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Treatment controversies in a rare case of a simultaneous branch retinal artery and vein occlusion secondary to hyperhomocysteinemia and hypertension

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International Journal of Ophthalmology(English edition) 2018年第12期11卷 2024-2026页

作者： Panayiotis Christodoulou ioannis Katsimpris General Hospital of Patras "Agios Andreas" Ophthalmology Clinic

Dear Editor,Combined vascular occlusions involving retinal arteries and veins have been reported in the past. Combined occlusion of the central retinal vein （CRVO） and artery （CRAO）is well described;. Cilioretinal... 详细信息

关键词： Treatment controversies in a rare case of a simultaneous branch retinal artery and vein occlusion secondary to hyperhomocysteinemia and hypertension Figure NVD FFA

A framework for risk analysis of the shellfish aquaculture:The case of the Mediterranean mussel farming in Greece

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Aquaculture and Fisheries 2023年第4期8卷 375-384页

作者： John A.Theodorou ioannis Tzovenis Department of Animal Production Fisheries&AquacultureUniversity of PatrasMesolonghi30200Greece Laboratory of Ecology&Systematics Biology Dept.University of AthensPanepistimioupolisZografou15784Greece

Mediterranean mussel farming in Greece developed considerably during the last 40 years reaching a gross commodity product up to the limits of the country’s production capacity(35–40,000 tonnes/year).Despite the achievements in the sector’s growth,little or no effort has been attributed yet to risk assessment and moreover to risk management of the *** present effort aims at developing a working framework for the shellfish aquaculture of Greece to be used as a tool by the sector’s decision makers to advance strategies for risk elimination or *** work was based on a generic risk management standard tool,the Joint Australian and New Zealand Risk Management Standard AS/NZS ISO 31000:2009 that has been adapted to the specific national characteristics of all levels of the mussel farming business-activities and the industry *** framework supported by data sets regarding development,production,profits and losses,retrieved by surveys through distributed questionnaires or interviews during site-visits,as well as by collecting data from national and international *** input covered technology,farm size,farmer risk-attitude,risk-management strategies,risk-perceptions and socioeconomic *** risks and risk management options were identified providing aid for remediation risk policies to the stakeholders.

关键词： ISO 31000 Risk analysis Mediterranean mussel farming Aquaculture insurance

Non-alcoholic fatty liver disease,diabetes medications and blood pressure

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World Journal of Diabetes 2021年第10期12卷 1809-1811页

作者： ioannis Ilias Costas Thomopoulos Department of Endocrinology Diabetes and MetabolismElena Venizelou HospitalAthens 11521Greece Department of Cardiology Elena Venizelou HospitalAthens 11521Greece

New glucose-lowering agents reduce liver enzyme levels and blood pressure(BP).Whether this finding can be extended to non-alcoholic fatty liver disease(NAFLD)patients,in whom a bidirectional association of NAFLD measu... 详细信息

关键词： Antidiabetic drugs Blood pressure reduction Non-alcoholic fatty liver disease Sodium glucose cotransporter 2 Alanine aminotransferase Aspartate aminotransferase

Immunogenicity of recombinant hepatitis B vaccine in treatment-nave and treatment-experienced chronic hepatitis C patients: The effect of pegylated interferon plus ribavirin treatment

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World Journal of Gastroenterology 2006年第27期12卷 4420-4424页

作者： ioannis S Elefsiniotis Elena Vezali Konstantinos Kamposioras Konstantinos D Pantazis Radostina Tontorova ioannis Ketikoglou Antonios Moulakakis George Saroglou Department of Internal Medicine Hepatology UnitHippokration Hospital of AthensAthensGreeceDepartment of Internal MedicineFaculty of NursingUniversity of AthensAthensGreece Department of Internal Medicine Hepatology UnitHippokration Hospital of AthensAthensGreece Department of Internal Medicine Faculty of NursingUniversity of AthensAthensGreece

