzyme activity were also studied. TiO2 nanoparticles （Aeroxide~ P25）, two phase composition ofanatase （65%） and rutile （35%） with an average particle size value of 27.64-11 nm were used. Results on the ECs0 for the tested aquatic organisms showed toxicity for the bacteria, the algae and the crustacean, being the algae the most sensitive tested organism. The aquatic plant Lemna minor showed no effect on growth. The fish Carassius auratus showed no effect on a 21 day survival test, though at a biochemical level the cytosolic Glutathione-S-Transferase total activity, in intestines, showed a general significant decrease （p〈0.05） after 14 days of exposure for all tested concentrations. The presence of TiO2 nanoparticles aggregates were observed in the intestine lumen but their internalization by intestine cells could not be confirmed.

关键词： ecotoxicity enzymatic analysis histology,transmission electron microscopy (TEm) TiO2-nanoparti-cles

Graphene oxide/multi-walled carbon nanotubes/gold nanoparticle hybridfunctionalized disposable screen-printed carbon electrode to determine Cd(II)and Pb(II)in soil

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International Journal of Agricultural and Biological Engineering 2019年第3期12卷 194-200页

作者： Hui Wang Yuan Yin Guo Zhao Fernando Bienvenido isabel m.Flores-Parrad Zhiqiang Wang Gang Liu Key Laboratory of modern Precision Agriculture System Integration Research Ministry of Education and Key Laboratory of Agricultural Information Acquisition TechnologyMinistry of AgricultureChina Agricultural UniversityBeijing 100083China Department of Informatics University of AlmeriaAlmeriaSpain College of Computer Science and Technology Shandong University of TechnologyZibo 255049China Research Institute of Wood Industry Chinese Academy of ForestryBeijing 100091China

Cadmium(Cd)and lead(Pb)in soil or water environment cause the ecological destruction and environmental deterioration when their contents exceed the natural background *** trace the concentrations of Cd(II)and Pb(II),a sensitive and selective electrode was developed using disposable screen-printed carbon electrode(SPE)immobilized with a composite film of reduced graphene oxide/carboxylation multi-walled carbon nanotubes/gold nanoparticle hybrid(RGO-mWNT-AuNP)throughπ-π*** highly conductive nano-composite layer,“RGO-mWNT-AuNP,”was characterized by scanning electron microscopy,UV-visible spectrometer,cyclic voltammetry,and electrochemical impedance *** wave stripping voltammetry was applied to RGO-mWNT-AuNP/SPE to electroplate bismuth film and monitor the Cd(II)and Pb(II)*** obtain high current responses,the detecting parameters were *** optimized conditions,the current responses showed a linear relationship with the concentrations of Cd(II)and Pb(II)in the range from 1.0 to 80.0μg/L with a lower detection limit of 0.7μg/L and 0.3μg/L(S/N=3),***,the prepared electrode was further employed to detect Cd(II)and Pb(II)in soil samples with good results.

关键词： electrochemical electrode heavy metal contamination screen-printed carbon electrode graphene gold nanoparticle lead cadmium multi-walled carbon nanotube

Adverse hepatic reactions associated with calcium carbimide and disulfiram therapy: Is there still a role for these drugs?

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World Journal of Gastroenterology 2006年第31期12卷 5078-5080页

作者： Carmen Verge m isabel Lucena Enrique López-Torres m José Puche-García Enrique Fraga manuel Romero-Gomez Raúl J Andrade Clinical Pharmacology ServiceVirgen de la Victoria University Hospital School of MedicineMálagaSpain Gastroenterology ServiceUniversity Hospital Reina Sofia CórdobaSpain Gastroenterology ServiceUniversity Hospital Virgen de Valme SevillaSpain Liver UnitDepartment of Gastroenterology University HospitalMálagaSpain

Disulfiram and calcium carbimide are two alcohol deterrants widely used in alcoholism treatment, however, there exist great concerns over their safety. Reports on hepatotoxicity, mainly related to disulfiram therapy, have been published. The hepatotoxic potential of calcium carbimide is less well characterized. Here, we describe four cases of liver damage related to this therapeutic group that were submitted to a Registry of hepatotoxicity and point out the limitations that we face when prescribing these compounds. A reassessment of the role of these compounds in the management of alcohol dependence is clearly needed.

关键词： Calcium carbimide Disulfiram Hepatotoxicity

Digital Financial Inclusion and Consumption Smoothing in China

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China & World Economy 2020年第1期28卷 64-93页

作者： Jennifer T.Lai isabel K.m.Yan Xingjian Yi Hao Zhang School of Finance Guangdong University of Foreign StudiesChina Department of Economics and Finance.City University of Hong Kong China

In this paper,we investigate the effect of digital financial inclusion(DFI)on household consumption smoothing in *** use four waves of the biennial China Family Panel Studies from 2010 to 2016,during which time DFI has significantly developed alongside financial technology across *** split household income shocks into permanent and transitory components,and evaluate if DFI may help households to buffer against these *** find that households are not able to insure against permanent shocks to income,but they can smooth approximately 70 percent of transitory shocks to *** also find that DFI has diminished households'ability to insure against transitory income *** is partly because online purchase may lead to the oversensitivity of consumption to *** addition,we find that contrary to DFI,traditional financial sector development contributes to better household consumption smoothing against transitory income shocks.

关键词： consumption smoothing digital financial inclusion insurance permanent income shock transitory income shock