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Engineering 2023年第7期26卷 108-118,I0005页

作者： Julija Juric Hongli Peng Manshu Song Frano Vuckovic JelenaŠimunovic irena trbojevicakmacic Youxin Wang Jiaonan Liu Qing Gao Hao Wang Qiaoyun Chu Marija Pezer Wei Wang Gordan Lauc Genos Glycoscience Research Laboratory Zagreb 10000Croatia Hospital of Traditional Chinese Medicine Fengtai DistrictBeijing 100076China Beijing Municipal Key Laboratory of Clinical Epidemiology School of Public HealthCapital Medical UniversityBeijing 100069China Centre for Precision Health Edith Cowan UniversityPerthWA 6027Australia School of Basic Medical Sciences Capital Medical UniversityBeijing 100069China Department of Biochemistry and Molecular Biology Faculty of Pharmacy and Biochemistry at University of ZagrebZagreb 10000Croatia

Immunoglobulin G(IgG)is the most abundant plasma glycoprotein and a prominent humoral immune *** composition affects the affinity of IgG to ligands and consequent immune *** modification of IgG N-glycosylation is considered to be one of the various mechanisms by which sex hormones modulate the immune *** the menstrual cycle is the central sex hormonerelated physiological process in most women of reproductive age,IgG N-glycosylation dynamics during the menstrual cycle have not yet been *** fill this gap,we profiled the plasma IgG Nglycans of 70 healthy premenopausal women at 12 time points during their menstrual cycles(every 7 days for 3 months)using hydrophilic interaction ultra-performance liquid chromatography(HILIC-UPLC).We observed cyclic periodic changes in the N-glycosylation of IgG in association with the menstrual cycle phase and sex hormone concentration in *** the integrated cohort level,the modeled average menstrual cycle effect on the abundance of IgG N-glycosylation traits was low for each trait,with the highest being 1.1%for agalactosylated ***,intrapersonal changes were relatively high in some cases;for example,the largest difference between the minimum and maximum values during the menstrual cycle was up to 21%for sialylated *** all measurements,the menstrual cycle phase could explain up to 0.72%of the variation in the abundance of a single IgG glycosylation trait of *** contrast,up to 99%of the variation in the abundance of digalactosylation could be attributed to interpersonal differences in IgG *** conclusion,the average extent of changes in the IgG N-glycopattern that occur during the menstrual cycle is small;thus,the IgG N-glycoprofiling of women in large sample-size studies can be performed regardless of menstrual cycle phase.

关键词： N-glycosylation Immunoglobulin G Menstrual cycle Female sex hormones Estrogen Progesterone Testosterone Women

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Cytotoxicity of new Ho(Ⅲ) and Pr(Ⅲ) complexes

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Journal of Rare Earths 2010年第S1期28卷 40-46页

作者： irena Kostova Tsvetanka Stefanova Department of Chemistry Faculty of PharmacyMedical University2 Dunav St.Sofia 1000Bulgaria Department of Immunology Institute of MicrobiologyBulgarian Academy of Sciences26 Acad.G.Bonchev St.Sofia 1113Bulgaria

New complexes of coumarin-3-carboxylic acid(HCCA) with Ho(Ⅲ) and Pr(Ⅲ) were synthesized and their structures and spectral properties were investigated by elemental analysis,IR,Raman and NMR *** to the experimental data the complexes’ formula and geometries were *** frequencies,IR intensities and Raman activities as well as 1H NMR chemical shifts of HCCA and its Ho(Ⅲ) and Pr(Ⅲ) complexes were *** comparative experimental vibrational and NMR analyses of both the ligand and the Ln(Ⅲ) complexes predicted the bidentate binding to Ho(Ⅲ) and Pr(Ⅲ) through the deprotonated carboxylic oxygen and the carbonylic oxygen of the *** cytotoxic/cytostatic properties of the ligand and the newly synthesized complexes of coumarin-3-carboxylic acid with Ho(Ⅲ) and Pr(Ⅲ) were tested by MTT reduction assay against two mouse tumor cell lines:melanoma B16 and fibrosarcoma *** were also tested for cytotoxicity against normal mouse peritoneal *** proliferation inhibitory effect of the complexes compared to that of the ligand proved their cytotoxic/cytostatic properties against both the tumor cell *** addition,the complexes were less cytotoxic against normal mouse macrophages and were able to modulate NO release by activated *** obtained results were in accordance with our previously published data concerning the activity of lanthanide(Ⅲ) complexes with other coumarin derivatives.