AIM： To retrospectively evaluate the vaccinationinduced anti-HBs seroconversion rates in treatmentnaive and treatment-experienced chronic hepatitis C （CHC） patients. Also to prospectively evaluate the seroconversion rates in CHC patients during pegylated interferon （PEG） plus ribavirin （RIB） treatment. METHODS： Seventy treatment-naive CHC patients （group A）, 22 sustained virological responders-SVR following interferon （IFN） plus RIB treatment CHC patients （group B） and 121 healthy subjects （group C） had been participated in the same HBV vaccination schedule （20 μg, 0-1-6 mo）. Seroconversion was considered if anti-HBs levels were above 10 mIU/mL within 3 mo following the third dose of the vaccine. Moreover, we prospectively selected 30 non-cirrhotic CHC patients and evaluated them for the efficacy of the same vaccine schedule randomizing them in two groups： Group-1, 15 CHC patients received the first dose of the vaccine in parallel with the initiation of PEG plus RIB treatment and Group-2, 15 patients received the same vaccination schedule without concomitant treatment. Determination of anti-HBs was performed at mo 1, 2, and 7. Statistical analysis of data was based on ANOVA student＇s t-test and chi-square analysis （P 〈 0.05）. RESULTS： Fifty-eight of 70 group A patients （82.85%）, 20/22 group B （90.9%） and 112/121 healthy subjects （92.56%） had been seroconverted. The seroconversion rates were significantly higher in the control group than in treatment-naive CHC patients （P = 0.04）. The corresponding rates were comparable between group A and group B CHC patients （P = 0.38）. The vast majority of non-responders （10/14, 71.43%） had been infected by genotype-1 of HCV. The seroconversion rates were comparable between group 1 and 2 CHC patients at mo 1 （20% versus 26.7%, P = 0.67）, mo 2 （46.7% vs 60%, P = 0.46） and mo 7 （86.7% versus 93.3%, P = 0.54） of follow-up. CONCLUSION： The immunogenicity of HBV vaccine seems to be lower in CHC patients compared to healthy subjects

关键词： Hepatitis B vaccine Chronic hepatitis C Interferon Ribavirin

Relationship between serum b2-microglobulin levels and virological breakthrough in HBeAg-negative chronic hepatitis B patients,under long-term treatment schedules including lamivudine

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World Journal of Gastroenterology 2005年第13期11卷 1922-1928页

作者： ioannis S.Elefsiniotis Antonios Moulakakis Konstantinos D.Pantazis Irene Glynou ioannis Ketikoglou Elena Vezali Helen Kada Epameinondas Tsianos Department of Internal Medicine Department of Microbiology Department of Hepatogastroenterology

AIM: Predictive value of serum b2-microglobulin (b2m)levels for virological breakthrough (VB) in HBeAg-negative chronic hepatitis B (CHB) patients under long-term treatment schedules including lamivudine (LAM).METHODS: Serum b2m levels were calculated during treatment in 25 CHB patients under long-term LAM monotherapy (group A) and 12 patients under initial interferon plus LAM treatment followed by LAM monotherapy (group B), using the MEIA technology. We used Cox proportional hazard models in order to investigate the association between serum b2m levels and ***: Seven of 25 patients (28%), 9/25 (36%) and 14/25 (56%) from group A and 0/12, 2/12 (16.6%) and 3/12 (25%) from group B exhibited VB at months 12, 24 and 36 of treatment, respectively. All patients, from both groups, who did not show VB exhibited b2m elevation in mo 3. The duration of b2m elevation was significantly longer in the virological responder's subgroup from group A than the non-responder's one (7.3±2.6 vs 3.8±3.4 mo,P = 0.02). In comparison to group A patients whose b2m levels were increased at 3 mo, patients whose b2m levels were decreased had 4.6 times higher risk of experiencing VB (RR = 4.6, P = 0.024). When baseline variables were simultaneously included in the same Cox model, decreased b2m status was still associated with increased risk of VB (RR = 12.2, P = 0.03).CONCLUSION: In HBeAg-negative CHB patients under either long-term LAM monotherapy or initial combination treatment, serum b2m levels at 3 mo of treatment,compared to baseline ones, might be a predictor of risk for VB.

关键词： Chronic hepatitis B Lamivudine Interferon Virological breakthrough B2-microglobulin

Multipotent role of platelets in inflammatory bowel diseases:A clinical approach

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World Journal of Gastroenterology 2014年第12期20卷 3180-3190页

作者： Evangelos Voudoukis Konstantinos Karmiris ioannis E Koutroubakis Department of Gastroenterology Venizelion General Hospital Department of Gastroenterology University Hospital Heraklion

There is evidence that inflammatory bowel diseases (IBD) combine both inflammation and coagulation in their pathogenesis and clinical manifestations. Although platelets (PLT) are well known for their role in hemostasis, there are a rising number of studies supporting their considerable role as inflammatory amplifiers in chronic inflammatory conditions. IBD are associated with several alterations of PLT, including number, shape, and function, and these abnormalities are mainly attributed to the highly activated state of circulating PLT in IBD patients. When PLT activate, they increase in size, release a great variety of bio-active inflammatory and procoagulant molecules/particles, and express a variety of inflammatory receptors. These inflammatory products may represent a part of the missing link between coagulation and inflammation, and can be considered as possible IBD pathogenesis instigators. In clinical practice, thrombocytosis is associated both with disease activity and iron deficiency anemia. Controlling inflammation and iron replacement in anemic patients usually leads to a normalization of PLT count. The aim of this review is to update the role of PLT in IBD and present recent data revealing the possible therapeutic implications of anti-PLT agents in future IBD remedies.

