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Magnetic lipid nanovehicles synergize the controlled thermal release of chemotherapeutics with magnetic ablation while enabling non-invasive monitoring by MRI for melanoma theranostics

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Bioactive Materials 2022年第2期7卷 153-164页

作者： Lorena Garcia-Hevia inigo casafont Jessica Oliveira Nuria Teran Monica L.Fanarraga Juan Gallo Manuel Banobre-Lopez Advanced(Magnetic)Theranostic Nanostructures Lab.International Iberian Nanotechnology Laboratory Avda.Mestre Jose Veiga s/n4715-330BragaPortugal Grupo de Nanomedicina.Universidad de Cantabria-IDIVAL Herrera Oria s/n39011SantanderSpain

Nowadays,a number of promising strategies are being developed that aim at combining diagnostic and therapeutic capabilities into clinically effective ***,the combination of a modified release provided by an organic encapsulation and the intrinsic physico-chemical properties from an inorganic counterpart opens new perspectives in biomedical ***,a biocompatible magnetic lipid nanocomposite vehicle was developed through an efficient,green and simple method to simultaneously incorporate magnetic nanoparticles and an anticancer drug(doxorubicin)into a natural *** theranostic performance of the final magnetic formulation was validated in vitro and in vivo,in melanoma *** systemic administration of the proposed magnetic hybrid nanocomposite carrier enhanced anti-tumoral activity through a synergistic combination of magnetic hyperthermia effects and antimitotic therapy,together with MRI reporting *** application of an alternating magnetic field was found to play a dual role,(i)acting as an extra layer of control(remote,on-demand)over the chemotherapy release and(ii)inducing a local thermal ablation of tumor *** combination of chemotherapy with thermotherapy establishes a synergistic platform for the treatment of solid malignant tumors under lower drug dosing schemes,which may realize the dual goal of reduced systemic toxicity and enhanced anti-tumoral efficacy.

关键词： Drug delivery systems Theranosis Magnetic hyperthermia Magnetic resonance imaging Melanoma

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On the simulation of shared autonomous micro-mobility

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Communications in Transportation Research 2022年第1期2卷 104-115页

作者： Naroa Coretti Sanchez inigo Martinez Luis Alonso Pastor Kent Larson MIT Media Lab CambridgeMAUSA University of Navarra San SebastianSpain

Fast urbanization and climate change require innovative systems for an efficient movement of people and goods in *** trends towards vehicle-sharing,autonomous vehicles,and the use of micro-mobility systems gain strength,the intersection of these fields appears as an area of great *** could potentially bring the convenience of on-demand mobility into already prevalent shared micro-mobility systems(SMMS),increasing their efficiency and incentivizing more people to use active mobility *** novelty of introducing autonomous driving technology into SMMS and their inherent complexity requires tools to assess and quantify the potential impact of autonomy on fleet performance and user *** paper presents an ad-hoc agentbased simulator for the assessment of the fleet behavior of autonomous SMMS in realistic scenarios,including a rebalancing system based on demand *** also allows comparing its performance to station-based and dockless *** proposed simulation framework is highly configurable and flexible and works with high resolution and precision geospatial *** results of studies carried out with this simulation tool could provide valuable insights for many stakeholders,including vehicle design engineers,fleet operators,city planners,and governments.

关键词： Future mobility Autonomous vehicles Micro-mobility Agent-basedsimulation Multi-agentsystems

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On the performance of shared autonomous bicycles:A simulation study

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Communications in Transportation Research 2022年第1期2卷 116-151页

作者： Naroa Coretti Sanchez inigo Martinez Luis Alonso Pastor Kent Larson MIT Media Lab CambridgeMAUSA University of Navarra San SebastianSpain

