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Energy restriction and exercise modulate angiopoietins and vascular endothelial growth factor expression in the cavernous tissue of high-fat diet-fed rats

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Asian Journal of Andrology 2012年第4期14卷 635-642页

作者： ines tomada Nuno tomada Henrique Almeida Delminda Neves Department of Experimental Biology Faculty of MedicineUniversidade do Porto--Alameda ProfHernmai MonteiroPorto 4200-319Portugal Instituto de Biologia Molecular e Celular(IBMC) Universidade do Porto--Rua do Campo Alegre 823Porto 4150-180Portugal Department of Urology Centro Hospital S.JoaoEPE-Alameda ProfessorHernmani MonteiroPorto 4200-319Portugal

The purpose of the current study was to evaluate the effect of a high-fat （HF） diet, energy restriction and exercise on the expression of vascular endothelial growth factor （VEGF）, angiopoietin （Ang） I and 2, and their receptors in rat corpus cavernosum （CC）. Male Wistar rats were fed adlibitum with an H F diet for 8 or 16 weeks. After 8 weeks of the H F diet, a group of rats was subjected to energy restriction with or without exercise for 8 weeks. Control animals had free access to standard diet for the same period. After euthanasia, blood was collected and the penises removed for immunofluorescence assays （VEGF, VEGF receptor （VEGFR） I and 2, Angl, Ang2 and Tie2） and semiquantification of VEGF, VEGFR 1, VEGFR2, Angl, Ang2, Tie2, endothelial nitric oxide synthase （eNOS） and Aktlphospho-Akt by Western blotting. HF diet-fed rats exhibited lower high-density lipoprotein cholesterol （HDL-c） levels, higher systolic blood pressure and an increased atherogenic index. A significant increase in Ang2 expression in the CC was verified and coupled to a decrease in VEGF and VEGFRs. The Akt pathway was activated by the HF diet. Energy restriction and exercise increased eNOS expression and restored most HF diet-induced modifications except for VEGFR2 expression. These results emphasize the role of diet on vascular function regulation, demonstrating that cavernous imbalance of VEGF/VEGFRs and Angs/Tie2 systems occurs before serum lipid changes and obesity onset, antedating structural atherosclerotic features.

关键词： angiopoietins corpus cavernosum endothelial dysfunction energy restriction exercise high-fat diet VEGF

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BEZIER SPLines INTERPOLATION ON STIEFEL AND GRASSMANN MANIFOLDS

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Journal of Computational Mathematics 2024年第6期42卷 1554-1578页

作者： ines Adouani Chafik Samir Department of Mathematics University of SousseTunisia LIMOS-CNRS University of Clermont AuvergneFrance

We propose a new method for smoothly interpolating a given set of data points on Grassmann and Stiefel manifolds using a generalization of the De Casteljau *** that end,we reduce interpolation problem to the classical Euclidean setting,allowing us to directly leverage the extensive toolbox of spline *** interpolated curve enjoy a number of nice properties:The solution exists and is optimal in many common *** applications,the structures with respect to chosen Riemannian metrics are detailed resulting in additional computational advantages.

关键词： Optimization B´ezier spline Curve fitting Grassmann manifolds Stiefel manifolds Canonical metrics

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A drop of immunity

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Molecular Plant 2021年第9期14卷 1437-1438页

作者： ines Trindade Institute for Biochemistry and Biology University of Potsdam14476 PotsdamGermany

Editor's Highlight Molecular Plant snRNA-seq to bulk RNA-seq from whole roots and protoplast suspensions,and captured additional cell subtypes using snRNA-seq that were missed in other published single-cell RNA-seq(scRNA-seq)*** de novo clustering of nuclei based on chromatin accessibility and integration of snATAC-seq with snRNA-seq produced similar clusters,suggesting that the complex Arabidopsis root cellular identities can be revealed by single-nuclei chromatin accessibility profiles(Farmer et al.t 2021).

关键词： immunity roots Arabidopsis

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Synchronization of the minimal models of bursting neurons coupled by delayed chemical or electrical synapses

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Chinese Physics B 2012年第1期21卷 29-36页

作者： Neboja Vasovi Nikola Buri Kristina Todorovi ines Grozdanovi Department of Applied Mathematics Faculty of Mining and GeologyBelgrade 162 Serbia Institute of Physics University of Beograd PO Box 68 11080 Beograd-Zemun Serbia Department of Physics and Mathematics Faculty of Pharmacy University of Belgrade Vojvode Stepe 450 Belgrade Serbia

The minimal two-dimensional model of bursting neuronal dynamics is used to study the influence of time-delay on the properties of synchronization of bursting neurons. Generic properties of bursting and dependence of the stability of synchronization on the time-lag and the strength of coupling are described, and compared with the two common types of synaptical coupling, i.e., time-delayed chemical and electrical synapses.

