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Synthesis and Characteristics of an Aspartame Analogue,L-Asparaginyl L-3-Phenyllactic Acid Methyl Ester

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Acta Biochimica et Biophysica Sinica 2004年第6期36卷 385-389页

作者： Hu TAO1, Da-Fu CUI1, and You-Shang ZHANG1,2. 1institute of Biochemistry and Cell Biology, shanghai institutes for Biological Sciences, Chinese Academy of Sciences, Graduate School of the Chinese Academy of Sciences, shanghai 2.0031, China institute of protein research, tongji university, shanghai 2.0031, China institute of Biochemistry and Cell Biology Shanghai Institutes for Biological Sciences Chinese Academy of Sciences Graduate School of the Chinese Academy of SciencesShanghai 200031 China institute of protein research Tongji UniversityShanghai 200031 China

An aspartame analogue, L-asparaginyl L-3-phenyllactic acid methyl ester was synthesized with aspartic acid replaced by asparagine and peptide bond replaced by ester bond. The aspartic acid of aspartame could be replaced by asparagine as reported in the literature. In this analogue, the hydrogen of amide group could still form a hydrogen bond with the oxygen of ester bond and the ester bond was isosteric with peptide bond. However, the product was not sweet, showing that the peptide bond could not be replaced by ester bond. The peptide C-N bond behaves as a double bond that is not free to rotate and the C, O, N and H atoms are in the same plane. The replacement of peptide bond by ester bond destroyed the unique conformation of peptide bond, resulting in the loss of sweet taste.

关键词： artificial sweetener aspartame derivative peptide bond

Possible Role of Histone H1 in the Regulation of Furin-dependent Proprotein Processing

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Acta Biochimica et Biophysica Sinica 2007年第3期39卷 173-180页

作者： Jinbo HAN~1 Jianxin GU~2.Chengwu CHI~(1,3*) 1 institute of Biochemistry and Cell Biology,Chinese Academy of Sciences,Graduate School of the Chinese Academy of Sciences,shanghai{2.,China 2.Gene research Center,Medical Center of Fudan university,shanghai 2.0032.China 3 institute of protein research,tongji university,shanghai 2.0092.China institute of Biochemistry and Cell Biology Chinese Academy of Sciences Graduate School of the Chinese Academy of Sciences Shanghai China.

Histone H1 and its C-terminal lysine rich fragments were recently found to be potent inhibitorsof furin,a mammalian proprotein ***,its role in the regulation of furin-dependent proproteinprocessing remains *** we report that histone H1 efficiently blocks furin-dependent pro-yonWillebrand factor（pro-vWF）processing in a dose-dependent *** and immunof-luorescence studies confirmed that histone H1 could interact with furin,and the interaction mainly took placeon the cell *** noted that histone H1 was released from cells undergoing necrosis and apoptosisinduced by *** findings suggested that histone H1 might be involved in extracellular and/or intracellu-lar furin regulation.

关键词： furin histone H1 pro-vWF proprotein processing

中国政治经济学年度发展报告（2.2.）（下）

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政治经济学评论 2024年第3期 90+207-208页

作者： Center for Studies of Contemporary Political Economy,research institute for 2.st-Century Marxism,Nankai{2.·university of Chinese Academy of Social Science Center for Teaching and research on Capital,Renmin{2. of China National institute of Socialist Political Economy with Chinese Characteristics,Renmin{2. of China 南开大学·中国社会科学院大学2.世纪马克思主义研究院当代政治经济学研究中心中国人民大学《资本论》教学与研究中心中国人民大学全国中国特色社会主义政治经济学研究中心

编者按2.2.年，高质量发展扎实推进，新质生产力加快形成，我国经济总体回升向好，圆满实现发展主要预期目标。为针对性地破解经济恢复发展中的难题，聚焦推进中国式现代化进程中的重点、难点问题，中国政治经济学界开展系统深入研究，...

编者按2.2.年，高质量发展扎实推进，新质生产力加快形成，我国经济总体回升向好，圆满实现发展主要预期目标。为针对性地破解经济恢复发展中的难题，聚焦推进中国式现代化进程中的重点、难点问题，中国政治经济学界开展系统深入研究，取得系列代表性成果。为准确刻画学界研究进展和轨迹，推动中国经济学理论体系的构建和完善，本刊精选议题如期奉上《中国政治经济学年度发展报告（2.2.）》。自2.10年起，本刊连续十四年发布《中国政治经济学年度发展报告》，“年度发展报告”专栏已成为本刊标志性特色栏目。2.2.年报告聚焦12.专题，分为（上）（下）两篇，其中专题1—6于报告（上）篇刊登，专题7—12.报告（下）篇刊登。2.2.年报告（下）选题如下：

