检索结果-南通市图书馆

Relation of COVID-19 with liver diseases and their impact on healthcare systems:The portuguese case

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2023年第6期29卷 1109-1122页

作者： Sara fernandes Milaydis Sosa-Napolskij Graça Lobo isabel Silva Instituto de Ciências Biomédicas Abel Salazar da Universidade do porto(ICBAS-Up) Porto 4050-313Portugal CINTESIS@RISE Center for Health Technology and Services Research at The Associate Laboratory RISE–Health Research NetworkFaculty of Medicine of The University of PortoPorto 4200-219Portugal Laboratory of pharmacology and Neurobiology–Department of Immuno-physiology and pharmacology Instituto de Ciências Biomédicas Abel Salazar da Universidade do Porto(ICBAS-UP)Porto 4050-313Portugal Center for Drug Discovery and Innovative Medicines(MedInUp) Instituto de Ciências Biomédicas Abel Salazar da Universidade do Porto(ICBAS-UP)Porto 4050-313Portugal

BACKGROUND The impact caused by the coronavirus disease 2019(COVID-19)on the portuguese population has been addressed in areas such as clinical manifestations,frequent comorbidities,and alterations in consumption ***,comorbidities like liver conditions and changes concerning the portuguese population's access to healthcare-related services have received less *** To(1)Review the impact of COVID-19 on the healthcare system;(2)examine the relationship between liver diseases and COVID-19 in infected individuals;and(3)investigate the situation in the portuguese population concerning these *** For our purposes,we conducted a literature review using specific *** COVID-19 is frequently associated with liver ***,liver injury in COVID-19 individuals is a multifactor-mediated ***,it remains unclear whether changes in liver laboratory tests are associated with a worse prognosis in portuguese individuals with *** COVID-19 has impacted healthcare systems in portugal and other countries;the combination of COVID-19 with liver injury is *** liver damage may represent a risk factor that worsens the prognosis in individuals with COVID-19.

关键词： COVID-19 Healthcare systems Liver portuguese individuals Comorbidities Clinical outcomes

Immunological mechanisms of fecal microbiota transplantation in recurrent Clostridioides difficile infection

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2022年第33期28卷 4762-4772页

作者： Lucas F Soveral Gabriela G Korczaguin pedro S Schmidt isabel S Nunes Camilo fernandes Carlos R Zarate-Blades Laboratory of Immunoregulation Department of MicrobiologyImmunologyand ParasitologyCenter for Dysbiosis ControlFederal University of Santa CatarinaFlorianopolis 88037-000Brazil Division of Infectious Diseases Hospital Nereu RamosFlorianopolis 88025-301Brazil

Fecal microbiota transplantation(FMT)is a successful method for treating recurrent Clostridioides difficile(***)infection(rCDI)with around 90%*** to the relative simplicity of this approach,it is being widely used and currently,thousands of patients have been treated with FMT ***,the mechanisms underlying its effects are just beginning to be *** indicate that FMT effectiveness is due to a combination of microbiological direct mechanisms against ***,but also through indirect mechanisms including the production of microbiota-derived metabolites as secondary bile acids and short chain fatty ***,the modulation of the strong inflammatory response triggered by *** after FMT seems to rely on a pivotal role of regulatory T cells,which would be responsible for the reduction of several cells and soluble inflammatory mediators,ensuing normalization of the intestinal mucosal immune *** this minireview,we analyze recent advances in these immunological aspects associated with the efficacy of FMT.

关键词： Fecal microbiota transplantation Immunity Mechanism Dysbiosis pseudomembranous colitis Clostridioides difficile

Emerging role of liquid biopsy in rat sarcoma virus mutated metastatic colorectal cancer:A case report

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastrointestinal Oncology 2024年第1期16卷 234-243页

作者： João Gramaça isabel Gomes fernandes Carolina Trabulo Joana Gonçalves Rita Gameiro dos Santos Adriano Baptista Idília pina Centro Hospitalar Barreiro Montijo Centro Hospitalar Barreiro MontijoSetúbalBarreiro 2830-003Portugal Medical Oncology Unit Centro Hospitalar Barreiro MontijoSetúbalBarreiro 2830-003Portugal

