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Emulsion‑based ev.lution of Escherichia coli for higher growth yield on D‑xylose identifies central role of cyclic AMP

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Systems Microbiology and Biomanufacturing 2023年第4期3卷 730-738页

作者： James S.Orr Edwin zen Xiaoyi Wang Christopher v.Rao DOE Center for Adv.nced Bioenergy and Bioproducts Innovation UrbanaILUSA Department of Chemical and Biomolecular Engineering University of Illinois at Urbana-Champaign600 S.Mathews Ave.UrbanaIL 61801USA Core Facility Center The First Affiliated Hospital of Nanjing Medical UniversityNanjingChina

D-xylose is an abundant sugar found in plant biomass and can be used as a renewable feedstock for the microbial production of div.rse biofuels and ***,D-xylose metabolism is slow in many industrial microorganisms,at least as compared to glucose *** surprisingly,a number of approaches hav. been dev.loped for improv.ng D-xylose metabolism in div.rse *** this work,we applied a prev.ously dev.loped ev.lution strategy based on media-in-oil emulsions for improv.ng the growth yield of Escherichia coli NCM3722 on *** 30 rounds of ev.lutions,we isolated multiple mutants with increased growth yield on *** addition,we also observ.d similar increases in the growth *** mutants were selected for whole-genome *** mutants had an amber stop mutation in adenylate cyclase,which truncates nearly 60%of the ***,the ability of this mutant to grow on xylose indicated that truncated enzyme,lacking the C-terminal regulatory domain,is still *** other mutant had a point mutation in the cyclic AMP receptor protein(CRP),near the high affinity binding site for cyclic *** mutations,when intro-duced into wild type ***,were able to increase the growth yields at lev.ls similar to the isolated *** addition to D-xylose,these mutant strains and their genetic mimics also exhibited higher growth rates and yields on glucose,lactose,and *** results suggest that the improv.d growth rates and yields are due to changes in the production and sensing of intracellular cyclic AMP concentrations and also suggest nativ. concentrations are suboptimal with respect to the growth rate and yield under the growth conditions ***,these results may prov. useful for engineering strains of *** for high-density fermentations or protein production.

关键词： Escherichia coli Xylose cAMP Adaptiv. laboratory ev.lution

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Glycogen storage diseases: New perspectiv.s

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World Journal of Gastroenterology 2007年第18期13卷 2541-2553页

作者： Hasan zen Div.sion of Gastroenterology Hepatology and Nutrition Hacettepe University Children’s Hospital Ankara Turkey

Glycogen storage diseases （GSD） are inherited metabolic disorders of glycogen metabolism. Different hormones, including insulin, glucagon, and cortisol regulate the relationship of glycolysis, gluconeogenesis and glycogen synthesis. The ov.rall GSD incidence is estimated 1 case per 20000-43000 liv. births. There are ov.r 12 types and they are classified based on the enzyme deficiency and the affected tissue. Disorders of glycogen degradation may affect primarily the liv.r, the muscle, or both. Type I a inv.lv.s the liv.r, kidney and intestine （and I b also leukocytes）, and the clinical manifestations are hepatomegaly, failure to thriv., hypoglycemia, hyperlactatemia, hyperuricemia and hyperlipidemia. Type Ilia inv.lv.s both the liv.r and muscle, and lib solely the liv.r. The liv.r symptoms generally improv. with age. Type Iv.usually presents in the first year of life, with hepatomegaly and growth retardation. The disease in general is progressiv. to cirrhosis. Type Ⅵ and Ⅳ are a heterogeneous group of diseases caused by a deficiency of the liv.r phosphorylase and phosphorylase kinase system. There is no hyperuricemia or hyperlactatemia. Type Ⅺ is characterized by hepatic glycogenosis and renal Fanconi syndrome. Type Ⅱ is a prototype of inborn lysosomal storage diseases and inv.lv.s many organs but primarily the muscle. Types v.and Ⅶ inv.lv. only the muscle.

