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TCGA whole-transcriptome sequencing data reveals significantly dysregulated genes and signaling pathways in hepatocellular carcinoma

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Frontiers of Medicine 2015年第3期9卷 322-330页

作者： Daniel Wai-Hung Ho Alan Ka-Lun Kai irene Oi-Lin Ng Department of Pathology and State Key Laboratory for Liver Research The University of Hong Kong ttong Kong SAR China

This study systematically evaluates the TCGA whole-transcriptome sequencing data of hepatocellular carcinoma （HCC） by comparing the global gene expression profiles between tumors and their corresponding non- tumorous liver tissue. Based on the differential gene expression analysis, we identified a number of novel dysregulated genes, in addition to those previously reported. Top-listing upregulated （CENPF and FOXM1） and downregulated （CLEC4G, CRHBP, and CLEC1B） genes were successfully validated using qPCR on our cohort of 65 pairs of human HCCs. Further examination for the mechanistic overview by subjecting significantly upregulated and downregulated genes to gene set enrichment analysis showed that different cellular pathways were involved. This study provides useful information on the transcriptomic landscape and molecular mechanism of hepatocarcinogenesis for development of new biomarkers and further in-depth characterization.

关键词： TCGA whole-transcriptome sequencing HCC liver cancer

Investigative Review of Design Techniques of Parabolic Trough Solar Collectors

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Frontiers in Heat and Mass Transfer 2024年第1期22卷 317-339页

作者： Roba Tarek AbdelFatah irene S.Fahim Mohamed Mahran Kasem Smart Engineering Systems Research Center(SESC) Nile UniversityShaikh Zayed City12588Egypt

Parabolic trough solar collectors(PTCs)are among the most cost-efficient solar thermal *** have several applications,such as feed heaters,boilers,steam generators,and electricity generators.A PTC is a concentrated solar power system that uses parabolic reflectors to focus sunlight onto a tube filled with heattransfer *** performance can be investigated using optical and thermal mathematical *** models calculate the amount of energy entering the receiver,the amount of usable collected energy,and the amount of heat loss due to convection and *** are several methods and configurations that have been developed so far;however,it is usually difficult for a designer to choose the appropriate method or configuration for his *** present work investigates different PTC configurations and methods of solution,compares their efficiency and accuracy,summarizes their key behaviors and trends,and improves the available methods by maximizing the positives and minimizing the negatives among *** investigated three methods and seven *** findings suggest that optimizing the collector structure,tracking system,and reflector can lead to high PTC performance and reduced capital *** investigating and comparing the recent mathematical models,the study identified a clear deficiency in estimating the output *** PTC’s solution methods are investigated,and a novel method is developed to give more accurate estimations of the output temperature.

关键词： Parabolic trough collectors solar collector PTC mathematical models

Antiglutamatergic agents for obsessive-compulsive disorder:Where are we now and what are possible future prospects?

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World Journal of Psychiatry 2021年第9期11卷 568-580页

作者： Annalisa Maraone Lorenzo Tarsitani irene Pinucci Massimo Pasquini Department of Human Neurosciences Sapienza University of RomeRome 00185LazioItaly

Recent data suggest that obsessive-compulsive disorder(OCD)is driven by an imbalance among the habit learning system and the goal-directed *** frontostriatal loop termed cortico-striatal-thalamo-cortical(CSTC)circuitry loop is involved in habits and their dysfunction plays an important role in *** neurotransmission is the principal neurotransmitter implicated in the CSTC model of *** in the CSTC loop implies a high level of glutamate in the cortical-striatal pathways as well as a dysregulation of GABA ergic transmission,and could represent the pathophysiology of ***,the dysregulation of glutamate levels can lead to neurotoxicity,acting as a neuronal *** hypothesis of a role of neurotoxicity in the pathophysiology of OCD clinically correlates to the importance of an early intervention for ***,some studies have shown that a reduction of duration of untreated illness is related to an earlier onset of *** robust data supporting a progression of such brain changes are not available so far,an early intervention could help interrupt damage from ***,agents targeting glutamate neurotransmission may represent promising therapeutical option in OCD patients.

关键词： Obsessive-compulsive disorder Antiglutamatergic agents Glutammate Early intervention Neurophysiopathology Duration of untreated illness

Rescue of autoimmune hepatitis by soluble MHC class II molecules in an altered concanavalin A-induced experimental model

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Animal Models and Experimental Medicine 2020年第3期3卷 264-272页

作者： Katerina Bakela Maria Georgia Dimitraki Evangelia Skoufa irene Athanassakis Laboratory of Immunology Department of BiologyUniversity of CreteHeraklionCreteGreece

