检索结果-南通市图书馆

HLA-G and single nucleotide polymorphism(SNP)associations with cancer in African populations:Implications in personal medicine

引用

Genes & Diseases 2022年第5期9卷 1220-1233页

作者： Ismael Chatita Adolf Amany Almars Nazima Dharsee Teddy Mselle Gokce Akan irene Jeremiah Nguma Abdolrahman S.Nateri Fatmahan Atalar Mbeya College of Health and Allied Sciences University of Dar es SalaamMbeyaP.O Box 608Tanzania Cancer Genetics&Stem Cell Group BioDiscovery InstituteDivision of Cancer and Stem CellsSchool of MedicineUniversity of NottinghamNottinghamNG72UHUK Ocean Road Cancer Institute Department of OncologyDar es SalaamP.O Box 3592Tanzania Muhimbili University of Health and Allied Sciences MUHAS Genetic LaboratoryDepartment of BiochemistryDar es SalaamP.O Box 65001Tanzania Clinical Oncology Department Mbeya Zonal Referral Hospital(MZRH)Mbeya P.O Box 419Tanzania Child Health Institute Department of Rare DiseasesIstanbul UniversityIstanbul 34093Turkey

The immune system plays an important role in protecting the body against *** cancer immunoediting,the immune system can recognize and keep checking the tumor cells by down-expression of some self-molecules or by increasing expression of some novel ***,the microenvironment created in the course of cancer development hampers the immune ability to recognize and destroy the transforming *** Leukocyte Antigen G(HLA-G)is emerging as immune checkpoint molecule produced more by cancer cells to weaken the immune response against ***-G is a non-classical HLA class I molecule which is normally expressed in immune privileged tissues as a soluble or membrane-bound ***-G locus is highly polymorphic in the non-coding 3′untranslated region(UTR)and in the 5′upstream regulatory region(5′URR).HLA-G expression is controlled by polymorphisms located in these regions,and several association studies between these polymorphic sites and disease predisposition,response to therapy,and/or HLA-G protein expression have been *** polymorphisms are demonstrated to modulate its expression and this is increasingly finding more significance in cancer *** review focuses on the relevance of the HLA-G gene and its polymorphisms in cancer *** highlight population genetics of HLA-G as evidence to espouse the need and importance of exploring potential utility of HLA-G in cancer diagnosis,prognosis and immunotherapy in the currently understudied African population.

关键词： African population Cancer HLA-G Immune system checkpoints MHC Single nucleotide polymorphism

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Retinal and Choroidal Alterations in Migraine Patients Compared to Normal Healthy Controls

引用

Journal of Behavioral and Brain Science 2023年第10期13卷 185-197页

作者： Miriam L. Conway irene Ctori Department of Optometry and Visual Science City University of London London UK

Purpose: Migraine is an incapacitating neurovascular disorder that primarily affects the working-age population. Researchers have postulated that the transient vascular alterations during each migraine attack lead to ischemic damage in the eye which can be measured via optical coherence tomography. Methods: We recruited 29 volunteers: 13 migraineurs (mean age 28 ± 8.8 years;12 female and 1 male) and 16 age-matched controls (mean age 26.6 ± 6.9;9 female and 7 male). All individuals underwent a detailed ophthalmic examination by a qualified optometrist and a Migraine Disability Assessment. The investigators were blind to the migraine diagnosis. Retinal Nerve Fiber Layer (RNFL) thickness, Retinal Thickness (RT), Ganglion Cell Complex (GCL), ranging from the inner-limiting membrane to the inner plexiform layer, and Choroidal Thickness (CT) were measured using the 3D OCT-1Maestro, Topcon, a Spectral Domain OCT (SD-OCT) device. Results: In the migraine population average RNFL was lower for several parameters. However, results did not reach statistical significance. A significant decrease in the right eye inferior parafoveal ganglion cell layer in the migraine group of patients (mean = 25.15, SD = 4.08) compared to normal healthy controls (mean = 28.81, SD = 4.85;t = (27) = 2.17, p = 0.039) was documented. No other ganglion cell layer or choroidal thickness reached significance. No significant relationship between ocular thickness parameters and MIDAS score, parameters and either MIDAS score or frequency of headaches was found. Conclusion: A significant decrease in the right inferior parafoveal ganglion cell layer for migraine patients was reported. All other parameters did not reach significance. .

