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Interaction of arylsulfatases A and B with maspin: A possible explanation for dysregulation of tumor cell metabolism and invasive potential of colorectal cancer

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World Journal of Clinical Cases 2019年第23期7卷 3990-4003页

作者： Zsolt Kovacs ioan jung Krisztina Szalman Laura Banias Tivadar Jr Bara Simona Gurzu Department of Pathology University of MedicinePharmacySciences and Technology“George Emil Palade”Targu Mures 530149Romania Department of Internal Medicine University of MedicinePharmacySciences and Technology“George Emil Palade”Targu Mures 530149Romania Department of Surgery University of MedicinePharmacyScience and Technology“George Emil Palade”Tirgu Mures 530149Romania Research Center(CCAMF) University of MedicinePharmacySciences and TechnologyTargu Mures 540139Romania

BACKGROUND Although it has been shown that arylsulfatases are lost in colorectal cancer(CRC)cell lines,their exact role in the carcinogenesis and behavior of this cancer was not *** data about the correlation between serum and immunohistochemical(IHC)level of arylsulfatases(ARSA,ARSB)in patients with CRC were published *** To evaluate the possible prognostic value of ARSA and/or ARSB in CRC,at circulating and protein *** The present study included 45 consecutive patients who were prospectively diagnosed with *** IHC stains(protein expression)ARSA,ARSB and maspin expression were *** these markers,cytoplasmic expression was taken into *** gene expression study,circulating mRNA was isolated from all patients,before surgery.A group of 45 healthy patients without inflammatory or tumor pathologies was used as control *** transcription and Taqman Gene Expression Array were used for ARSB gene *** The preoperative circulating RNA level of the ARSB gene was significantly decreased in patients with CRC(RQ1).A more significant decrease(RQ<0.5)occurred in ulcero-infiltrative maspinpositive adenocarcinomas,with a higher degree of tumor budding,diagnosed in locally advanced stages(pT3/4).ARSA/maspin immunopositivity indicated a higher risk for lymph node metastasis,while triple positivity for maspin/ARSA/ARSB and ARSB gene expression level<0.5 were indicators of CRC aggressive behavior,independent of lymph node *** The significant independent negative prognostic factors of CRC are the ulceroinfiltrative aspect,high budding degree,triple positivity for maspin,ARSA and ARSB,and low ARSB gene expression.

关键词： Arylsulfatase Maspin Colorectal cancer ARSB gene Blood Tissue

Epithelial-mesenchymal, mesenchymal-epithelial, and endothelial-mesenchymal transitions in malignant tumors: An update

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World Journal of Clinical Cases 2015年第5期3卷 393-404页

作者： Simona Gurzu Sabin Turdean Attila Kovecsi Anca Otilia Contac ioan jung Department of Pathology University of Medicine and Pharmacy of Tirgu-Mures540139 Tirgu MuresRomania

Epithelial-to-mesenchymal transition(EMT) represents conversion of an epithelial cell in an elongated cell with mesenchymal phenotype, which can occur in physiologic and pathologic processes such as embryogenesis(type 1 EMT), wound healing and/or fibrosis(type 2 EMT) and malignant tumors(type 3 EMT). The proliferation rate, metastasizing and recurrence capacity, as also the individualized response at chemotherapics, in both epithelial and mesenchymal malignant tumors is known to be influenced by reversible switch between EMT and mesenchymal-to-epithelial transition(MET). Although much research work has already been done in these fields, the specific molecular pathways of EMT, relating to the tumor type and tumor localization, are yet to be elucidated. In this paper, based on the literature and personal experience of the authors, an update in the field of EMT vs MET in epithelial and mesenchymal tumors is presented. The authors tried to present the latest data about the particularities of these processes, and also of the so-called endothelialto-mesenchymal transition, based on tumor location. The EMT-angiogenesis link is discussed as a possible valuable parameter for clinical follow-up and targeted therapeutic oncologic management. The paper begins with presentation of the basic aspects of EMT, its classification and assessment possibilities, and concludes with prognostic and therapeutic perspectives. The particularities of EMT and MET in gastric and colorectal carcinomas, pancreatic cancer, hepatocellular and cholangiocarcinomas, and lung, breast and prostate cancers, respectively in sarcomas and gastrointestinal stromal tumors are presented in detail.

