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COVID-19 and liver injury: An ongoing challenge

World Journal of Gastroenterology 2023年第2期29卷 257-271页

作者： ioanna papagiouvanni Serafeim-Chrysovalantis Kotoulas Athanasia Pataka Dionisios G Spyratos Konstantinos Porpodis Afroditi K Boutou Georgios papagiouvannis ioanna Grigoriou Christos Vettas Ioannis Goulis Fourth Department of Internal Medicine Aristotle University of ThessalonikiThessaloniki 54642ThessalonikiGreece Intensive Care Unit Hippokration General HospitalThessaloniki 54642Greece Department of Respiratory Medicine G Papanikolaou HospitalResp Failure UnitAristotle University of ThessalonikiThessaloniki 57001Greece Pulmonary Department Aristotle University of ThessalonikiThessaloniki 57001Greece Pulmonary Department G Papanikolaou HospitalResp Failure UnitAristotle University of ThessalonikiThessaloniki 54642Greece Department of Pharmacy School of Health SciencesFrederick UniversityNicosia 1036Cyprus Respiratory Failure Clinic Papanikolaou General HospitalThessloniki 57001Greece Fourth Department of Internal Medicine Hippokration General HospitalThessaloniki 54642Greece

The new coronavirus severe acute respiratory syndrome coronavirus 2(SARSCoV-2)was identified in December 2019,in Wuhan,*** virus was rapidly spread worldwide,causing coronavirus disease 2019(COVID-19)*** COVID-19 is presented,usually,with typical respiratory symptoms(i.e.,dyspnea,cough)and fever,extrapulmonary manifestations are also *** injury is a common feature in patients with COVID-19 and ranges from mild and temporary elevation of liver enzymes to severe liver injury and,even,acute liver *** pathogenesis of liver damage is not clearly defined;multiple mechanisms contribute to liver disorder,including direct cytopathic viral effect,cytokine storm and immune-mediated hepatitis,hypoxic injury,and druginduced liver *** with underlying chronic liver disease(i.e.,cirrhosis,non-alcoholic fatty liver disease,alcohol-related liver disease,hepatocellular carcinoma,etc.)may have greater risk to develop both severe COVID-19 and further liver deterioration,and,as a consequence,certain issues should be considered during disease *** aim of this review is to present the prevalence,clinical manifestation and pathophysiological mechanisms of liver injury in patients with SARS-CoV-2 ***,we overview the association between chronic liver disease and SARS-CoV-2 infection and we briefly discuss the management of liver injury during COVID-19.

关键词： COVID-19 Liver injury Cytokine storm Hypoxic hepatitis Drug-induced liver injury Chronic liver disease

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Outpatient management after hospitalisation for acute decompensation of cirrhosis:A practical guide

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World Journal of Hepatology 2024年第12期16卷 1377-1394页

作者： Adonis A Protopapas Alexandra Tsankof ioanna papagiouvanni Georgia Kaiafa Lemonia Skoura Christos Savopoulos Ioannis Goulis First Propaedeutic Department of Internal Medicine Aristotle University of ThessalonikiAHEPA University HospitalThessaloniki 54636Greece Fourth Department of Internal Medicine Aristotle University of ThessalonikiHippokration General HospitalThessaloniki 54642Greece Department of Microbiology Aristotle Universityοf ThessalonikiAHEPA University HospitalThessaloniki 54636Greece

Acute decompensation in cirrhotic patients signifies the onset of clinically evident events due to portal *** transition from compensated to decom-pensated cirrhosis involves hemodynamic changes leading to multiorgan dysfun-ction,managed predominantly in outpatient settings with regular *** mortality risk is elevated in decompensated ***,diligent outpatient management should focus on regular medical follow-ups,medication adjustments,patient education,addressing emergent issues and evaluation for liver *** ultimate goal is to improve quality of life,prevent di-sease progression,reduce complications,and assess possible *** guide provides valuable recommendations for medical experts managing de-compensated cirrhotic patients post-hospitalization.

关键词： Cirrhosis Decompensated Outpatient Complications Treatment

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Is there a correlation between the changes in airway inflammation and the changes in respiratory mechanics after vaping in patients with asthma?

