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Defence Technology（防务技术） 2024年第1期31卷 288-294页

作者： er-hai An Xiao-xia Li Cun-juan Yu Ying-xin Tan Zi-jun Fan Qing-xia Li Peng Deng Xiong Cao School of Environment and Safety Engin.ering North University of ChinaTaiyuan030051PR China College of Safety and Emergency Management Engin.ering Taiyuan University of Science and TechnologyTaiyuan030024PR China

Fe/n-based biomass porous carbon composite(Fe/n-p Carbon) was prepared by a facile high-temperature carbonization method from biomass,and the effect of Fe/n-p Carbon on the thermal decomposition of energetic molecular perovskite-based material DAP-4 was *** porous carbonaceous materials was considered as the micro/nano support layers for in situ deposition of Fe/n ***/np Carbon was prepared simply by the high-temperature carbonization *** was found that it showed the in.erent catalysis properties for thermal decomposition of *** heat release of DAP-4/Fe/n-p Carbon by DSC curves tested had increased slightly,compared from DAP-4/Fe/n-p *** decomposition temperature peak of DAP-4 at the presence of Fe/n-p Carbon had reduced by 79°C from384.4°C(pure DAP-4) to 305.4°C(DAP-4/Fe/n-p Carbon-3).The apparent activation energy of DAP-4thermal decomposition also had decreased by 29.1 J/*** possible catalytic decomposition mechanism of DAP-4 with Fe/n-p Carbon was proposed.

关键词： Biomass materials Porous carbon DAP-4 Thermal decomposition Facile method

Subpopulations of regulatory T cells are associated with subclinical atherosclerotic plaques,levels of LDL,and cardiorespiratory fitness in the elderly

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Journal of Sport and Health Science 2024年第3期13卷 288-296,I0002页

作者： Tim Böttrich Pascal Bauer Vincent Gröβer Magdalena Huber Hartmann Raifer Torsten Frech Svenja nolte Theresa Dombrowski Franz Cemic natascha Sommer Robert Ringseis Klaus Eder Karsten Krüger Christopher Weyh Department of Exercise Physiology and Sports Therapy Institute of Sports ScienceJustus-Liebig-UniversityGiessen 35394Germany Department of Cardiology and Angiology Justus-Liebig-University GiessenGiessen 35392Germany Institute for Systems Immunology Center for Tumor und ImmunologyMarburg 35032Germany TH Mittelhessen Department of Computer ScienceUniversity of Applied Sciences GiessenGiessen 35390Germany Department of in.ernal Medicine Universities of Giessen and Marburg Lung Center(UGMLC)Member of the German Center for Lung Research(DZL)Giessen 35394Germany Excellence Cluster Cardio-Pulmonary Institute(CPI) Justus-Liebig UniversityGiessen 35394Germany Institute of Animal nutrition and nutrition Physiology Justus-Liebig-University GiessenGiessen 35390Germany

Background:Atherosclerosis forms the pathological basis for the development of cardiovascular *** pathological processes initially develop without clinically relevant symptoms,the identification of early markers in the subclinical stage plays an important role for initiating early *** is evidence that regulatory T cells(Tregs)are involved in the development of ***,the present study aimed to identify and investigate associations with Tregs and their subsets in a cohort of healthy elderly individuals with and without subclinical atherosclerotic plaques(SAP).In addition,various lifestyle and risk factors,such as cardiorespiratory fitness,were investigated as associated ***:A cross-sectional study was performed in 79 participants(male:n=50;age=63.6±3.7 years;body mass index=24.9±3.1 kg/m2;mean±SD)who had no previous diagnosis of chronic disease and were not taking *** of the carotids to identify SAP,cardiovascular function measurement for vascular assessment and a cardiorespiratory fitness test to determine peak oxygen uptake were ***,tests were conducted to assess blood lipids and determine glucose *** of Tregs and their subtypes(resting(rTregs)and effector/memory(mTregs))was performed by 8-chanel flow *** were categorized according to atherosclerotic plaque *** and logistic regression models were used to analyze associations between ***:SAP was detected in a total of 29 *** participants with plaque were older(64.8±3.6 years vs.62.9±3.5 years)and had higher peripheral systolic blood pressure(133.8±14.7 mmHg vs.125.8±10.9 mmHg).The participants with SAP were characterized by a lower percentage of rTregs(28.8%±10.7%vs.34.6%±10.7%)and a higher percentage of mTregs(40.3%±14.7%vs.30.0%±11.9%).Multiple logistic regression identified age(odds ratio(OR)=1.20(95%confidence in.erval(95%CI):1.011.42))and

