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Expert consensus on radiotherapy combined with immunotherapy for esophageal cancer(2024 edition)

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Radiation Medicine and Protection 2024年第2期5卷 59-67页

作者： Professional Committee of Radiation Oncology china Anti-cancer Association Branch of Radiation Oncology Chinese medical Association Branch of Radiation Oncology TreatmentPhysician Chinese medical Doctor Association Qingsong Pang Jun Wang Zhouguang Hui Wencheng Zhang 不详 Tianjin medical university cancer institute&Hospital Tianjin 300060China the Fourth Hospital of Hebei medical university Shijiazhuang 050011China National cancer Center National Clinical Research Center for CancerCancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Tianjin medical university cancer Hospital China

Radiotherapy represents an essential treatment approach for esophageal *** recent years,immunotherapy combined with chemotherapy has become the first-line standard treatment for patients with advanced esophageal *** phase III studies on immunotherapy combined with radiotherapy for locally advanced esophageal cancer are currently *** evidence-based medical data are urgently needed to support the integration of immunotherapy and chemoradiotherapy as a new treatment strategy for patients with locally advanced esophageal *** consensus,formulated based on the latest study results,in-depth research,and thorough discussions,provides a comprehensive set of *** document extensively covers treatment strategies and evaluation methods for radiotherapy combined with immunotherapy across patients with operable esophageal cancer,inoperable locally advanced esophageal cancer,and advanced esophageal ***,common complications and radiation-related issues associated with radiotherapy combined with immunotherapy are discussed,serving as clinical *** expert group comprised members from the Professional Committee of Radiation Oncology,china Anti-cancer Association,the Branch of Radiation Oncology,Chinese medical Association,and the Branch of Radiation Oncology Treatment Physician,Chinese medical Doctor Association.

关键词： Esophageal squamous cell carcinoma Esophageal adenocarcinoma Immunotherapy Chemoradiotherapy Radiotherapy Expert consensus

Chinese national clinical practice guidelines on the prevention,diagnosis,and treatment of early gastric cancer

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Chinese medical Journal 2024年第8期137卷 887-908页

作者： Peng Li Ziyu Li Enqiang Linghu Jiafu Ji Society of Digestive Endoscopy of the Chinese medical Association Colorectal Surgery Group of the Chinese medical Association Chinese Association of Gastroenterologists&Hepatologists National Clinical research Center for Digestive Diseases Chinese medical Journal Clinical Practice Guideline Collaborative Department of Gastroenterology Beijing Friendship HospitalCapital Medical UniversityNational Clinical Research Center for Digestive DiseaseBeijing 100050China Department of Gastrointestinal Surgery Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education)Peking University Cancer Hospital and InstituteBeijing 100142China Department of Gastroenterology and Hepatology the First Medical CenterChinese People’s Liberation Army General HospitalBeijing 100853China 不详

Background:Gastric cancer is one of the most common malignant tumors in the digestive system in *** comprehensive practice guidelines for early gastric cancer in china are currently ***,we created the Chinese national clinical practice guideline for the prevention,diagnosis,and treatment of early gastric ***:This clinical practice guideline(CPG)was developed in accordance with the World Health Organization’s recommended process and with the Grading of Recommendations Assessment,Development,and Evaluation(GRADE)in assessing evidence *** used the Evidence to Decision framework to formulate clinical recommendations to minimize bias and increase transparency in the CPG development *** used the Reporting Items for practice Guidelines in HealThcare(RIGHT)statement and the Appraisal of Guidelines for research and Evaluation II(AGREE II)as reporting and conduct guidelines to ensure completeness and transparency of the ***:This CPG contains 40 recommendations regarding the prevention,screening,diagnosis,treatment,and follow-up of early gastric cancer based on available clinical studies and *** provide recommendations for the timing of Helicobacter pylori eradication,screening populations for early gastric cancer,indications for endoscopic resection and surgical gastrectomy,follow-up interval after treatment,and other ***:This CPG can lead to optimum care for patients and populations by providing up-to-date medical *** intend this CPG for widespread adoption to increase the standard of prevention,screening,diagnosis,treatment,and follow-up of early gastric cancer;thereby,contributing to improving national health care and patient quality of life.