BACKGROUND In patients with metastatic colorectal cancer(mCRC),the treatment options are limited and have been proved to be affected by rat sarcoma virus(RAS)mutational *** RAS wild-type(wt)patients,the combination of antiepidermal growth factor receptor(EGFR)monoclonal antibodies with chemotherapy(CT)is more effective than CT *** the other hand,RAS-mutated patients are not eligible for treatment with anti-EGFR *** SUMMARY Eleven patients with initially RAS-mutated mCRC were followed from diagnosis to May *** the time of cell-free DNA determination,five patients had undergone one CT line,five patients had undergone two CT lines,and one patient had undergone three CT lines(all in combination with bevacizumab).At the second and third treatment lines[second line(2L),third line(3L)],patients with neo-RAS wt received a combination of CT and *** neo-RAS wt patients treated with anti-EGFR,our findings indicated an increase in progression-free survival for both 2L and 3L(14.5 mo,p=0.119 and 3.9 mo,p=0.882,respectively).Regarding 2L overall survival,we registered a slight increase in neo-RAS wt patients treated with anti-EGFR(33.6 mo vs 32.4 mo,p=0.385).At data cut-off,two patients were still alive:A RAS-mutated patient undergoing 3L treatment and a neo-RAS wt patient who received 2L treatment with anti-EGFR(ongoing).CONCLUSION Our case series demonstrated that monitoring RAS mutations in mCRC by liquid biopsy may provide an additional treatment line for neo-RAS wt patients.

关键词： Metastatic colorectal cancer Rat sarcoma virus mutational status Liquid biopsy Rat sarcoma virus wild-type Neo-rat sarcoma virus wild-type Anti-epidermal growth factor receptor therapy Case report

Lymphocyte subsets predictive value and possible involvement of human papilloma virus infection on breast cancer molecular subtypes

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Clinical Oncology 2018年第7期9卷 123-132页

作者： Andreína fernandes Adriana pesci-Feltri isabel García-Fleury Marco López Vincent Guida Marisol De Macedo María Correnti Oncology and Hematology Institute University Hospital of Caracas

AIM To detect human papilloma virus(HpV) presence and to characterize cellular immune response in breast cancer patients. METHODS A total of 74 women were included, of which 48 samples were from patients diagnosed with breast cancer and 26 patients with benign pathology of the breast. Molecular subtype classification was performed based on the immunohistochemical reports of the tumor piece. HpV genome detection and genotyping from fresh breast biopsies was performed using the INNO-LIpA HpV Genotyping Extra test(Innogenetics, Ghent, Belgium). CD3+, CD4+, CD8+ and natural killer(NK)+ cells levels from peripheral blood samples from patients with breast cancer and benign pathology were measured by flow cytometry. RESULTS Luminal A was the most frequent breast cancer molecular subtype(33.33%). HpV was detected in 25% of the breast cancer patients, and genotype 18 was the most frequent in the studied population. The mean of CD3+, CD4+ and CD8+ subpopulations were decreased in patients with breast cancer, in relation to those with benign pathology, with a statistically significant difference in CD8+ values(p = 0.048). The mean of NK+ cells was increased in the benign pathology group. The average level of CD3+, CD4+, CD8+ and NK+ cells decreased as the disease progressed. HER2+ and Luminal B HER2+ tumors had the lowest counts of cell subsets. HpV breast cancer patients had elevated counts of cellular subsets. CONCLUSION Determining level changes in cellular subsets in breast cancer patients is a useful tool to evaluate treatment response.

关键词： Breast cancer Human papilloma virus Molecular subtypes Immune response T lymphocytes NK cells

Carbon Footprint of Tourism Sector in portugal-Calculator Development

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Tourism and Hospitality Management 2021年第6期9卷 365-380页

作者： Marco fernandes pedro Neves patrícia Araújo isabel Brás Elisabete Silva polytechnic Institute of Viseu ViseuPortugal Biosphere portugal ViseuPortugal

A carbon footprint(CF)calculator was developed to apply to a portuguese touristic accommodation to contribute to a sustainable touristic *** some calculators are available online,they are related to the country reality or use outdated emission factors.A calculator based on national emission factors is *** calculator was developed in Microsoft Excel(version 365)and is based on the CO2e emissions resulting from electricity,water,fuels and food use,laundry and waste *** calculator development involved:study the accommodation emission sources,selection the environmental indicators,determination of the emission factors and development of the CF *** CF calculation was made considering the partial CF per component,a monthly and annual comparison of each indicator’s emissions contribution using *** emissions amount per overnight stay,per room,per area,were also assessed and these values were transformed into global hectare(gha).Avoided emissions calculation gives the information about the efforts in CF reduction,and two indicators were considered:electricity production from renewable energy sources and the amount of separated waste for *** was considered reforestation measures to achieve carbon *** calculator incorporates four components not often used:water,laundry,waste,food,and avoided emissions.