关键词： Anemia, Crohn’ s disease, Platelets, Thrombocytosis, Ulcerative colitis

Prevention and treatment of childhood and adolescent obesity: a systematic review of meta-analyses

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World Journal of Pediatrics 2019年第4期15卷 350-381页

作者： Theodora Psaltopoulou Stamatios Tzanninis ioannis Ntanasis-Stathopoulos George Panotopoulos Myrto Kostopoulou ioannis-Georgios Tzanninis Anastasia Tsagianni Theodoros N.Sergentanis Department of Hygiene Epidemiology and Medical StatisticsSchool of MedicineNational and Kapodistrian University of Athens75M.Asias Str115 27 AthensGreece Department of Medicine University Hospital Southampton NHS Foundation TrustSouthamptonUK Department of Clinical Therapeutics School of MedicineNational and Kapodistrian University of AthensAthensGreece Hellenic Association for the Study of Obesity Metabolism and Eating Disorders(HASOMED)AthensGreece Division of Internal Medicine University of Pittsburgh Medical Center(UPMC)PittsburghPAUSA

Background The goal of this systematic review is to synthesize the published meta-analyses assessing the role of nutritional,behavioral and physical activity factors/interventions on the prevention or treatment of pediatric and adolescent *** An online search was conducted in PubMed (end-of-search:September 30,2015);English-language meta-analyses pooling observational and/or interventional studies examining weight-related indices on children and adolescents were *** Sixty-six meta-analyses corresponding to more than 900,000 children and adolescents were *** majority of meta-analyses included interventional studies most of which referred to mixed or combined interventions,including components such as diet,physical activity and sedentary behavior *** between meta-analyses on observational and interventional studies were *** interventions including physical activity and nutritional modifications seemed to represent the most effective means for tackling childhood *** Synthesis of interventional or observational evidence may yield discrepant *** combination of enhanced physical activity and improved nutrition emerged as a promising intervention in the fight against childhood/adolescent ***,further research is needed about the most effective multidimensional prevention strategy.

关键词： Childhood obesity Diet Meta-analysis Physical activity Systematic review

On Newton’s Method for Solving Nonlinear Equations and Function Splitting

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Numerical Mathematics(Theory,Methods and Applications) 2011年第1期4卷 53-67页

作者： ioannis K.Argyros Saïd Hilout Cameron University Department of Mathematics SciencesLawtonOK 73505USA Universitéde Poitiers Laboratoire de Mathématiques et ApplicationsBd.Pierre et Marie CurieTéléport 2B.P.3017986962 Futuroscope Chasseneuil CedexFrance

We provided in[14]and[15]a semilocal convergence analysis for Newton’s method on a Banach space setting,by splitting the given *** this study,we improve the error bounds,order of convergence,and simplify the sufficie... 详细信息

关键词： Newton’s method Banach space majorizing sequence semilocal convergence splitting of an operator

Artificial night light and thyroid cancer

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World Journal of Methodology 2024年第1期14卷 87-93页

作者： Athanasios Tselebis Eftychia Koukkou Charalampos Milionis Lina Zabuliene Argyro Pachi ioannis Ilias Department of Psychiatry “Sotiria”General Chest Diseases HospitalAthens GR-11527Greece Department of Endocrinology Diabetes and MetabolismElena Venizelou General HospitalAthens GR-11521Greece Faculty of Medicine Vilnius UniversityVilnius LT-03101Lithuania

BACKGROUND The occurrence of thyroid cancer(TC)has increased in recent *** to outdoor artificial light at night(ALN)is associated with an increased risk of *** To investigated the impact of ALN,as a significant environmental pollutant,on TC incidence *** The assessment involved analyzing satellite ALN data in conjunction with TC incidence data[adjusted standardized rate(ASR)],while considering the quality of cancer registries(QCR),gross domestic product(GDP)per person,and health expenditure per person(HEP)for each *** Results indicated a correlation between higher ASR and ALN exposure percentages,particularly in countries with higher GDP or HEP quartiles(all P0.10).CONCLUSION The findings suggest a potential link between higher GDP and adverse health conditions,serving as possible risk factors for TC,rather than a direct association with *** include the use of cross-sectional data,temporal misalign ment,and reliance on ALN as a socioeconomic *** is proposed that light pollution might be connected to a lifestyle conducive to ***,the presence of higher GDP/HEP could enhance access to diagnostic resources,potentially facilitating TC diagnosis and inclusion in cancer registries.

关键词： Lighting Human Epidemiology Thyroid Cancer