检索结果-南通市图书馆

Advances and challenges in laparoscopic surgery in the management of hepatocellular carcinoma

World Journal of Gastrointestinal Surgery 2017年第12期9卷 233-245页

作者： ioannis a ziogas Georgios Tsoulfas Medical School Aristotle University of Thess-aloniki 1~(st) Department of Surgery Aristotle University of Thessaloniki

Hepatocellular carcinoma is the fifth most common malignancy and the third most common cause of cancer-related mortality worldwide. From the wide variety of treatment options, surgical resection and liver transplantation are the only therapeutic ones. However, due to shortage of liver grafts, surgical resection is the most common therapeutic modality implemented. Owing to rapid technological development, minimally invasive approaches have been incorporated in liver surgery. Liver laparoscopic resection has been evaluated in comparison to the open technique and has been shown to be superior because of the reported decrease in surgical incision length and trauma, blood loss, operating theatre time, postsurgical pain and complications, R0 resection, length of stay, time to recovery and oral intake. It has been reported that laparoscopic excision is a safe and feasible approach with near zero mortality and oncologic outcomes similar to open resection. Nevertheless, current indications include solid tumors in the periphery < 5 cm, especially in segments Ⅱ through Ⅵ, while according to the consensus laparoscopic major hepatectomy should only be performed by surgeons with high expertise in laparoscopic and hepatobiliary surgery in tertiary centers. It is necessary for a surgeon to surpass the 60-cases learning curve observed in order to accomplish the desirable outcomes and preserve patient safety. In this review, our aim is to thoroughly describe the general principles and current status of laparoscopic liver resection for hepatocellular carcinoma, as well as future prospects.

关键词： Hepatocellular carcinoma Laparoscopic liver resection Minimally invasive surgery Laparoscopic hepatectomy Liver malignant disease Surgical excision

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Evolving role of Sorafenib in the management of hepatocellular carcinoma

引用

World Journal of Clinical Oncology 2017年第3期8卷 203-213页

作者： ioannis a ziogas Georgios Tsoulfas Aristotle University of Thessaloniki School of Medicine 1st Department of Surgery Aristotle University of Thessaloniki

Hepatocellular carcinoma(HCC) is one of the most common malignant diseases worldwide and comes third in cancer-related *** there is a broad spectrum of treatment options to choose from,only a few patients are eligible candidates to receive a curative therapy according to their stage of disease,and thus palliative treatment is implemented in the majority of the patients suffering from liver ***,a multikinase inhibitor,is the only currently approved agent for systemic therapy in patients with advanced stage HCC and early stage liver *** has been shown to improve the overall survival,but with various side effects,while its cost is not *** has been in the market for a decade and has set the stage for personalized targeted *** role during this time has ranged from monotherapy to neoadjuvant and adjuvant treatment with surgical resection,liver transplantation and chemoembolization or even in combination with other chemotherapeutic *** this review our aim is to highlight in depth the current position of Sorafenib in the armamentarium against HCC and how that has evolved over time in its use either as a single agent or in combination with other therapies.

关键词： Sorafenib Hepatocellular carcinoma Liver neoplasm Multikinase inhibitor Targeted therapy Tumor angiogenesis Signaling pathways Adjuvant therapy Liver cancer Liver transplantation Liver resection

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Obstetrical and gynecologic challenges in the liver transplant patient

引用

World Journal of Transplantation 2020年第11期10卷 320-329页

作者： ioannis a ziogas Muhammad H Hayat Georgios Tsoulfas Medical School Aristotle University of ThessalonikiThessaloniki 54124Greece Department of Medicine Division of GastroenterologyHepatology and NutritionVanderbilt University Medical CenterNashvilleTN 37212United States Department of Surgery Papageorgiou University HospitalAristotle University of ThessalonikiThessaloniki 54622Greece