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Conus Peptides-A Rich Pharmaceutical Treasure

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Acta Biochimica et Biophysica Sinica 2004年第11期36卷 713-723页

作者： Cheng-Zhong WANG and Cheng-Wu CHIinstitute of Biochemistry and Cell Biology, shanghai institute of Biological Sciences, the Chinese Academy of Sciences, shanghai 2.0031, China institute of Neuroscience, the Chinese Academy of Sciences, shanghai 2.0031, China institute of protein research, tongji university, shanghai 2.0092. China institute of Biochemistry and Cell Biology Shanghai Institute of Biological Sciences the Chinese Academy of SciencesShanghai 200031 China institute of Neuroscience the Chinese Academy of SciencesShanghai 200031 China institute of protein research Tongji UniversityShanghai 200092 China

Marine predatory cone snails (genus Conus) with over 500 species represent what is arguably the largest single genus of marine animals alive today. All Conus are venomous and utilize a complex mixture of Conus peptide... 详细信息

关键词： Conus peptide conotoxin neuropathic disorder pharmaceutical potency

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同福里地块过渡临时校园,上海,中国

世界建筑 2024年第4期 66-67页

作者： Arcplus institute of shanghai Architectural Design &{2. FREE STUDIO 华建集团上海建筑设计研究院有限公司沈钱建筑创作工作室

项目坐落于上海市人民广场北侧,场地周边早期石库门住宅群与当代超高层建筑群交织,处于复杂城市化的高密度城区中,新建筑在此地的涌现将折射出城市当代与传统的共生性。作为一座临时学校,校园包含12.班的幼儿园和15个班的小学,满足两... 详细信息

项目坐落于上海市人民广场北侧,场地周边早期石库门住宅群与当代超高层建筑群交织,处于复杂城市化的高密度城区中,新建筑在此地的涌现将折射出城市当代与传统的共生性。作为一座临时学校,校园包含12.班的幼儿园和15个班的小学,满足两个学段的独立性和教学需求,也为未来其他城市公共功能预留好应变性。在用地紧张的现状下,为了让建筑更紧凑高效且满足更多的日照,设计采用了“围合布局”和“双外廊”两个操作,打造出自由有趣、内外联动的校园空间。

关键词：高密度城区人民广场校园空间用地紧张石库门住宅超高层建筑群应变性围合

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cDNA Cloning of Two Novel T-superfamily Conotoxins from Conus leopardus

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Acta Biochimica et Biophysica Sinica 2006年第4期38卷 287-291页

作者： Wei-Hua CHEN~(1,2.) Yu-Hong HAN~(2.3#) Qi WANG~(2.3#) Xiao-Wei MIAO~(2.4) Ling OU~1 Xiao-Xia SHAO~2. 1 Bioengineering institute,East China university of Science and Technology,{2. 2.02.7,China 2.institute of protein research,tongji university,{2. 2.0092.China 3 institute of Biochemistry and Cell Biology,{2. institute of Biochemical Sciences,Chinese Academy of Sciences,{2. 2.0031,China 4 Department of Biological Engineering,School of Life Science,{2. university,{2. 2.0436,China Bioengineering institute East China University of Science and TechnologyShanghai 200237 China institute of protein research Tongji UniversityShanghai 200092 China institute of Biochemistry and Cell Biology Shanghai Institute of Biochemical Sciences Chinese Academy of SciencesShanghai 200031 China Department of Biological Engineering School of Life Science Shanghai UniversityShanghai 200436 China

The full-length cDNAs of two novel T-superfamily conotoxins,Lp5.1 and Lp5.2.were clonedfrom a vermivorous cone snail Conus leopardus using 3'/5'-rapid amplification of cDNA *** cDNA ofLp5.1 encodes a precursor of 65 residues,including a 2.-residue signal peptide,a 2.-residue propeptide anda 15-residue mature ***5.1 is processed at the common signal site -X-Arg- immediately before themature peptide *** the case of Lp5.2.the precursor includes a 2.-residue signal peptide anda 43-residue sequence comprising the propeptide and mature peptide,which is probably cleaved to yield a2.-residue propeptide and a 14-residue mature *** these two conotoxins share a similar signalsequence and a conserved disulfide pattern with the known T-superfamily,the pro-region and mature peptidesare of low identity,especially Lp5.2.with an identity as low as 10.7% compared with the reference *** elucidated cDNAs of these two toxins will facilitate a better understanding of the species distribution,the sequence diversity of T-superfamily conotoxins,the special gene structure and the evolution of thesepeptides.