关键词： Cardiorespiratory fitness Elderly Regulatory T cells Subclinical atherosclerosis

Etiological Agent, Pathogenesis, Diagnosis, Treatment, Measures for Prevention and Control of Caseous Lymphadenitis Disease in the Small Ruminants with Special Reference to Sheep

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Journal of Biosciences and Medicines 2024年第5期12卷 154-170页

作者： eréndira de la Fuente Mancera Abel Ciprian Carrasco Susana Mendoza Elvira Facultad de Estudios Superiores Cuautitlá n Universidad Nacional Aut&#243noma de M&#233xico M&#233xico City M&#233xico

Caseous lymphadenitis (CL) is a chronic infectious disease caused by Corynebacterium pseudotuberculosis (C. pseudotuberculosis) that is transmitted mainly by contact with contaminated exudate wounds. Caseous lymphadenitis affects different species of animals and is considered an occupational zoonotic disease. CL is responsible for important economic losses in the small ruminant industry, which include decreased production, damaged quality of milk and wool, reproductive disorders, total or partial confiscation of carcasses, and depreciation of the skin. Caseous lymphadenitis disease can present in two clinical pictures: a skin or superficial picture and a visceral or deep picture. The presumptive diagnosis of CL in the skin is based on the exploration of superficial lymph nodes. These have little value in diagnosing visceral CL, where the main sign is emaciation. The prevention and control of CL involve identifying the skin condition and debriding the abscesses. In addition to the treatment of superficial lesions, the animal facilities must be repaired and adapted. To avoid exposure of negative herds to CL, new animals must be subjected to observation to identify any of the clinical manifestations. Another form of control is vaccination, though only some countries have commercial vaccines. General information on the etiological agent and its characteristics can be used to improve the understanding of this disease.

关键词： Abscess CMnR Corynebacterium pseudotuberculosis Goat CL Lymph nodes Pseudotuberculosis Sheep

SARS-CoV-2 envelope protein impairs airway epithelial barrier function and exacerbates airway inflammation via increased intracellular Cl^(-)concentration

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Signal Transduction and Targeted Therapy 2024年第4期9卷 1745-1759页

作者： Jian-Bang Xu Wei-Jie Guan Yi-Lin Zhang Zhuo-er Qiu Lei Chen Xiao-Chun Hou Junqing Yue Yu-Yun Zhou Jie Sheng Lei Zhao Yun-Xin Zhu Jing Sun Jincun Zhao Wen-Liang Zhou nan-Shan Zhong State Key Laboratory of Respiratory Disease National Clinical Research Center for Respiratory DiseaseNational Center for Respiratory MedicineDepartment of Respiratory and Critical Care MedicineGuangzhou Institute of Respiratory HealthThe First Affiliated Hospital of Guangzhou Medical UniversityGuangzhouP.R.China Department of Thoracic Surgery Guangzhou Institute for Respiratory HealthThe First Affiliated Hospital of Guangzhou Medical UniversityGuangzhouP.R.China Guangzhou national Laboratory GuangzhouP.R.China School of Life Sciences Sun Yat-sen UniversityGuangzhouP.R.China Guangdong Provincial Key Laboratory of Pharmaceutical Functional Genes School of Life SciencesSun Yat-sen UniversityGuangzhouP.R.China Department of Physiology School of Basic Medical SciencesGuangzhou Medical UniversityGuangzhouP.R.China

Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection disrupts the epithelial barrier and triggers airway *** envelope(E)protein,a core virulence structural component of coronaviruses,may play a role in this *** could in.erfere with transepithelial Cl^(-)transport via impairment of the cystic fibrosis transmembrane conductance regulator(CFTR),which modulates nuclear factor kB(nF-kB)***,the pathological effects of SARS-CoV-2 E protein on airway epithelial barrier function,Cl^(-)transport and the robust inflammatory response remain to be ***,we have demonstrated that E protein down-regulated the expression of tight junctional proteins,leading to the disruption of the airway epithelial *** addition,E protein triggered the activation of Toll-like receptor(TLR)2/4 and downstream c-Jun n-terminal kinase(JnK)signaling,resulting in an increased intracellular Cl^(-)concentration([Cl^(-)]_(i))via up-regulating phosphodiesterase 4D(PDE4D)expression in airway epithelial *** elevated[Cl^(-)]_(i);contributed to the heightened airway inflammation through promoting the phosphorylation of serum/glucocorticoid regulated kinase 1(SGK1).Moreover,blockade of SGK1 or PDE4 alleviated the robust inflammatory response induced by E ***,these findings provide novel insights into the pathogenic role of SARS-CoV-2 E protein in airway epithelial damage and the ongoing airway inflammation during SARS-CoV-2 infection.

关键词： airway inflammation elevated

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比例电磁阀内置式CDC减振器设计与验证

液压与气动 2024年第4期48卷 83-90页

作者：丁二名戴开宇蒂森克虏伯普利斯坦汽车零部件(上海)有限公司上海200122 江苏大学机械工程学院江苏镇江212013

设计了一种比例电磁阀内置式连续阻尼可调(Continuously Damping Control,CDC)减振器,分析了其主要结构组成及工作原理,并基于流体力学建立了参数化仿真模型。通过仿真和试验的方法获得了该CDC减振器的示功特性曲线和速度特性曲线,并从... 详细信息

设计了一种比例电磁阀内置式连续阻尼可调(Continuously Damping Control,CDC)减振器,分析了其主要结构组成及工作原理,并基于流体力学建立了参数化仿真模型。通过仿真和试验的方法获得了该CDC减振器的示功特性曲线和速度特性曲线,并从2组特性曲线的形态变化来分析了其阻尼特性的可调范围和调节特点。结果表明:仿真和试验结果相对误差小于10%,仿真模型准确有效;该CDC减振器的阻尼力随着激励电流的增大而减小,这种减小趋势的速率随着激励电流的增加先增大后减小;速度特性曲线的斜率在“拐点速度”之前逐渐变大,在“拐点速度”之后基本不变,且随着激励电流的增大而逐渐减小;该CDC减振器在复原行程的阻尼力可调范围为1544~4914 n,压缩行程的阻尼力可调范围为-1415~-1937.7 n。

关键词： CDC 减振器比例电磁阀阻尼特性可调范围拐点速度

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Microbial phenolic metabolites are associated with better frontal lobe cognition

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Food Science and Human Wellness 2024年

作者： Inés Domínguez-López Isabella Parilli-Moser Anna Vallverdú-Queralt Anna Tresserra-Rimbau Cinta Valls-Pedret Zenaida Vázquez-Ruiz Olga Casta?er Ramon Estruch Emili Ros Rosa M.Lamuela-Raventós Lipid Clinic Endocrinology and nutrition Service Institut d'Investigacions Biomèdiques August Pi i Sunyer Hospital Clínic 08036 Barcelona Spain Unit of Cardiovascular Risk and nutrition Institut Hospital del Mar de Investigaciones Médicas (IMIM) Department of Preventive Medicine and Public Health University of navarra Departament de nutrició Ciències de l'Alimentació i Gastronomía Facultat de Farmacia Universitat de Barcelon (UB) Av.de Joan XXII Department of Endocrinology Hospital Clinic IDIBAPS Barcelona Spain Department of in.ernal Medicine Hospital Clinic Institut d'Investigació Biomèdica August Pi i Sunyer (IDIBAPS) University of Barcelona CIBer Fisiopatología de la Obesidad y nutrición (CIBerOBn) Instituto de Salud Carlos III Institut de nutrició i Seguretat Alimentària (InSA) Universitat de Barcelona (UB)

