Physical-Chemical and Pharmacological Research on New Lignin Enterosorbent
Physical-Chemical and Pharmacological Research on New Lignin Enterosorbent作者机构：Department of Biotechnology Tashkent Pharmaceuticallnstitute Tashkent 100015 Uzbekistan Laboratory on Natural Pharmaceuticals and Medical Sorbents Uzbek Chemical and Pharmaceutical Research Institute Tashkent100125 Uzbekistan Department of Pharmaco-toxicology Tashkent MedicalAeademy Tashkent 100047 Uzbekistan
出 版 物：《Journal of Pharmacy and Pharmacology》 (药剂与药理学（英文版）)
年 卷 期：2014年第2卷第11期
页 面：642-651页
学科分类：1007[医学-药学(可授医学、理学学位)] 10[医学]
主 题：Medical sorbents cotton hydrolyzed lignin detoxification absorbing properties adsorbing capacity functional groups atomic-adsorptive method pharmacological research.
摘 要：The technology on obtaining enterosorbent from local feedstock--hydrolyzed lignin of cotton seed hulls named Zerotox was developed. The purpose of this research is to conduct a complex study on its physical-chemical and pharmacological properties. Samples of cotton hydrolyzed lignin based enterosorbent Zerotox were investigated, wood hydrolyzed lignin based enterosorbent Polifepan （Russia） was used as a comparison drug. The technology of new medical enterosorbent Zerotox, based on cotton hydrolyzed lignin, has been developed with its physical-chemical and pharmacological characteristics being researched. Comparative research on adsorbing capacity of sorbent Zerotox （80 mg/g） and its analogue--Polipefan （55 mg/g）, which is obtained from wood hydrolyzed lignin, has displayed advantages of the new sorbent. IR-spectroscopy research on lignin sorbent Zerotox has shown presence of oxygen-containing functional groups which determine its high absorbing capacity due to its chemisorption. Atomic-adsorptive method has proved high absorbing capacity of the sorbent towards heavy metals ions. Acute and chronic toxicity and antidiarrheal activity of enterosorbent Zerotox have also been studied.
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