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Endoscopic submucosal dissection and endoscopic mucosal resection for esophageal and gastric lesions:A comparison of procedures

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Laparoscopic, Endoscopic and robotic Surgery 2024年第2期7卷 66-71页

作者： Gustav holm Schæbel Andreas Weise Mucha Charlotte Egeland Michael Patrick Achiam Department of Surgery and Transplantation Copenhagen University Hospital RigshospitaletBlegdamsvej 92100 CopenhagenDenmark

Objective Esophageal and gastric lesions are effectively managed with minimally invasive upper endoscopic procedures such as endoscopic mucosa resection(EMr)and endoscopic submucosal dissection(ESD),offering patients alternatives to invasive *** ESD is well established in Eastern Asia,its adoption in Denmark for superficial esophageal cancer is *** study presents real-world data on the feasibility,safety,and hospitalization duration associated with ESD and EMr for esophageal and gastric *** A retrospective analysis was conducted on patients who underwent ESD or EMr at a specialized center in Denmark from October 2016 to June *** on treatment,indication,lesion location,hospitalization duration,procedure duration,specimen size,complications,recurrence,and one-year overall survival were *** comparisons utilized the Mann-Whitney U test,independent sample median test,and chi-squared *** The study included 130 patients(144 procedures):72 underwent ESD and 58 underwent *** with EMr,ESD resulted in greater percentages of en bloc and r0 resections(98.8%vs.64.1%,preater complication rates(28.7%vs.3.1%,pr procedure times(119.5 min vs.37.0 min,procedure time significantly decreased over time(p=0.01).The local recurrence rates were 14.5%for ESD and 23.8%for EMr(p=0.767).The one-year overall survival rates were similar between the groups(95.8%vs.94.8%,p=0.553).Conclusion Both ESD and EMr are safe and viable for treating esophageal and gastric *** offers advantages but requires more time and *** findings support the literature,emphasizing the importance of considering patient-specific factors and surgeon proficiency in selecting the appropriate procedure.

关键词： Endoscopic submucosal dissection Endoscopic mucosa resection Gastroesophageal cancer real-world data

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燃料灵活性是航运脱碳的关键——访瓦锡兰海洋业务总裁兼集团执行副总裁roger holm

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中国船检 2024年第6期 56-60页

作者：薛龙玉 roger holm 不详瓦锡兰

随着航运业脱碳进程加速推进,越来越多替代燃料开始在船上应用。究竟哪些燃料将成为未来的主流船舶燃料?为了帮助业界应对未来燃料选择与应用相关的各种不确定性,为船东和运营商定制最适合他们的脱碳最优解,船用和能源市场全球领先的创... 详细信息

随着航运业脱碳进程加速推进,越来越多替代燃料开始在船上应用。究竟哪些燃料将成为未来的主流船舶燃料?为了帮助业界应对未来燃料选择与应用相关的各种不确定性,为船东和运营商定制最适合他们的脱碳最优解,船用和能源市场全球领先的创新技术提供商瓦锡兰(Wärtsilä)对各类潜在未来燃料选项进行了广泛的研究和投资,开发了具有高度燃料灵活性的发动机技术和生命周期解决方案,全面赋能航运业的脱碳之旅。

关键词：航运业能源市场瓦锡兰替代燃料生命周期不确定性技术提供商船舶燃料

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Moisture Absorption, Mass Loss and Evaporative resistance of Clothing in Transient Condition

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Journal of Donghua University(English Edition) 2006年第5期23卷 54-58页

作者： Chuansi Gao ingva. holmr The Thermal Environment Laboratory Division of Ergonomics Department of Design Sciences Faculty of Engineering Lund University Box 118 22100 Lund Sweden