关键词： coumarins Ho(Ⅲ),Pr(Ⅲ) FT-IR,FT-Raman NMR cytotoxic/cytostatic activity rare earths

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Cadmium regulation by Lasius niger A contribution to understanding high metal levels in ants

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Insect Science 2009年第1期16卷 89-92页

作者： irena M. Grzes Institute of Environmental Sciences Jagiellonian University Gronostajowa 7 30-387 Krakow Poland

Ants （Formicinae, Hymenoptera） are considered efficient accumulators of Zn and Cd. In this study the relationship between Cd concentrations in soil and in Lasius niger workers was assessed for 20 colonies located along a gradient of Cd pollution. As soil Cd concentration increased from 1 to 8 mg/kg, ant body Cd concentration increased rapidly to about 40 mg/kg, and remained stable at this level, through a progressive increase of soil Cd concentration from 8 to 21 mg/kg. The phase of rapid increase confirms the high ability of L. niger for Cd accumulation, while the stabilization of Cd body concentration indicates either increasing elimination rate or decreasing rate of uptake. Therefore it can be concluded that Lasius niger has a high ability to accumulate Cd, but simultaneously an ability for Cd regulation was detected.

关键词： accumulation ants elimination heavy metals pollution gradient regulation

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International patterns in incidence and mortality trends of pancreatic cancer in the last three decades: A joinpoint regression analysis

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World Journal of Gastroenterology 2022年第32期28卷 4697-4714页

作者： irena Ilic Milena Ilic Faculty of Medicine University of BelgradeBelgrade 11000Serbia Department of Epidemiology Faculty of Medical SciencesUniversity of KragujevacKragujevac 34000Serbia

BACKGROUND Pancreatic cancer,as the one of most fatal malignancies,remains a critical issue in the global burden of *** To estimate trends in pancreatic cancer incidence and mortality worldwide in the last three *** A descriptive epidemiological study was *** cancer incidence and mortality data were obtained from the database of the World Health *** of pancreatic cancer incidence and mortality during 2020 was *** age-standardized rates(ASRs,expressed per 100000)were *** estimate trends of incidence and mortality of pancreatic cancer,joinpoint regression analysis was used:the average annual percent change(AAPC)with the corresponding 95%confidence interval(95%CI)was ***,analysis was performed by sex and *** this paper,the trend analysis included only countries with high and medium data *** A total of 495773(262865 male and 232908 female)new cases and 466003(246840 male and 219163 female)deaths from pancreatic cancer were reported worldwide in *** both sexes,most of the new cases(191348;38.6%of the total)and deaths(182074;39.1%of the total)occurred in the Western Pacific *** both sexes,the highest ASRs were found in the European Region,while the lowest rates were reported in the South-East Asia *** general pattern of rising pancreatic cancer incidence and mortality was seen across countries worldwide in observed *** of all countries with an increase in pancreatic cancer incidence,females in France and India showed the most marked rise in incidence rates(AAPC=+3.9%and AAPC=+3.7%,respectively).Decreasing incidence trends for pancreatic cancer were observed in some countries,but without *** of all countries with an increase in pancreatic cancer mortality rates,Turkmenistan showed the most marked rise both in males(AAPC=+10.0%,95%CI:7.4–12.5)and females(AAPC=+6.4%,95%CI:3.5–9.5).The mortality trends of pancreatic cancer were decreasin

关键词： Pancreatic cancer Incidence Mortality Joinpoint analysis International pattern

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Epidemiology of pancreatic cancer

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World Journal of Gastroenterology 2016年第44期22卷 9694-9705页

作者： Milena Ilic irena Ilic Faculty of Medical Sciences University of Kragujevac

Cancer of the pancreas remains one of the deadliest cancer types. Based on the GLOBOCAN 2012 estimates, pancreatic cancer causes more than 331000 deaths per year, ranking as the seventh leading cause of cancer death in both sexes together. Globally, about 338000 people had pancreatic cancer in 2012, making it the 11^(th) most common cancer. The highest incidence and mortality rates of pancreatic cancer are found in developed countries. Trends for pancreatic cancer incidence and mortality varied considerably in the world. A known cause of pancreatic cancer is tobacco smoking. This risk factor is likely to explain some of the international variations and gender differences. The overall five-year survival rate is about 6%(ranges from 2% to 9%), but this vary very small between developed and developing countries. To date, the causes of pancreatic cancer are still insufficiently known, although certain risk factors have been identified, such as smoking, obesity, genetics, diabetes, diet, inactivity. There are no current screening recommendations for pancreatic cancer, so primary prevention is of utmost importance. A better understanding of the etiology and identifying the risk factors is essential for the primary prevention of this disease.