关键词： Retinal Choroidal Migraine

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

The Effect of Gum Acacia on Post-Prandial Glucose and Insulin Levels in Healthy Subjects

引用

Food and Nutrition Sciences 2022年第4期13卷 424-438页

作者： Udo Bongartz Constantin Erlenbeck irene Wohlfahrt analyze & realize GmbH Berlin Germany

This double-blind, controlled, randomized, three-way cross-over study evaluates the effect of 40 g (D1 group) and 20 g (D2 group) of acacia gum (AG) versus no treatment (NT group) on post-prandial glucose (PPG) levels in normal-weight and overweight subjects. Additionally, post-prandial insulin (PPI) levels as well as the safety and tolerability of gum acacia were assessed. 35 healthy subjects aged 25 - 60 years, body mass index 18.5 kg/m2 - 29.9 kg/m2, received one treatment of 20 g, 40 g, or 0 g of AG each. Glucose and insulin values were determined at -15 min and prior to the intake (time “0”) as well as 15, 30, 45, 60, 90 120, and 180 min after the “0 min” blood draw. The mean PPG levels were lower (34% in D1 group, p = 0.003;35% in D2 group, p = 0.005) than in the NT group. PPI concentration was statistically significantly lower at all time points except baseline in both treatment groups compared to NT groups. Global benefit and tolerability were rated as “very good” or “good” by 100% of subjects in the treatment groups. This study provides robust evidence of the significant benefits of AG consumption on PPG and PPI levels in healthy subjects. Moreover, very good tolerability was demonstrated.

关键词： Acacia Gum Post-Prandial Glucose Post-Prandial Insulin Glycemic Response Control

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Serum biomarkers for the differentiation of autoimmune pancreatitis from pancreatic ductal adenocarcinoma

引用

World Journal of Gastrointestinal Oncology 2023年第2期15卷 268-275页

作者： Octavio Caba Carmelo Diéguez-Castillo Joaquina Martínez-Galán irene González-Cebrián Cristina Jiménez-Luna Institute of Biopathology and Regenerative Medicine(IBIMER) University of GranadaGranada 18016Spain Biosanitary Institute of Granada(ibs.GRANADA) 18014 GranadaSpain Department of Gastroenterology San Cecilio University HospitalGranada 18016Spain Department of Medical Oncology Virgen de las Nieves University HospitalGranada 18014Spain.Biosanitary Institute of Granada(ibs.GRANADA)18014 GranadaSpain Department of Digestive Cancer San Cecilio University HospitalGranada 18016Spain

Autoimmune pancreatitis(AIP),a chronic inflammation caused by the immune system attacking the pancreas,usually presents imaging and clinical features that overlap with those of pancreatic ductal adenocarcinoma(PDAC).Serum biomarkers,substances that quantitatively change in sera during disease development,are a promising non-invasive tool with high utility for differentiating between these *** this way,the presence of AIP is currently suspected when serum concentrations of immunoglobulin G4(IgG4)antibody are ***,this approach has some ***,IgG4 antibody concentrations are also elevated in sera from some patients with *** review focuses on the most recent and relevant serum biomarkers proposed to differentiate between AIP and PDAC,evaluating the usefulness of immunoglobulins,autoantibodies,chemokines,and *** proposed serum biomarkers have proven useful,although most studies had a small sample size,did not examine their presence in patients with PDAC,or did not test them in *** addition,current evidence suggests that a single serum biomarker is unlikely to accurately differentiate these diseases and that a set of biomarkers will be needed to achieve adequate specificity and sensitivity,either alone or in combination with clinical data and/or radiological images.

关键词： Autoimmune pancreatitis Pancreatic ductal adenocarcinoma Serum Biomarkers Differentiation

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Hormone abuse in sports： the antidoping perspective

引用

Asian Journal of Andrology 2008年第3期10卷 391-402页

作者： Osquel Barroso irene Mazzoni Olivier Rabin Science Department World Anti-Doping Agency （WADA） Montreal Quebec H4Z 1B7 Canada

