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Current status of the efficacy and effectiveness of albendazole and mebendazole for the treatment of Ascaris lumbricoides in North-Western Indonesia

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Asian Pacific Journal of Tropical Medicine 2012年第8期5卷 605-609页

作者： inke nadia diniyanti lubis Syahril Pasaribu Chairuddin Panusunan lubis Department of Paediatrics School of MedicineUniversity of North SumateraMedanIndonesia

Objective:To investigate the efficacy and effectiveness of albendazole and mebendazole in the treatment of Ascaris lumbricoides(***) in the North-Western ***: 229 primary school children who were positive for *** in their stool were recruited in the study.123 children received single-dose of 400 mg albendazole and 106 children received single-dose 500 mg of *** 1 week,their stools were examined for the cure rate (CR) and egg reduction rate(ERR).Egg culture was also performed and observation was made on week-1,-3,-***:have shown a non-significant difference in CR 96.7%vs.100%:and ERR of 99.3%vs.100.0%for albendazole and mebendazole groups respectively(P>0.05).In-vitro egg culture has shown trends of decrease in the percentage of the unfertilized eggs and in≥2 cell eggs in both treatment groups(P<0.05).The embryonated eggs from the albendazole groups has shown an increase from 7.3%on week-1 to 13.8%on week-4,whilst the mebendazole group has shown a constant increase during the whole 4 weeks of culture from 7.5%to 28.3%(P<0.01). Conclusions:No evidence of drug resistance is noted so far from the area of North-Western part of *** addition,although both drugs showed incomplete ovicidal effects,single-dose albendazole is better than mebendazole in sterilizing *** eggs.

关键词： Ascaris lumbricoides Albendazole Mebendazole Drug resistance

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