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Long-term treatment outcomes of clevudine in antiviral-naive patients with chronic hepatitis B

World Journal of Gastroenterology 2012年第47期18卷 6943-6950页

作者： Suk Bae Kim Il Han Song Young Min Kim Ran Noh Ha Yan Kang Hyang Ie lee Hyeon Yoong Yang An Na Kim hee Bok Chae Sae Hwan lee Hong Soo Kim Tae hee lee Young Woo Kang Eaum Seok lee Seok Hyun Kim Byung Seok lee Heon Young lee Department of Internal Medicine Dankook University College of MedicineCheonan 330-715South Korea Department of Internal Medicine Eulji University College of MedicineDaejeon 302-779South Korea Department of Internal Medicine Chungbuk University College of MedicineCheongju 362-711South Korea Department of Internal Medicine Soonchunhyang University College of MedicineCheonan 330-090South Korea Department of Internal Medicine Konyang University College of MedicineDaejeon 371-718South Korea Department of Internal Medicine Chungnam University College of MedicineDaejeon 301-721South Korea

AIM:To evaluate the treatment outcomes of clevudine compared with entecavir in antiviral-naive patients with chronic hepatitis B(CHB).METHODS:We retrospectively analyzed the clinical data of CHB patients treated with clevudine 30 mg/d and compared their clinical outcomes with patients treated with entecavir 0.5 mg/*** biochemical response,as assessed by serum alanine aminotransferase(ALT) activity,virologic response,as assessed by serum hepatitis B virus DNA(HBV DNA) titer,serologic response,as assessed by hepatitis B e antigen(HBeAg) status,and virologic breakthrough with genotypic mutations were ***:Two-hundred and fifty-four patients [clevudine(n = 118) vs entecavir(n = 136)] were *** clevudine-treated patients,the cumulative rates of serum ALT normalization were 83.9% at week 48 and 91.5% at week 96(80.9% and 91.2% in the entecavir group,respectively),the mean titer changes in serum HBV DNA were-6.03 and-6.55 log 10 copies/mL(-6.35 and-6.86 log 10 copies/mL,respectively,in the entecavir group),and the cumulative non-detection rates of serum HBV DNA were 72.6% and 83.1%(74.4% and 83.8%,respectively,in the entecavir group).These results were similar to those of entecavir-treated *** cumulative rates of HBeAg seroconversion were 21.8% at week 48 and 25.0% at week 96 in patients treated with clevudine,which was similar to patients treated with entecavir(22.8% and 27.7%,respectively).The virologic breakthrough in the clevudine group occurred in 9(7.6%) patients at weeks 48 and 15(12.7%) patients at week 96,which primarily corresponded to genotypic mutations of rtM204I and/or *** was no virologic breakthrough in the entecavir ***:In antiviral-naive CHB patients,longterm treatment outcomes of clevudine were not inferior to those of entecavir,except for virologic breakthrough.

关键词：慢性乙型肝炎治疗效果抗病毒患者克拉血清学反应病毒DNA HBeAg

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WNT5A drives interleukin-6-dependent epithelial-mesenchymal transition via the JAK/STAT pathway in keloid pathogenesis

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Burns & Trauma 2022年第1期10卷 200-215页

作者： Young In lee Jung Eun Shim Jihee Kim Won Jai lee Jae Woo Kim Kee Hyun Nam Ju hee lee Department of Dermatology Severance HospitalCutaneous Biology Research InstituteYonsei University College of MedicineSeoul 03722Korea Bioinformatics Collaboration Unit Yonsei University College of MedicineSeoul 03722Korea Department of Plastic and Reconstructive Surgery Severance HospitalYonsei University College of MedicineSeoul 03722Korea Scar Laser and Plastic Surgery Center Yonsei Cancer HospitalYonsei University College of MedicineSeoul 03722Korea Department of Biochemistry and Molecular Biology Chronic Intractable Disease for Systems Medicine Research CenterYonsei University College of MedicineSeoul 03722Korea Department of Surgery Severance HospitalYonsei University College of MedicineSeoulKorea