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World Journal of Methodology 2024年第2期14卷 127-133页

作者： Serafeim-Chrysovalantis Kotoulas Kalliopi Domvri Alexandros Tsantos ioanna papagiouvanni Anastasia Michailidou Dionisios G Spyratos Konstantinos Porpodis ioanna Grigoriou Despina Papakosta Athanasia Pataka Intensive Care Unit Hippokration General HospitalThessaloniki 54642Greece Pulmonary Department-Oncology Unit Aristotle University of ThessalonikiThessaloniki 57010Greece 2nd Department of Internal Medicine General Hospital of Thessaloniki‘’Ippokration’’Thessaloniki 54642Greece Fourth Department of Internal Medicine Aristotle University of ThessalonikiThessaloniki 54642ThessalonikiGreece 2nd Propaedeutic Department of Internal Medicine General Hospital of Thessaloniki“Ippokration”Thessaloniki 54642Greece Department of Pulmonary Aristotle University of ThessalonikiThessaloniki 57001Greece Respiratory Failure Clinic Papanikolaou General HospitalThessloniki 57001Greece Department of Respiratory Medicine Aristotle Univ ThessalonikiSch MedG Papanikolaou HospResp Failure UnitAristotle University of ThessalonikiThessaloniki 57001Greece

BACKGROUND Electronic cigarettes(ECs)have been promoted as alternatives to traditional *** investigate ECs’effects on respiratory system,especially in patients with respiratory *** We randomly selected 25 smokers with stable moderate asthma and matched them with 25 healthy *** were subjucted to pulmonary function tests(PFTs),impulse oscillometry(IOS),fraction exhaled Nitric Oxide(FeNO),exhaled breathe condensate(EBC)and biomarker measurements before and after vaping one nicotinecontaining *** The increase in FeNO 30 minutes after EC,reflecting airway inflammation,significantly correlated with increase of residual volume(RV),total lung capacity,respiratory impedance at 5 Hz(Z5Hz)and respiratory resistance at 5 and 20 Hz(R5Hz and R20Hz).No significant correlations were found between EBC biomarkers'changes and respiratory *** This is the first study demonstrating that the changes in airway inflammation caused by EC have direct effects in respiratory mechanics of asthmatic patients.

关键词： Asthma Electronic cigarette Airway inflammation Lung function Impulse oscillometry FeNO

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Understanding the link between type 2 diabetes mellitus and Parkinson's disease:role of brain insulin resistance

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Neural Regeneration Research 2025年第11期20卷 3113-3123页

作者： Theodora Ntetsika Sergiu-Bogdan Catrina ioanna Markaki Department of Clinical Neuroscience Karolinska InstituteStockholmSweden Department of Neurology Karolinska University HospitalStockholmSweden Department of Molecular Medicine and Surgery Karolinska InstituteStockholmSweden Center for Diabetes Academic Specialist CenterStockholmSweden Center for Neurology Academic Specialist CenterStockholmSweden

Type 2 diabetes mellitus and Parkinson's disease are chronic diseases linked to a growing pandemic that affects older adults and causes significant socio-economic *** data supporting a close relationship between these two aging-related diseases have resulted in the investigation of shared pathophysiological molecular *** insulin signaling in the brain has gained increasing attention during the last decade and has been suggested to contribute to the development of Parkinson's disease through the dysregulation of several pathological *** contribution of type 2 diabetes mellitus and insulin resistance in neurodegeneration in Parkinson's disease,with emphasis on brain insulin resistance,is extensively discussed in this article and new therapeutic strategies targeting this pathological link are presented and reviewed.

关键词： brain insulin resistance brain insulin signaling diabetes type 2 GLP-1 receptor agonists GLP-1 signaling insulin resistance insulin signaling neurodegeneration Parkinson's disease targeted therapy

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Medical transportation and the contribution of air medical evacuation in isolated mountainous areas of Greece-Case study,Municipality of Agrafa

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Journal of Mountain Science 2022年第11期19卷 3178-3191页

作者： ioanna KARANI Anastasios BALASKAS Dimitris KALIAMPAKOS School of Rural Surveying and Geoinformatics EngineeringNational Technical University of AthensAthens 15780Greece School of Mining and Metallurgical Engineering National Technical University of AthensAthens 15780Greece Metsovion Interdisciplinary Research Center National Technical University of AthensAthens 15780Greece

In every emergency medical situation,access to emergency medical services is an inalienable right of any *** average acceptable time to provide first aid assistance is 60 *** this paper,the possibility of using helicopters for air travel in mountainous areas was examined for the first time for all of Greece and especially for a mountainous and isolated area such as the Municipality of ***,the time distance-virtual distance,from the hospitals was calculated at the national level of Greece,with an acceptable first contact time of 60 minutes(golden hour),i.e.,less than two hours from the nearest hospital to the incident and back to the hospital and the relevant conclusions are ***,the case study of Municipality of Agrafa,one of the most mountainous areas in Greece,was *** time distance of the settlements from the nearest primary health point,namely the Primary Health Centre(PHC)of West Fragkista,was calculated and the transportation by ground means was compared with the corresponding time by flying means,to investigate the contribution of air transportation or not,of the timely arrival of the patients in the appropriate health ***,possible helicopter landing locations were identified,using a geographic information system to facilitate the process of air medical transportation in the Municipality of Agrafa.

