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Early life investment in antlers and body growth reflects adult performance in roe deer population under supplementary feeding conditions

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Integrative Zoology 2022年第3期17卷 396-407页

作者： Marta PELÁEZ Isabel SAnUY Juan Carlos PERAL JoséLuisÁlvarez ESTEBAN Santiago LAVÍN Emmanuel SERRANO Ramón PEREA Departamento de Sistemas y Recursos Naturales Universidad Politécnica de MadridMadridSpain Wildlife Ecology&Health group(WE&H)and Servei d’Ecopatologia de Fauna Salvatge(SEFaS).Facultat de Veterinària Universitat Autònoma de Barcelona(UAB)BarcelonaSpain Centro Cinegético I+D de Valsemana Junta de Castilla y LeónLa ErcinaLeónSpain

Recent research has challenged the idea that cervid antlers are such costly traits,supporting the assertion early-life antler investment is an honest signal of adult phenotypic quality.However,inferences were made based on antler measurements while growing(velvet)and thus,studies on fully-formed clean antlers are needed to avoid possible bias caused by the inter-individual variation in antler growth phenology.We studied a semi-captive population of European roe deer inhabiting a sub-Mediterranean area(Valsemana research station)and living under optimal conditions(ad libitum food supply and veterinary care).Based on repeated measurements taken from 146 individuals,we assessed whether allocation to secondary sexual traits during early life affected body mass or antler development during adulthood.Furthermore,we evaluated which body measurements better predicted future male quality.Additionally,using 488 individuals,we described age-class-specific variation in male body measurements and assessed the decline in antler size between adult and senescent stages(i.***.magnitude of senescence).Results agree with the assertion that there is no negative effect of a high investment in antler during early life on adult antler size or body mass,but we suggest the use of clean antlers as a more robust and reliable measure.The variables that better predicted body mass during adulthood were yearling body mass and body size at 6 months.Antler score between 10 and 18 months resulted in the best indicator of adult antler size.Finally,we support the idea that the magnitude of senescence in antler size is smaller in environments with higher resource availability during winter.

关键词： antler size body mass early-life investment Mediterranean environments secondary sexual traits and senescence trade-offs

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Fine‑tuning genomic and pedigree inbreeding rates in equine population with a deep and reliable stud book:the case of the Pura Raza Española horse

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Journal of Animal Science and Biotechnology 2023年第2期14卷 515-528页

作者： Davinia isabel Perdomo‑Gonzalez Nora Laseca Sebastian Demyda‑Peyras Mercedes Valera isabel Cervantes Antonio Molina Departamento Agronomia Escuela Tecnica Superior de Ingenieria AgromomicaUniversidad de SevillaCtra Utrera Km 141013 SevillaSpain Departamento de Genetica Universidad de CordobaCordobaSpain Facultad de Ciencias Veterinarias Universidad Nacional de La PlataLa PlataArgentina Consejo Nacional de Investigaciones Cientificas y Tecnicas(CONICET) La PlataArgentina Departamento de Produccion Animal Facultad de VeterinariaUniversidad Complutense de MadridMadridSpain.

Background:Estimating inbreeding,which is omnipresent and inevitable in livestock populations,is a primary goal for management and animal breeding especially for those interested in mitigating the negative consequences of inbreeding.Inbreeding coefficients have been historically estimated by using pedigree information;however,over the last decade,genome-base inbreeding coefficients have come to the forefront in this field.The Pura Raza Espanola(PRE)horse is an autochthonous Spanish horse breed which has been recognised since 1912.The total PRE population(344,718 horses)was used to estimate Classical(F),Ballou’s ancestral,Kalinowski’s ancestral,Kalinowski’s new and the ancestral history coefficient values.In addition,genotypic data from a selected population of 805 PRE individuals was used to determine the individual inbreeding coefficient using SNP-by-SNP-based techniques(methods of moments-FHOM-,the diagonal elements of the genomic-FG-,and hybrid matrixes-FH-)and ROH measures(FRZ).The analyse of both pedigree and genomic based inbreeding coefficients in a large and robust population such as the PRE horse,with proven parenteral information for the last 40 years and a high degree of completeness(over 90%for the last 70 years)will allow us to understand PRE genetic variability better and the correlations between the estimations will give the data greater reliability.Results:The mean values of the pedigree-based inbreeding coefficients ranged from 0.01(F for the last 3 generations-F3-)to 0.44(ancestral history coefficient)and the mean values of genomic-based inbreeding coefficients varied from 0.05(FRZ for three generations,FH and FHOM)to 0.11(FRZ for nine generations).Significant correlations were also found between pedigree and genomic inbreeding values,which ranged between 0.58(F3 with FHOM)and 0.79(F with FRZ).In addition,the correlations between FRZ estimated for the last 20 generations and the pedigree-based inbreeding highlight the fact that fewer generations of genomic data are required when comparing total

