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oxypropylation of Brazilian Pine-Fruit Shell Evaluated by Principal Component Analysis

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journal of Renewable Materials 2018年第7期6卷 715-723页

作者： Stephany Cde Rezende joão APinto isabel PFernandes Fernanda VLeimann Maria-Filomena Barreiro Laboratory of Separation and Reaction Engineering-Laboratory of Catalysis and Materials(LSRE-LCM) Polytechnic Institute of BragançaBragançaPortugal Programa de Pós-Graduação em Tecnologia de Alimentos(PPGTA) Universidade Tecnológica Federal do Paraná-UTFPR Campus Campo MourãoVia Rosalina Maria Dos Santos1233.CEP 87301-899.Caixa Postal:271Campo Mourão-PR-Brasil Mountain Research Centre(CIMo) Polytechnic Institute of BragançaBragançaPortugal

Pine-fruit shell (PFS) is a lignocellulosic residue derived from the fruit of Araucaria angustifolia, a coniferoustree native of South America, part of a whole vegetation of the Atlantic Forest, found in the South and Southwestof Brazil. In this work PFS will be characterized and used in the production of PFS-based polyols throughoxypropylation. Three series were chosen (PFS/propylene oxide (Po) (w/v, g/mL) of 30/70, 20/80 and 10/90)with four catalyst levels (5%, 10%, 15% and 20%, (w/w, PFS based)). oxypropylation occurred at moderateconditions of temperature, pressure and time giving rise to liquid polyols with a homopolymer content (PPo)ranging from 4-65%, a hydroxyl number (IoH) between 257-605 mg KoH/g and viscosities (V) varying from0.76 Pa.s to 373.90 Pa.s (20°C) for the series 20/80 and 10/90, while for the series 30/70, the viscosity reachedvalues higher than 500 Pa.s, 20°C. The unreacted PFS (UR) varied between 3.6% and 77.4% (PFS-basis). Afterthe PFS-based polyols production and characterization, a principal component analysis (PCA) was performed inorder to evaluate the established interactions between the used formulation variables and the obtained polyolproperties. The PCA analysis allowed to clarify the interactions between PFS and Po contents and the finalbiopolyol properties (PPo, IoH, V and UR). This approach showed to be a simple method to rationally analyzethe influence of the input formulation variables on the final polyol properties.

关键词： Principal components analysis Brazilian pine-fruit shell (PFS) oxypropylation polyols

Genoprotection and metabolic benefits of marine macroalgae-Insights into the concept of functional foods through direct and indirect consumption

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Food Bioscience 2022年第3期47卷 524-533页

作者： Ana Marques joão Ferreira Ana Cerqueda-Pacheco Vitória Pereira Helena Abreu Rui Pereira Maria joão Pires Fernanda Seixas Paula oliveira isabel Gaivão Mário Pacheco Laboratory of Physiotoxicology CESAM-Centre for Environmental and Marine StudiesDepartment of BiologyUniversity of AveiroCampus Universitário de Santiago3810-193AveiroPortugal CECAV-Animal and Veterinary Research Center AL4AnimalsUniversity of Trás-os-Montes and Alto DouroQuinta de Prados5000-801Vila RealPortugal Department of Genetics and Biotechnology University of Trás-os-Montes and Alto DouroQuinta de Prados5000-801Vila RealPortugal Department of Biology and Environment University of Trás-os-Montes and Alto DouroQuinta de Prados5000-801Vila RealPortugal CITAB-Centre for the Research and Technology of Agro-Environmental and Biological Sciences Inov4AgroUniversity of Trás-os-Montes and Alto DouroQuinta de Prados5000-801Vila RealPortugal Department of Veterinary Sciences University of Trás-os-Montes and Alto DouroQuinta de Prados5000-801Vila RealPortugal ALGAplus Lda.Travessa Alexandre da Conceição s/n3830-196ÍlhavoPortugal