An increasing number of childbearing agewomen undergo liver transplantation(LT)in the United *** in this patient subgroup poses a significant challenge regarding the plans for future fertility,particularly in terms of immunosuppression and optimal timing of *** LT is only rarely performed as the outcome is commonly dismal for the mother or more commonly the *** the other hand,the outcomes of pregnancy in LT recipients are favorable,and children born to LT recipients are relatively *** on pregnancy should start before LT and continue after LT up until pregnancy,while all pregnant LT recipients must be managed by amultidisciplinary team,including both an obstetrician and a transplant ***,an interval of at least 1-2 years after successful LT is recommended before considering ***-induced hypertension,pre-eclampsia,and gestational diabetes mellitus are reported more commonly during the pregnancies of LT recipients than in the pregnancies of non-transplant *** adverse fetal outcomes,such asmiscarriage,abortion,stillbirth,or ectopic pregnancy,may occur more often than in the non-transplant population,early planning or delivery either through a planned induction of labor or cesarean section is critical to minimize the risk of *** significant long-term physical or phycological abnormalities have been reported in children born to LT recipients.

关键词： Liver transplantation Pregnancy Obstetric complications Immunosuppression Fetal outcomes End-stage liver disease

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Pediatric transplantation during the COVID-19 pandemic

引用

World Journal of Transplantation 2022年第5期12卷 88-99页

作者： Christos Dimitrios Kakos ioannis a ziogas Georgios Tsoulfas Surgery Working Group Society of Junior DoctorsAthens 15123Greece Division of Hepatobiliary Surgery and Liver Transplantation Department of SurgeryVanderbilt University Medical CenterNashvilleTN 37232United States Department of Transplantation Surgery Aristotle University School of MedicineThessaloniki 54622Greece

Children infected by severe acute respiratory syndrome coronavirus 2(SARSCoV-2)seem to have a better prognosis than ***,pediatric solid organ transplantation(SOT)has been significantly affected by the unprecedented coronavirus disease 2019(COVID-19)pandemic during the pre-,peri-,and posttransplant ***,immunosuppression constitutes a real challenge for transplant clinicians as increased immunosuppression may prolong disease recovery,while its decrease can contribute to more severe *** date,most pediatric SOT recipients infected by SARS-CoV-2 experience mild disease with only scarce reports of life-threatening *** a consequence,after an initial drop during the early phase of the pandemic,pediatric SOTs are now performed with the same frequency as during the pre-pandemic *** review summarizes the currently available evidence regarding pediatric SOT during the COVID-19 pandemic.

关键词： Pediatric Transplantation SARS-CoV-2 COVID-19 Immunosuppression

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Liver transplantation during COVID-19: Adaptive measures with future significance

引用

World Journal of Transplantation 2022年第9期12卷 288-298页

作者： Argyrios Gyftopoulos ioannis a ziogas Martin I Montenovo School of Medicine National Kapodistrian University of AthensAthens 14564Greece Department of Surgery University of Colorado Anschutz Medical CampusAuroraCO 80045United States Division of Hepatobiliary Surgery and Liver Transplantation Department of SurgeryVanderbilt University Medical CenterNashvilleTN 37232United States

Following the outbreak of coronavirus disease 2019(COVID-19),a disease caused by the novel severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),the field of liver transplantation,along with many other aspects of healthcare,underwent drastic *** an initial increase in waitlist mortality and a decrease in both living and deceased donor liver transplantation rates,through the implementation of a series of new measures,the transplant community was able to recover by the summer of *** in waitlist prioritization,the gradual implementation of telehealth,and immunosuppressive regimen alte-rations amidst concerns regarding more severe disease in immunocompromised patients,were among the changes implemented in an attempt by the transplant community to adapt to the *** recently,with the advent of the Pfizer BNT162b2 vaccine,a powerful new preventative tool against in-fection,the pandemic is slowly beginning to *** pandemic has cert-ainly brought transplant centers around the world to their *** the unspeakable tragedy,COVID-19 constitutes a valuable lesson for health systems to be more prepared for potential future health crises and for life-saving tran-splantation not to fall behind.

关键词： Liver transplantation COVID-19 SARS-CoV-2 Vaccine Immunosuppression Telehealth

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Metabolic syndrome and liver disease in the era of bariatric surgery: What you need to know!