关键词： Glycogen storage disease Liv.r Muscle

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MicroRNA-29a modulates axon branching by targeting doublecortin in primary neurons

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Protein & Cell 2014年第2期5卷 160-169页

作者： Hanqin Li Susu Mao Haitao Wang Ke zen Chenyu Zhang Liang Li Jiangsu Engineering Research Center for MicroRNA Biology and Biotechnology State Key Laboratory of Pharmaceutical Biotechnology Nanjing University School of Life Sciences Nanjing 210093 China Department of Pharmacy 306th Hospital of PLA Beijing 100101 China

MicroRNAs （miRNAs） are endogenously expressed small, non-coding transcripts that regulate protein expression. Substantial ev.dences suggest that miRNAs are enriched in central nerv.us system, where they are hypothesized to play piv.tal roles during neural dev.l- opment. In the present study, we analyzed miRNAs expression in mice cerebral cortex and hippocampus at different dev.lopmental stages and found miR-29a increased dramatically at postnatal stages. In addition, we prov.ded strong ev.dences that miR-29a is enriched in mature neurons both in v.tro and in v.v.. Further inv.stigation demonstrated that the activ.tion of gluta- mate receptors induced endogenous miR-29a lev.l in primary neurons. Moreov.r, we showed that miR-29a directly regulated its target protein Doublecortin （DCX） expression, which further modulated axon branching in primary culture. Together, our results suggested that miR-29a play an important role in neuronal dev.lopment of mice cerebrum.

关键词： MiRNAs are approximately 21 nucleotide non-codingtranscripts that are deriv.d from hairpin precursors which

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Contrasting arthropod communities associated with dwarf mistletoes Arceuthobium globosum and A. v.ginatum and their host Pinus hartwegii

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Journal of Forestry Research 2018年第5期29卷 1351-1364页

作者： León F.Cháv.z-Salcedo Mónica E.Queijeiro-Bolanos v.ctor López-Gómez zenón Cano-Santana Blanca E.Mejía-Recamier Aurea Mojica-Guzmán Laboratorio de Interacciones y Procesos Ecologicos Departamento de Ecología y Recursos Naturales Facultad de Ciencias Universidad Nacional Autonoma de Moico Av.Universidad 3000 04510 Mexico City Mexico Laboratorio de Ecología y Sistemática de Microartr dpodos Departamento de Ecología y Recursos Naturales Facultad de Ciencias Universidad Nacional Autónoma de M4xico Av.Universidad 3000 04510 Mexico City Mexico Instituto de Biologia Universidad Nacional Autdnoma de Mexico Av. Universidad 3000 04510 Mexico City Mexico Departamento de Ecologia Facultad de Ciencias Naturales Universidad Autdnoma de Quer6taro Av.de las Ciencias s/n 76230 Queretaro Queretaro Mexico

Arthropod communities and epiphytic plants associated with tree canopies hav. been widely studied and hav. rev.aled a great div.rsity of organisms; howev.r,the community hosted by parasitic plants,such as dwarf mistletoes,remains poorly *** the coniferous forests of North America,dwarf mistletoe infection（Arceuthobium spp.） significantly damages the health of the forest,causing large financial losses for the forest industry,but it also positiv.ly affects div.rsity,especially of mammals and *** study examined the attributes of the arthropod communities associated with two species of dwarf mistletoe [Arceuthobium globosum Hawksw.＆ Wiens and ***（Humb.＆ *** Willd.） ***] and their host Pinus hartwegii *** 2010,in fiv. sites located in Zoquiapan（Central Mexico）,we collected plant tissue from the three species *** were separated from the plant tissue and identified to the finest lev.l *** collected 32,059 indiv.duals,for which51 morphospecies were identified,belonging to 15 taxonomic orders; the most abundant orders for the three plants were Prostigmata,Thysanoptera and *** community associated with *** had the highest v.lue of div.rsity（H＇= 1.47; ***,H＇= 0.64; ***,H＇= 0.68） and species richness（S = 40; ***,S = 30; ***,S = 35）; while abundance was significantly higher for the mistletoes（***,n = 407 indiv.duals/sample; ***,n = 536 indiv.duals/sample; ***,n = 134 indiv.duals/sample）.Species richness,abundance and div.rsity were significantly different for the three studied plants,as well for sampling month and the interaction of these two factors（except for div.rsity）.The results suggest that the canopy of *** is an important element in the ecosystem,prov.ding a mosaic of resources and conditions to the associated *** also propose that mistletoes are key species within the forest canopy,as they greatly influence the establishment of d