The consumption of marine macroalgae has been linked with health benefits,albeit some actions,including genoprotection,remain ***,we evaluated the genoprotective potential of a mixture of Ulva rigida,Fucus vesiculosus and Gracilaria gracilis,through direct consumption or via indirect intake using fish(Sparus aurata)as a vector of algal ***(Mus musculus)were subjected to a 1-month dietary supplementation with 5%of macroalgae mix or 10%of fillet of fish previously fed with an algae-supplemented aquafeed(for comparison purposes,10%supplementation with fillet of fish standardly fed was also considered).Thereafter,mice were challenged by the genotoxicant methyl methanesulfonate(MMS),and the genetic damage was evaluated through the micronuclei ***,a wider evaluation was carried out encompassing the assessment of energy metabolism,haematological and histological parameters,as well as growth *** unequivocally protected against MMS-induced *** activity profile of hepatic lactate and isocitrate dehydrogenases promoted by the supplemented diets reflected an improved energy *** properties were not transferred via fish fed with the algae-supplemented aquafeed,though the transference of phytocomponents with beneficial properties(*** balance improvement)should not be ***,these findings highlighted the genoprotection afforded by marine macroalgae,likely promoted by desmutagenic factors,reinforcing their definition as functional *** possibility of using fish as an indirect source of algae-borne phytocomponents proved to be plausible and worthy of further investigations.

关键词： Antigenotoxicity Desmutagens Fish consumption Functional food Marine macroalgae consumption Metabolic benefits

Not all liver tumors are alike—an accidentally discovered primary hepatic leiomyosarcoma:A case report

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World journal of Hepatology 2022年第4期14卷 860-865页

作者： isabel Garrido Patrícia Andrade joão Pacheco Elisabete Rios Guilherme Macedo Gastroenterology and Hepatology Department Centro Hospitalar Universitário de São JoãoPorto 4200-319Portugal World Gastroenterology organization Porto Training Center Porto 4200-319Portugal Pathology Department Centro Hospitalar Universitário de São JoãoPorto 4200-319Portugal

BACKGRoUND Primary hepatic leiomyosarcoma is a very rare entity that originates from smooth *** diagnosis requires a high degree of suspicion due to atypical clinical presentation and non-specific imaging *** SUMMARY We report the case of a 42-year-old man,with no relevant past medical history,accidentally diagnosed with a nodular liver lesion on a routine abdominal *** function tests and hematology parameters as well as tumor markers were normal.A contrast-enhanced abdominal computed tomography scan revealed a heterogenous hepatic lesion measuring 40 mm 30 mm,adjacent to the left branch of the portal vein and the round *** to the unclear diagnosis,the patient underwent surgical *** and immunohistochemical examinations confirmed complete(R0)resection of a hepatic *** patient remains without any signs of tumor recurrence for more than 2 *** We report a rare case of accidentally diagnosed primary hepatic leiomyosarcoma originating from the portal vein or the round *** this tumor has aggressive metastatic potential,a tumor-free resection margin is essential to improve survival.

关键词： Primary hepatic leiomyosarcoma Portal vein Round ligament Surgical resection Case report

Neuropsychological features of progranulin-associated frontotemporal dementia: a nested case-control study

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Neural Regeneration Research 2021年第5期16卷 910-915页

作者： Marisa Lima Miguel Tábuas-Pereira Diana Duro joão Durães Daniela Vieira Inês Baldeiras Maria Rosário Almeida isabel Santana Neurology Department Centro Hospitalar e Universitário de CoimbraCoimbraPortugal University of Coimbra Faculty of MedicineCoimbraPortugal University of Coimbra Center for Neuroscience and Cell BiologyCoimbraPortugal University of Coimbra Center for Research in Neuropsychology and Cognitive Behavioral Intervention(CINEICC)Faculty of Psychology and Educational SciencesCoimbraPortugal

