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Regenerative Biomaterials 2021年第2期8卷 94-103页

作者： Seung hee Hong Min-Ah Koo Mi hee lee Gyeung Mi Seon Ye Jin Park HaKyeong Jeong Dohyun Kim Jong-Chul Park Cellbiocontrol Laboratory Department of Medical Engineering Department of Medical Engineering Graduate School of Medical ScienceBrain Korea 21 Project Department of Medical Device Engineering and Management Yonsei UniversityCollege of MedicineSeoul 03722Republic of Korea

Reactive oxygen species(ROS)are byproducts of cellular metabolism;they play a significant role as secondary messengers in cell *** cells,high concentrations of ROS induce apoptosis,senescence,and contact inhibition,while low concentrations of ROS result in angiogenesis,proliferation,and cytoskeleton ***,controlling ROS generation is an important factor in cell *** designed a chlorin e6(Ce6)-immobilized polyethylene terephthalate(PET)film(Ce6-PET)to produce extracellular ROS under red-light *** application of Ce6-PET films can regulate the generation of ROS by altering the intensity of light-emitting diode *** confirmed that the Ce6-PET film could effectively promote cell growth under irradiation at 500 μW/cm^(2) for 30 min in human umbilical vein endothelial *** also found that the Ce6-PET film is more efficient in generating ROS than a Ce6-incorporated polyurethane film under the same ***6-PET fabrication shows promise for improving the localized delivery of extracellular ROS and regulating ROS formation through the optimization of irradiation intensity.

关键词： reactive oxygen species chlorin e6 dopamine covalent bond HUVEC proliferation

Topology optimization of reactive material structures for penetrative projectiles

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Defence Technology（防务技术） 2022年第7期18卷 1205-1218页

作者： Shinyu Kim Saekyeol Kim Taekyun Kim Sangin Choi Tae hee lee Jung Su Park Sang-Hyun Jung Department of Automotive Engineering Hanyang University222 Wangsimni-roSeongdong-guSeoul04763Republic of Korea The 4th R&D Institute Agency for Defense Development35Yuseong P.O.BoxDaejeon34186Republic of Korea

Recently,reactive materials have been developed for penetrative projectiles to improve impact resistance and energy ***,the design of a reactive material structure,involving shape and size,is challenging because of difficulties such as high non-linearity of impact resistance,manufacturing limitations of reactive materials and high expenses of penetration *** this study,a design optimization methodology for the reactive material structure is developed based on the finite element analysis.A finite element model for penetration analysis is introduced to save the expenses of the *** resistance is assessed through the analysis,and result is calibrated by comparing with experimental *** on the model,topology optimization is introduced to determine shape of the *** design variables and constraints of the optimization are proposed considering the manufacturing limitations,and the optimal shape that can be manufactured by cold spraying is *** on the optimal shape,size optimization is introduced to determine the geometric dimensions of the *** a result,optimal design of the reactive material structure and steel case of the penetrative projectile,which maximizes the impact resistance,is *** the design process proposed in this study,reactive material structures can be designed considering not only mechanical performances but also manufacturing limitations,with reasonable time and cost.

关键词： Reactive material Penetrative projectile Topology optimization Manufacturing constraint Cold gas dynamic spray Additive manufacturing

Long-term treatment outcomes of clevudine in antiviral-naive patients with chronic hepatitis B

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World Journal of Gastroenterology 2012年第47期18卷 6943-6950页

作者： Suk Bae Kim Il Han Song Young Min Kim Ran Noh Ha Yan Kang Hyang Ie lee Hyeon Yoong Yang An Na Kim hee Bok Chae Sae Hwan lee Hong Soo Kim Tae hee lee Young Woo Kang Eaum Seok lee Seok Hyun Kim Byung Seok lee Heon Young lee Department of Internal Medicine Dankook University College of MedicineCheonan 330-715South Korea Department of Internal Medicine Eulji University College of MedicineDaejeon 302-779South Korea Department of Internal Medicine Chungbuk University College of MedicineCheongju 362-711South Korea Department of Internal Medicine Soonchunhyang University College of MedicineCheonan 330-090South Korea Department of Internal Medicine Konyang University College of MedicineDaejeon 371-718South Korea Department of Internal Medicine Chungnam University College of MedicineDaejeon 301-721South Korea