关键词： calculator carbon footprint greenhouse gases environmental indicators sustainable tourism

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

壳聚糖基皮革抗菌涂层的研究(续)

中国皮革 2014年第5期43卷 49-53页

作者： isabel p. fernandes Joana S. Amaral Vera pinto Maria José Ferreira Maria Filomena Barreiro 陈小珂分离与反应工程实验室(LSRE)副实验室LSRE/LCM布拉干萨理工学院葡萄牙布拉干萨5301857 药剂学院波尔图大学葡萄牙波尔图4050313 布拉干萨理工学院葡萄牙布拉干萨5301857 葡萄牙制鞋技术中心葡萄牙圣若昂3700121

关键词：壳聚糖皮革鞋类抗菌涂料

Roots and rhizomes of wild Asparagus:Nutritional composition,bioactivity and nanoencapsulation of the most potent extract

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Food Bioscience 2022年第1期45卷 349-360页

作者： Khaoula Adouni Ana Júlio Celestino Santos-Buelga Ana M.Gonzalez-paramas patrícia Filipe patricia Rijo Sofia A.Costa Lima Salette Reis Angela fernandes isabel C.F.R.Ferreira Virginia Fernandez-Ruiz patricia Morales Guido Flamini Lotfi Achour pedro Fonte Laboratoire de Recherche“Bioressources:Biologie Integrative&Valorisation” Institut Superieur de Biotechnologie de MonastirAvenue Tahar HaddedBP 74Universite de Monastir5000MonastirTunisia CBIOS-Research Center for Biosciences&Health Technologies Universidade Lusofona de Humanidades e TecnologiasCampo Grande 3761749-024LisbonPortugal Department of Biomedical Sciences University of Alcal´aCtra.Madrid-Barcelona Km.33.60028871Alcala de HenaresMadridSpain Grupo de Investigacion en polifenoles(GIp-USAL) Facultad de FarmaciaUniversidad de SalamancaCampus Miguel de UnamunoE-37007SalamancaSpain Research Institute for Medicines(iMed.ULisboa) Faculty of PharmacyUniversidade de LisboaAv.Professor Gama Pinto1649-003LisboaPortugal LAQV REQUIMTEDepartment of Chemical Sciences–Applied Chemistry LabFaculty of Pharmacy10 University of PortoRua Jorge de Viterbo Ferreira 2284050-313PortoPortugal Centro de Investigacao de Montanha(CIMO) Instituto Politecnico de BragancaCampus de Santa Apolonia5300-253BragancaPortugal Department of Nutrition and Food Science Faculty of PharmacyComplutense University of Madrid(UCM)Plaza Ramon y Cajal s/n28040MadridSpain Dipartimento di Farmacia University of Pisavia Bonanno 656126PisaItaly Centro Interdipartimentale di Ricerca“Nutraceutica e Alimentazione per la Salute”University of pisa Via del Borghetto 8056124PisaItaly Center for Marine Sciences(CCMar) University of AlgarveGambelas Campus8005-139FaroPortugal Department of Chemistry and pharmacy Faculty of Sciences and TechnologyUniversity of AlgarveGambelas Campus8005-139FaroPortugal iBB-Institute for Bioengineering and Biosciences Department of BioengineeringInstituto Superior TecnicoUniversidade de Lisboa1049-001LisboaPortugal Associate Laboratory i4HB—Institute for Health and Bioeconomy at Instituto Superior Tecnico Universidade de LisboaAv.Rovisco Pais1049-001LisboaPortugal