The water vapour resistance of clothing ensembles is not as commonly determined as dry thermal insulation. The measurement techniques are more complicated and the measurement values differ among laboratories. Due to complicated moisture transfer process through clothing ensemble, the moisture absorbed and evaporated varies in transient and steady state phases depending on properties, thickness of clothing, and environmental conditions. The purpose of this study was to measure moisture gain inside hygroscopic underwear, and hydrophobic and permeable outer wear as a function of time, to investigate mass loss from ＂skin＂ as well as from the manikin, to quantify evaporative heat loss and total heat loss from the manikin, and to determine water vaponr resistance of clothing. Manikin Tore was used by wearing wet ＂skin＂ to simulate sweating condition. Moisture content in the inner garment gain shows an exponential relation against time. Moisture in the outer permeable layer shows little gain. On the contrary, mass loss directly from the wet skin decreases exponentially. The mass loss from the manikin is relatively stable throughout three test phases. The evaporative heat loss is about 2/3 of the total heat loss from the sweating manikin. While measuring the evaporative resistance of clothing ensembles with hygroscopic inner garment and permeable outer garment, unlike to measure ensembles with impermeable outer layer, one hour measurement time is enough to get relatively stable results. The variation between the 1^rt hour and the 3^nd hour is less than 5%. The length of transient period and measurement time is dependent on the permeability, thickness of clothing ensembles and environmental conditions.

关键词： moisture absorption mass loss evaporative resistance transient condition clothing ensemble.

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The tensor embedding for a Grothendieck cosmos

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Science China Mathematics 2023年第11期66卷 2471-2494页

作者： Henrik holm Sinem Odabasi Department of Mathematical Sciences University of CopenhagenCopenhagen 02100Denmark Instituto de Ciencias Físicas y Matemáticas Universidad Austral de ChileValdivia 5090000Chile

While the Yoneda embedding and its generalizations have been studied extensively in the literature,the so-called tensor embedding has only received a little *** this paper,we study the tensor embedding for closed symmetric monoidal categories and show how it is connected to the notion of geometrically purity,which has recently been investigated in the works of Enochs et al.(2016)and Estrada et al.(2017).More precisely,for a Grothendieck cosmos,i.e.,a bicomplete Grothendieck category V with a closed symmetric monoidal structure,we prove that the geometrically pure exact category(V,ε■)has enough relative injectives;in fact,every object has a geometrically pure injective *** also show that for some regular cardinalλ,the tensor embedding yields an exact equivalence between(V,ε■)and the category ofλ-cocontinuous V-functors from Presλ(V)to V,where the former is the full V-subcategory ofλ-presentable objects in *** many cases of interest,λcan be chosen to be■0 and the tensor embedding identifies the geometrically pure injective objects in V with the(categorically)injective objects in the abelian category of V-functors from fp(V)to *** we explain,the developed theory applies,e.g.,to the category Ch(r)of chain complexes of modules over a commutative ring r and to the category Qcoh(X)of quasi-coherent sheaves over a(suitably nice)scheme X.

关键词： enriched functor exact category (pre)envelope (pure)injective object purity symmetric monoidal category tensor embedding Yoneda embedding

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On the Performance of Active Analog Self-Interference Cancellation Techniques for Beyond 5G Systems

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China Communications 2021年第10期18卷 158-168页

作者： Haifeng Luo Mark holm Tharmalingam ratnarajah Institute for Digital Communications School of EngineeringThe University of EdinburghEdinburghUK Huawei Technologies(Sweden)AB GothenburgSweden

The in-band full-duplex(IBFD)mechanism is of interest in beyond 5 G systems due to its potential to enhance spectral efficiency and reduce *** achieve the maximum gain of IBFD systems,the significant self-interference(SI)must be efficiently *** challenges of wideband selfinterference cancellation(SIC)lie in the radio frequency(rF)domain,where the performance will be limited by the *** paper reviews current rF cancellation mechanisms and investigates an efficient mechanism for future wideband systems with minimum *** working principle and implementation details of multi-tap cancellers are first introduced,then an optical domain-based rF canceller is reviewed,and a novel low-cost design is *** minimize the cost and complexity of the canceller,the minimum required number of taps are *** results show that with the commonly used 12-bits analog-to-digital converter(ADC)at the receiver,the novel optical domain-based canceller can enable efficient SIC in the 3 GPP LTE specifications compatible system within 400 MHz bandwidth.