关键词： Genomic inbreeding Horses Pedigree inbreeding

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Recent Advances and Challenges Toward Application of Fibers and Textiles in Integrated Photovoltaic Energy Storage Devices

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Nano-Micro Letters 2023年第3期15卷 190-247页

作者： Amjid Rafique isabel Ferreira Ghulam Abbas Ana Catarina Baptista CENIMAT|I3N Department of Materials ScienceSchool of Science and TechnologyNOVA University LisbonCampus de Caparica2829‑516 CaparicaPortugal

Flexible microelectronic devices have seen an increasing trend toward development of miniaturized,portable,and integrated devices as wearable electronics which have the requirement for being light weight,small in dimension,and suppleness.Traditional three-dimensional(3D)and two-dimensional(2D)electronics gadgets fail to effectively comply with these necessities owing to their stiffness and large weights.Investigations have come up with a new family of one-dimensional(1D)flexible and fiber-based electronic devices(FBEDs)comprising power storage,energy-scavenging,implantable sensing,and flexible displays gadgets.However,development and manufacturing are still a challenge owing to their small radius,flexibility,low weight,weave ability and integration in textile electronics.This paper will provide a detailed review on the importance of substrates in electronic devices,intrinsic property requirements,fabrication classification and applications in energy harvesting,energy storage and other flexible electronic devices.Fiber-and textile-based electronic devices for bulk/scalable fabrications,encapsulation,and testing are reviewed and presented future research ideas to enhance the commercialization of these fiber-based electronics devices.

关键词： Flexible electronics Electronic textiles Energy harvesting Supercapacitors Photovoltaic devices

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Closed loop ileus caused by a defect in the broad ligament:A case report

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World Journal of Clinical Cases 2023年第5期11卷 1182-1187页

作者： isabel Zucal Christian A Nebiker Department of General Surgery Cantonal Hospital of AarauAarau 5001Switzerland

BACKGROUND Closed loop ileus caused by entrapment of bowel in a defect of the broad ligament is a rarity.Only a few cases have been reported in the literature.CASE SUMMARY We present the case of a 44-year-old,healthy patient with no prior history of abdominal surgery who developed a closed loop ileus due to an internal hernia secondary to a defect in the right broad ligament.She first presented to the emergency department with diarrhea and vomiting.As she had had no previous abdominal surgery,she was diagnosed with probable gastroenteritis and discharged.The patient subsequently returned to the emergency department due to a lack of improvement in her symptoms.Blood tests showed an elevated white blood cell count and a closed loop ileus was diagnosed on an abdominal computer tomography scan.Diagnostic laparoscopy revealed an internal hernia entrapped in a 2 cm large defect in the right broad ligament.The hernia was reduced and the ligament defect was closed using a running,barbed suture.CONCLUSION Bowel incarceration through an internal hernia may present with misleading symptoms and laparoscopy may reveal unexpected findings.