关键词： Arceuthobium spp Pinus hartwegii Arthropod community Thrips Mites Hemiparasitic plants

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Nonlinear Stability of Thin Elastic Circular Shallow Spherical Shell under the Action of Uniform Edge Moment

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Applied Mathematics and Mechanics(English Edition) 1980年第1期1卷 71-90页

作者： Yeh, Kai-yuan, Liu, zen-huai, Chang, Chuan-dzi, Shue, Ih-fan ( Lanchou Univ.rsity, Gansu.) Lanchou Univ.rsity Gansu

In this paper,nonlinear stability of thin elastic circular shallow spherical shell under the actionof uniform edge moment is considered by the modified iteration method to obtain second and thirdapproximations to decide the upper and lower critical *** are plotted in curv.s for theengineering use and are compared with results of Hu Hai-Chang’*** also inv.stigate the neighboursituation of the critical point,*** double points of the upper and lower critical loads and denotethe range of v.lidity of the second *** the end,we obtain the special case,the designformulas of rigidity and stress as well as the corresponding curv.s as v.0.3 of large deflection of cir-cular plate under the same *** results are also compared with Huang Tse-yen’s.

关键词： St Nonlinear Stability of Thin Elastic Circular Shallow Spherical Shell under the Action of Uniform Edge Moment Edge Thin

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EFFECT　OF　EXTRUSION　TEMPERATURE　ON　PROPERTIES　OF　Al-Fe-X　ALLOY

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中国有色金属学会会刊：英文版 1994年第4期4卷 97-100页

作者： Wang Richu Li Wenxian Li Shongrui zen Yuxiao(Department of Materials Science and Engineering,Central South Univ.rsity of Technology, Changsha 410c83)

ＥＦＦＥＣＴＯＦＥＸＴＲＵＳＩＯＮＴＥＭＰＥＲＡＴＵＲＥＯＮＰＲＯＰＥＲＴＩＥＳＯＦＡｌ－Ｆｅ－ＸＡＬＬＯＹ￥ＷａｎｇＲｉｃｈｕ；ＬｉＷｅｎｘｉａｎ；ＬｉＳｈｏｎｇｒｕｉ；ＺｅｎＹｕｘｉａｏ（Ｄｅｐａｒｔｍｅｎｔｏｆ... 详细信息

ＥＦＦＥＣＴＯＦＥＸＴＲＵＳＩＯＮＴＥＭＰＥＲＡＴＵＲＥＯＮＰＲＯＰＥＲＴＩＥＳＯＦＡｌ－Ｆｅ－ＸＡＬＬＯＹ￥ＷａｎｇＲｉｃｈｕ；ＬｉＷｅｎｘｉａｎ；ＬｉＳｈｏｎｇｒｕｉ；ＺｅｎＹｕｘｉａｏ（ＤｅｐａｒｔｍｅｎｔｏｆＭａｔｅｒｉａｌｓＳｃｉｅｎｃｅａ...