关键词： Pancreatic cancer Epidemiology Incidence Mortality Trend Risk factors

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Epidemiology of stomach cancer

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World Journal of Gastroenterology 2022年第12期28卷 1187-1203页

作者： Milena Ilic irena Ilic Department of Epidemiology Faculty of Medical SciencesUniversity of KragujevacKragujevac 34000Serbia Faculty of Medicine University of BelgradeBelgrade 11000Serbia

Despite a decline in incidence and mortality during the last decades,stomach cancer is one of the main health challenges *** to the GLOBOCAN 2020 estimates,stomach cancer caused approximately 800000 deaths(accounting for 7.7%of all cancer deaths),and ranks as the fourth leading cause of cancer deaths in both genders *** 1.1 million new cases of stomach cancer were diagnosed in 2020(accounting for 5.6%of all cancer cases).About 75%of all new cases and all deaths from stomach cancer are reported in *** cancer is one of the most lethal malignant tumors,with a five-year survival rate of around 20%.There are some well-established risk factors for stomach cancer:Helicobacter pylori infection,dietary factors,tobacco,obesity,and *** date,the most important way of preventing stomach cancer is reduced exposure to risk factors,as well as screening and early *** research on risk factors can help identify various opportunities for more effective *** programs for stomach cancer have been implemented in a few countries,either as a national or opportunistic screening of high-risk individuals ***,due to its high aggressiveness and heterogeneity,stomach cancer still remains a severe global health problem.

关键词： Stomach cancer Epidemiology Incidence Mortality Survival Predictive factors Prevention

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Cancer mortality in Serbia, 1991-2015: an age-period-cohort and joinpoint regression analysis

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Cancer Communications 2018年第1期38卷 120-135页

作者： Milena Ilic irena Ilic Department of Epidemiology Faculty of Medical SciencesUniversity of KragujevacS.Markovica 69Kragujevac 34000Serbia Faculty of Medicine University of BelgradeBelgrade 11000Serbia

Background:As the result of dramatic political changes,civil wars,and a long-term refugee crisis from the end of the last to beginning of this century,the population of Serbia has experienced significant health *** aim of this study was to assess cancer mortality trends in ***:This nationwide study was carried out to analyze cancer mortality in Serbia during 1991-2015 using offi-cial *** age-standardized mortality rates(per 100,000)were calculated by direct standardization,using the world standard population by *** average annual percent change(AAPC)and corresponding 95%confidence interval(CI)were computed using joinpoint regression ***-period-cohort analysis was performed to address the possible underlying reasons for the observed temporal ***:Over the 25-year study period,there were 466,075 cancer deaths(266,043 males and 200,032 females)in *** cancer mortality increased between 1991 and 2009 in both males(by+0.9%per year)and females(by+0.8%per year)and has been decreasing since then,by−0.9%annually in both *** almost all major cancers except stomach cancer,cancer mortality in Serbia demonstrated upward trends during the study *** largest increases were noted in lung cancer among females(AAPC=+3.7,95%CI 3.5-3.9)and prostate cancer in males(AAPC=+1.9,95%CI 1.4-2.3).Conclusions:After two decades of increase,cancer mortality rates are finally declining in *** this,these rates place Serbia among the countries with the highest cancer mortality in the world.

关键词： Cancer Mortality Trend Joinpoint regression analysis Age-period-cohort analysis

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DESCENT DIRECTION STOCHASTIC APPROXIMATION ALGORITHM WITH ADAPTIVE STEP SIZES

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Journal of Computational Mathematics 2019年第1期37卷 76-94页

作者： Zorana Luzanin irena Stojkovska Milena Kresoja Department of Mathematics and Informatics Faculty of SciencesUniversity of Novi Sad Novi SadSerbia Department of Mathematics.Faculty of Natural Sciences and Mathematics Ss.Cyril and Methodius UniversitySkopjeMacedonia

A stochastic approximation (SA)algorithm with new adaptive step sizes for solving unconstrained minimization problems in noisy environment is *** adaptive step size scheme uses ordered statistics of fixed number of previous noisy function values as a criterion for accepting good and rejecting bad *** scheine allows the algorithm to move in bigger steps and avoid steps proportional to 1/k when it is expected that larger steps will improve the *** algorithin with the new adaptive scheme is defined for a general descent *** ahnost sure convergence is *** performance of new algorithm is tested on a set of standard test problems and compared with relevant *** results support theoretical expectations and verify efficiency of the algorithm regardless of chosen search direction and noise *** results on probleins arising in machine learning are also *** regression problem is considered using real data *** results suggest that the proposed algorithln shows proinise.