关键词： full-duplex beyond 5G system self-interference cancellation optical domain-based canceller

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State Modelling and Simultaneous Control of Discrete Part Manufacturing Product Transformation Processes and resource Allocation

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厦门大学学报（自然科学版） 2002年第S1期41卷 251-252页

作者： Hans holm Department of Production

As competition in the market for discrete part prod uc ts gets harder and harder the requirements for extreme manufacturing operati on efficiencies get increasingly accentuated. Therefore requirements for well behaved manufacturing operation control get more and more significant. The purpose of the paper is to establish a framework for development of formal m ethods for design of systems for simultaneous control of continuous manufacturin g task processes and resource allocation of discrete part manufacturing. In the paper states which are needed for feedback control of continuous manufact uring task processes are defined and an example is presented. States which are necessary for feedback control of distribution of manufacturing resources are defined. The definition is based on the states defined for feedba ck control of the continuous processes of discrete part manufacturing tasks. An exemple is presented. Based on use of the state variables two types of equations are described, the pu rpose of which it is to represent the constraints to which control of the manufa cturing system is subject. Characteristic instances of the equations are presen ted. Methods for design of systems which can control continuous tasks are presented. Methods for design of systems which can control resource allocation are presente d. Methods for design of systems which can simultaneously control continuous tas k processes and resource allocation as the resource allocation is subject to con tinuos task execution constraints are presented.

关键词： Transformation allocation competition simultaneous behaved extreme formal constraints execution

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Challenges and trends in apomorphine drug delivery systems for the treatment of Parkinson's disease

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Asian Journal of Pharmaceutical Sciences 2018年第6期13卷 507-517页

作者： Nrupa Borkar Huiling Mu rené holm Department of Pharmacy Faculty of Health and Medical Sciences University of Copenhagen Drug Product Development Janssen Research and Development Johnson & Johnson

Parkinson's disease(PD) is a chronic debilitating disease affecting approximately 1% of the population over the age of 60. The severity of PD is correlated to the degree of dopaminergic neuronal loss. Apomorphine has a similar chemical structure as the neurotransmitter dopamine and has been used for the treatment of advanced PD patients. In PD patients,apomorphine is normally administered subcutaneously with frequent injections because of the compound's extensive hepatic first-pass metabolism. There is, hence, a large unmet need for alternative administrative routes for apomorphine to improve patient *** present review focuses on the research and development of alternative delivery of apomorphine, aiming to highlight the potential of non-invasive apomorphine therapy in PD,such as sublingual delivery and transdermal delivery.

关键词： Apomorphine Drug delivery Parkinson’s disease Alternative apomorphine therapy Non-invasive delivery Excipients

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Quantitative analysis of Arctic ice flow acceleration with increasing temperature

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Acta Oceanologica Sinica 2021年第1期40卷 22-32页

作者： Zemin Wang Boya Yan Songtao Ai Kim holmén Jiachun An Hongmei Ma Chinese Antarctic Center of Surveying and Mapping Wuhan UniversityWuhan 430079China Norwegian Polar Institute Longyearbyen 9170Norway Polar research Institute of China Shanghai 200136China

This study explores the ice flow acceleration(21.1%)of Pedersenbreen during 2016–2017 after the extremely warm winter throughout the whole Arctic in 2015/2016 using in situ data and quantitatively analyses the factors contributing to this *** data sets,including 2008–2018 air temperature data from Ny-?lesund,ten-year in situ GPS measurements and Elmer/Ice ice flow modelling under different ice temperature scenarios,suggest that the following factors contributed to the ice flow acceleration:the softened glacier ice caused by an increase in the air temperature(1.5℃)contributed 2.7%–30.5%,while basal lubrication contributed 69.5%–97.3%.The enhanced basal sliding was mostly due to the increased surface meltwater penetrating to the bedrock under the rising air temperature conditions;consequently,the glacier ice flow acceleration was caused mainly by an increase in subglacial *** Pedersenbreen,there was an approximately one-year time lag between the change in air temperature and the change in glacier ice flow velocity.