关键词： neuronal nursting minimal model synchronization

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Microglial exosomes in retinal neuroinflammation: focus in glaucoma

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Neural Regeneration Research 2021年第9期16卷 1801-1802页

作者： ines Dinis Aires Ana Raquel Santiago University of Coimbra Coimbra Institute for Clinical and Biomedical Research(iCBR)Faculty of MedicineCoimbraPortugal University of Coimbra Center for Innovative Biomedicine and Biotechnology(CIBB)CoimbraPortugal Clinical Academic Center of Coimbra(CACC) CoimbraPortugal Association for Innovation and Biomedical Research on Light and Image(AIBILI) CoimbraPortugal

Glaucoma is a leading cause of irreversible blindness, expected to affect 140 million people worldwide by the year 2040. The pathophysiology of glaucoma involves retinal ganglion cell loss, optic nerve atrophy and cupping of the optic disk, culminating in visual field loss(Boia et al., 2020). Glaucoma is a multifactorial disease in which increased intraocular pressure is the main risk factor.

关键词： glaucoma inflammation al.

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Conduction properties of condensed lanthanum phosphates:La(PO_3)_3 and LaP_5O_(14)

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Journal of Rare Earths 2010年第3期28卷 321-328页

作者： ines Hammas Karima Horchani-Naifer Mokhtar Férid Research Unit of Rare Earth Materials National Research Center in Sciences of MaterialsB.P.95 Hammam-Lif2050Tunisia

Single crystals of LaP3O9·3H2O were prepared using a classical method of aqueous chemistry whereas those of the ultraphosphate LaP5O14 were obtained by flux *** treatment of LaP3O9·3H2O up to 700 °C allowed us to obtain the lanthanum polyphosphate La(PO3)*** conductivity as well as the vibrational study of the lanthanum ultraphosphate and polyphosphate were analysed in order to explain the mechanism of *** energies of 0.45 and 0.84 eV,deduced from the Arrhenius relation,were r...

关键词： condensed lanthanum phosphates electrical conductivity Grotthuss mechanism rare earths

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A comparative study on the reactivity of charged Ni-rich and Ni-poor positive electrodes with electrolyte at elevated temperatures using accelerating rate calorimetry

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Journal of Energy Chemistry 2021年第9期30卷 523-530页

作者： Dongxu Ouyang Yulong Liu ines Hamam Jian Wang Jeff Dahn State Key Laboratory of Fire Science University of Science and Technology of ChinaHefei 230026AnhuiChina Department of Physics and Atmospheric Science Dalhousie UniversityHalifax B3H4R2Canada Department of Process Engineering and Applied Science Dalhousie UniversityHalifax B3H3J5Canada

The reactivity between charged Li(Li_(0.115)Mn_(0.529)Ni_(0.339)Al_(0.017))O_(2)(Li-rich),single crystal Li(Ni_(0.8)Mn_(0.1)Co_(0.1))O_(2)(SC-NMC811),LiFePO_(4)(LFP) and LiMn_(0.8)Fe_(0.2)PO_(4)(LMFP) positive electrodes at different states of charge(SOCs) and traditional carbonate-based electrolyte at elevated temperatures is systematically studied using accelerating rate calorimetry(ARC).The results show that the SOC greatly affects the thermal stability of the Li-rich and SC-NMC811 when traditional carbonate-based electrolyte is *** an increase in the SOC increases the energy density of lithium-ion cells,it also increases the reactivity between charged Li-rich and SC-NMC811 samples with electrolyte at elevated *** comparison with SC-NMC811,the Li-rich samples are much more stable at elevated temperatures,and the latter have higher specific ***-NMC811 samples are less reactive than traditional polycrystalline *** LFP and LMFP samples show excellent thermal stability at elevated *** substitution of Fe by Mn in the olivine series positive materials does not impact the reactivity with electrolyte.

关键词： Lithium-ion cells Accelerating rate calorimetry Positive electrodes Safety

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Endoscopic and surgical resection of T1a/T1b esophageal neoplasms: A systematic review

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World Journal of Gastroenterology 2013年第9期19卷 1424-1437页

作者： George Sgourakis ines Gockel Hauke Lang Department of General and Abdominal Surgery Johannes Gutenberg University Hospital of Mainz 2nd Surgical Department and Surgical Oncology Unit of "Korgialenio-Benakio" Red Cross Hospital of Athens

AIM: To investigate potential therapeutic recommendations for endoscopic and surgical resection of T1a/ T1b esophageal neoplasms. METHODS: A thorough search of electronic databases MEDLINE, Embase, Pubmed and Cochrane Library, from 1997 up to January 2011 was performed. An analysis was carried out, pooling the effects of outcomes of 4241 patients enrolled in 80 retrospective studies. For comparisons across studies, each reporting on only one endoscopic method, we used a random effects meta-regression of the log-odds of the outcome of treatment in each study. "Neural networks" as a data mining technique was employed in order to establish a prediction model of lymph node status in superficial submucosal esophageal carcinoma. Another data mining technique, the "feature selection and root cause analysis", was used to identify the most impor-tant predictors of local recurrence and metachronous cancer development in endoscopically resected patients, and lymph node positivity in squamous carcinoma (SCC) and adenocarcinoma (ADC) separately in surgically resected patients. RESULTS: Endoscopically resected patients: Low grade dysplasia was observed in 4% of patients, high grade dysplasia in 14.6%, carcinoma in situ in 19%, mucosal cancer in 54%, and submucosal cancer in 16% of patients. There were no significant differences between endoscopic mucosal resection and endoscopic submucosal dissection (ESD) for the following parameters: complications, patients submitted to surgery, positive margins, lymph node positivity, local recurrence and metachronous cancer. With regard to piecemeal resection, ESD performed better since the number of cases was significantly less [coefficient: -7.709438, 95%CI: (-11.03803, -4.380844), P < 0.001]; hence local recurrence rates were significantly lower [coefficient: -4.033528, 95%CI: (-6.151498, -1.915559),P < 0.01]. A higher rate of esophageal stenosis was observed following ESD [coefficient: 7.322266, 95%CI: (3.810146, 10.83439), P < 0.001]. A