关键词： Unconstrained optimization Stochastic optimization Stochastic approximation Noisy function Adaptive step size Descent direction Linear regression model

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Geographic variability in the alarm calls of the European ground squirrel

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Current Zoology 2020年第4期66卷 407-415页

作者： irena SCHNEiDEROA Lucie Stefanska Lukas Kratochvil Prague Zoological Garden U Trojskeho zamku 3/120Praha 117100Czech Republic Department of Animal Science and Food ProcGssing Faculty of Tropical AgriSciencesCzech University of Life SciencesKamycka 12916500Praha 6-SuchdolCzech Republic Nature Conservation Agency of the Czech Republic Kaplanova 1931/1Praha 1114800Czech Republic Department of Ecology Faculty of ScienceCharles University in PragueVinicna 112800Praha 2Czech Republic

Geographic variability in vocalizations has been documented in many mammalian species. We examined to what extent it applies to the alarm calls of the European ground squirrel Spermophilus citellus. We recorded the calls of 82 adult individuals from 5 natural colonies in the Czech Republic and 24 adult individuals from an artificial seminatural colony located in a Czech zoo. The founders of this colony originated from 4 different natural colonies in the Czech Republic. Our results showed that there are hardly any differences in the acoustic structure of the alarm calls between male and female European ground squirrels. Discriminant function analysis showed the highest degree of discriminability for the most isolated sites (54-74% of individuals classified correctly), whereas the lowest degree of discriminability was found for 2 interconnected colonies (38-40% individuals classified correctly). Individuals from the artificial seminatural colony were often classified correctly to this colony (58% classified correctly);however, the precision of the classification was comparatively relatively low, that is, many individuals from other colonies were incorrectly classified into this seminatural colony. This likely corresponds to the different origins of its founders. These findings indicate that there is a rather substantial geographic variability in the alarm calls of the European ground squirrel, and our study highlights its possible impact on conservation measures such as establishing artificial colonies or reintroductions.

关键词： artificial population intraspecies variability mammalian vocalization Rodentia Spermophilus citellus

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Trends in suicide by hanging, strangulation, and suffocation in Serbia, 1991-2020: A joinpoint regression and age-period-cohort analysis

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World Journal of Psychiatry 2022年第3期12卷 505-520页

作者： Milena Ilic irena Ilic Department of Epidemiology Faculty of Medical SciencesUniversity of KragujevacKragujevac 34000Serbia Faculty of Medicine University of BelgradeBelgrade 11000Serbia

BACKGROUND Hanging is one of the most commonly used methods for suicide in both sexes *** a number of countries,hanging mortality has increased over the last ***,there is a scarcity of studies that have explored the patterns and trends for mortality of suicide by hanging on global,regional and national levels,as most evaluations are limited to certain *** To assess the trends of suicide mortality by hanging,strangulation,and suffocation in Serbia,from 1991 to *** This nationwide study,with epidemiological descriptive study design,was carried out based on official *** age-standardized rates(ASRs,expressed per 100000 persons)were calculated by direct standardization,using the World Standard *** trends from suicide by hanging were assessed using the joinpoint regression analysis:The average annual percent change(AAPC)with the corresponding 95%confidence interval(95%CI)was ***-period-cohort analysis was performed to address the possible underlying reasons for the observed suicide *** Over the 30-year period studied,there were 24340 deaths by hanging(17750 males and 6590 females)in *** 2020,the ASR of deaths by hanging was 4.5 per 100000 persons in both sexes together(7.6 in males vs 1.7 in females).The trends of suicide mortality by hanging decreased significantly between 1991 and 2020 in both males(AAPC=-1.7%per year;95%CI:-2.0 to-1.4)and females(AAPC=-3.5%per year;95%CI:-3.9 to-3.1).Mortality rates of suicide by hanging had a continuously decreasing tendency in both sexes together in all age groups:The only exception was among males in 40-49 age group,with an increasing trend of suicide by hanging from 1991 to 2011(by+0.3%per year).CONCLUSION The trends in suicide mortality by hanging have been decreasing in Serbia in the last three decades in both sexes,but this was more pronounced in women than in *** the decreasing trends observed in mortality of suicide by hang

关键词： Suicide Hanging Mortality Trends Joinpoint analysis

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