AIM:To evaluate the treatment outcomes of clevudine compared with entecavir in antiviral-naive patients with chronic hepatitis B(CHB).METHODS:We retrospectively analyzed the clinical data of CHB patients treated with clevudine 30 mg/d and compared their clinical outcomes with patients treated with entecavir 0.5 mg/*** biochemical response,as assessed by serum alanine aminotransferase(ALT) activity,virologic response,as assessed by serum hepatitis B virus DNA(HBV DNA) titer,serologic response,as assessed by hepatitis B e antigen(HBeAg) status,and virologic breakthrough with genotypic mutations were ***:Two-hundred and fifty-four patients [clevudine(n = 118) vs entecavir(n = 136)] were *** clevudine-treated patients,the cumulative rates of serum ALT normalization were 83.9% at week 48 and 91.5% at week 96(80.9% and 91.2% in the entecavir group,respectively),the mean titer changes in serum HBV DNA were-6.03 and-6.55 log 10 copies/mL(-6.35 and-6.86 log 10 copies/mL,respectively,in the entecavir group),and the cumulative non-detection rates of serum HBV DNA were 72.6% and 83.1%(74.4% and 83.8%,respectively,in the entecavir group).These results were similar to those of entecavir-treated *** cumulative rates of HBeAg seroconversion were 21.8% at week 48 and 25.0% at week 96 in patients treated with clevudine,which was similar to patients treated with entecavir(22.8% and 27.7%,respectively).The virologic breakthrough in the clevudine group occurred in 9(7.6%) patients at weeks 48 and 15(12.7%) patients at week 96,which primarily corresponded to genotypic mutations of rtM204I and/or *** was no virologic breakthrough in the entecavir ***:In antiviral-naive CHB patients,longterm treatment outcomes of clevudine were not inferior to those of entecavir,except for virologic breakthrough.

关键词： Chronic hepatitis B Hepatitis B virus Clevudine Entecavir Treatment outcomes

Fermented rice bran prevents atopic dermatitis in DNCB-treated NC/Nga mice

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The Journal of Biomedical Research 2016年第4期30卷 334-343页

作者： Evelyn Saba Chun hee lee Da Hye Jeong Kija lee Tae-Hwan Kim Seong-Soo Roh Seung-Hyung Kim Man hee Rhee Department of Veterinary Medicine College of Veterinary MedicineKyungpook National UniversityDaegu 41566Korea Enzyme LAPA Co. Cheonan 31164 Korea College of Korean Medicine Daegu Haany University Daegu 42158Korea Institute of Traditional Medicine&Bioscience Daejeon University Daejeon 34520 Korea

The fermentation of natural plants has a favorable effect on the functional and biological activities of living systems. These include anti-oxidative, anti-inflammatory, and anti-platelet aggregation activities. This is attributed to the chemical conversion of the parent plants to functional constituents, which show more potent biological activity. In our study, rice bran along with oriental medicinal plants （Angelicae gigantis, Cnidium officinale, Artemisia princeps, and Camellia sinensis） was fermented by Lactobacillus rhamnosus and Pichia deserticola （FRBE）. We evaluated the effects of oral administration of FRBE on atopic dermatitis in 1-chloro-2,4-dinitrobenzene （DNCB）-treated NC/Nga mice. FRBE significantly ameliorated the macroscopic and microscopic appearance of skin lesions in DNCB-induced atopic dermatitis and reduced levels of serum immunoglobulin E and the differential white blood cell count. In addition, it reduced skin thickness compared to that of atopic dermatitis-affected skin. FRBE treatment also reduced mast cell incorporation in skin lesions of atopic dermatitis. The total cell number in dorsal skin tissue and the axillary lymph node increased following DNCB application, and this was normalized by FRBE treatment. Moreover, it decreased the levels ofCD8＋ helper T cells and Gr-1 ＋/CD1 lb＋ B cells in peripheral blood mononuclear cells and skin lesions in DNCB-induced atopic dermatitis. Using real-time polymerase chain reaction analysis, we demonstrated that FRBE significantly inhibited mRNA expression of cytokines （e.g., interleukin-5 and interleukin-13） and cyclooxygenase-2 in AD skin lesions. These results suggest that FRBE could be a valuable herbal remedy for the treatment of atopic dermatitis.