Background:Soluble major histocompatibility complex class II(sMHCII)molecules have been described to maintain tolerance through the suppression of autoreactive T *** order to evaluate their ability to rescue autoimmune hepatitis(AIH)symptoms,the present work attempted to administer sMHCII molecules to an in vitro as well as in vivo concanavalin A(ConA)-induced AIH ***:The in vitro AIH model consisted of splenocyte stimulation with ConA in the presence or absence of serum-isolated sMHCII *** in vivo ConAmodified model with or without sMHCII treatment was *** cytokine profile in culture supernatants and serum was tested by *** markers were evaluated by immunofluorescence,while cell proliferation by tritiated thymidine *** symptoms were assessed by daily observations for the establishment of a disease severity scoring system and liver histology was evaluated using a biomolecular ***:The presence of sMHCII molecules in the ConA-stimulated cell cultures leads to a significant reduction of cell *** administration of sMHCII molecules to the ConA-treated animals showed a significant reduction in the levels of IL-2,IL-4,and IL-10,as well as a decrease in the number of spleen CD4+and CD8+*** development of a scoring system,it was shown that the sMHCII treatment was accompanied by a slower progression of the disease,while rescuing fibrotic liver ***:The results presented in this study confirm the ability of sMHCII proteins to alleviate autoimmune hepatitis,possibly highlighting new therapeutic approaches for autoimmune diseases.

关键词： autoimmune hepatitis cytokines immunosuppression inflammation

Silver Recovery from Spent Silver Oxide Button Cell by Liquid-Liquid Extraction

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Journal of Materials Science and Chemical Engineering 2015年第7期3卷 148-153页

作者： Zeferino Gamino-Arroyo Antonio Tapia-Cisneros Osvaldo M.Zamacona-Saucedo irene Cano-rodríguez Alberto F.Aguilera-Alvarado Lorena E.Sánchez-Cadena fernando I.Gómez-Castro Departamento de Ingeniería Química Universidad de Guanajuato Guanajuato México Departamento de Ingeniería Civil Universidad de Guanajuato Guanajuato México

Button cell batteries are used in clocks, thermometers, remote controls, toys and other devices, and they are usually discarded in the trash once its useful life is over. Some models of these batteries contain silver oxide. In this paper we propose liquid-liquid extraction as separation process to recover the metal. First, silver determination is performed in different models of these batteries and leaching with nitric acid is carried out. Affinity study is done between several commercial extractants for silver. The best performing extractant is the bis(2-ethylhexyl) dithiophosphoric acid (D2EHDTPA). Furthermore, a study of the extraction yields as a function of extractant concentration and time is performed. The distribution isotherm is determined;complex extracted in organic phase and stripping conditions have been identified. With the aim of obtaining industrial application, a number of steps for a countercurrent process were defined by the McCabe-Thiele method. Finally, a study was done in micropilot scale. The results show that it is possible to recover silver from this type of waste.

关键词： Silver Spent Button Cells Leaching Recovery

Data augmentation and machine learning techniques for control strategy development in bio-polymerization process

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Environmental Science and Ecotechnology 2022年第3期11卷 40-48页

作者： Sizhou Wei Zhiyuan Chen Senthil Kumar Arumugasamy irene Mei Leng Chew School of Computer Science University of NottinghamNottinghamNG81BBUnited Kingdom School of Computer Science University of Nottingham MalaysiaSemenyih43500Malaysia Department of Chemical and Environmental Engineering University of Nottingham MalaysiaSemenyih43500Malaysia School of Engineering Monash University MalaysiaSubang Jaya47500Malaysia

Machine learning has been increasingly used in ***,in organic chemistry and other experiment-based fields,data collected from real experiments are inadequate and the current coronavirus disease(COVID-19)pandemic has made the situation even *** limited data resources may result in the low performance of modeling and affect the proper development of a control *** paper proposes a feasible machine learning solution to the problem of small sample size in the biopolymerization *** avoid overfitting,the variational auto-encoder and generative adversarial network algorithms are used for data *** random forest and artificial neural network algorithms are implemented in the modeling *** results prove that data augmentation techniques effectively improve the performance of the regression *** machine learning models were compared and the experimental results show that the random forest model with data augmentation by the generative adversarial network technique achieved the best performance in predicting the molecular weight on the training set(with an R^(2) of 0.94)and on the test set(with an R^(2) of 0.74),and the coefficient of determination of this model was 0.74.