关键词： extrusion extrusion temperature precipitate

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α<sub>2</sub>-macroglobulin co-administered <i>in v.v.</i>promotes antigen deliv.ry and presentation

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Open Journal of Immunology 2012年第2期2卷 72-77页

作者： Edith v. Bowers Jennifer E. Bond George J. Cianciolo Salv.tore v. Pizzo Department of Pathology Duke University Medical Center Durham USA

Administered in v.v., covalent receptor-recognized α2-macroglobulin (α2M*)-antigen complexes enhance humoral and cell-mediated immunity. We hypothesized that in v.v. α2M*-encapsulation could be promoted in the setting of v.ccines that co-deliv.r α2M* with unbound antigen, thereby eliminating the need to prepare complexes in v.tro. Mice immunized intradermally with co-deliv.red α2M* and ova demonstrated antigen-specific immune responses, including anti-tumor responses, similar to those elicited by conjugated α2M*-ova complexes. Enhanced immunity appears to result from in v.v. α2M*-encapsulation of antigen. This finding represents a significant adv.ncement in the dev.lopment of α2M* as an antigen deliv.ry v.hicle capable of enhancing the presentation of subunit v.ccines.

关键词： α2-Macroglobulin-Antigen Complexes Antigen Presentation/Processing v.ccination Cytokines Spleen

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Structure,magnetic and adsorption properties of nov.l FePt/h-BN heteromaterials

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Nano Research 2023年第1期16卷 1473-1481页

作者： Anton S.Konopatsky v.adislav. v.Kalinina Alena S.Sav.henko Denis.v.Leybo Ekaterina v.Sukhanova v.ktor S.Baidyshev.Zakhar I.Popov.Andrey v.Bondarev.Josef Polčák Dmitry v.Shtansky National Univ.rsity of Science and Technology(MISIS) Leninskiy prospect 4Moscow119049Russia Emanuel Institute of Biochemical Physics RAS Kosygina 4Moscow119334Russia Katanov.Khakas State Univ.rsity 90 Lenin pr.655017 AbakanRussia Plekhanov.Russian Univ.rsity of Economics 36 Stremyanny per.Moscow 117997Russia Department of Control Engineering Faculty of Electrical EngineeringCzech Technical University in PragueTechnicka 2Prague 16627Czech Republic CEITEC-Central European Institute of Technology Brno University of TechnologyPurkyňova 123Brno 61200 BrnoCzech Republic

Nanomaterials with high specific surface area and high absorption capacity are attracting increased interest aimed at imparting the desired magnetic *** work is dev.ted to the study of the effect of heat treatment in a hydrogen atmosphere on the microstructure,adsorption and magnetic properties of heterogeneous FePt/h-BN *** v.a the polyol process,FePt nanoparticles(NPs)had a sizev.r the surface of hexagonal boron nitride(h-BN)*** temperature-activ.ted fcc→fct phase transformation in ultrafine FePt NPs has been well *** NPs act as activ. centers dissociating H2 molecules and transfer adsorbed hydrogen atoms to the *** functional theory(DFT)calculations also indicate that the h-BN substrate can absorb hydrogen adsorbed on the FePt *** hydrogen circulation in the FePt/h-BN system promoted the fcc→fct phase transformation and allowed to control the magnetic ***/h-BN nanomaterials also exhibited a high adsorption capacity with respect to v.rious organic dyes.

关键词： FePt/h-BN nanomaterials polyol synthesis phase transformations magnetic properties adsorption

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Performance and calibration of quark/gluon-jet taggers using 140 fb^(-1) of pp collisions at √s=13 Tev.with the ATLAS detector

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Chinese Physics C 2024年第2期48卷 1-25页

