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Conus Peptides-A Rich Pharmaceutical Treasure

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Acta Biochimica et Biophysica Sinica 2004年第11期36卷 713-723页

作者： Cheng-Zhong WANG and Cheng-Wu CHIinstitute of Biochemistry and Cell Biology, shanghai institute of Biological sciences, the chinese academy of sciences, shanghai 20003., china institute of neuroscience, the chinese academy of sciences, shanghai 20003., china institute of Protein Research, Tongji University, shanghai 200092, china institute of Biochemistry and Cell Biology Shanghai Institute of Biological Sciences the Chinese Academy of SciencesShanghai 200031 China institute of neuroscience the Chinese Academy of SciencesShanghai 200031 China institute of Protein Research Tongji UniversityShanghai 200092 China

Marine predatory cone snails (genus Conus) with over 500 species represent what is arguably the largest single genus of marine animals alive today. All Conus are venomous and utilize a complex mixture of Conus peptide... 详细信息

关键词： Conus peptide conotoxin neuropathic disorder pharmaceutical potency

Progress in glial cell studies in some laboratories in china

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Science china(Life sciences) 2010年第3期53卷 330-337页

作者： DUAN ShuMin institute of neuroscience,State Key Laboratory of neuroscience,shanghai institutes for Biological sciences,chinese academy of sciences,shanghai china,20003. institute of neuroscience State Key Laboratory of Neuroscience Shanghai Institutes for Biological Sciences Chinese Academy of Sciences Shanghai China

Glial cells in the central nervous system(CNS) consist of a heterogeneous population of cell types,each characterized by distinct morphological features,physiological properties,and specific *** contrast to the previous view that glial cells were passive elements in the brain,accumulating evidence suggests that glial cells are active participants in various brain functions and brain *** review summarizes recent progress of glial cell studies from several groups in china,ranging from studies about the mechanisms of neuron-glia crosstalking to investigations on the roles of glial cells in various CNS disorders.

关键词： neuron-glia interaction ATP plasticity pain ischemia neural injury and repair

Synapse formation and remodeling

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Science china(Life sciences) 2010年第3期53卷 315-321页

作者： LUO ZhenGe institute of neuroscience and State Key Laboratory of neuroscience,shanghai institutes for Biological sciences,chinese academy of sciences,shanghai 20003.,china institute of neuroscience and State Key Laboratory of neuroscience Shanghai Institutes for Biological Sciences Chinese Academy of Sciences Shanghai China

Synapses are specialized structures that mediate information flow between neurons and target cells,and thus are the basis for neuronal system to execute various functions,including learning and *** are around 1011 neurons in the human brain,with each neuron receiving thousands of synaptic inputs,either excitatory or inhibitory.A synapse is an asymmetric structure that is composed of pre-synaptic axon terminals,synaptic cleft,and postsynaptic *** formation involves a number of cell adhesion molecules,extracellular factors,and intracellular signaling or structural *** the establishment of synaptic connections,synapses undergo structural or functional changes,known as synaptic plasticity which is believed to be regulated by neuronal activity and a variety of secreted *** review summarizes recent progress in the field of synapse development,with particular emphasis on the work carried out in china during the past 10 years(1999-2009).

关键词： synapse development neuronal activity synaptic plasticity

Pain research in china

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Science china(Life sciences) 2010年第3期53卷 356-362页

作者： ZHANG Xu institute of neuroscience,State Key Laboratory of neuroscience,shanghai institutes for Biological sciences,chinese academy of sciences,shanghai 20003.,china institute of neuroscience State Key Laboratory of Neuroscience Shanghai Institutes for Biological Sciences Chinese Academy of Sciences Shanghai China

In addition to investigating the anatomy,neurochemistry and neurophysiology of pain pathways,chinese researchers have extended their work into the molecular and cellular mechanisms of sensory afferent transmission at the spinal cord level as well as cognitive processing in the *** mechanism underlying acupuncture analgesia remains a subject of special interest for chinese pain researchers,with the aim of combining clinical practice with the understanding of pain transmission and analgesic mechanism.