关键词： Gastrointestinal stromal tumor Carcinoma Gastrointestinal cancer Hepatic cancer Sarcoma

Paradoxical expression pattern of the epithelial mesenchymal transition-related biomarkers CD44, SLUG, N-cadherin and VSIG1/Glycoprotein A34 in gastrointestinal stromal tumors

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World Journal of Gastrointestinal Oncology 2017年第11期9卷 436-443页

作者： Attila Kovecsi Simona Gurzu Zoltan Szentirmay Zsolt Kovacs Tivadar Jr Bara ioan jung Department of Pathology University of Medicine and Pharmacy Research Center University of Medicine and Pharmacy Department of Pathology National Institute of Oncology Department of Biochemistry University of Medicine and Pharmacy Department of Surgery University of Medicine and Pharmacy

AIM To evaluate the immunohistochemical(IHC) expression of five biomarkers, commonly involved in epithelial mesenchymal/mesenchymal epithelial transition(EMT/MET), in gastrointestinal stromal tumors(GISTs). METHODS In 80 consecutive GISTs the IHC examinations were performed using the EMT-related antibodies E-cadherin,N-cadherin, SLUG, V-set and immunoglobulin domain containing 1(VSIG1) and CD44. RESULTS The positivity rate was 88.75% for SLUG, 83.75% for VSIG1, 36.25% for CD44 and 10% for N-cadherin. No correlation was noted between the examined markers and clinicopathological parameters. Nuclear positivity for SLUG and VSIG1 was observed in all cases with distant metastasis. The extra-gastrointestinal stromal tumors(e-GISTs) expressed nuclear positivity for VSIG1 and SLUG, with infrequent positivity for N-cadherin and CD44. The low overall survival was mainly dependent on VSIG1 negativity(P = 0.01) and nuclear positivity for SLUG and/or CD44. CONCLUSION GIST aggressivity may be induced by nuclear upregulation of SLUG and loss or cytoplasm-to-nuclear translocation of VSIG1. SLUG and VSIG1 may act as activated nuclear transcription factors. The CD44, but not N-cadherin, might also have an independent prognostic value in these tumors. The role of the EMT/MET-related transcription factors in the evolution of GISTs, should be revisited with a larger dataset. This is the first study exploring the IHC pattern of VSIG1 in GISTs.

关键词：蛞蝓 Glycoprotein A34 N-cadherin 包含胃肠的 stromal 肿瘤的 V 集合和免疫球蛋白领域

Cystic jejunal duplication with Heinrich's type Ⅰ ectopic pancreas, incidentally discovered in a patient with pancreatic tail neoplasm

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World Journal of Clinical Cases 2016年第9期4卷 281-284页

作者： Simona Gurzu Tivadar Bara Jr Tivadar Bara Annamaria Fetyko ioan jung Department of Pathology University of Medicine and Pharmacy Department of Surgery University of Medicine and Pharmacy

The aim of this study was to present a case of enteric duplication cyst and criteria for a proper differential diagnosis. A 51-year-old male was hospitalized for pancreatic tail neoplasm and distal pancreatectomy with splenectomy was performed. During surgery, a jejunal cystic lesion was incidentally detected and jejunectomy was performed. Microscopically, the cyst was observed to be covered by Keratin 7/Keratin 20 positive intestinal type epithelium and the muscularis layer was shared by the cyst and adjacent jejunum, without a cleavage plane between the cyst wall and jejunal muscularis propria. In the deep muscularis propria, a Heinrich's type Ⅰ ectopic pancreas was also noted. In the pancreatic tail, a low grade intraepithelial lesion(panIN-1a) was diagnosed. This case highlights the necessity for a correct differential diagnosis of such rare lesions. Roughly 30 cases of jejunal duplication cysts have been reported to date in the PubM ed database.

关键词： Intestine Duplication Embryogenesis Ectopic pancreas

Angiogenesis of hepatocellular carcinoma: An immunohistochemistry study

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World Journal of Hepatology 2019年第3期11卷 294-304页

作者： Decebal Fodor ioan jung Sabin Turdean Catalin Satala Simona Gurzu Department of Pathology University of MedicinePharmacy Sciences and Technology Research Center (CCAMF) University of Medicine Pharmacy Sciences and Technology

BACKGROUND Although hepatocellular carcinoma(HCC) is one of the most vascular solid tumors, antiangiogenic therapy has not induced the expected *** To uncover immunohistochemical(IHC) aspects of angiogenesis in *** A retrospective cohort study was performed and 50 cases of HCC were randomly selected. The angiogenesis particularities were evaluated based on the IHC markers Cyclooxygenase-2(COX-2), vascular endothelial growth factor(VEGF) A and the endothelial area(EA) was counted using the antibodies CD31 and *** The angiogenic phenotype evaluated with VEGF-A was more expressed in small tumors without vascular invasion(pT1), whereas COX-2 was rather expressed in dedifferentiated tumors developed in non-cirrhotic liver. The CD31-related EA value decreased in parallel with increasing COX-2 intensity but was higher in HCC cases developed in patients with cirrhosis. The CD105-related EA was higher in tumors developed in patients without associated *** In patients with HCC developed in cirrhosis, the newly formed vessels are rather immature and their genesis is mediated via VEGF. In patients with non-cirrhotic liver, COX-2 intensity and number of mature neoformed vessels increases in parallel with HCC dedifferentiation.