The distinction between sporadic and genetic behavioural-variant frontotemporal dementia(bvFTD)regarding some neuropsychological(NP)features remains ***,progranulin(GRN)-associated bvFTD frequently presents with early episodic memory impairment and some degree of parietal dysfunction which are supporters of Alzheimer’s disease(AD)*** this context,we aimed to characterize the NP profile of GRN-bvFTD as compared to sporadic-bvFTD and AD in patients with mild dementia(Mini-Mental State Examination score≥17 and Clinical Dementia Rating Scale score≤*** identified 21 patients at Centro Hospitalar e Universitário de Coimbra,Portugal with GRN mutations belonging to fifteen different *** our focus was bvFTD variants,FTD-related aphasic forms(3 patients)were *** remaining 18 GRN-bvFTD were further matched with 18 sporadic-bvFTD and 18 AD patients according to disease staging,age and *** patients completed the Mini-Mental State Examination,Montreal Cognitive Assessment(MoCA)and a comprehensive NP assessment *** were converted into *** between groups in individual NP measures and NP domains were assessed through non-parametric tests(Kruskal-Wallis test analysis)and eta squared(ŋ2)was calculated as a measure of effect *** comparisons show that GRN patients have worse performances on verbal retrieval processes(P=0.039,ŋ2=0.110)and visuoconstructive abilities(P=0.039,ŋ2=0.190)than sporadic bvFTD *** compared to AD,GRN patients present a higher impairment in frontal(P=0.001,ŋ2=0.211)and parietal(P=0.041,ŋ2=0.129)measures and a better performance in memory tasks(P=0.020,ŋ2=0.120).Sporadic-bvFTD forms are worse than AD in frontal measures(P=0.032,ŋ2=0.200),being better in both memory(P=0.010,ŋ2=0.131)and visuospatial skills(P=0.023,ŋ2=0.231).Considering these results,we conclude that GRN-bvFTD patients present a NP profile that associates the typical patterns of FTD and AD ***

关键词： Alzheimer’s disease behavioral variant frontotemporal dementia cognitive profile frontotemporal dementia genetics memory neuropsychology progranulin visuoconstructive ability

Hyperbaric oxygen therapy as a complementary treatment for radiation proctitis:Useless or useful?-A literature review

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World journal of Gastroenterology 2021年第27期27卷 4413-4428页

作者： Diogo Alpuim Costa Carla Espiney Amaro Ana Nunes joana Santos Cardoso Pedro Modas Daniel isabel Rosa joão Vieira Branco Department of Haematology and oncology CUF OncologiaLisboa 1998-018Portugal Centro de Medicina Subaquática e Hiperbárica(CMSH) Portuguese NavyLisboa 1649-020Portugal Centro de Investigação Naval(CINAV) Portuguese NavyBase Naval do AlfeiteAlmada 2810-001Portugal oVA Medical School Faculdade de Ciências MédicasLisboa 1169-056Portugal Department of otorhinolaryngology Hospital das Forças Armadas(HFAR)Lisboa 1649-020Portugal Department of Gastroenterology Hospital das Forças Armadas(HFAR)Lisboa 1649-020Portugal Department of Vascular Surgery Centro Hospitalar Universitário de Lisboa CentralHospital de Santa MartaLisboa 1169-024Portugal Department of Intensive Care Unit Hospital das Forças Armadas(HFAR)Lisboa 1649-020Portugal Department of General Surgery Hospital das Forças Armadas(HFAR)Lisboa 1649-020Portugal

Radiotherapy(RT)is the backbone of multimodality treatment of more than half of cancer *** new modern RT techniques,late complications may occur such as radiation proctitis(RP).The natural history of RP is *** symptoms may resolve spontaneously or require conservative *** the other hand,for similar and uncomplicated clinical contexts,symptoms may persist and can even be refractory to the progressive increase in treatment *** the last decades,an enormous therapeutic armamentarium has been considered in RP,including hyperbaric oxygen therapy(HBoT).Currently,the evidence regarding the impact of HBoT on RP and its benefits is *** prospective and randomised studies are necessary to validate HBoT’s effectiveness in the‘real world’clinical *** article reviewed the relevant literature on pathophysiology,clinical presentation,different classifications and discuss RP management including a proposal for a therapeutic algorithm with a focus on HBoT.