关键词： Civil air transport Mountain areas Landing sites Travel time Greece

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Toward development of ecosystem asset accounts at the national level

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Ecosystem Health and Sustainability 2019年第1期5卷 36-46,I0022页

作者： Dava Vačkářů ioanna Grammatikopoulou Department of Human Dimensions of Global Change Global Change Research Institute of the Czech Academy of SciencesBrnoCzech Republic

Ecosystem accounting has become one of the key components in the revision of international statistical *** of the System of Environmental-Economic Accounting for ecosystem services follows the rapid progress of science in this area as well as expanding applications to sustainability *** this contribution,we discuss approaches to accounting of ecosystem assets as a natural capital basis that is critical for ecosystem service *** on examples from the Czech Republic,a Central European country,we illustrate the construction of ecosystem extent accounts based on the methodology of Land and Ecosystem *** analysis is complemented by monetary ecosystem asset accounting through quantification of the present value of future ecosystem service *** condition is represented by the Mean Species Abundance indicator,which gauges the direction of ecosystem *** on the demonstration of approaches to ecosystem asset accounting,we discuss selected aspects of ecosystem condition measurements,valuation,and policy implications of ecosystem asset accounting at the national level.

关键词： Ecosystem accounting ecosystem services land cover change Mean Species Abundance value transfer Czech Republic

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Mucins in neoplasms of pancreas,ampulla of Vater and biliary system

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World Journal of Gastrointestinal Oncology 2016年第10期8卷 725-734页

作者： Dimitrios Moschovis Giorgos Bamias ioanna Delladetsima Department of Gastroenterology Agios Panteleimon General Hospital Academic Department of Gastroenterology Medical SchoolNational and Kapodistrian University of AthensLaikon Hospital First Department of Pathology Medical SchoolNational and Kapodistrian University of Athens

Tumors of the pancreas,the ampulla of Vater,and the extrahepatic and intrahepatic bile ducts have significant histological similarities due to the common embryonic origin of the pancreatobiliary *** obviates the need for discovery of biomarkers with diagnostic and prognostic value for these ***,especially MUC-1,-2,-4 and-5AC,are important candidates for developing into such reliable *** expression of MUC1 occurs in pancreatic ductal adenocarcinomas and is associated with increased degrees of dysplasia in pancreatic intraepithelial neoplasia(Pan IN).Positive expression of MUC2 in intraductal papillary mucinus neoplasms(IPMN) of the intestinal type indicates high potential progression to invasive carcinoma with de novo expression of MUC1,while absence of MUC2 expression in IPMNs of gastric type implies low potential to malignant *** novo MUC4 expression correlates to the severity of dysplasia in Pan IN and is associated with a poor prognosis in patients with pancreatic ductal *** biliary intraepithelial neoplasia(Bil IN),increased expression of MUC1 is associated with higher degrees of *** cholangiocarcinomas(ICC) are characterized by increased expression of all glycoforms of *** MUC2 expression in intraductal papillary neoplasm of the bile ducts(IPNB) of the intestinal type indicates high malignant potential with de novo expression of MUC1 in the invasive *** MUC2 expression in any degree of Bil IN may prove useful in differentiating them from *** novo expression of MUC4 is associated with poor prognosis in patients with ICC or carcinoma of the extrahepatic bile ducts(EHBDC).High de novo expression of MUC5 AC is found in all degrees of Bil IN and all types of IPNB and *** MUC5 AC is useful in the detection of neoplastic lesions of the bile duct at an early *** expression of mucin MUC1 in carcinoma of the ampulla of Vater associated with unfavorable b

关键词： Ampulla Vater neoplasms Biliary system neoplasms Mucins Pancreatic neoplasms

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Atrial fibrillation in patients with systolic heart failure:pathophysiology mechanisms and management

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Journal of Geriatric Cardiology 2021年第5期18卷 376-397页

作者： ioanna Koniari Eleni Artopoulou Dimitrios Velissaris Nicholas Kounis Grigorios Tsigkas Manchester Heart Institute Manchester University Foundation TrustManchesterUnited Kingdom Department of Internal Medicine University Hospital of PatrasPatrasGreece Department of Cardiology University Hospital of PatrasPatrasGreece