关键词： fermentation rice bran gas chromatography Lactobacillus rhamnosus Pichia deserticola

Development of a Specific CHIKV-E2 Monoclonal Antibody for Chikungunya Diagnosis

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Virologica Sinica 2019年第5期34卷 563-571页

作者： Jaemoo Kim Jihyun Yang Young Bong Kim hee-Jung lee Sehyun Kim Haryoung Poo Infectious Disease Research Center Korea Research Institute of Bioscience and BiotechnologyDaejeon 34141Republic of Korea Department of Biosystems and Bioengineering University of Science and TechnologyDaejeon 34113Republic of Korea Department of Biomedical Science and Engineering Konkuk UniversitySeoul 05029Republic of Korea Department of Bio-Industrial Technologies Konkuk UniversitySeoul 05029Republic of Korea

Chikungunya fever is a vector-borne viral disease transmitted to humans by chikungunya virus(CHIKV)-infected *** have been many outbreaks of CHIKV infection worldwide,and the virus poses ongoing risks to global *** prevent and control CHIKV infection,it is important to improve the current CHIKV diagnostic approaches to allow for the detection of low CHIKV concentrations and to correctly distinguish CHIKV infections from those due to other mosquito-transmitted viruses,including dengue virus(DENV),Japanese encephalitis virus(JEV),and Zika virus(ZIKV).Here,we produced monoclonal antibodies(mAbs)against the CHIKV envelope 2 protein(CHIKV-E2)and compared their sensitivity and specificity with commercially available mAbs using enzyme-linked immunosorbent assays(ELISA).Two anti-CHIKV-E2 mAbs,19-1 and 21-1,showed higher binding affinities to CHIKV-E2 protein than the commercial mAbs *** particular,the 19-1 mAb had the strongest binding affinity to inactivated ***,the 19-1 mAb had very little cross-reactivity with other mosquito-borne viruses,such as ZIKV,JEV,and *** results suggest that the newly produced anti-CHIKV-E2 mAb,19-1,could he used for CHIKV diagnostic approaches.

关键词： Chikungunya virus(CHIKV) Envelope 2 Monoclonal antibody Diagnosis• Sensitivity Specificity

Relationship between treatment types and blood–brain barrier disruption in patients with acute ischemic stroke:Two case reports

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World Journal of Clinical Cases 2022年第7期10卷 2351-2356页

作者： Youngbeom Seo Jonghoon Kim Min Cheol Chang Hyungkyu Huh Eun-hee lee Department of Neurosurgery College of MedicineYeungnam UniversityDaegu 42415South Korea Department of Rehabilitation Medicine College of MedicineYeungnam UniversityDaegu 42415South Korea Medical Interdisciplinary Team Medical Device Development CenterDaegu-Gyeongbuk Medical Innovation FoundationDaegu 41061South Korea

BACKGROUND Blood-brain barrier(BBB)disruption plays an important role in the development of neurological dysfunction in ischemic ***,diagnostic modalities that can clearly diagnose the degree of BBB disruption in ischemic stroke are ***,we describe two cases in which the usefulness of dynamic contrastenhanced magnetic resonance imaging(DCE-MRI)in detecting BBB disruption was evaluated after treatment of acute ischemic stroke using two different *** SUMMARY The two patients of similar age and relatively similar cerebral infarction locations were treated conservatively or with thrombectomy,although their sex was *** a result of analysis by performing DCE-MRI,it was confirmed that BBB disruption was significantly less severe in the patient who underwent thrombectomy(P=3.3×10^(-7)),whereas the average Ktrans of the contralateral hemisphere in both patients was similar(2.4×10^(-5)min^(-1) and 2.0×10^(-5)min^(-1)).If reperfusion is achieved through thrombectomy,it may indicate that the penumbra can be saved and BBB recovery can be *** Our cases suggest that BBB disruption could be important if BBB permeability is used to guide clinical treatment.