关键词： Broad ligament Ileus Internal hernia Laparoscopy Case report

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Low-power SiPM readout BETA ASIC for space applications

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Nuclear Science and Techniques 2024年第3期35卷 153-169页

作者： Anand Sanmukh Sergio Gómez Albert Comerma Joan Mauricio Rafel Manera Andreu sanuy Daniel Guberman Roger Catala Albert Espinya Marina Orta Oscar de la Torre David Gascon Departament de Física Quàntica i Astrofísica(FQA) Institut de Ciències del Cosmos(ICCUB)Universitat de Barcelona(UB)08028 BarcelonaSpain Institut d’Estudis Espacials de Catalunya(IEEC) 08034 BarcelonaSpain Electronics Department Serra Hunter fellow at Polytechnic University of Catalonia(UPC)08019 BarcelonaSpain

The BETA application-specific integrated circuit(ASIC)is a fully programmable chip designed to amplify,shape and digitize the signal of up to 64 Silicon photomultiplier(SiPM)channels,with a power consumption of approximately~1 mW/channel.Owing to its dual-path gain,the BETA chip is capable of resolving single photoelectrons(phes)with a signal-to-noise ratio(SNR)>5 while simultaneously achieving a dynamic range of~4000 phes.Thus,BETA can provide a cost-effective solution for the readout of SiPMs in space missions and other applications with a maximum rate below 10 kHz.In this study,we describe the key characteristics of the BETA ASIC and present an evaluation of the performance of its 16-channel version,which is implemented using 130 nm technology.The ASIC also contains two discriminators that can provide trigger signals with a time jitter down to 400 ps FWHM for 10 phes.The linearity error of the charge gain measurement was less than 2%for a dynamic range as large as 15 bits.

关键词： Radiation detectors Silicon photomultipliers Photon sensors Front-end electronics Mixed-mode ASICs Space technology

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Platelet-rich plasma： combinational treatment modalities for musculoskeletal conditions

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Frontiers of Medicine 2018年第2期12卷 139-152页

作者： isabel Andia Michele Abate Regenerative Medicine Laboratory RioCruces Health Research Institute Cruces University Hospital 48903 Barakaldo Spain Department of Medicine and Science of Aging University G. d'Annunzio Chieti-Pescara 66013 Chieti Scalo Italy

Current research on common musculoskeletal problems, including osteoart]cular cona]t]ons, tendinopathies, and muscle injuries, focuses on regenerative translational medicine. Platelet-rich plasma therapies have emerged as a potential approach to enhance tissue repair and regeneration. Platelet-rich plasma application aims to provide supraphysiological concentrations of platelets and optionally leukocytes at injured/pathological tissues mimicking the initial stages of healing. However, the efficacy of platelet-rich plasma is controversial in chronic diseases because patients＇ outcomes show partial improvements. Platelet-rich plasma can be customized to specific conditions by selecting the most appropriate formulation and timing for application or by combining platelet-rich plasma with synergistic or complementary treatments. To achieve this goal, researchers should identify and enhance the main mechanisms of healing. In this review, the interactions between platelet-rich plasma and healing mechanisms were addressed and research opportunities for customized treatment modalities were outlined. The development of combinational platelet-rieh plasma treatments that can be used safely and effectively to manipulate healing mechanisms would be valuable and would provide insights into the processes involved in physiological healing and pathological failure.

关键词： regenerative medicine joint conditions muscle injuries platelet rich plasma tendinopathy healing mechanisms

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Long-term monitoring data reveal effects of age,population density,and environmental aspects on hatching success of Common Cranes(Grus grus)

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Avian Research 2022年第3期13卷 347-355页

作者： isabel Barwisch Wolfgang Mewes Angela Schmitz Ornes AG Vogelwarte Zoological Institute and MuseumUniversity of GreifswaldSoldmannstr.23GreifswaldGermany Grüner Weg 3 19395Plau Am SeeOT KarowGermany

Facing climate and land use change,a species’ability to successfully adapt to changing environments is crucial for its survival.Extensive drainage and intensification of agriculture and forestry set wetlands and associated species at risk of population declines.The population of Common Cranes(Grus grus)has experienced considerable fluctuations over the last century.Despite increasing population numbers,hatching success seemed to have decreased over the last years.The aim of this study was to identify factors influencing hatching success and nest survival of Common Cranes based on analyses of long-term individual-based monitoring data from northeastern Germany and evaluate the species ability to adapt to changing environments.Hatching success decreased over the course of the study period from 0.75 to 0.55.Surprisingly,nest survival and hatching success did not vary across different nesting habitats,whereas factors such as female age,timing of nest initiation and breeding pair density were found to have significant effects on hatching success.Older females showed higher hatching success,even though the proportion of unhatched eggs was highest in females aged 20 years or older.Early nest initiation had a positive effect on hatching success.Water levels are more favorable early in the nesting season,whereas increasing evaporation with time causes water levels to decrease,granting easier access for predators.Independently of female age,hatching success decreased with increasing numbers of breeding pairs within a 2-km radius around a nesting site.High population densities intensify competition for resources and promote intraspecific interactions,affecting reproductive outcome negatively.This study gives first insights into mechanisms behind population regulation in Common Cranes,highlighting the importance of population dynamics and individual features.We suggest to further investigate density dependent effects including landscape and habitat features as well as reproductive success in terms of chick survival,since suc