As society faces global challenges such as population growth and climate change,rethinking cities is now more imperative than *** design of cities can not be abstracted from the design of their mobility ***,efficient solutions must be found to transport people and goods throughout the city efficiently and *** autonomous bicycle-sharing system would combine the most relevant benefits of vehicle-sharing,autonomy,and micro-mobility,increasing the efficiency and convenience of bicycle-sharing systems and incentivizing more people to bike and enjoy their cities in an environmentally friendly *** to the novelty of introducing autonomous driving technology into bicycle-sharing systems and their inherent complexity,there is a need to quantify the potential impact of autonomy on fleet performance and user *** paper presents the results of an agent-based simulation that provides an in-depth understanding of the fleet behavior of autonomous bicycle-sharing systems in realistic scenarios,including a rebalancing system based on demand *** addition,this work describes the impact of different parameters on system efficiency and service ***,it quantifies the extent to which an autonomous system would outperform current station-based and dockless bicycle-sharing *** obtained results show that with a fleet size three and a half times smaller than a station-based system and eight times smaller than a dockless system,an autonomous system can improve overall performance and user experience even with no rebalancing.

关键词： Future mobility Bicycle-sharing systems Autonomous vehicles Micro-mobility Agent-based simulation Multi-agent systems

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Morphological Characterization and Hydrodynamic Behavior of Shortfin Mako Shark(Isurus oxyrinchus)Dorsal Fin Denticles

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Journal of Bionic Engineering 2019年第4期16卷 730-741页

作者： Fernandez-Waid Patricia Diez Guzman Bidaguren inigo Izagirre Urtzi Blanco Jesus Maria Soto Manu Department of Zoology and Animal Cell Biology Research Centre for Experimental Marine Biology and Biotechnology(PiE-UP V/EHU)University of the Basque CountryBilbao and Areatza z/gPlentzia 48620BizkaiaSpain Marine Research Division AZTITxatxarramendi s/n Sukarrieta 48395BizkaiaSpain Department of Nuclear Engineering and Fluid Mechanics School of Engineering(UP V/EHU)University of the Basque CountryPlaza lngeniero Torres Quevedo 148013 BilbaoBizkaiaSpain

The shortfin mako shark(Isurus oxyrinchus)is one of the fastest marine fishes,reaching speeds of up to 70 km·h^-*** speed is related to the skin surface design composed of dermal *** vary in size and shape according to placement on the body and minimize turbulence around the *** objective of this study is to analyze the interaction between seawater flow and denticles on the dorsal ***-resolution microscopy(scanning electron microscopy and confocal microscopy)were used to measure defined parts of the dermal *** measurements,along with ratios based on length-to-width define three morphologies(rounded,semi-rounded,long)that were 3D *** fluid dynamics simulated fluid passage over reconstructed denticles and describe hy-drodynamic efficiency under different *** increase in angle of inclination produced a relevant increase in the drag coefficient,especially for high velocity *** lowest drag coefficient values were found in long and semi-rounded,followed by rounded *** hydrodynamic behavior of shark skin demonstrates a relation to the morphological characteristics of dermal denticles on the dorsal *** is concluded that the best hydroefficiency relies on the rounded morphology and may serve to design hydrodynamically efficient surfaces or manmade assemblies.

关键词： denticles hydrodynamic mako shark computational fluid dynamics

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Development and validation of multicentre study on novel Artificial Intelligence-based Cardiovascular Risk Score(AICVD)

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Family Medicine and Community Health 2024年第S1期12卷 20-33页

作者： Shiv Kumar Jalepalli Prashant Gupta Andre L A J Dekker inigo Bermejo Sujoy Kar Apollo Hospitals HyderabadTelanganaIndia Azure Microsoft Research IndiaBengaluruIndia Department of Radiation Oncology(Maastro) Maastricht UniversityMaastrichtNetherlands

Objective Cardiovascular diseases(CVD)are one of the most prevalent diseases in India amounting for nearly 30%of total deaths.A dearth of research on CVD risk scores in Indian population,limited performance of conventional risk scores and inability to reproduce the initial accuracies in randomised clinical trials has led to this study on large-scale patient *** objective is to develop an Artificial Intelligence-based Risk Score(AICVD)to predict CVD event(eg,acute myocardial infarction/acute coronary syndrome)in the next 10 years and compare the model with the Framingham Heart Risk Score(FHRS)and *** Our study included 31599 participants aged 18–91 years from 2009 to 2018 in six Apollo Hospitals in India.A multistep risk factors selection process using Spearman correlation coefficient and propensity score matching yielded 21 risk factors.A deep learning hazards model was built on risk factors to predict event occurrence(classification)and time to event(hazards model)using multilayered neural ***,the model was validated with independent retrospective cohorts of participants from India and the Netherlands and compared with FHRS and *** The deep learning hazards model had a good performance(area under the curve(AUC)0.853).Validation and comparative results showed AUCs between 0.84 and 0.92 with better positive likelihood ratio(AICVD−6.16 to FHRS−2.24 and QRisk3−1.16)and accuracy(AICVD−80.15%to FHRS 59.71%and QRisk351.57%).In the Netherlands cohort,AICVD also outperformed the Framingham Heart Risk Model(AUC−0.737 vs 0.707).Conclusions This study concludes that the novel AI-based CVD Risk Score has a higher predictive performance for cardiac events than conventional risk scores in Indian population.