关键词： Blood-brain barrier Ischemic stroke Dynamic contrast-enhanced magnetic resonance imaging Thrombectomy Penumbra Case report

Bronchobiliary fistula after ramucirumab treatment for advanced gastric cancer: A case report

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World Journal of Clinical Cases 2019年第19期7卷 3039-3046页

作者： Hong-Beum Kim Yong Sub Na hee-Jeong lee Sang-Gon Park Department of Premedical Course Chosun University School of MedicineDong-guGwangju 501-717South Korea Department of Internal Medicine PulomonologyChosun University HospitalDong-guGwangju 501-717South Korea Department of Internal Medicine Hemato-oncologyChosun University HospitalDong-guGwangju 501-717South Korea

BACKGROUND Bronchobiliary fistula(BBF)is a rare disease characterized by an abnormal connection between the biliary system and *** causes of BBF include trauma and infections,and more recent causes include malignancies and certain cancer *** is an antivascular endothelial growth factor receptor 2 monoclonal antibody,currently used as a second-line treatment for gastric *** SUMMARY A 43-year-old man visited our hospital with the complaint of *** was diagnosed with inoperable advanced gastric cancer owing to invasion of the hepatic hilum by the *** percutaneous transhepatic biliary drainage(PTBD)and stent placement,capecitabine and oxaliplatin were administered as first-line palliative *** tumor progressed,and paclitaxel and ramucirumab were administered as second-line ***,on the first day of the second cycle,the patient suddenly developed dyspnea and *** was diagnosed on the basis of the presence of bilious sputum and the results of computed tomography,and PTBD was *** This is the first report of BBF after administration of the new antiangiogenic agent ramucirumab.

关键词： Ramucirumab Liver Bronchobiliary fistula Advanced gastric cancer Case report

Flash‑Induced High‑Throughput Porous Graphene via Synergistic Photo‑Effects for Electromagnetic Interference Shielding

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Nano-Micro Letters 2023年第11期15卷 1-18页

作者： Jin Soo lee Jeong‑Wook Kim Jae hee lee Yong Koo Son Young Bin Kim Kyoohee Woo Chanhee lee Il‑Doo Kim Jae Young Seok Jong Won Yu Jung Hwan Park Keon Jae lee Department of Materials Science and Engineering Korea Advanced Institute of Science and Technology(KAIST)291 Daehak‑roYuseong‑guDaejeon 34141Republic of Korea School of Electrical Engineering Korea Advanced Institute of Science and Technology(KAIST)291 Daehak‑roYuseong‑guDaejeon 34141Republic of Korea Department of Printed Electronics Nano‑Convergence Manufacturing Systems Research DivisionKorea Institute of Machinery and Materials(KIMM)156 Gajeongbuk‑RoYuseong‑GuDaejeon 34103Republic of Korea Department of Mechanical System Design Engineering Seoul National University of Science and Technology232 Gongneung‑roNowon‑guSeoul 01811Republic of Korea Department of Mechanical Engineering(Department of Aeronautics Mechanical and Electronic Convergence Engineering)Kumoh National Institute of Technology61 Daehak‑roGumiGyeongbuk 39177Republic of Korea

Porous 2D materials with high conductivity and large surface area have been proposed for potential electromagnetic interference(EMI)shielding materials in future mobility and wearable applications to prevent signal noise,transmission inaccuracy,system malfunction,and health ***,we report on the synthesis of lightweight and flexible flash-induced porous graphene(FPG)with excellent EMI shielding *** broad spectrum of pulsed flashlight induces photo-chemical and photo-thermal reactions in polyimide films,forming 5×10 cm^(2)-size porous graphene with a hollow pillar structure in a few *** resulting material demonstrated low density(0.0354 g cm^(−3))and outstanding absolute EMI shielding effectiveness of 1.12×10^(5) dB cm^(2) g^(−1).The FPG was characterized via thorough material analyses,and its mechanical durability and flexibility were confirmed by a bending cycle ***,the FPG was utilized in drone and wearable applications,showing effective EMI shielding performance for internal/external EMI in a drone radar system and reducing the specific absorption rate in the human body.