关键词： Conus leopardus T-superfamily conotoxin cDNA cloning

research on nonlinear constitutive relationship of permanent deformation in asphalt pavements

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Science China(Physics,Mechanics & Astronomy) 2006年第6期49卷 671-682页

作者： PENG Miaojuan1 & XU Zhihong2.1. Department of Civil Engineering,shanghai university,shanghai 2.0072.China 2. School of Transportation Engineering,tongji university,shanghai 2.0092.China Department of Civil Engineering Shanghai University Shanghai China School of Transportation Engineering Tongji University Shanghai China

To predict correctly the rut depths in asphalt pavements,a new nonlinear viscoelastic-elastoplastic constitutive model of permanent deformation in asphalt pave-ments is presented. The model combines a generalized Maxwell model with an elasto-plastic one. Then from the creep theory,the linear and nonlinear constitutive equations of the generalized Maxwell model are obtained. From the nonlinear finite element method for the rutting of the asphalt pavement,the rut depths of 4 asphalt-aggregate mixtures are obtained. And the results are compared with the ones from the finite element method by SHRP and the experiments by SWK/UN. The results in this paper are better than the ones by SHRP,and agree with the ones of the experiment by SWK/UN. This shows that the nonlinear viscoelastic-elastoplastic constitutive model,which is presented in this paper for the rutting of the asphalt pavement,is effective. The properties,such as nonlinear elastic-ity,plasticity,viscoelasticity and nonlinear viscoelasticity,which affect the rutting of an asphalt pavement,can be shown in the model. And the characteristics of the permanent deformation of the asphalt pavement can be presented entirely in the model.

关键词： asphalt pavement,permanent deformation,nonlinear viscoelastic-elastoplastic constitutive relationship,generalized Maxwell model,creep compliance.

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山东淄博鼎成森林城第四代住宅项目

建筑实践 2024年第3期 152-159页

作者： Topsum shanghai Architectural Design & Urban Planning Co., Ltd. Galaxy shanghai{2. of Architectural Design & research 上海砼森建筑规划设计有限公司上海云汉建筑设计事务所有限公司

本项目是山东省首个按照“城市森林花园住宅模式”建设并获得成功的高品质人居社区。项目位于淄博市新区,房宁路以东、汇英路以北,由8栋高层住宅及配套设施组成,于2.19年开工建设,目前已全部竣工交付。本项目建成后,较好地实现了前期的...

本项目是山东省首个按照“城市森林花园住宅模式”建设并获得成功的高品质人居社区。项目位于淄博市新区,房宁路以东、汇英路以北,由8栋高层住宅及配套设施组成,于2.19年开工建设,目前已全部竣工交付。本项目建成后,较好地实现了前期的设计构想,取得了积极的社会评价,对推广和提升高品质住宅设计发挥了积极的示范作用。伴随着不断加速的城市化进程,中国的城市住宅越来越呈现出高层、高强、高密的特征,虽然提高了人均居住面积,也改善了居住条件,但人居环境越来越远离自然的趋势,违背了人类渴望接近土地、亲近自然的天性。

关键词：

Boundary element-free method for elastodynamics

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Science China(Physics,Mechanics & Astronomy) 2005年第6期48卷 641-657页

作者： CHENG Yumin1 & PENG Miaojuan2.1. shanghai institute of Applied Mathematics and Mechanics, shanghai university, shanghai 2.0072. China 2. Department of Civil Engineering, shanghai university, shanghai 2.0072. China shanghai institute of Applied Mathematics and Mechanics Shanghai University Shanghai China Department of Civil Engineering Shanghai University Shanghai China

The moving least-square approximation is discussed first. Sometimes the method can form an ill-conditioned equation system, and thus the solution cannot be obtained correctly. A Hilbert space is presented on which an orthogonal function system mixed a weight function is defined. Next the improved moving least-square approximation is discussed in detail. The improved method has higher computational efficiency and precision than the old method, and cannot form an ill-conditioned equation system. A boundary element-free method (BEFM) for elastodynamics problems is presented by combining the boundary integral equation method for elastodynamics and the improved moving least-square approximation. The boundary element-free method is a meshless method of boundary integral equation and is a direct numerical method compared with others, in which the basic unknowns are the real solutions of the nodal variables and the boundary conditions can be applied easily. The boundary element-free method has a higher computational efficiency and precision. In addition, the numerical procedure of the boundary element-free method for elastodynamics problems is presented in this paper. Finally, some numerical examples are given.

关键词： moving least-square approximation, improved moving least-square approximation, elastodynamics, boundary integral equation, meshless method, boundary element-free method, Fourier eigen transform.

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