关键词： Adaptation Age Cranes Grus grus Habitat Nest survival Population density Reproduction

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联合国安理会对非洲冲突的反应：刚果民主共和国（DRC）案例研究

联合国安理会对非洲冲突的反应：刚果民主共和国（DRC）案例研究

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作者： Chimedza isabel Netsai 吉林大学

学位级别：硕士

联合国安全理事会(安理会)是联合国的一个机构,其主要责任是维护国际和平与安全。它发挥联合国的执行作用,并与其他区域机构合作执行其维持和平的作用。安全理事会是根据《联合国宪章》(以下简称《宪章》)第五章设立的,根据其第二十四... 详细信息

联合国安全理事会(安理会)是联合国的一个机构,其主要责任是维护国际和平与安全。它发挥联合国的执行作用,并与其他区域机构合作执行其维持和平的作用。安全理事会是根据《联合国宪章》(以下简称《宪章》)第五章设立的,根据其第二十四条第一款,安全理事会被赋予"维护国际和平与安全的首要责任"。因此,安全理事会设立了一些机构,以便充分执行其任务。联合国自成立以来一直参与会员国的各种危机、争端和侵略行为。因此,必须评估或评价安全理事会在努力解决特定危机方面的成功程度。该研究评估了安全理事会在解决21世纪非洲冲突方面的成功,特别是在刚果民主共和国(DRC)。刚果民主共和国自从比利时独立以来一直面临着无休止的冲突,如继承冲突,种族战争,起义,叛乱,入侵和叛变,迄今为止该国未能解除冲突群体的武装。自1960年以来,联合国安全理事会以联合国刚果行动(UNOC)的名义介入了这场冲突,部署了大量维和部队,以遏制危机并限制大型冲突的可能性。此外,从1999年起,《卢萨卡协定》(1999年)、《大湖区问题国际会议》(2000年)、《三方加一》(2004年)、《戈马会议》(2009年)、《坎帕拉协定》(2013年)和《亚的斯亚贝巴框架》(2013年)等多项和平倡议,尽管有这些和平倡议,但刚果民主共和国的安全局势并没有改善。这项研究评估了联合国安理会的有效性执行机制。联合国安理会通过维护国际和平与安全,作为第三次世界大战的出现而受到欢迎、欢迎和赞扬。然而,它在几个非洲国家,特别是刚果民主共和国执行其职责,留下了很多需要,一些问题没有得到回答。因此,需要回答的主要问题是联合国安理会在多大程度上有效。为了认识到刚果民主共和国持续冲突的原因,本研究试图回答三个研究问题:刚果民主共和国冲突的性质和来源是什么?联合国安理会及其机构为解决非洲冲突所使用的机制是什么?为什么联合国安理会在试图回答这些问题时未能解决刚果的冲突?本研究采用定性研究方法,使研究人员对刚果民主共和国的冲突以及联合国安理会及其相关机构如何干预解决冲突有更多的了解和深入的了解。桌面方法用于收集辅助数据。为了使研究人员分析收集的数据并提出建议和建议,还使用了内容分析方法。研究报告的结论是,安全理事会没有取得成效和成效。研究共五章,第一章着重介绍联合国安全理事会在解决非洲冲突方面的作用,特别是在刚果民主共和国、研究问题和论点、进行研究的意义、进行研究所采用的方法,如桌面、内容分析、个案研究和描述性方法。本章还解释了来自不同作者的一些文献如何讨论这个主题,这些文献解释了UNSC及其机制在解决非洲冲突中的作用,主要是在刚果民主共和国。本章还包括本毕业论文的结构。第二章说明了刚果民主共和国冲突的性质和根源,概述了刚果冲突的性质和根源。第三章分析了联合国安理会在非洲的实际干预框架。第四章分析联合国安理会第28届会议执行框架的优缺点。