关键词： Hepatocellular carcinoma Angiogenesis Endothelial area Antiangiogenic therapy

Primary rhabdomyosarcoma: An extremely rare and aggressive variant of male breast cancer

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World Journal of Clinical Cases 2020年第19期8卷 4466-4474页

作者： Catalin Bogdan Satala ioan jung Tivadar Jr Bara Patricia Simu Iunius Simu Madalina Vlad Rita Szodorai Simona Gurzu Department of Pathology Clinical County Emergency HospitalTirgu Mures 540139Romania Department of Pathology George Emil Palade University of MedicinePharmacySciences and TechnologyTargu Mures 530149Romania Department of Surgery Clinical County Emergency HospitalTargu Mures 540136Romania Department of Radiology George Emil Palade University of MedicinePharmacySciences and TechnologyTargu Mures 530149Romania Department of Pathology Clinical County Emergency HospitalTargu Mures 540136Romania Department of Pathology George Emil Palade University of MedicinePharmacyScience and TechnologyTargu Mures 530149Romania Research Center(CCAMF) University of MedicinePharmacySciences and TechnologyTargu Mures 540139Romania

BACKGROUND Rhabdomyosarcoma(RMS)of the breast,a mesenchymal neoplasm with skeletal muscle differentiation,is an extremely rare tumour in males,with less than 30 cases published in English-language *** report on the first case of a male breast RMS,with an unusual ectomesenchymal/neuroectodermal *** SUMMARY A 55-year-old,previously healthy male,underwent a radical left mastectomy for an ulcerated tumour mass,occupying the breast and left anterior thoracic *** biopsy specimen indicated the presence of a tumour with neural origins,namely a peripheral neuroectodermal tumour(PNET).The surgical specimens identified two *** rhabdomyosarcomatous component(over 70%)was represented by large pleomorphic cells with positivity for desmin,sarcomeric actin and *** PNET-like ectomesenchymal component,which was admixed with the RMS cells,and was also revealed during the preoperative biopsy,consisted of small cells which expressed neurofilament,neuron specific enolase and *** microscopic examination,along with the immunohistochemical profile,allowed the diagnosis of an RMS,with unusual ectomesenchymal *** patient refused the postoperative oncologic therapy and died three months after *** In patients with RMS of the breast,the PNET-like ectomesenchymal component increases the diagnosis difficulty,especially in biopsy *** differentiation can be immunohistochemically proven and might highlight the possible development of high-grade sarcoma of the breast from remnants of the embryological ectodermal layer.

关键词： Mammary gland Rhabdomyosarcoma Ectomesenchymoma Male Case report CD99

Cystic low-grade collecting duct renal carcinoma with liver compression—A challenging diagnosis and therapy: A case report

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World Journal of Gastrointestinal Surgery 2020年第6期12卷 298-306页

作者： Zsolt Zoltan Fulop Simona Gurzu ioan jung Patricia Simu Laura Banias Emoke Fulop Emoke Dragus Tivadar Jr Bara Department of Surgery George Emil Palade University of MedicinePharmacyScience and TechnologyTargu Mures 540139Romania Department of Pathology George Emil Palade University of MedicinePharmacyScience and TechnologyTargu Mures 540139Romania Department of Pathology Clinical County Emergency HospitalTargu Mures 540067Romania Department of Radiology George Emil Palade University of MedicinePharmacyScience and TechnologyTargu Mures 540139Romania Department of Urology Clinical County HospitalTargu Mures 540167Romania

BACKGROUND A collecting duct carcinoma is a very rare, malignant renal epithelial *** metastases are present in one third of cases at the time of diagnosis. It is known to have a poor *** SUMMARY A 42-year-old male was sent to our surgery clinic for removal of a 119.2 mm ×108.3 mm encapsulated cystic mass, which was localized in the 8th segment of the right liver lobe. The lesion was first identified on ultrasonography. A computed tomography scan confirmed the presence of a Bosniak type Ⅲ cystic lesion,which affected the liver and convexity of the right kidney. Surgical intervention involved a right nephrectomy, with removal of the cystic mass. The patient was mobilized on the first postoperative day and was discharged after 7 d. The histological and immunohistochemical examination revealed a low-grade collecting duct renal carcinoma, which is a rare variant of papillary carcinoma,with low malignant potential. The patient did not receive chemotherapy and after 21 mo of follow-up, a radiological examination and laboratory analyses showed normal aspects. No relapse or other complications were *** To manage renal tumors properly, a correct histopathological diagnosis is crucial,as is early diagnosis and correct surgical treatment.

