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国外畜牧学(猪与禽) 1985年第6期 28-28页

作者： ingemar Hansson 殷勤云瑞典农业大学家畜遗传育种系

自70年代以来,瑞典一直用光学探针测定最后肋骨后缘的背膘厚度,并以此为基础将猪胴体分为四级。但是,在过去五年内对这种分级法进行了彻底的考核,发现它不能应用于现代设备,也不能作为向养猪户付款的依据。因此,瑞典从1984年4月30日起... 详细信息

自70年代以来,瑞典一直用光学探针测定最后肋骨后缘的背膘厚度,并以此为基础将猪胴体分为四级。但是,在过去五年内对这种分级法进行了彻底的考核,发现它不能应用于现代设备,也不能作为向养猪户付款的依据。因此,瑞典从1984年4月30日起采用了瘦肉率估测法。新的检测设备是Hennessy分级探测器(GP)及与其相联的、装有数据储存、处理及监测等程序

关键词：背膘厚度肋骨产肉性能瘦肉率背中线分级法瑞典北欧

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A new prognostic histopathologic classification of nasopharyngeal carcinoma

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Chinese Journal of Cancer 2016年第6期35卷 30-45页

作者： Hai-Yun Wang Yih-Leong Chang Ka-Fai To Jacqueline S.G.Hwang Hai-Qiang Mai Yan-Fen Feng Ellen T.Chang Chen-Ping Wang Michael Koon Ming Kam Shie-Lee Cheah Ming Lee Li Gao Hui-Zhong Zhang Jie-Hua He Hao Jiang Pei-Qing Ma Xiao-Dong Zhu Liang Zeng Chun-Yan Chen Gang Chen Ma-Yan Huang Sha Fu Qiong Shao An-Jia Han Hai-Gang Li Chun-Kui Shao Pei-Yu Huang Chao-Nan Qian Tai-Xiang Lu Jin-Tian Li Weimin Ye ingemar Ernberg Ho Keung Ng Joseph T.S.Wee Yi-Xin Zeng Hans-Olov Adami Anthony T.C.Chan Jian-Yong Shao State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer Medicine Sun Yat-sen University Cancer Center Department of Molecular Diagnostics Sun Yat-sen University Cancer Center Department of Pathology National Taiwan University HospitalNational Taiwan University College of Medicine Department of Anatomical and Cellular Pathology Hong Kong Cancer Institute and Sir YK Pao Centre for CancerFaculty of MedicineThe Chinese University of Hong Kong Department of Pathology Singapore General Hospital Department of Nasopharyngeal Carcinoma Sun Yat-sen University Cancer Center Department of Pathology Sun Yat-sen University Cancer Center Division of Epidemiology Department of Health Research and PolicyStanford University School of Medicine Health Sciences Practice ExponentInc. Department of Otolaryngology National Taiwan University HospitalNational Taiwan University College of Medicine Department of Clinical Oncology Hong Kong Cancer Institute and Sir YK Pao Centre for CancerFaculty of MedicineThe Chinese University of Hong Kong Division of Radiation Oncology National Cancer CenterSingapore Department of Radiation Oncology Cancer Institute and HospitalChinese Academy of Medical Sciences Department of Radiation Oncology The Affiliated Hospital of Bengbu Medical College Department of Pathology Cancer Institute and HospitalChinese Academy of Medical Sciences Department of Radiation Oncology Guangxi Medical University Department of Pathology Hunan Provincial Cancer Hospital Department of Radiation Oncology Sun Yat-sen University Cancer Center Department of Pathology Fujian Provincial Cancer Hospital Department of Pathology The First Affiliated HospitalSun Yat-sen University Department of Pathology Sun Yat-sen Memorial HospitalSun Yat-sen University Department of Pathology The Third Affiliated HospitalSun Yat-sen University Department of Experiment Research Sun Yat-sen University Cancer Center Department of Medical Epidemiology and Biostatistics Karolinska Institutet Departments of Mi