With increasing life expectancy， neurodegenerative diseases have become one of the leading causes of ill-health in the elderly. Preventive strategies include following healthy diets， such as the Mediterranean diet， which is particularly rich in polyphenols， bioactive compounds with neuroprotective properties. The aim of this study was to assess the association of microbial phenolic metabolites (MPM) with cognition. This cross-sectional analysis was performed with 200 participants of the PREDIMED trial (Barcelona-Clinic recruitment center). A novel method based on liquid chromatography coupled to mass spectrometry was used to identify urinary MPM (protocatechuic acid， enterodiol glucuronide， enterolactone glucuronide， urolithin B glucuronide， and vanillic acid glucuronide)， and cognitive function was evaluated with neuropsychological tests. Multivariable-adjusted ordinary least squares regression was used to assess the associations between cognitive function and MPM， and a score was calculated as the weighted sum of MPM. A higher MPM score was associated with better frontal lobe function. Among individual metabolites， vanillic acid glucuronide was correlated with frontal cognitive performance. Participants with higher concentrations of vanillic acid glucuronide and urolithin B glucuronide obtained better scores in the Color Trail Test part 2. A higher score for urinary multi-MPM was associated with better frontal cognitive performance in an older Mediterranean population.

关键词：

基于EFDC模型的表面流人工湿地水力性能和净化效果影响因素分析

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农业工程学报 2024年第7期40卷 172-181页

作者：王佳儿崔远来张博超廖斌贺天忠郭健武汉大学水资源与水电工程科学国家重点实验室武汉430072 湖北省漳河工程管理局荆门448156

为探究长宽比、水深和水力负荷对表面流人工湿地水力性能和净化效果的影响及其定量关系,采用EFDC(environmental fluid dynamics Code)模型建立表面流人工湿地水动力-水质耦合模型并对模型进行率定和验证,基于构建的模型设置3因素6水平... 详细信息

为探究长宽比、水深和水力负荷对表面流人工湿地水力性能和净化效果的影响及其定量关系,采用EFDC(environmental fluid dynamics Code)模型建立表面流人工湿地水动力-水质耦合模型并对模型进行率定和验证,基于构建的模型设置3因素6水平的全因子模拟试验,通过分析216组试验结果研究湿地长宽比、水深和水力负荷及其交互作用对湿地水力性能和净化效果的影响,进而采用多元非线性回归模型将多因子影响与7个评价指标之间建立定量关系。结果表明:长宽比、水深和水力负荷之间的交互作用对水力性能和净化效果均有显著影响(P<0.05)。构建的参数与评价指标的回归模型说明水力效率、有效容积率和莫里尔离散指数与长宽比呈指数相关,总氮浓度去除率与水深呈指数相关,回归方程的建模决定系数均大于0.9,经试验数据验证的相对误差在20%以下,说明模型是可靠的。研究可为表面流人工湿地设计和运行提供依据。

关键词：磷氮湿地水力性能净化效果 EFDC模型

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丹参酮ⅡA通过调节TGF-β1/Smad2/MMPs信号通路改善卵巢摘除大鼠关节软骨退行性改变

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四川大学学报（医学版） 2024年第4期55卷 878-885页

作者：郭琴郭苑莉廖凤儿陶莹广东药科大学附属第一医院/第一临床医学院妇产科广州510080

目的探讨丹参酮ⅡA(tanshinoneⅡA, Tan)对卵巢切除(绝经后雌激素缺乏模型)大鼠骨关节退行性变的缓解作用及其机制。方法将8周龄SD雌性大鼠随机分为5组(每组10只):假手术组(Sham),卵巢切除组(OVX)及低、中和高剂量Tan组。双侧卵巢切除... 详细信息

目的探讨丹参酮ⅡA(tanshinoneⅡA, Tan)对卵巢切除(绝经后雌激素缺乏模型)大鼠骨关节退行性变的缓解作用及其机制。方法将8周龄SD雌性大鼠随机分为5组(每组10只):假手术组(Sham),卵巢切除组(OVX)及低、中和高剂量Tan组。双侧卵巢切除术8周后,分别给予大鼠5、10和20 mg/kg Tan治疗28 d。通过X射线、解剖学观察、HE染色和甲苯胺蓝染色组织学观察评估大鼠关节软骨情况。免疫组织化学检测软骨组织中转化生长因子β1(transforming growth factor β1, TGF-β1)、磷酸化的Smad2(phosphorylated-smad2, p-Smad2)、Ⅱ型胶原(typeⅡcollagen, CⅡ)、基质金属蛋白酶9 (matrix metalloproteinase 9, MMP-9)和MMP-13的表达水平。结果 X射线、解剖学观察和组织学检测结果显示,OVX组大鼠膝关节表现为关节间隙狭窄、骨赘形成、软骨侵蚀甚至局部软骨出现裂隙、软骨表面甲苯胺蓝染色变淡,软骨细胞排列紊乱、潮线不清甚至中断,Kellgren-Lawrence分级评分、Pelletier分级评分、Mankin评分和OARSI评分均较Sham组增高(Pn可剂量依赖性改善OVX导致的上述膝关节退行性变,提高Kellgren-Lawrence分级评分、Pelletier分级评分、Mankin评分和OARSI评分。免疫组化检测显示,相对于OVX组,Tan组软骨组织中TGF-β1、p-Smad2、CⅡ表达增高(Pn可减轻卵巢去势大鼠关节软骨退变,其作用可能与其调节TGF-β1/Smad2/MMPs信号通路有关。