关键词： Early gastric cancer Prevention Screening Diagnosis Treatment Follow-up

Progress of gastric cancer etiology:N-nitrosamides in the 1990s

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World Journal of Gastroenterology 2000年第4期6卷 613-618页

作者： Da Jun Deng Laboratory of cancer Etiology,Beijing medical university School of Oncology& Beijing institute for cancer research,100034,china 北京医科大学北京

Stomach carcinoma is still the leading cause of cancer death in china and the second one in the world. Its possible causes include: A) chemical factors such as intragastric formation of N-nitroso compounds (NOC) and high salt intake; B ) biological factors such as infection of Helicobacter pylori and biotoxins intake; and C ) nutritional factors such as deficiency of vitamin C, selenium, and other antioxidants. Nitrogenous precursors of NOC, e.g., alkylamines, alkylureas, alkylguanidines, and alkylamides, occur widely in nature and potential nitrosating agents, e.g., nitrite (NO2-) and NOx (the gaseous oxides of nitrogen ) are similarly widespread. Relationship between exposure to NOC and causes of human cancer was investigated extensively ten years ago. Results indicated that the exposures of NOC might contribute to the occurrences of malignancy in the upper digestive tracts including stomachs. It was also observed that both high salt intake and deficiency of some micronutrients enhanced NOC-induced carcinogenicity. Recent studies show that infection of H. pylori can lead to atrophic gastritis and achlorhydria, and promote endogenous formation of NOC indirectly[1] . Much attention has been paid to stomach cancer and NOC regarding the characterization of natural N-nitrosamides in human environment in the 1990s.

关键词： stomach neoplasms/etiology nitroso compounds nitrosamides/nitrosourea epidemiology chromatography liquid microorganisms

Novel Product and Its Derivatives from the Reaction of Lappaconitine with HIO_4

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Chinese Chemical Letters 2000年第8期11卷 689-692页

作者： Qiao Hong CHEN, Feng Peng WANG, Kai Bai YU (Department of Chemistry of Medicinal Natural Products. School of Pharmacy, west china university of medical sciences, chengdu 610041) (chengdu institute of Organic Chemistry. Chinese Academy of sciences, chengdu Dept. of Chem. of Med. Nat. Products School of Pharmacy W. China Univ. of Medical Sciences Chengdu 610041 China chengdu Inst. of Organic Chemistry Chinese Academy of Sciences Chengdu 610041 China

Treatment of lappaconitine 1 with HIO4 at room temperature afforded 2 in 41% yield, to which Br2-HOAc solution was added and allowed to stand at room temperature for 2 days to give 3 (13%) and 4(31%).

关键词： Norditerpenoid alkaloid lappaconitine oxidation.

Modifications of Norditerpenoid Alkaloids:Ⅲ. Preparation of 7 ,17-seco Yunnaconitine Derivatives via Rearrangement of Chloroamine

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Chinese Chemical Letters 1999年第5期10卷 379-382页

作者： Fend Pane WANG Ju Zheng FAN Xi Xian JIAN Bo Gang LI(Department of Chemistry of Medicinal Natural Products. School of Pharmacy. west china university of medical sciences. chengdu 610041 chengdu institute of Biology. CHinese Academy of sciences. chengdu Dept. of Chem. of Med. Nat. Products School of Pharmacy W. China Univ. of Medical Sciences Chengdu 610041 China chengdu institute of Biology Chinese Academy of Sciences Chengdu 610041 China

Preparation of both 7. 17-seco yunnaconitine derivatives 6 starting from yunnaconitine 3via rearrangement of choroamine 5 is described.

关键词： Norditerpenoid Alkaloids 7. 17-seco ynnaconitine

Possible Role of Histone H1 in the Regulation of Furin-dependent Proprotein Processing

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Acta Biochimica et Biophysica Sinica 2007年第3期39卷 173-180页

作者： Jinbo HAN~1 Jianxin GU~2 Chengwu CHI~(1,3*) 1 institute of Biochemistry and Cell Biology,Chinese Academy of sciences,Graduate School of the Chinese Academy of sciences,Shanghai 200031,china 2 Gene research Center,medical Center of Fudan university,Shanghai 200032,china 3 institute of Protein research,Tongji university,Shanghai 200092,china institute of Biochemistry and Cell Biology Chinese Academy of Sciences Graduate School of the Chinese Academy of Sciences Shanghai China.