关键词： Bio-polymerization Variational autoencoder generative adversarial network Random forest Artificial neural network

Enhancement of biogas potential of primary sludge by co-digestion with cow manure and brewery sludge

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International Journal of Agricultural and Biological Engineering 2015年第4期8卷 86-94页

作者： irene Nansubuga Noble Banadda Mohammed Babu Jo De Vrieze Willy Verstraete Korneel Rabaey Laboratory of Microbial Ecology and Technology(LabMET) Ghent UniversityCoupure links 653B-9000 GentBelgium Department of Agricultural and Bio-Systems Engineering Makerere UniversityP.O.Box 7062KampalaUganda National Water and Sewerage corporation Plot 39Jinja RoadP.O.Box 7053KampalaUganda

Anaerobic digestion(AD)has long been used to treat different types of organic wastes especially in the developed ***,organic wastes are still more often considered as a waste instead of a resource in the developing world,which contributes to environmental pollution arising from their *** study has been conducted at Bugolobi Sewage Treatment Plant(BSTP),where two organic wastes,cow manure and brewery sludge were co-digested with primary sludge in different *** study was done in lab-scale reactors at mesophilic temperature and sludge retention time of 20 *** main objective was to evaluate the biodegradability of primary sludge generated at BSTP,Kampala,Uganda and enhance its ability of biogas *** the brewery sludge was added to primary STP sludge at all proportions,the biogas production rate increased by a factor of *** was significantly(p<0.001)higher than observed gas yield(337±18)mL/(L·d))in the control treatment containing(only STP sludge).Co-digesting STP sludge with cow manure did not show different results compared to the control *** conclusion,Bugolobi STP sludge is poorly anaerobically degradable with low biogas production but co-digestion with brewery sludge enhanced the biogas production rate,while co-digestion with cow manure was not beneficial.

关键词： wastewater treatment co-digestion cow manure brewery primary sludge biogas energy recovery

Association of autoimmune type atrophic corpus gastritis with Helicobacter pylori infection

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World Journal of Gastroenterology 2010年第1期16卷 83-88页

作者： Lea irene Veijola Aino Mirjam Oksanen Pentti Ilmari Sipponen Hilpi Iris Kaarina Rautelin Herttoniemi Hospital City of Helsinki Department of Bacteriology and Immunology Haartman InstituteUniversity of Helsinki Repolar Oy Box 2602101 EspooFinland HUSLAB Helsinki University Central Hospital Laboratory Department of Medical Sciences University of Uppsala

AIM:To study the association between Helicobacter pylori(***)infection and autoimmune type atrophic gastritis. METHODS:Twenty-three patients with different grades of atrophic gastritis were analysed using enzyme immunoassay-based serology,immunoblot-based serology,and histology to reveal a past or a present *** *** addition,serum markers for gastric atrophy(pepsinogenⅠ,pepsinogenⅠ/Ⅱand gastrin)and autoimmunity[parietal cell antibodies(PCA), and intrinsic factor(IF),antibodies]were determined. RESULTS:Of the 14 patients with severe gastricatrophy,as demonstrated by histology and serum markers,and no evidence for an ongoing *** infection,eight showed *** antibodies by *** eight had elevated PCA and 4/8 also had IF *** the six immunoblot-negative patients with severe corpus atrophy,PCA and IF antibodies were detected in *** the patients with low to moderate grade atrophic gastritis(all except one with an ongoing *** infection),serum markers for gastric atrophy and autoimmunity were seldom ***,one *** negative patient with mild atrophic gastritis had PCA and IF antibodies suggestive of a pre-atrophic autoimmune gastritis. CONCLUSION:Signs of *** infection in autoimmune gastritis,and positive autoimmune serum markers in *** gastritis suggest an etiological role for *** in autoimmune gastritis.

关键词： Helicobacter pylori Autoimmune gastritis Gastric atrophy Vitamin B12 deficiency

Predicting sandy soil moisture content with hyperspectral imaging

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International Journal of Agricultural and Biological Engineering 2017年第6期10卷 175-183页

作者： Qi Haijun Jin Xiu Zhao Liu DEDO irene Maxime Li Shaowen School of Information and Computer Anhui Agricultural UniversityHefei 230036China University of Abomey-Calavi CotonouBenin

In this study,a rapid and non-invasive technology for predicting soil moisture content(SMC)was presented based on hyperspectral imaging(HSI).Firstly,a set of HSI system was developed to collect both spectral(400-1000 nm)and spatial(1620×841 pixels)information from sandy soil samples with variable SMC levels in the *** component analysis(PCA)transformation,K-means clustering,and several other image processing methods were performed to obtain a region of interest(ROI)of soil sample from the original HSI ***,256 optimal spectral wavelengths were selected from the average reflectance of the ROI,and 28 textural features were extracted using a gray-level co-occurrence matrix(GLCM).Data dimensionality reduction was conducted on both the spectral information and textural information by using a partial least square *** latent variables(LVs)extracted from the spectral information,four LVs extracted from the textural information and fused data were used to build regression models with a three-layer BPNN,*** results showed that all of the three calibration models achieved high prediction accuracy,particularly when using spectral information with R^(2)_(C)=0.9532 and RMSEC=***,validation models demonstrate that predicting SMC using fused data is more effective than using spectral reflectance and textural features separately,with a R^(2)_(P)=0.9350 and RMSEP=0.0141,thus proving that the HSI technique is capable of detecting SMC.

关键词： hyperspectral imaging soil moisture content image processing prediction model fused data BPNN regression