引用

World Journal of Hepatology 2020年第10期12卷 709-721页

作者： ioannis a ziogas Konstantinos Zapsalis Dimitrios Giannis Georgios Tsoulfas Aristotle University School of Medicine Thessaloniki 54124Greece Center for Health Innovations and Outcomes Research(CHIOR) The Feinstein Institute for Medical ResearchManhassetNY 11030United States The First Department of Surgery Aristotle University of ThessalonikiThessaloniki 54124Greece

Metabolic syndrome(MS)is defined as the constellation of obesity,insulin resistance,high serum triglycerides,low high-density lipoprotein cholesterol,and high blood *** increasingly affects more and more people and progressively evolves into a serious issue with widespread healthcare,cost,and quality of life associated *** is associated with increased morbidity and mortality due to cardiovascular or chronic liver *** treatment,which includes diet,exercise,and antidiabetic agents,is the mainstay of treatment,but depends on patient compliance to medical treatment and adherence to lifestyle modification *** surgery has recently emerged as an appropriate alternative treatment with promising longterm *** gastrectomy and Roux-en-Y gastric bypass constitute the most commonly performed procedures and have been proven both cost-effective and safe with low complication *** transplantation is the only definitive treatment for end-stage liver disease and its utilization in patients with nonalcoholic steatohepatitis has increased more than fivefold over the past 15 *** this review,we summarize current state of evidence on the surgical treatment of MS.

关键词： Metabolic syndrome Bariatric surgery Sleeve gastrectomy Gastric bypass Non-alcoholic fatty liver disease Non-alcoholic steatohepatitis Liver transplantation

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Global dissemination of minimally invasive living donor hepatectomy: What are the barriers?

引用

World Journal of Gastrointestinal Surgery 2023年第5期15卷 776-787页

作者： Christos Dimitrios Kakos Angelos Papanikolaou ioannis a ziogas Georgios Tsoulfas Surgery Working Group Society of Junior DoctorsAthens 15123Greece Department of Transplant Surgery Aristotle University of ThessalonikiSchool of MedicineThessaloniki 54622Greece Department of Surgery Johns Hopkins University School of MedicineBaltimoreMD 21287United States Department of Surgery University of Colorado Anschutz Medical CampusAuroraCO 80045United States

Minimally invasive donor hepatectomy(MIDH)is a relatively novel procedure that can potentially increase donor safety and contribute to faster rehabilitation of *** an initial period in which donor safety was not effectively validated,MIDH currently seems to provide improved results,provided that it is conducted by experienced *** selection criteria are crucial to achieve better outcomes in terms of complications,blood loss,operative time,and hospital *** a pure laparoscopic technique,various approaches have been recommended such as hand-assisted,laparoscopic-assisted,and robotic *** latter has shown equal outcomes compared to open and laparoscopic approaches.A steep learning curve seems to exist in MIDH,mainly due to the fragility of the liver parenchyma and the experience needed for adequate control of *** review investigated the challenges and the opportunities of MIDH and the barriers to its global *** need expertise in liver transplantation,hepatobiliary surgery,and minimally invasive techniques to perform *** can be categorized into surgeon-related,institutionalrelated,and *** robust data and the creation of international registries are needed for further evaluation of the technique and the acceptance from more centers worldwide.

关键词： Minimally invasive donor hepatectomy Liver transplantation Living donation Laparoscopic donor hepatectomy Global surgery

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Frailty and Liver resection: where do we stand?

引用

Hepatoma Research 2020年第2期6卷 11-19页

作者： Georgios S.Sioutas ioannis A.ziogas Georgios Tsoulfas Department of Medicine School of Health SciencesDemocritus University of ThraceAlexandroupolis 68100Greece First Department of Surgery Papageorgiou University HospitalAristotle University of ThessalonikiThessaloniki 54622Greece

As the world population is continuously aging, the number of older patients requiring liver surgery is also on the rise. Data have shown that age should not be a limiting factor for liver resection, as it cannot accurately predict postoperative outcomes. Instead, frailty can serve as a more reliable measure of the patient's overall health and functional reserves. Several frailty assessment tools have been implemented for preoperative risk stratification before liver surgery, and higher scores have commonly been associated with postoperative morbidity, mortality, and length of hospital stay. However, no consensus has been reached on the most useful screening tool. Future studies should focus on comparing the currently available assessment tools, constructing a liver resection-specific tool, and assessing the role of frailty assessment tools in preoperative patient optimization.