关键词： AICVD Cardiovascular acute

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Better understanding of the activated sludge process combining fluorescence-based methods and flow cytometry:A case study

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Journal of Environmental Sciences 2020年第4期32卷 51-58页

作者： Vanesa Benito Javier Etxebarria Felipe Goni-de-Cerio inigo Gonzalez Pilar Brettes Ana Urkiaga GAIKER Parque TecnológicoEd.20248170ZamudioBizkaiaSpain EDAR Galindo Bilbao Bizkaia Water ConsortiumSestao 48910BizfcaiaSpain

This study aims to demonstrate the validity of fluorescence-based methods,together with flow cytometry,as a complementary tool to conventional physicochemical analyses carried out in wastewater treatment plants(WWTPs),for the control of the currently largely unknown activated sludge *** with SYTO 9,propidium iodide and 5-(and 6)-carboxy-2’,7’-difluorodihydrofluorescein diacetate(carboxy-H2 DFFDA)was used for cell viability and oxidative stress monitoring of the bacterial population forming the activated sludge of a *** the period of research,several unstable periods were detected,where the non-viable bacteria exceeded the 75%of the total bacterial population in the activated sludge,but only in one case the cells with oxidative stress grew to 9%,exceeding the typical values of2%-5%of this *** periods coincided in two cases with high values of total suspended solids(SST)and chemical oxygen demand(COD)in the effluent,and with an excess of ammonia in other case.A correlation between flow cytometric and physicochemical data was found,which enabled to clarify the possible origin of each case of instability in the biological *** experience supports the application of bacterial fluorescence staining,together with flow cytometric analysis,as a simple,rapid and reliable tool for the control and better understanding of the bacteria dynamics in a biological wastewater treatment process.

关键词： Activated sludge Wastewater treatment Cell viability Oxidative stress Fluorescent dyes Flow cytometry

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The Vascular Vegetation Populating the Flora in Building Materials of Historic Monuments Cities of the West Central Region of Morocco

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Open Journal of Ecology 2014年第9期4卷 565-570页

作者： Bouamar Baghdad A.Taleb A.Carlo inigo inigo H.El Hadi M.Dalimi Department Natural Resources and Environment Agronomic and Veterinary Institute-Hassan ⅡRabatMorocco Instituto de Recursos Naturales y Agrobiologia de Salamanca(IRNASA) Consejo Superior de Investigaciones Cientificas(CSIC)SalamancaSpain Laboratory of Applied Geology Geomatics and EnvironmentFaculty of Science of Ben M’SikHassan Ⅱ UniversityCasablancaMorocco Department of Chemistry Faculty of Science and TechnologyUniversity Hassan ⅡMohammediaMorocco

In the concern of the preservation of the main historic monuments of the cities of Rabat and Sale (Morocco), a botanical study was conducted in 2009. The prospecting of these monuments allowed raising an inventory of the flora populating their building materials, and it has proved that this flora is rich and diversified. Indeed, it consists of 171 adventitious species distributed in 46 botanical families. The most represented families are Asteraceae, Poaceae, Fabaceae, Caryophyllaceae, Geraniaceae, Brassicaceae and Lamiaceae. They supply, to them only 49.7% of the specific size. The annual therophytes and the dicotyledon are dominant with respectively 66.7% and 84.7% of the specific size. Nevertheless, the presence of more than 20 species of trees and perennials constitutes a serious danger for bulwarks walls, especially by the phenomenon of fissuring by the action of the huge roots of these vegetables. These vegetables fitting into are placed on joints or cracks fissures have a chemical action on stones by acids that they release, and also a mechanical action by the growth of roots inside cracks fissures. They remain one of these are one of the important biological factors of the degradation of historic monuments. It is to note that the bulwarks walls of the site of Chella (Roman ruins) present more floral diversity than the other canvassed monuments (91 species) that are 53% of the total size.

