Angiogenesis of hepatocellular carcinoma: An immunohistochemistry study
Angiogenesis of hepatocellular carcinoma: An immunohistochemistry study作者机构：Department of Pathology University of MedicinePharmacy Sciences and Technology Research Center (CCAMF) University of Medicine Pharmacy Sciences and Technology
出 版 物：《World Journal of Hepatology》 (世界肝病学杂志（英文版）（电子版）)
年 卷 期：2019年第11卷第3期
页 面：294-304页
学科分类：10[医学]
主 题：Hepatocellular carcinoma Angiogenesis Endothelial area Antiangiogenic therapy
摘 要：BACKGROUND Although hepatocellular carcinoma(HCC) is one of the most vascular solid tumors, antiangiogenic therapy has not induced the expected *** To uncover immunohistochemical(IHC) aspects of angiogenesis in *** A retrospective cohort study was performed and 50 cases of HCC were randomly selected. The angiogenesis particularities were evaluated based on the IHC markers Cyclooxygenase-2(COX-2), vascular endothelial growth factor(VEGF) A and the endothelial area(EA) was counted using the antibodies CD31 and *** The angiogenic phenotype evaluated with VEGF-A was more expressed in small tumors without vascular invasion(pT1), whereas COX-2 was rather expressed in dedifferentiated tumors developed in non-cirrhotic liver. The CD31-related EA value decreased in parallel with increasing COX-2 intensity but was higher in HCC cases developed in patients with cirrhosis. The CD105-related EA was higher in tumors developed in patients without associated *** In patients with HCC developed in cirrhosis, the newly formed vessels are rather immature and their genesis is mediated via VEGF. In patients with non-cirrhotic liver, COX-2 intensity and number of mature neoformed vessels increases in parallel with HCC dedifferentiation.
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