关键词： Frailty age elderly liver resection liver surgery morbidity morbidity complications

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Liver transplantation for hepatoblastoma

引用

Hepatoma Research 2022年第1期8卷 382-392页

作者： Dimitrios N.Varvoglis ioannis A.ziogas Georgios Tsoulfas Department of General Surgery Faculty of MedicineSchool of Human SciencesUniversity of ThessalyBiopolisLarissa 41100Greece Surgery Working Group Society of Junior DoctorsAthens 15123Greece Division of Hepatobiliary Surgery and Liver Transplantation Department of SurgeryVanderbilt University Medical CenterNashvilleTN 37232USA Department of Transplantation Surgery Aristotle University School of MedicineThessaloniki 54124Greece

Liver transplantation is the only potentially curative option for unresectable *** introduction of platinum-based chemotherapy drastically improved the survival outcomes of patients with ***,the use of neoadjuvant chemotherapy and the optimal number of cycles required in patients listed for liver transplantation,as well as the potential use of adjuvant chemotherapy,remain ***,the shortage of donor liver grafts,along with the lack of clear consensus on the management of metastatic hepatoblastoma,makes the decision on whether to proceed to liver transplantation even more complex and *** advances may optimize intraoperative imaging of both the primary tumor and metastatic sites,thus facilitating complete *** improvements,along with the wider use of social media platforms to increase public awareness,could potentially pave the way for more optimal implementation of liver transplantation for the treatment of patients with unresectable hepatoblastoma.

关键词： Hepatoblastoma liver transplantation chemotherapy liver tumors pediatric

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Pediatric surgery during the COVID-19 pandemic

引用

World Journal of Clinical Pediatrics 2020年第2期9卷 7-16页

作者： Aikaterini Dedeilia Stepan M Esagian ioannis a ziogas Dimitrios Giannis ioannis Katsaros GeorgiosTsoulfas Surgery Working Group Society of Junior DoctorsAthens 15123Greece National and Kapodistrian University of Athens Athens 15772Greece Department of Surgery Division of Hepatobiliary Surgery and Liver TransplantationVanderbilt University Medical CenterNashvilleTN 37232United States Institute of Health Innovations and Outcomes Research the Feinstein Institute forΜedical ResearchManhassetNY 11030United States Department of Surgery Metaxa Cancer HospitalPiraeus 18537Greece First Department of Surgery Aristotle University of ThessalonikiThessaloniki 54622Greece

The coronavirus disease 2019(COVID-19)pandemic has had a major impact on pediatric *** infection is often asymptomatic and atypical in children,while overlapping presentations with other infectious diseases generate additional diagnostic *** high probability of missed pediatric cases and the invasive nature of surgery generate great concern for widespread transmission in this *** guidelines suggest that triage of cases should be made on a case-by-case basis by a multidisciplinary team of *** can be assisted by classifying cases as elective,urgent,or an emergency according to the risks of delaying their surgical management.A workflow diagram should ideally guide the management of all cases from admission to *** surgery is necessary,all staff should use appropriate personal protective equipment,and high-risk practices,such as aerosol-generating tools or procedures,should be avoided if ***,carefully designed organizational protocols should be established to minimize transmission while ensuring the uninterrupted operation of pediatric surgery *** example,surgical teams can be divided into small weekly rotating groups,and healthcare workers should be continuously monitored for COVID-19 ***,team protocols in the operating room can optimize communication and improve adherence to personal protective equipment *** operating rooms,pediatric intensive care units,and surgical wards should be specifically designed for suspected or confirmed COVID-19 ***,transportation of patients should be minimal and follow designated short *** these measures can help mitigate the effects of the COVID-19 pandemic on pediatric surgery units.

关键词： Pediatric surgery COVID-19 SARS-CoV-2 Coronavirus Emergency surgery Personal protective equipment

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：