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Physical-Chemical and Pharmacological Research on New Lignin Enterosorb.nt

Journal of Pharmacy and Pharmacology 2014年第11期2卷 642-651页

作者： Mokhinur G. Ismailovat Khamida G. Yunuskhodjaeva Pazaat L. Ismailova inessa b. boyko Department of b.otechnology Tashkent Pharmaceuticallnstitute Tashkent 100015 Uzbekistan Lab.ratory on Natural Pharmaceuticals and Medical Sorb.nts Uzbek Chemical and Pharmaceutical Research Institute Tashkent100125 Uzbekistan Department of Pharmaco-toxicology Tashkent MedicalAeademy Tashkent 100047 Uzbekistan

The technology on ob.aining enterosorb.nt from local feedstock--hydrolyzed lignin of cotton seed hulls named Zerotox was developed. The purpose of this research is to conduct a complex study on its physical-chemical and pharmacological properties. Samples of cotton hydrolyzed lignin b.sed enterosorb.nt Zerotox were investigated, wood hydrolyzed lignin b.sed enterosorb.nt Polifepan （Russia） was used as a comparison drug. The technology of new medical enterosorb.nt Zerotox, b.sed on cotton hydrolyzed lignin, has b.en developed with its physical-chemical and pharmacological characteristics b.ing researched. Comparative research on adsorb.ng capacity of sorb.nt Zerotox （80 mg/g） and its analogue--Polipefan （55 mg/g）, which is ob.ained from wood hydrolyzed lignin, has displayed advantages of the new sorb.nt. IR-spectroscopy research on lignin sorb.nt Zerotox has shown presence of oxygen-containing functional groups which determine its high ab.orb.ng capacity due to its chemisorption. Atomic-adsorptive method has proved high ab.orb.ng capacity of the sorb.nt towards heavy metals ions. Acute and chronic toxicity and antidiarrheal activity of enterosorb.nt Zerotox have also b.en studied.

关键词： Medical sorb.nts cotton hydrolyzed lignin detoxification ab.orb.ng properties adsorb.ng capacity functional groups atomic-adsorptive method pharmacological research.

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