关键词： dorsal root ganglion spinal cord nociception receptors ion channels gene expression

Embryonic and adult neural stem cell research in china

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Science china(Life sciences) 2010年第3期53卷 338-341页

作者： JIAO JianWei institute of neuroscience,State Key Laboratory of neuroscience,chinese academy of sciences,shanghai 20003.,china institute of neuroscience State Key Laboratory of Neuroscience Chinese Academy of Sciences Shanghai China

Neural stem cells(NSCs) are one specific type of multipotential stem cells that have the ability to proliferate for a long time and to differentiate into neural cells,including neurons,astrocytes and *** NSCs exist in both the embryonic and adult central nervous system(CNS) of all mammalian *** has been made in the understanding of the developmental regulation of NSCs and their function in *** review discusses recent progress in this area,with emphasis on work done by investigators in china.

关键词： neural stem cells neurogenesis stem cell niche reprogramming hippocampus

Ion channels in neuronal survival

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Science china(Life sciences) 2010年第3期53卷 342-347页

作者： WANG YiZheng & XU TianLe institute of neuroscience and State Key Laboratory of neuroscience,shanghai institutes for Biological sciences,chinese academy of sciences,shanghai 20003.,china institute of neuroscience and State Key Laboratory of neuroscience Shanghai Institutes for Biological Sciences Chinese Academy of Sciences Shanghai China

The study of ion channels represents one of the most active fields in neuroscience research in *** the last 10 years,active research in various chinese neuroscience institutions has sought to understand the mechanisms responsible for sensory processing,neural development and neurogenesis,neural plasticity,as well as *** addition,extensive studies have been directed to measure ion channel activity,structure-function relationships,as well as many other biophysical and biochemical *** review focuses on the progress achieved in the investigation of ion channels in neuronal survival during the past 10 years in china.

关键词： ion channels neuronal survival and ischemia.

Recent progress in neurodegenerative disorder research in china

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Science china(Life sciences) 2010年第3期53卷 348-355页

作者： ZHOU JiaWei institute of neuroscience,shanghai institutes for Biological sciences,chinese academy of sciences,shanghai,20003. institute of neuroscience Shanghai Institutes for Biological Sciences Chinese Academy of Sciences Shanghai China

Neurodegenerative disorders,including Alzheimer's disease(AD) and Parkinson's disease(PD),are common disorders of the central nervous system among aging *** the last 10 years insights concerning the etiology,diagnosis and pathogenesis of these diseases have come from research carried out by chinese *** findings include the description of chinese patients with autosomal recessive early-onset PD,the function of the tau protein,molecular mechanisms underlying protein aggregation,and the identification of biomarkers for AD diagnosis and molecules/compounds with potential neuroprotective activities.

关键词： neurodegenerative disorders pathogenesis diagnosis neuroprotection Alzheimer’s disease Parkinson’s disease

Valence Distribution in AT_xV_(6-X)O_(11) Compounds

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Journal of Materials Science & Technology 1999年第6期15卷 551-554页

作者： Hongchao LIU and Changlin KUO(shanghai institute of Ceramics, chinese academy of sciences, shanghai 200050, china) shanghai institute of Ceramics Chinese Academy of Sciences Shanghai 200050 China

The distribution of trivalent and tetravalent cations in several ATxV6-xO11 compounds was quantitatively studied by the bond valence method. In SrV6O11, the M(3) sites were mainly occupied by trivaient cations; while M(1) and M(2) sites were shared by trivalent and tetravalent cations, the relative content of tetravalent at M(1) sites was higher than at M(2) sites. During substitution process, the trivalent cations preferred to occupy M(3) sites, tetravalent ones preferred to occupy M(2) sites. The occupancy of trivalent and tetravalent cations at M sites would change with the substitution

关键词： AT X)O Valence Distribution in AT_xV Compounds

X-ray Powder Diffraction Pattern of Bi_4(SiO_4)_3

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Journal of Materials Science & Technology 1997年第2期13卷 145-148页

作者： Hongchao LIU Changlin KUO (shanghai institute of Ceramics, chinese academy of sciences, shanghai 200050, china) shanghai institute of Ceramics Chinese Academy of Sciences Shanghai 200050 China

In cooperation with figure-of-merits the Rietveld analysis can appraise both angular and intensity data of powder diffraction. In this work, X-ray diffraction pattern of Bi4(SiO4)3 was redetermined with intensity figure-of-merits, which qualify agreement between observed and calculated relative intensities. F30 is 158.90 (0.0059, 32), intensity figure of merit Rint is 8.7, I20(17), 8.0. The values of figure-of-merits show that the data of JCPDS cards are distorted. Both the experimental and calculated peak positions and heights are listed in detail.

关键词： SiO4 X-ray Powder Diffraction Pattern of Bi4 Bi