关键词： Degradation Historic Monuments Building Materials Flora Morocco

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Bulk lateral shearing interferometry for spatiotemporal study of time-varying ultrashort optical vortices

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Photonics Research 2022年第4期10卷 922-931页

作者： Miguel Lopez-Ripa inigo J.Sola Benjamin Alonso Grupo de Aplicaciones del Laser y Fotonica(ALF) Departamento de Fisica AplicadaUniversidad de Salamanca37008 SalamancaSpain

The spatiotemporal measurement of ultrashort laser beams usually involves techniques with complex set-ups or limited by instabilities that are unable to accurately retrieve the frequency-resolved wavefront. Here, we solve these drawbacks by implementing a simple, compact, and ultra-stable spatiotemporal characterization technique based on bulk lateral shearing spectral interferometry using a birefringent uniaxial crystal. We apply it to retrieve complex spatiotemporal structures by characterizing ultrafast optical vortices with constant and time-varying orbital angular momentum. This technique can operate in all the transparency range of the anisotropic elements,enabling the characterization in different spectral ranges like infrared, visible, or ultraviolet.

关键词： ultrashort shearing interferometry

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Earth’s Serious Anisotropy, Non-Inertiality, Ether, Gain of Free Energy, Revealed, Part 2

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Journal of Applied Mathematics and Physics 2018年第6期6卷 1332-1345页

作者： Panos Theoharis Pappas Benjamin inigo Jones Theoharis Panos Pappas Lefteris Panos Pappas Technical University of Piraeus Athens Greece 87 Heathcroft London NW11 England University of Athens Athens Greece

The present paper is of historic importance as well as the second part of [1]. In this second part, we detect important details about the orbit of the Earth and about the velocity (of magnitude 217 km/s) of the solar system around the center of the Milky Way galaxy. Some of these details concern the perihelion and aphelion of the orbit of the Earth. For several years we have observed that the return pulses, on the oscilloscope screen, appear to be more energetic than the initial pulses (See Part 1, Figure 2, for which the blue return pulse crests are much higher than the yellow initial crests). The used oscilloscope is and only must be, a storage oscilloscope, in other words, a computerized oscilloscope with a digital memory. The first oscilloscopes like this, came out, only after 1995, a relatively recent time that all wire velocity experiments and measurements were already completely investigated by science. We do astronomy, without receiving images by an astronomical telescope, but instead by sending signals around a loop and making an analysis using the same oscilloscope as in Part 1. We recommend to the reader to study Part 1 as a prerequisite. The Earth surface is accelerating with a centripetal acceleration, due to its rotation, thus it is not an inertial frame. Also, the Earth is evidently anisotropic, due to the same rotation, a second reason for it being a non-inertial rotating frame.

关键词： Inertiality Isotropy Anisotropy Gain of Free Energy Ether Energy Storage Digital Computerized Oscilloscope

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Berth Management in Container Terminals： Quality of Service

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Journal of Shipping and Ocean Engineering 2012年第6期2卷 340-362页

作者： Lopez-Ansorena inigo Camarero-Orive Alberto Gonzalez-Cancelas Nicoletta Camarero-Orive Alfonso Department of Civil Engineering: Transportation Polytechnic University Madrid 28040 Spain

This paper empirically evaluates container terminal service attributes. The methodology proposed focuses on statistical control, Based on the concept of service segmentation, the authors employed control charts to classify container terminal services. The purpose of control charts is to allow simple detection of events that are indicative of actual process change. This simple decision can be difficult where the process characteristic is continuously varying, the control chart provides statistically objective criteria of change. When change is detected and considered good its cause should be identified and possibly become the new way of working, where the change is bad then its cause should be identified and eliminated. Both theoretical and practical implications of the research findings are discussed in this paper.

关键词： Container terminals quality of service control chart.

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