Since ancient times, unethical athletes have attempted to gain an unfair competitive advantage through the use of doping substances. A list of doping substances and methods banned in sports is published yearly by the World AntiDoping Agency （WADA）. A substance or method might be included in the List if it fulfills at least two of the following criteria： enhances sports performance; represents a risk to the athlete＇s health; or violates the spirit of sports. This list, constantly updated to reflect new developments in the pharmaceutical industry as well as doping trends, enumerates the drug types and methods prohibited in and out of competition. Among the substances included are steroidal and peptide hormones and their modulators, stimulants, glucocorticosteroids, β2-agonists, diuretics and masking agents, narcotics, and cannabinoids. Blood doping, tampering, infusions, and gene doping are examples of prohibited methods indicated on the List. From all these, hormones constitute by far the highest number of adverse analytical findings reported by antidoping laboratories. Although to date most are due to anabolic steroids, the advent of molecular biology techniques has made recombinant peptide hormones readily available. These substances are gradually changing the landscape of doping trends. Peptide hormones like erythropoietin （EPO）, human growth hormone （hGH）, insulin, and insulin-like growth factor Ⅰ （IGF-Ⅰ） are presumed to be widely abused for performance enhancement. Furthermore, as there is a paucity of techniques suitable for their detection, peptide hormones are all the more attractive to dishonest athletes. This article will overview the use of hormones as doping substances in sports, focusing mainly on peptide hormones as they represent a pressing challenge to the current fight against doping. Hormones and hormones modulators being developed by the pharmaceutical industry, which could emerge as new doping substances, are also discussed.

关键词： World Anti-Doping Agency doping hormone sport

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Interface-facilitated stable plasticity in ultra-fine layered FeAl/FeAl_(2) micro-pillar at high temperature

引用

Journal of Materials Science & Technology 2021年第14期73卷 61-65页

作者： Lulu Li irene J.Beyerlein Weizhong Han Center for Advancing Materials Performance from the Nanoscale State Key Laboratory for Mechanical Behavior of MaterialsXi’an Jiaotong UniversityXi'an 710049China Department of Mechanical Engineering Materials DepartmentUniversity of CaliforniaSanta Barbara.CA.93106-5070USA

Fe-Al compounds possess a combination of high strength and corrosion resistance at high ***,increasing Al content to make them lighter results in ***,we investigate the high-temperature behavior of a novel,lightweight,ultra-fine-layered FeAl/FeAl_(2) *** report a transition from unstable to stable plasticity at 450℃.Below 450℃,deformation is dominated by localized shear deformation within the soft FeAl layers,while above 450℃,it proceeds by co-deformation between Fe Al and the brittle FeAl_(2) *** show that co-deformation is associated with the temperature at which the interface converts from sliding to sourcing dislocations for Fe Al_(2).

关键词： Fe-Al alloy Compression High-temperature Interface Dislocation

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

A Complex Systems Science Perspective on Wireless Networks

引用

Journal of Systems Science & Complexity 2016年第4期29卷 1034-1056页

作者： MACALUSO irene GALIOTTO Carlo MARCHETTI Nicola DOYLE Linda CTVR Telecommunications Research Center Trinity College Dublin

The paper targets a future world where all wireless networks are self-organising entities and in which the predominant mode of spectrum access is dynamic. The paper explores whether the behaviour of a collection of autonomous self-organising wireless systems can be treated as a complex system and whether complex systems science can shed light on the design and deployment of these networks. The authors focus on networks that self-organise from a frequency perspective to understand the behaviour of a collection of wireless self-organising nodes. Each autonomous network is modelled as a cell in a lattice and follows a simple set of self-organisation rules. Two scenarios are considered, one in which each cell is based on cellular automata and which provides an abstracted view of interference and a second in which each cell uses a self-organising technique which more accurately accounts for interference. The authors use excess entropy to measure complexity and in combination with entropy gain an understanding of the structure emerging in the lattice for the self-organising networks. The authors show that the self-organising systems presented here do exhibit complex behaviour. Finally,the authors look at the robustness of these complex systems and show that they are robust against changes in the environment.

关键词：动态光谱存取过量熵坚韧性组织无线网络的自我

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Multi-scale investigation of short-range order and dislocation glide in MoNbTi and TaNbTi multi-principal element alloys

引用

npj Computational Materials 2023年第1期9卷 1430-1442页

作者： Hui Zheng Lauren T.W.Fey Xiang-Guo Li Yong-Jie Hu Liang Qi Chi Chen Shuozhi Xu irene J.Beyerlein Shyue Ping Ong Department of NanoEngineering University of California San DiegoLa JollaCA 92093-0448USA Materials Department University of CaliforniaSanta BarbaraCA 93106-5050USA Department of Materials Science and Engineering University of MichiganAnn ArborMI 48109USA Department of Materials Science and Engineering Drexel UniversityPhiladelphiaPA 19104USA Department of Mechanical Engineering University of CaliforniaSanta BarbaraCA 93106-5070USA

Refractory multi-principal element alloys(RMPEAs)are promising materials for high-temperature structural ***,we investigate the role of short-range ordering(SRO)on dislocation glide in the MoNbTi and TaNbTi RMPEAs using a multi-scale modeling *** carlo/molecular dynamics simulations with a moment tensor potential show that MoNbTi exhibits a much greater degree of SRO than TaNbTi and the local composition has a direct effect on the unstable stacking fault energies(USFEs).From mesoscale phase-field dislocation dynamics simulations,we find that increasing SRO leads to higher mean USFEs and stress required for dislocation *** gliding dislocations experience significant hardening due to pinning and depinning caused by random compositional fluctuations,with higher SRO decreasing the degree of USFE dispersion and hence,amount of ***,we show how the morphology of an expanding dislocation loop is affected by the applied stress.