关键词： Porous graphene Flash lamp Photo-pyrolysis High-throughput Electromagnetic interference shielding

Non-secretory multiple myeloma expressed as multiple extramedullary plasmacytoma with an endobronchial lesion mimicking metastatic cancer:A case report

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World Journal of Clinical Cases 2022年第22期10卷 7899-7905页

作者： Seul Bi lee Chi Young Park hee Jeong lee Ran Hong Woo Shin Kim Sang-Gon Park Department of Hemato-oncology Chosun University HospitalGwangju 501-717South Korea Department of Pathology Chosun University HospitalGwangju 501-717South Korea Department of Laboratory Medicine Chosun University HospitalGwangju 501-717South Korea

BACKGROUND Non-secretory multiple myeloma(MM)is a rare condition that accounts for only 3%of MM cases and is defined by normal serum and urine immunofixation and a normal serum free light chain ***-secretory MM with multiple extramedullary plasmacytomas derived from endobronchial lesions is extremely rare and can be misdiagnosed as metastasis of solid *** SUMMARY A 36-year-old man presented with progressive facial swelling and nasal congestion with *** imaging studies revealed an endobronchial mass in the left bronchus and a large left maxillary mass with multiple destructive bone metastatic *** initially presented with lung cancer and multiple ***,pathologic reports showed multiple extramedullary plasmacytomas in the left maxilla and the left *** was no change in the serum and urine monoclonal protein levels,and no abnormalities were observed in laboratory examinations,including hemoglobin,calcium,and creatinine *** bone marrow was hypercellular,with 13.49%plasma *** patient was diagnosed with non-secretory MM expressed as multiple extramedullary plasmacytomas with endobronchial lesions in a rare *** therapy for symptomatic lesions with high-dose dexamethasone was started,and the size of the left maxillary sinus lesion dramatically *** the future,chemotherapy will be administered to control lesions in other *** We present a rare case of non-secretory MM with multiple extramedullary plasmacytoma with an endobronchial lesion.

关键词： Maxillary mass lesion Destructive bone metastatic lesion Multiple extramedullary plasmacytoma Endobronchial lesion Non-secretory multiple myeloma Case report

Anti-inflammatory effects of traditional mixed extract of medicinal herbs(MEMH)on monosodium urate crystal-induced gouty arthritis

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Chinese Journal of Natural Medicines 2017年第8期15卷 561-575页

作者： Ju-Suk Nam Supriya Jagga Ashish Ranjan Sharma Joon-hee lee Jong Bong Park Jun-Sub Jung Sang-Soo lee Institute For Skeletal Aging&Orthopedic Surgery Hallym University-Chuncheon Sacred Heart HospitalChuncheonGangwon-do24252Republic of Korea Institute of Natural Medicine College of MedicineHallym UniversityChucheonGangwon-do 24252Republic of Korea Hana Oriental Clinic ChucnheonGangwon-do 24433Republic of Korea

Korean oriental medicine prescription is widely used for the treatment of gouty diseases. In the present study, we investigated anti-inflammatory effects of modified Korean herbal formulation, mixed extract of medicinal herbs(MEMH), and its modulatory effects on inflammatory mediators associated with gouty arthritis. Both in vitro and in vivo studies were carried out to assess the anti-inflammatory efficacy of MEMH on monosodium urate(MSU) crystals-induced gouty inflammation. MSU crystals stimulated human chondrosarcoma cell line, SW1353, and human primary chondrocytes were treated with MEMH in vitro. The expression levels of pro-inflammatory mediators and metalloproteases were analyzed. The effect of MEMH on NFκB signaling pathway in SW1353 cells was examined. Effect of MEMH on the mR NA expression level of pro-inflammatory mediators and chemotactic factor from human monocytic cell line, THP-1, was also analyzed. The probable role of MEMH in the differentiation process of osteoblast like cells, SaO S-2, after MSU treatment was also observed. To investigate the effects of MEMH in vivo, MSU crystals-induced ankle arthritic model was established. Histopathological changes in affected joints and plasma levels of pro-inflammatory mediators(IL-1β and TNFα) were recorded. MEMH inhibited NFκB signaling pathway and COX-2 protein expression in chondrocytes. MSU-induced mR NA expressions of pro-inflammatory mediators and chemotactic cytokines were suppressed by MEMH. In MSU crystals-induced ankle arthritic mouse model, administration of MEMH relieved inflammatory symptoms and decreased the plasma levels of IL-1β and TNFα. The results indicated that MEMH can effectively inhibit the expression of inflammatory mediators in gouty arthritis, demonstrating its potential for treating gouty arthritis.

关键词： Gout Monosodium urate crystals Inflammation Chondrocyte Oriental medicine