关键词： Radiation proctitis Radiation proctopathy Radiotherapy Radio-induced lesion Late radiation tissue injury Delayed radiation injury Late sequelae Hyperbaric oxygen therapy Hyperbaric oxygen Review

Emerging role of liquid biopsy in rat sarcoma virus mutated metastatic colorectal cancer:A case report

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World journal of Gastrointestinal oncology 2024年第1期16卷 234-243页

作者： joão Gramaça isabel Gomes Fernandes Carolina Trabulo joana Gonçalves Rita Gameiro dos Santos Adriano Baptista Idília Pina Centro Hospitalar Barreiro Montijo Centro Hospitalar Barreiro MontijoSetúbalBarreiro 2830-003Portugal Medical oncology Unit Centro Hospitalar Barreiro MontijoSetúbalBarreiro 2830-003Portugal

BACKGRoUND In patients with metastatic colorectal cancer(mCRC),the treatment options are limited and have been proved to be affected by rat sarcoma virus(RAS)mutational *** RAS wild-type(wt)patients,the combination of antiepidermal growth factor receptor(EGFR)monoclonal antibodies with chemotherapy(CT)is more effective than CT *** the other hand,RAS-mutated patients are not eligible for treatment with anti-EGFR *** SUMMARY Eleven patients with initially RAS-mutated mCRC were followed from diagnosis to May *** the time of cell-free DNA determination,five patients had undergone one CT line,five patients had undergone two CT lines,and one patient had undergone three CT lines(all in combination with bevacizumab).At the second and third treatment lines[second line(2L),third line(3L)],patients with neo-RAS wt received a combination of CT and *** neo-RAS wt patients treated with anti-EGFR,our findings indicated an increase in progression-free survival for both 2L and 3L(14.5 mo,P=0.119 and 3.9 mo,P=0.882,respectively).Regarding 2L overall survival,we registered a slight increase in neo-RAS wt patients treated with anti-EGFR(33.6 mo vs 32.4 mo,P=0.385).At data cut-off,two patients were still alive:A RAS-mutated patient undergoing 3L treatment and a neo-RAS wt patient who received 2L treatment with anti-EGFR(ongoing).CoNCLUSIoN our case series demonstrated that monitoring RAS mutations in mCRC by liquid biopsy may provide an additional treatment line for neo-RAS wt patients.

关键词： Metastatic colorectal cancer Rat sarcoma virus mutational status Liquid biopsy Rat sarcoma virus wild-type Neo-rat sarcoma virus wild-type Anti-epidermal growth factor receptor therapy Case report

Using meshes to change the characteristics of simulated rainfall produced by spray nozzles

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International Soil and Water Conservation Research 2014年第2期2卷 67-78页

作者： Sílvia C.P.Carvalho joão L.M.P.de Lima M.isabel P.de Lima Department of Civil Engineering Faculty of Science and TechnologyUniversity of CoimbraCoimbraPortugal Department of Civil Engineering Campus II-University of CoimbraRua Luís Reis Santos3030-788 CoimbraPortugal

Rainfall simulators have been used for many years contributing to the understanding of soil and water conservation ***,rainfall simulators’design and operation might be rather demanding for achieving specific rainfall intensity distributions and drop characteristics and are still open for *** study explores the potential of combining spray nozzle simulators with meshes to change rainfall characteristics,namely drop properties(drop diameters and fall speeds).A rainfall simulator laboratory set-up was prepared that enabled the incorporation of different wire meshes beneath the spray *** tests conducted in this exploratory work included different types of spray nozzles,mesh materials(plastic and steel),square apertures and wire thicknesses,and positions of the meshes in relation to the *** intensity and drop size distribution and fall speed were *** showed that the meshes combined with nozzles increased the mean rainfall intensity on the 1 m^(2) control plot below the nozzle and altered the rain drops’properties,by increasing the mass-weighted mean drop diameter,for example.