关键词：联合国安全理事会刚果民主共和国冲突联合国宪章非洲

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Refractive error study in young subjects：results from a rural area in Paraguay

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International Journal of Ophthalmology(English edition) 2017年第3期10卷 467-472页

作者： isabel Signes-Soler Non-govemmental Organization Vision Without Borders (Visio Sense Fronteres) Alicante 03710 Spain School of Advanced Education Research and Accreditation (SAERA) Castellon de la Plana 12001 Spain Faculty of Optics and Optometry University Complutense of Madrid Madrid 28037 Spain European University of Madrid Madrid 28108 Spain Foundation for the Visual Quality (FUNCAVIS) Alicante 03016 Spain Department of Optics Pharmacology and Anatomy University of Alicante Alicante 03690 Spain

AIM：To evaluate the distribution of refractive error in young subjects in a rural area of Paraguay in the context of an international cooperation campaign for the prevention of blindness. METHODS：A sample of 1466 young subjects（ranging from 3 to 22 years old）,with a mean age of 11.21±3.63 years old,were examined to assess their distance visual acuity（VA）and refractive error. The first screening examination performed by trained volunteers,included visual acuity testing,autokeratometry and non-cycloplegic autorefraction. Inclusion criteria for a second complete cycloplegic eye examination by an optometrist were VA 〈20/25（0.10 log MAR or 0.8 decimal）and/or corneal astigmatism ≥1.50 D. RESULTS：An uncorrected distance VA of 0 log MAR（1.0decimal）was found in 89.2% of children. VA 〈20/25 and/or corneal astigmatism ≥1.50 D was found in 3.9% of children（n=57）,with a prevalence of hyperopia of 5.2%（0.2%of the total）in this specific group. Furthermore,myopia（spherical equivalent ≤-0.5 D）was found in 37.7% of the refracted children（0.5% of the total）. The prevalence of refractive astigmatism（cylinder ≤-1.50 D）was 15.8%（0.6% of the total）. Visual impairment（VI）（0.05≤VA≤0.3）was found in 12/114（0.4%）of the refracted eyes. Main causes for VI were refractive error（58%）,retinal problems（17%,2/12）,albinism（17%,2/12）and unknown（8%,1/12）.CONCLUSION：A low prevalence of refractive error has been found in this rural area of Paraguay,with higher prevalence of myopia than of hyperopia.

关键词： refractive error blindness visual impairment myopia hyperopia

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Evolution and Continuity of Linguistic Systems

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Language and Semiotic Studies 2022年第1期8卷 24-36页

作者： isabel Victoria Galleguillos Jungk Pontifical Catholic University of Sao Paulo University of Sao Paulo Brazil

In the inspiring extract highlighted in this paper,Saussure observes how the relation between the elements of the sign change and evolve over time.In his Cours,he also details the elements of the linguistic sign and the principles governing them,defining language as a system of signs.Despite the natural resistance to changes in language in order to enable it to continually fulfill its function,that is,despite the necessary immutability of linguistic signs,they change over time,by being in constant contact with the communities of speakers,to whom language actually belongs.This may seem paradoxical because language is composed of arbitrary relations between signified and signifier that seek to represent concepts.Saussure refers to a principle of change in language linked to a principle of continuity.The present study focuses on the semiotic and communicational aspects of the development of linguistic systems in time,understood from a systemic perspective.It is sought to evince how signs perpetuate themselves and evolve through their constant interaction with real communities of language users.This approach can offer new insights about the continuity of linguistic systems as systems of signs that present immutable and mutable characters,and whose evolution can be understood based on open systems parameters,such as permanence,autonomy and sensitivity to flows of information,as studied by current theories and authors,showing that,to preserve its semiological life (CGL,1959,p.76),a living language must continuously reflect the purposes of its users.

关键词： linguistic systems linguistic mutability evolution continuity systems parameters

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