Histone H1 and its C-terminal lysine rich fragments were recently found to be potent inhibitorsof furin,a mammalian proprotein ***,its role in the regulation of furin-dependent proproteinprocessing remains *** we report that histone H1 efficiently blocks furin-dependent pro-yonWillebrand factor（pro-vWF）processing in a dose-dependent *** and immunof-luorescence studies confirmed that histone H1 could interact with furin,and the interaction mainly took placeon the cell *** noted that histone H1 was released from cells undergoing necrosis and apoptosisinduced by *** findings suggested that histone H1 might be involved in extracellular and/or intracellu-lar furin regulation.

关键词： furin histone H1 pro-vWF proprotein processing

Spinal processing of bee venom-induced pain and hyperalgesia

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生理学报 2008年第5期60卷 645-652页

作者： Jun CHEN institute for Biomedical sciences of Pain and institute for Functional Brain Disorders,Tangdu Hospital,the Fourth Military medical university,Xi’an 710038,china institute for Biomedical sciences of Pain,Capital medical university,Beijing 100069,china institute for Biomedical sciences of Pain and institute for Functional Brain Disorders Tangdu Hospital the Fourth Military Medical University Xi'an 710038

Subcutaneous injection of bee venom causes long-term neural activation and hypersensitization in the dorsal horn of the spinal cord,which contributes to the development and maintenance of various pain-related *** unique behavioral 'phenotypes' of nociception and hypersensitivity identified in the rodent bee venom test are believed to reflect a complex pathological state of inflammatory pain and might be appropriate to the study of phenotype-based mechanisms of pain and *** this review,the spinal processing of the bee venom-induced different 'phenotypes' of pain and hyperalgesia will be *** accumulative electrophysiological,pharmacological,and behavioral data strongly suggest that different 'phenotypes' of pain and hyperalgesia are mediated by different spinal signaling *** the phenotype-based mechanisms of pain might be useful in development of novel therapeutic drugs against complex clinic pathological pain.

关键词：脊髓痛觉过敏蜂毒疼痛治疗方法

Carotenoid Analysis of Several Dark-Green Leafy Vegetables Associated With a Lower Risk of cancers

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Biomedical and Environmental sciences 1996年第4期9卷 386-392页

作者： YANG YI HUANG CHENG-YU PENG SHU-SHENG AND LI JIAN (Department of Clinical Oncology, medical institute of Biorngulation,Kyushu university 69, Beppu 874, Japan School of Public Health, west china university of medical sciences (WCUMS),chengdu, china) Department of Clinical Oncology Kyushu University Beppu Japan.

We have examined the carotenoid contents of several dark green vegetables found to be associated with a lower risk of various epithelial cancers in our epidemiological study and animal study. Samples of these vegetables were quantitatively examined by highperformance liquid chromatography (HPLC) on a C-18 reversed-phase column for individual carotenoid content. Pure reference compounds (alpha-carotene, beta-carotent, lycopene, canthaxanthin, and lutein) and internal standard (beta-Apo-8'-carotenal) were employed to quantify xanthophylls and carotenes in these vegetables. The results indicated that fresh, dark-green, leafy vegetables were high in beta-carotene (0.94-9.36 mg/100 g) and oxygenated carotenoids or xanthophylls, primarily lutein (0.94-7.39 mg/100 g),whereas lycopene and alpha-carotene were not prominent and canthaxanthin was non existent in these vegetables. These analyses suggest that consumption of carotenoids such as lutein in addition to beta-carotene may be associated with a lower risk of cancers

关键词： Res Am Carotenoid Analysis of Several Dark-Green Leafy Vegetables Associated With a Lower Risk of cancers

Apoptosis in oncology

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Cell research 2001年第1期11卷 1-7页

作者： FAN XIAO QIANG, YA JUN GUO (International Joint cancer institute, The Second Military medical university, Shanghai 200423, china) 1International Joint cancer institute The Second Military Medical University Shanghai 200433 China 1International Joint cancer institute The Second Military Medical University Shanghai 200433 China

Apoptosis is a complex process involving a large array of genes and mutation of any of these genes may lead to malignancy formation. Re-acquirement of FasL by tumor cells may enable them to evade the surveillance of immune system and thus contributes to the growth of tumor. Apart from traditional therapies, inducing apoptosis of tumor cell by new methods employing death receptor ligands and making use of Fas counterattack is also being developed.

关键词： Apoptosis mitochondria death receptor death receptor ligand tumor therapy.