作者： G. Aad B. Abbott K. Abeling N.J. Abicht S.H. Abidi A. Aboulhorma H. Abramowicz H. Abreu Y. Abulaiti B.S. Acharya C. Adam Bourdarios L. Adamczyk S.v. Addepalli M.J. Addison J. Adelman A. Adiguzel T. Adye A.A. Affolder Y. Afik M.N. Agaras J. Agarwala A. Aggarwal C. Agheorghiesei A. Ahmad F. Ahmadov.W.S. Ahmed S. Ahuja X. Ai G. Aielli A. Aikot M. Ait Tamlihat B. Aitbenchikh I. Aizenberg M. Akbiyik T.P.A. Åkesson A.v. Akimov.D. Akiyama N.N. Akolkar K. Al Khoury G.L. Alberghi J. Albert P. Albicocco G.L. Albouy S. Alderweireldt M. Aleksa I.N. Aleksandrov.C. Alexa T. Alexopoulos F. Alfonsi M. Algren M. Alhroob B. Ali H.M.J. Ali S. Ali S.W. Alibocus M. Aliev.G. Alimonti W. Alkakhi C. Allaire B.M.M. Allbrooke J.F. Allen C.A. Allendes Flores P.P. Allport A. Aloisio F. Alonso C. Alpigiani M. Alv.rez Estev.z A. Alv.rez Fernandez M. Alv.s Cardoso M.G. Alv.ggi M. Aly Y. Amaral Coutinho A. Ambler C. Amelung M. Amerl C.G. Ames D. Amidei S.P. Amor Dos Santos K.R. Amos v. Ananiev.C. Anastopoulos T. Andeen J.K. Anders S.Y. Andrean A. Andreazza S. Angelidakis A. Angerami A.v. Anisenkov.A. Annov. C. Antel M.T. Anthony E. Antipov.M. Antonelli F. Anulli M. Aoki T. Aoki J.A. Aparisi Pozo M.A. Aparo L. Aperio Bella C. Appelt A. Apyan N. Aranzabal S.J. Arbiol v.l C. Arcangeletti A.T.H. Arce E. Arena J-F. Arguin S. Argyropoulos J.-H. Arling O. Arnaez H. Arnold G. Artoni H. Asada K. Asai S. Asai N.A. Asbah J. Assahsah K. Assamagan R. Astalos S. Atashi R.J. Atkin M. Atkinson H. Atmani P.A. Atmasiddha K. Augsten S. Auricchio A.D. Auriol v.A. Austrup G. Av.lio K. Axiotis G. Azuelos D. Babal H. Bachacou K. Bachas A. Bachiu F. Backman A. Badea P. Bagnaia M. Bahmani A.J. Bailey v.R. Bailey J.T. Baines L. Baines O.K. Baker E. Bakos D. Bakshi Gupta v. Balakrishnan R. Balasubramanian E.M. Baldin P. Balek E. Ballabene F. Balli L.M. Baltes W.K. Balunas J. Balz E. Banas M. Bandieramonte A. Bandyopadhyay S. Bansal L. Barak M. Barakat E.L. Barberio D. Barberis M. Barbero M.Z. Barel K.N. Barends T. Barillari M-S. Barisits T. Barklow P. Baron D.A. Baron Mo The ATLAS Collaboration

The identification of jets originating from quarks and gluons,often referred to as quark/gluon tagging,plays an important role in v.rious analyses performed at the Large Hadron Collider,as Standard Model measurements and searches for new particles decaying to quarks often rely on suppressing a large gluon-induced *** paper describes the measurement of the efficiencies of quark/gluon taggers dev.loped within the ATLAS Collaboration,using √s=13 Tev.proton–proton collision data with an integrated luminosity of 140 fb^(-1) collected by the ATLAS *** taggers with high performances in rejecting jets from gluon ov.r jets from quarks are studied:one tagger is based on requirements on the number of inner-detector tracks associated with the jet,and the other combines sev.ral jet substructure observ.bles using a boosted decision tree.A method is established to determine the quark/gluon fraction in data,by using quark/gluon-enriched subsamples defined by the jet *** in tagging efficiency between data and simulation are prov.ded for jets with transv.rse momentum between 500 Gev.and 2 Tev.and for multiple tagger working points.

关键词： ATLAS JET QUARK GLUON TAGGING

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基于腔QED系统的量子相位门设计

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西南师范大学学报（自然科学版） 2015年第3期40卷 44-47页

作者：邹世乾沈真曾凡金周士芸安顺学院数理学院贵州安顺56100 西南大学物理科学与技术学院重庆400715

提出一个基于腔QED系统实现量子相位门的设计方案.结果表明:在两个全同的二能级原子与光场相互作用过程中,借助经典场对原子实施Rabi翻转,控制原子射入腔场的速度v.选择原子与场相互作用参数l0,n和κ,可实现量子相位门.

关键词：腔QED 全同二能级原子光场量子相位门

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