Systematic review of the prevalence and development of osteoporosis or low bone mineral density and its risk factors in patients with inflammatory bowel disease

作     者：Sofia Kärnsund Bobby Lo Flemming Bendtsen Jakob Holm Johan Burisch 

作者机构：GastrounitMedical DivisionCopenhagen University Hospital HvidovreHvidovre 2650Denmark Department of EndocrinologyCopenhagen University Hospital HerlevHerlev 4600Denmark 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2020年第26卷第35期

页      面：5362-5374页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：Takeda Pharma Tillots Pharma Celgene AbbVie Meso Scale Diagnostics, MSD Cilag 

主　　题：Inflammatory bowel disease Osteoporosis Systematic review Epidemiology Bone mineral density 

摘      要：BACKGROUND The inflammatory bowel diseases(IBD),Crohn’s disease(CD)and ulcerative colitis(UC)are chronic,immune-mediated disorders of the digestive *** is considered to be a risk factor for developing osteoporosis;however current literature on this matter is *** To assess prevalence and development of osteoporosis and low bone mineral density(BMD),and its risk factors,in IBD *** Systematic review of population-based *** were identified by electronic(January 2018)and manual searches(May 2018).Databases searched included EMBASE and PubMed and abstracts from 2014-2018 presented at the United European Gastroenterology Week,the European Crohn’s and Colitis Organisation congress,and Digestive Disease Week were *** were eligible for inclusion if they investigated either the prevalence of osteoporosis or osteopenia and/or risk factors for osteoporosis or low BMD in IBD *** on children under the age of 18 were *** population-based studies were *** risk factors for osteoporosis and low BMD investigated in any included article were *** quality and the possibility of bias were analysed using the Newcastle-Ottawa *** Twelve studies including 3661 IBD patients and 12789 healthy controls were *** of osteoporosis varied between 4%-9%in studies including both CD and UC patients;2%-9% in studies including UC patients, and 7%-15% instudies including CD patients. Among healthy controls, prevalence ofosteoporosis was 3% and 10% in two studies. CD diagnosis, lower body massindex (BMI), and lower body weight were risk factors associated withosteoporosis or low BMD. Findings regarding gender showed inconsistent *** patients had an increased risk for osteoporosis or low BMD over time, whileUC patients did not. Increased age was associated with decreased BMD, and therewas a positive association between weight and BMI and BMD over time. Greatheterogeneity was