关键词： Collecting duct renal carcinoma Hydatid cyst Immunohistochemistry Case report Kidney Therapy

Maspin subcellular expression in wild-type and mutant TP53 gastric cancers

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World Journal of Gastrointestinal Oncology 2020年第7期12卷 741-755页

作者： Simona Gurzu ioan jung Haruhiko Sugimura Raluca ioana Stefan-van Staden Hidetaka Yamada Hiroko Natsume Yuji Iwashita Rita Szodorai Janos Szederjesi Department of Pathology George Emil Palade University of MedicinePharmacySciences and TechnologyTechnologyTargu Mureș540139MureșRomania Research Center George Emil Palade University of MedicinePharmacySciences and TechnologyTargu Mureș540139MureșRomania Department of Tumor Pathology Hamamatsu University School of MedicineHamamatsu 431-3192Japan National Institute of Research for Electrochemistry and Condensed Matter Bucharest 060021Romania Intensive Care Unit George Emil Palade University of MedicinePharmacySciences and TechnologyTargu Mureș540139MureșRomania

BACKGROUND Although the role of p53 in the evolution and prognosis of gastric cancer(GC)has been extensively examined,the exact mechanism of action is incompletely *** the last years,p53-target genes were supposed to be involved in the p53 *** of them is the tumor-suppressor gene Maspin,which codifies the protein with the same *** activity depends on its subcellular *** our knowledge,the possible role of TP53 gene in Maspin subcellular localization,in GC cells,has not yet been studied in a large number of human *** To evaluate the possible role of wild-type and mutated p53 in Maspin subcellular *** The present study included 266 consecutive patients with GC in which TP53 gene status,and mutations in exons 2 to 11,respectively,were analyzed and correlated with immunohistochemical expression of p53 and *** None of the 266 cases showed mutations in exon *** rate of TP53 mutations was 33.83%.The mutation rate was slightly higher in distally-located GCs,with a lower degree(≤5 buds/high power fields)of dyscohesivity(P<0.01).The wildtype cases had a longer survival,compared with mutant GCs,especially in patients without lymph node metastases,despite the high depth of tumor infiltration(P=0.01).The Dukes-MAC-like staging system was proved to have the most significant independent prognostic value(P<0.01).The statistical correlations proved that TP53 gene mutations in exon 7 might induce knockdown of Maspin,but wild-type p53 can partially restore nuclear Maspin expression and decrease the metastatic potential of gastric adenocarcinoma *** Downregulated Maspin might be induced by mutations in exon 7 of the TP53 gene but wild-type p53 can partially restore nuclear Maspin *** findings should be proved in experimental studies.

关键词： p53 TP53 gene Maspin Gastric cancer Carcinoma

Current status of familial gastrointestinal polyposis syndromes

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World Journal of Gastrointestinal Oncology 2015年第11期7卷 347-355页

作者： ioan jung Simona Gurzu Gligore Sabin Turdean Depart-ment of Pathology University of Medicine and Pharmacy of Tirgu-Mures

Because of the rarity of familial gastrointestinal cancerpredisposing syndromes,their exploration in literature is not *** this review,an update of the clinicopathological and molecular criteria of gastrointestinal familial polyposis syndromes with potential malignant transformation is *** addition,a guide for screening and surveillance was synthesized and a distribution of gene mutations according to the specific syndromes and geographic distribution was *** following inherited polyposes syndromes were analyzed: familial adenomatous polyposis,the hamartomatous familial polyposes(Juvenile polyposis,Peutz-Jeghers syndrome,Cowden syndrome,BannayanRiley-Ruvalcaba syndrome,hereditary mixed polyposis syndrome,Gorlin syndrome,Birt-Hogg-Dube syndrome,neurofibromatosis type Ⅰand multiple endocrine neoplasia syndrome 2B),Li-Fraumeni syndrome,and MUTYHassociated adenomatous *** proper medical care,subspecialization of gastroenterologists,pathologists,and genticists in the field of familial diseases should be introduced in the medical curriculum.

关键词： Inherited polyposis syndromes Hereditary cancer St