关键词： Superficial esophageal cancer Endoscopic resection Mucosal infiltration Submucosal involvement Recurrent tumor Controversies in treatment Squamous cell carcinoma Adenocarcinoma Lymphatic invasion Vascular invasion Submucosal layer Superficial submucosal layer Middle third submucosal layer Deep third submucosal layer Esophageal cancer Endoscopic gastrointestinal surgical procedures Endoscopic gastrointestinal surgery Lymph node dissection Dysplasia

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Beta thalassemia syndromes:New insights

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World Journal of Clinical Cases 2025年第10期13卷 1-8页

作者： Ana Dordevic ines Mrakovcic-Sutic Sonja Pavlovic Milena Ugrin Jelena Roganovic Department of Business Development Jadran Galenski LaboratorijRijeka 51000Croatia Faculty of Medicine University of RijekaRijeka 51000Croatia Institute of Molecular Genetics and Genetic Engineering University of BelgradeBelgrade 11000Serbia Department of Pediatric Hematology and Oncology Children’s Hospital ZagrebZagreb 10000Croatia Faculty of Biotechnology and Drug Development University of RijekaRijeka 51000Croatia

Beta thalassemia(β-thalassemia)syndromes are a heterogeneous group of inherited hemoglobinopathies caused by molecular defects in the beta-globin gene that lead to the impaired synthesis of beta-globin chains of the *** hallmarks of the disease include ineffective erythropoiesis,chronic hemolytic anemia,and iron *** presentation ranges from asymptomatic carriers to severe anemia requiring lifelong blood transfusions with subsequent devastating *** management of patients with severeβ-thalassemia represents a global health problem,particularly in low-income *** recently,management strategies were limited to regular transfusions and iron chelation therapy,with allogeneic hematopoietic stem cell transplantation available only for a subset of *** understanding of the underlying pathophysiological mechanisms ofβ-thalassemia syndromes and associated clinical phenotypes has paved the way for novel therapeutic options,including pharmacologic enhancers of effective erythropoiesis and gene therapy.

关键词： Beta thalassemia Hemoglobin Molecular defects Ineffective erythropoiesis Hemolysis Transfusion Iron chelation Novel therapies

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Road traffic nanoparticle characteristics:Sustainable environment and mobility

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Geoscience Frontiers 2022年第1期13卷 388-403页

作者： ines Belkacem Ali Helali Salah Khardi Amani Chrouda Khalifa Slimi Laboratory of Thermal and Energy Systems Studies(LESTE) National Engineering SchoolUniversity of MonastirTunisia Environment PlanningSafety and Eco-design LaboratoryDepartment of MobilityPlanning and the EnvironmentGustave Eiffel UniversityUniversity of Lyon–LyonFrance Mechanical Laboratory of Sousse National Engineering School of SousseUniversity of SousseTunisia Department of Transportation Technology and Engineering Higher Institute of Transportation and LogisticsUniversity of SousseTunisia Contact and Structure Mechanics Laboratory LaMCoS Campus LyonTech La Doua–INSA Lyon.27bisAvenue Jean CapelleF69621 Villeurbanne cedexFrance Department of Chemistry College of Science at ZulfiMajmaah UniversityZulfi 11932Saudi Arabia

Human effects and environment impacts associated with nanoparticles generated from road traffic have recently attracted wide *** of the influencing variables on both number and mass of nanoparticles,sources,characteristics and limitations of advanced commercially accessible instruments for monitoring nanoparticles,are still scarce and not sufficient to make regulatory decision on solid particles smaller than 23 nm(SPN<23 nm).Given the harmful effects of nanoparticles on human health(*** impairment,cardiac-rhythm disturbance,heart attacks,premature death,etc.),their control and assessment seem to be an absolute *** this overview,we classify and analyze the existing knowledge of nanoparticles in road traffic atmosphere,recent progress,and emerging priorities in research related to these *** major aspects of ongoing research in this field,and a brief discussion of the main sources of atmosphere nanoparticles are *** subsequent section focuses on the influencing parameters of nanoparticles including climate conditions,height above the road surface and distance between source(road traffic)and sampling *** next section provides a comprehensive summary on sampling measurement methodologies and instrumental *** also review the health and environment implications associated with particle ***,an evaluation of the state of research related to nanoparticles together with highlights for future research activities are also presented.

关键词： Road traffic Nanoparticles Sustainable environment Air pollution Health

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