Background:The current World Health Organization(WHO) classification of nasopharyngeal carcinoma(NPC) con?veys little prognostic *** study aimed to propose an NPC histopathologic classification that can poten?tially be used to predict prognosis and treatment ***:We initially developed a histopathologic classification based on the morphologic traits and cell differentia?tion of tumors of 2716 NPC patients who were identified at Sun Yat?sen University Cancer Center(SYSUCC)(training cohort).Then,the proposed classification was applied to 1702 patients(retrospective validation cohort) from hospitals outside SYSUCC and 1613 patients(prospective validation cohort) from *** efficacy of radiochemotherapy and radiotherapy modalities was compared between the proposed *** used Cox proportional hazards models to estimate hazard ratios(HRs) with 95% confidence intervals(CI) for overall survival(OS).Results:The 5?year OS rates for all NPC patients who were diagnosed with epithelial carcinoma(EC;3708 patients),mixed sarcomatoid?epithelial carcinoma(MSEC;1247 patients),sarcomatoid carcinoma(SC;823 patients),and squamous cell carcinoma(SCC;253 patients) were 79.4%,70.5%,59.6%,and 42.6%,respectively(P < 0.001).In mul?tivariate models,patients with MSEC had a shorter OS than patients with EC(HR = 1.44,95% CI = 1.27–1.62),SC(HR = 2.00,95% CI = 1.76–2.28),or SCC(HR = 4.23,95% CI = 3.34–5.38).Radiochemotherapy significantly improved survival compared with radiotherapy alone for patients with EC(HR 49–0.75),and possibly for those with SCC(HR = 0.67,95% CI = 0.56–0.80),MSEC(HR = 0.58,95% CI = 0..74–1.28).= 0.63;95% CI = 0.40–0.98),but not for patients with SC(HR = 0.97,95% CI = 0Conclusions:The proposed classification offers more information for the prediction of NPC prognosis compared with the WHO classification and might be a valuable tool to guide treatment decisions for subtypes that are associ?ated with a poor prognosis.

关键词： Nasopharyngeal carcinoma Pathologic classification Prognosis

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华南地区鼻咽癌13号和14号染色体长臂发生高频率等位基因杂合性缺失(英文)

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Chinese Medical Journal 2002年第4期115卷 91-95,153页

作者：邵建永李宇红吴秋良梁小曼余杏娟黄丽惜侯景辉黄晓明曾益新中山医科大学肿瘤防治中心病理科广州510060

目的　分析鼻咽癌 (NPC) 13号染色体长臂 (13q)和 14号染色体长臂 (14q)上 2 1个位点的等位基因杂合子丢失(LOH) ,并分析这些位点的LOH与NPC临床病理及EBV感染的关系。方法　用聚合酶链反应 (PCR)为基础的微卫星多态性分析技术结合基因... 详细信息

目的　分析鼻咽癌 (NPC) 13号染色体长臂 (13q)和 14号染色体长臂 (14q)上 2 1个位点的等位基因杂合子丢失(LOH) ,并分析这些位点的LOH与NPC临床病理及EBV感染的关系。方法　用聚合酶链反应 (PCR)为基础的微卫星多态性分析技术结合基因扫描和基因绘图技术对 6 0例NPC进行LOH分析。结果　 13q染色体发生一个或多个位点LOH频率为 78% ,高频率LOH(大于 30 % )位点集中于 13q12 3 q14 3和13q32附近。 14q染色体发生至少一个位点LOH的频率为 80 % ,高频率丢失位点集中于 14q11 q13、14q2 1 q2 4和14q32附近。 13q31 q32位点的LOH与低滴度血清EBVEA/IgA有关 ;14q染色体的LOH与NPC细胞的分化差有关。结论　华南地区鼻咽癌在 13q和 14q染色体发生高频率的LOH ,这些缺失区可能存在多个在NPC发生发展过程中起重要作用的肿瘤抑制基因。

关键词：杂合性缺失染色体鼻咽癌

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