Heart failure(HF)and atrial fibrillation(AF)demonstrate a constantly increasing prevalence during the 21st century worldwide,as a result of the aging population and the successful interventions of the clinical practice in the deterioration of adverse cardiovascular *** and AF share common risk factors and pathophysiological mechanisms,creating the base of a constant *** impairs systolic and diastolic function,resulting in the increasing incidence of HF,whereas the structural and neurohormonal changes in HF with preserved or reduced ejection fraction increase the possibility of the AF *** temporal relationship of the development of either condition affects the diagnostic algorithms,the prognosis and the ideal therapeutic strategy that leads to euvolaemia,management of noncardiovascular comorbidities,control of heart rate or restoration of sinus rate,ventricular synchronization,prevention of sudden death,stroke,embolism,or major bleeding and maintenance of a sustainable quality of *** indicated treatment for the concomitant HF and AF includes rate or/and rhythm control as well as thromboembolism prophylaxis,while the progress in the understanding of their pathophysiological interdependence and the introduction of the genetic profiling,create new paths in the diagnosis,the prognosis and the prevention of these diseases.

关键词： prevention diagnosis management

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Arsenic speciation in fish from Greek coastal areas

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Journal of Environmental Sciences 2017年第6期29卷 300-312页

作者： ioanna Kalantzi Kyriaki Mylona Katerina Sofoulaki Manolis Tsapakis Spiros A.Pergantis Institute of Oceanography Hellenic Centre for Marine Science(HCMR)PO Box 2214Heraklion 71003CreteGreece Environmental Chemical Processes Laboratory Department of ChemistryUniuersity of CreteHeraklion 71003CreteGreece

Arsenic speciation analysis was conducted on fish samples （sardine and anchovy） collected from six areas along the Greek coastline, i.e. Artemisium Straits, Thermaikos Gulf, Amvrakikos Gulf, Strymonian Gulf, Thracian Sea, and Elefsina Gulf. Total arsenic levels ranging from 11.8 to 62.6 mg As/kg dry weight were determined. Arsenobetaine, a non-toxic form of arsenic, was found to be the main arsenic species, present at 8.6 to 58.8 mg As/kg dry weight, accounting for 67--95% of the total arsenic. Also detected in all fish samples was dimethylarsinic acid, although at considerably lower concentrations, ranging from 0.072-3.956 mg As/kg dry weight. Monomethylarsonic acid was detected at low levels in all anchovy samples, and only in sardines from one area. Finally, inorganic arsenic in the form of arsenate was detected only in fish at one area, indicating the possible effect of an environmental parameter on its presence at detectable amounts. Statistical analysis revealed the environmental variables, such as salinity, total organic carbon and nitrogen, ammonium, phosphate, total phosphorus, dissolved oxygen and pressure index, are potentially correlated to As species concentrations. Furthermore, based on factor analysis, the biological parameters, such as fish weight, lipids, protein and ash content, that are correlated to As species concentrations of fish were also identified. The interrelationship of arsenobetaine and dimethylarsinic acid concentrations within each fish species was evaluated.

关键词： Arsenic speciationArsenobetaineDimethylarsinic acidArsenateFishEnvironmental and biologicalparameters

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Role of NLRP3 inflammasome in inflammatory bowel diseases

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World Journal of Gastroenterology 2019年第33期25卷 4796-4804页

作者： Evanthia Tourkochristou ioanna Aggeletopoulou Christos Konstantakis Christos Triantos Division of Gastroenterology Department of Internal Medicine Medical School University of Patras

Inflammasomes are multiprotein intracellular complexes which are responsible for the activation of inflammatory responses. Among various subtypes of inflammasomes, NLRP3 has been a subject of intensive investigation. NLRP3 is considered to be a sensor of microbial and other danger signals and plays a crucial role in mucosal immune responses, promoting the maturation of proinflammatory cytokines interleukin 1β(IL-1β) and IL-18. NLRP3 inflammasome has been associated with a variety of inflammatory and autoimmune conditions, including inflammatory bowel diseases(IBD). The role of NLRP3 in IBD is not yet fully elucidated as it seems to demonstrate both pathogenic and protective effects. Studies have shown a relationship between genetic variants and mutations in NLRP3 gene with IBD pathogenesis. A complex interaction between the NLRP3 inflammasome and the mucosal immune response has been reported. Activation of the inflammasome is a key function mediated by the innate immune response and in parallel the signaling through IL-1β and IL-18 is implicated in adaptive immunity. Further research is needed to delineate the precise mechanisms of NLRP3 function in regulating immune responses. Targeting NLRP3 inflammasome and its downstream signaling will provide new insights into the development of future therapeutic strategies.

关键词： NLRP3 inflammasome Inflammatory bowel diseases Mucosal immune system Interleukin 1β Interleukin 18 NLRP3 gene polymorphisms

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