关键词： Rainfall simulators Spray nozzle meshes Drop characteristics

Low-Cost and Biodegradable Thermoelectric Devices Based on van der Waals Semiconductors on Paper Substrates

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Energy & Environmental Materials 2024年第1期7卷 201-206页

作者： Gulsum Ersu Carmen Munuera Federico J.Mompean Daniel Vaquero jorge Quereda joão Elias F.S.Rodrigues jose A.Alonso Eduardo Flores jose R.Ares isabel J.Ferrer Abdullah M.Al-Enizi Ayman Nafady Sruthi Kuriakose joshua o.Island Andres Castellanos-Gomez Materials Science Factory Instituto de Ciencia de Materiales de Madrid(ICMM-CSIC)Madrid E-28049Spain Nanotechnology Group USAL-NanolabUnivesidad de SalamancaSalamanca Junta de Castilla y León 37007Spain GISC Departamento de Física de MaterialesUniversidad Complutense de MadridMadrid E-28040Spain Departamento de Física Aplicada Centro de Investigación y Estudios AvanzadosMérida 97310Mexico MIRE Group Departamento de Física de MaterialesUniversidad Autónoma de MadridMadrid E-28049Spain Instituto Nicolás Cabrera Universidad Autónoma de MadridMadrid E-28049Spain Department of Chemistry College of ScienceKing Saud UniversityRiyadh 11451Saudi Arabia Department of Physics and Astronomy University of Nevada Las VegasLas Vegas NV 89154USA

We present a method to fabricate handcrafted thermoelectric devices on standard office paper *** devices are based on thin films of WS_(2),Te,and BP(P-type semiconductors)and TiS_(3)and TiS_(2)(N-type semiconductors),deposited by simply rubbing powder of these materials against *** thermoelectric properties of these semiconducting films revealed maximum Seebeck coefficients of(+1.32±0.27)mV K^(-1)and(-0.82±0.15)mV K^(-1)for WS_(2)and TiS_(3),***,Peltier elements were fabricated by interconnecting the P-and N-type films with graphite electrodes.A thermopower value up to 6.11 mV K^(-1)was obtained when the Peltier element were constructed with three *** findings of this work show proof-of-concept devices to illustrate the potential application of semiconducting van der Waals materials in future thermoelectric power generation as well as temperature sensing for low-cost disposable electronic devices.

关键词： paper-based electronics Seebeck effect semiconductors thermoelectrics van der Waals materials

Successful endoscopic resolution of a large gastric bezoar in a child

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World journal of Gastrointestinal Endoscopy 2011年第6期3卷 129-132页

作者： Sara Azevedo joo Lopes António Marques Paula Mourato Lucília Freitas Ana isabel Lopes Gastrenterology Unit Pediatric DepartmentUniversity Hospital Santa Maria Gastroenterology Department University Hospital Santa Maria Gastrenterology Unit Pediatric Department University Hospital Santa MariaMedical Faculty of Lisbon

Bezoars are masses or concretions of indigestible materials found in the gastrointestinal tract,usually in the *** reports of childhood gastric bezoars(particularly phytobezoars)are *** this age group they represent a therapeutic challenge,because of the combination of hard consistency and great *** present report concerns an 8-year-old boy with a history of high fruit intake,presenting with abdominal complaints due to a large gastric *** endoscopic fragmentation coupled with suction removal was accomplished,using a standard-channel *** laborious,it has been shown to be an efficacious and safe procedure,completed in one *** techniques for pediatric bezoar management may thus be cost effective,taking into account the avoidance ofsurgery,the length of the hospital stay and the number of endoscopic sessions.

关键词： Bezoar Children Endoscopic fragmentation