The nutritional composition and bioactive properties of roots and rhizomes of Asparagus stipularis were *** activity of extracts obtained by infusion was evaluated using free radicals scavenging and reducing power *** liver primary cell was used to check the hepatotoxicity of *** revealed that Asparagus samples are likely a source of nutrients,such as dietary fibre and essential fatty ***-DAD-ESI/MS characterization of infusions allowed the identification and quantitation of 7 phenolic compounds,all hydroxycinnamoyl derivatives,with caffeic acid as the most *** infusion contained the highest amounts of these *** also exhibited the highest antioxidant activity in all assays,with EC_(50) values of 0.44±0.01,0.98±0.03 and 0.64±0.01 mg/mL for DppH,ABTS and FRAp assays,respectively,with no toxicity towards pLp2 primary cell cultures(GI_(50)>400μg/mL).pLGA nanoparticles loaded with root extract were prepared using solvent-evaporation double emulsion *** size was about 260 nm and a polydispersity index around 0.1,with a zeta potential of about-36 mV,as well as a good encapsulation efficiency of approximately 83%.Their morphology was analysed by SEM and spherical polymeric nanoparticles with a smooth surface were *** and DSC were also performed,which allowed corroborating the efficacy of the encapsulation and to confirm the production of a stable and robust system to load Asparagus *** developed nanoparticles are expected to be used as delivery systems for bioactive compounds of *** and they could be used as an innovative dietary supplement.

关键词： Asparagus stipularis Nutritional composition Antioxidant activity Nanoparticles pLGA

Nursing Diagnostics of Nutrition Domain of NANDA International in Hemodialysis patients

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Open Journal of Nursing 2016年第3期6卷 204-212页

作者： Érida Maria Diniz Leite Sama Mikaella de Oliveira Maria isabel da Conceição Dias fernandes Maria das Graças Mariano Nunes Cyndi fernandes de Lima Ana Luisa Brandão de Carvalho Lira Department of Nursing Hospital Academic Onofre Lopes Natal Brasil Department of Nursing University of Rio Grande do Norte Natal Brasil

Introduction: The dialysis causes the loss of the nutrients and the elevation of catabolism, thus, patients in dialysis have at high risk for the loss of body reserves of protein and energy. Objective: To identify nursing diagnoses of nutrition domain of NANDA International in hemodialysis patients and to correlate them to the socioeconomic and clinical data. Design: Cross-sectional study. Setting: performed in a large university hospital in northeastern Brazil. participants: The first stage was carried out with 50 patients, selected with the following inclusion criteria: Being hospitalized and undergoing hemodialysis in that hospital;aged 18 years old or over;being conscious and oriented. Exclusion criteria were patients undergoing hemodialysis in that hospital with external service, pregnant women and patients being treated by plasmapheresis. In the second stage, participants were three nursing specialists in nephrology and nursing diagnoses. Methods: The defining characteristics of the nursing diagnoses inserted in the nutrition domain were observed in patients and then these data were judged by nurses, in order to identify diagnoses present in each patient. The Chi-square, Fisher’s exact and Mann-Whitney tests were used in the analysis of the relationship of socioeconomic and clinical data, with an adopted p value of p = 0.001), origin (p = 0.014), religion (p = 0.046) and income (p = 0.039), respectively. Conclusion: The variables that showed significant association were risk of impaired liver function and gender;imbalanced nutrition: More than body requirements and origin requirements;risk for deficient fluid volume and religion;and deficient fluid volume and income.

关键词： Nursing Nursing Diagnosis Risk Groups Nutrition Renal Dialysis

Analysis of Water Temperature Influenced by Arduino-Controlled on Solar Desalinator of Low Cost

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Mechanics Engineering and Automation 2019年第4期9卷 133-138页

作者： Joao Dehon da Rocha Junior Rafael Leandro fernandes Melo Joao Felipe Vieira Lima isabel Cristina da Costa Souza Jose Josemar de Oliveira Junior Luiz Guilherme Meira de Souza Departamento de Mecanica Instituto Federal do CearaTabuleiro do NorteCeara62960-000Brazil Departamento de Engenharia Mecanica Universidade Federal do ParanaCuritiba 81530-000Brazil Departamento Bioquimica e Biologia Molecular Universidade Federal do CearaFortaleza 60020-181Brazil Departamento de Engenharia Mecanica Universidade Federal do Rio Grande do NorteNatal 59014-615Brazil

The solar desalinator is a low cost installation and operation equipment that can contribute to tackling the problem of water shortages in the *** of the importance of this equipment,the present work has the objective to quantify the relation of the temperature of the water with the production of the *** this,a compact desalinator with glass cover in square pyramidal form and a heating system controlled by a logic programmer was *** a result,it was verified the efficiency of the logic controller as an auxiliary tool for experimental work and the relationship between temperature ranges and desalination production.

关键词： Solar desalinator temperature of water influence logical programmer solar energy compact desalinator