The Effect of Gum Acacia on Post-Prandial Glucose and Insulin Levels in Healthy Subjects
The Effect of Gum Acacia on Post-Prandial Glucose and Insulin Levels in Healthy Subjects作者机构：analyze & realize GmbH Berlin Germany
出 版 物：《Food and Nutrition Sciences》 (食品与营养科学（英文）)
年 卷 期：2022年第13卷第4期
页 面：424-438页
学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学]
主 题：Acacia Gum Post-Prandial Glucose Post-Prandial Insulin Glycemic Response Control
摘 要：This double-blind, controlled, randomized, three-way cross-over study evaluates the effect of 40 g (D1 group) and 20 g (D2 group) of acacia gum (AG) versus no treatment (NT group) on post-prandial glucose (PPG) levels in normal-weight and overweight subjects. Additionally, post-prandial insulin (PPI) levels as well as the safety and tolerability of gum acacia were assessed. 35 healthy subjects aged 25 - 60 years, body mass index 18.5 kg/m2 - 29.9 kg/m2, received one treatment of 20 g, 40 g, or 0 g of AG each. Glucose and insulin values were determined at -15 min and prior to the intake (time “0) as well as 15, 30, 45, 60, 90 120, and 180 min after the “0 min blood draw. The mean PPG levels were lower (34% in D1 group, p = 0.003;35% in D2 group, p = 0.005) than in the NT group. PPI concentration was statistically significantly lower at all time points except baseline in both treatment groups compared to NT groups. Global benefit and tolerability were rated as “very good or “good by 100% of subjects in the treatment groups. This study provides robust evidence of the significant benefits of AG consumption on PPG and PPI levels in healthy subjects. Moreover, very good tolerability was demonstrated.
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