关键词：丹参酮ⅡA 关节软骨卵巢切除大鼠

为波士顿非洲裔居民提供食品以帮助未经治疗的高血压成人终止高血压试验的基本原理和设计

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中华高血压杂志(中英文) 2024年第1期32卷 100-100页

作者： Turkson-Ocran Rn Cluett JL Fitzpatrick SL Kraemer KM Mc Manus K Mukamal KJ Davis RB Elborki M Ferro K Ismail n Laura AE Larbi KF Castilla-Ojo n Grobman B Seager R Hines AL Miller er Crews DC Juraschek SP 刘青

不健康的膳食是影响非洲裔成年人高血压差异的重要因素。终止高血压膳食疗法(dietary approaches to stop hypertension,DASH)的膳食模式可以降低血压,但食品荒漠的城市居民难以接触到DASH模式的食品,这是主要的障碍。方法:为波士顿非...

不健康的膳食是影响非洲裔成年人高血压差异的重要因素。终止高血压膳食疗法(dietary approaches to stop hypertension,DASH)的膳食模式可以降低血压,但食品荒漠的城市居民难以接触到DASH模式的食品,这是主要的障碍。方法:为波士顿非洲裔居民提供食品以帮助未经治疗的高血压成人终止高血压(Go Feshr,GF)研究是解决预防高血压的社会决定因素(addressing social determinants to prevent hypertension,RESTORE)网络的五个项目之一。

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Strong Anisotropic Order Parameters at All-nitride Ferromagnet/Superconductor in.erfaces

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Chinese Physics Letters 2024年第2期41卷 102-111页

作者： Qiao Jin Meng Yang Guozhu Song nan Zhao Shengru Chen Haitao Hong Ting Cui Dongke Rong Qianying Wang Yiyan Fan Chen Ge Can Wang Jiachang Bi Yanwei Cao Liusuo Wu Shanmin Wang Kui-Juan Jin Zhi-Gang Cheng er-Jia Guo Beijing national Laboratory for Condensed Matter Physics and Institute of PhysicsChinese Academy of SciencesBeijing 100190China Department of Physics&Center of Materials Science and Optoelectronics Engin.ering University of Chinese Academy of SciencesBeijing 100049China Department of Physics Southern University of Science and TechnologyShenzhen 518055China Songshan Lake Materials Laboratory Dongguan 523808China ningbo Institute of Materials Technology&Engin.ering Chinese Academy of SciencesNingbo 315201China

Proximity effects between superconductors and ferromagnets(SC/FM)hold paramount importance in comprehending the spin competition transpiring at their *** competition arises from the in.erplay between Cooper pairs and ferromagnetic exchange *** proximity effects between transition metal nitrides(TMns)are scarcely investigated due to the formidable challenges of fabricating high-quality SC/FM *** fabricated heterostructures comprising SC titanium nitride(Tin)and FM iron nitride(Fe_(3)n)with precise chemical compositions and atomically well-defined *** magnetoresistance of Fe_(3)n/Tin heterostructures shows a distinct magnetic anisotropy and strongly depends on the external ***,the superconducting transition temperatureT_(C) and critical field of Tin experience notable suppression when proximity to Fe_(3)*** observe the intriguing competition of in.erfacial spin orientations near𝑇T_(C)(∼1.25 K).These findings not only add a new materials system for investigating the in.erplay between superconductor and ferromagnets,but also potentially provide a building block for future research endeavors and applications in the realms of superconducting spintronic devices.

关键词： proximity Superconductor titanium