关键词： ice flow velocity Arctic temperature rising Pedersenbreen Elmer/Ice meltwater

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Systematic review of the prevalence and development of osteoporosis or low bone mineral density and its risk factors in patients with inflammatory bowel disease

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World Journal of Gastroenterology 2020年第35期26卷 5362-5374页

作者： Sofia Kärnsund Bobby Lo Flemming Bendtsen Jakob holm Johan Burisch Gastrounit Medical DivisionCopenhagen University Hospital HvidovreHvidovre 2650Denmark Department of Endocrinology Copenhagen University Hospital HerlevHerlev 4600Denmark

BACKGrOUND The inflammatory bowel diseases(IBD),Crohn’s disease(CD)and ulcerative colitis(UC)are chronic,immune-mediated disorders of the digestive *** is considered to be a risk factor for developing osteoporosis;however current literature on this matter is *** To assess prevalence and development of osteoporosis and low bone mineral density(BMD),and its risk factors,in IBD *** Systematic review of population-based *** were identified by electronic(January 2018)and manual searches(May 2018).Databases searched included EMBASE and PubMed and abstracts from 2014-2018 presented at the United European Gastroenterology Week,the European Crohn’s and Colitis Organisation congress,and Digestive Disease Week were *** were eligible for inclusion if they investigated either the prevalence of osteoporosis or osteopenia and/or risk factors for osteoporosis or low BMD in IBD *** on children under the age of 18 were *** population-based studies were *** risk factors for osteoporosis and low BMD investigated in any included article were *** quality and the possibility of bias were analysed using the Newcastle-Ottawa *** Twelve studies including 3661 IBD patients and 12789 healthy controls were *** of osteoporosis varied between 4%-9%in studies including both CD and UC patients;2%-9% in studies including UC patients, and 7%-15% instudies including CD patients. Among healthy controls, prevalence ofosteoporosis was 3% and 10% in two studies. CD diagnosis, lower body massindex (BMI), and lower body weight were risk factors associated withosteoporosis or low BMD. Findings regarding gender showed inconsistent *** patients had an increased risk for osteoporosis or low BMD over time, whileUC patients did not. Increased age was associated with decreased BMD, and therewas a positive association between weight and BMI and BMD over time. Greatheterogeneity was

关键词： Inflammatory bowel disease Osteoporosis Systematic review Epidemiology Bone mineral density

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Acute effects of Helicobacter pylori extracts on gastric mucosal blood flow in the mouse

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World Journal of Gastroenterology 2009年第2期15卷 219-225页

作者： Johanna Henriksns Christer Atuma Mia Phillipson Stellan Sandler Lars Engstrand Lena holm Department of Medical Cell Biology Uppsala University SE-751 23 Uppsala Sweden Department of Bacteriology Swedish Institute for Infectious Disease Control 171 82 Solna Sweden

AIM： To investigate the mechanisms underlying the reduction in gastric blood flow induced by a luminal water extract of Hellcobacter pylori （HPE）. METHODS： The stomachs of isoflurane-anesthetized mice were exteriorized, and the mucosal surface exposed. Blood flow was measured with the laserDoppler technique, and systemic arterial blood pressure monitored. C57BL/6 mice were exposed to water extract produced from Hpylori strain 88-23. To investigate the role of a nerveor iNOS-mediated pathway, we used intraluminal lidocaine and iNOS-/- mice. Blood flow response to the endogenous nitric oxide synthase inhibitor asymmetric dimethyl arginine （ADMA） was also assessed. rESULTS： In wild-type mice, HPE decreased mucosal blood flow by approximately 30%. This reduction was abolished in iNOS-deficient mice, and by pre-treatment with lidocaine. Luminally applied ADMA resulted in reduction in blood flow similar to that observed in wildtype mice exposed to HPE. CONCLUSION： A H py/ori water extract reduces gastric mucosal blood flow acutely through iNOS- and nerve-mediated pathways.

关键词： Gastric mucosal blood flow In vivo LaserDoppler flowmetry Mice Helicobacter pylori

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