关键词： alloys dislocation element

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Immediate and long-term effects of invasive plant species on soil characteristics

引用

Soil Ecology Letters 2022年第3期4卷 276-288页

作者： irene M.Unger Robert J.Kremer Kristen S.Veum Keith W.Goyne Department of Biology and Chemistry Baker UniversityP.O.Box 65Baldwin CityKS 66006USA School of Natural Resources University of Missouri 302 ABNR Bldg.ColumbiaMO 65211USA USDA-ARS Cropping Systems and Water Quality UnitUniversity of Missouri302 ABNR Bldg.ColumbiaMO 65211USA Department of Forest Resources and Environmental Conservation Virginia Tech324 Cheatham HallBlacksburgVA 24061USA

Invasive plant species may alter soil characteristics or interact with the soil microbial community resulting in a competitive *** objectives were to determine:i)if invasive plant species alter soil properties;and ii)the long-term effects of invasive plant species on soil properties and subsequent implications on ecological restoration *** focused on Lespedeza cuneata,a plant that may be *** samples were collected from four locations in Central Missouri,USA:an old-field with abundant ***,two reconstructed sites,and a remnant prairie that has never been *** health indictors were used to characterize soil properties at these *** every soil property differed significantly between the unplowed prairie reference site and the other three *** reconstructed sites,however,generally did not differ from the invaded *** results indicate that the reconstructed prairies are not fully *** above-ground traits,such as the plant community structure,appear similar to the prairie,the soil microbial community structure still resembles that of an invaded old-field *** results indicate that more time may be needed before soil microbial populations fully recover after invasive plant removal.

关键词： Sericea lespedeza Legacy effects Soil microorganisms

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Microarchitectural mimicking of stroma-induced vasculature compression in pancreatic tumors using a 3D engineered model

引用

Bioactive Materials 2023年第4期22卷 18-33页

作者： Marcel Alexander Heinrich irene Uboldi Praneeth Reddy Kuninty Marc J.K.Ankone Joop van Baarlen Yu Shrike Zhang Kartik Jain Jai Prakash Department of Advanced Organ Bioengineering and Therapeutics Engineered Therapeutics SectionTechnical Medical CentreUniversity of Twente7500AEEnschedethe Netherlands Laboratorium Pathologie Oost-Nederland(LabPON) 7550 AMHengelothe Netherlands Division of Engineering in Medicine Department of MedicineBrigham and Women’s HospitalHarvard Medical School65 Landsdowne StCambridgeMA02139USA Department of Thermal and Fluid Engineering Biofluid Dynamics SectionUniversity of Twente7500 AE Enschedethe Netherlands

Fibrotic tumors,such as pancreatic ductal adenocarcinoma(PDAC),are characterized for high desmoplastic reaction,which results in high intra-tumoral solid stress leading to the compression of blood *** microarchitectural alterations cause loss of blood flow and poor intra-tumoral delivery of ***,there is a lack of relevant in vitro models capable of replicating these mechanical characteristics and to test anti-desmoplastic ***,a multi-layered vascularized 3D PDAC model consisting of primary human pancreatic stellate cells(PSCs)embedded in collagen/fibrinogen(Col/Fib),mimicking tumor tissue within adjunct healthy tissue,is presented to study the fibrosis-induced compression of vasculature in *** is demonstrated how the mechanical and biological stimulation induce PSC activation,extracellular matrix production and eventually vessel *** clinical relevance is confirmed by correlating with patient transcriptomic ***,the effects of gradual vessel compression on the fluid dynamics occurring within the channel is evaluated in ***,it is demonstrated how cancer-associated fibroblast(CAF)-modulatory therapeutics can inhibit the cell-mediated compression of blood vessels in PDAC in vitro,in silico and in *** is envisioned that this 3D model is used to improve the understanding of mechanical characteristics in tumors and for evaluating novel anti-desmoplastic therapeutics.

关键词： Pancreatic ductal adenocarcinoma Cancer-associated fibroblasts Collagen Fibrinogen Computational flow dynamics 3D in vitro model

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：