Background:Keloid scarring is a fibroproliferative disease caused by aberrant genetic activation with an unclear underlying *** predisposition,aberrant cellular responses to environmental factors,increased inflammatory cytokines and epithelial-mesenchymal transition(EMT)phenomena are known as major *** this study,we aimed to identify the molecular drivers that initiate keloid ***:Bulk tissue RNA sequencing analyses of keloid and normal tissues along with ex vivo and in vitro tests were performed to identify the contributing genes to keloid *** animal model of inflammatory keloid scarring was reproduced by replication of a skin fibrosis model with intradermal bleomycin injection in C57BL/6 ***:Gene set enrichment analysis revealed upregulation of Wnt family member 5A(WNT5A)expression and genes associated with EMT in keloid ***,human keloid tissues and the bleomycin-induced skin fibrosis animal model showed significantly increased expression ofWNT5A and EMT *** activation of the interleukin(IL)-6/Janus kinase(JAK)/signal transducer and activator of transcription(STAT)pathway and subsequent elevation of EMT markerswas also observed in keratinocytes co-cultured withWNT5A-activated fibroblasts or keloid ***,WNT5A silencing and the blockage of IL-6 secretion via neutralizing IL-6 antibody reversed hyperactivation of the STAT pathway and EMT markers in ***,STAT3 silencing significantly reduced the EMT-like phenotypes in both keratinocytes and IL-6-stimulated ***:Intercellular communication via the WNT5A and STAT pathways possibly underlies a partial mechanism of EMT-like phenomena in keloid ***-6 secreted from WNT5A-activated fibroblasts or keloid fibroblasts activates the JAK/STAT signaling pathway in adjacent keratinocytes which in turn express EMT markers.A better understanding of keloid development and the

关键词： Keloid Wnt family member 5A Interleukin-6 JAK/STAT pathway Epithelial-mesenchymal transition Scar Epithelial mesenchymal transition

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Development of a Specific CHIKV-E2 Monoclonal Antibody for Chikungunya Diagnosis

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Virologica Sinica 2019年第5期34卷 563-571页

作者： Jaemoo Kim Jihyun Yang Young Bong Kim hee-Jung lee Sehyun Kim Haryoung Poo Infectious Disease Research Center Korea Research Institute of Bioscience and BiotechnologyDaejeon 34141Republic of Korea Department of Biosystems and Bioengineering University of Science and TechnologyDaejeon 34113Republic of Korea Department of Biomedical Science and Engineering Konkuk UniversitySeoul 05029Republic of Korea Department of Bio-Industrial Technologies Konkuk UniversitySeoul 05029Republic of Korea

Chikungunya fever is a vector-borne viral disease transmitted to humans by chikungunya virus(CHIKV)-infected *** have been many outbreaks of CHIKV infection worldwide,and the virus poses ongoing risks to global *** prevent and control CHIKV infection,it is important to improve the current CHIKV diagnostic approaches to allow for the detection of low CHIKV concentrations and to correctly distinguish CHIKV infections from those due to other mosquito-transmitted viruses,including dengue virus(DENV),Japanese encephalitis virus(JEV),and Zika virus(ZIKV).Here,we produced monoclonal antibodies(mAbs)against the CHIKV envelope 2 protein(CHIKV-E2)and compared their sensitivity and specificity with commercially available mAbs using enzyme-linked immunosorbent assays(ELISA).Two anti-CHIKV-E2 mAbs,19-1 and 21-1,showed higher binding affinities to CHIKV-E2 protein than the commercial mAbs *** particular,the 19-1 mAb had the strongest binding affinity to inactivated ***,the 19-1 mAb had very little cross-reactivity with other mosquito-borne viruses,such as ZIKV,JEV,and *** results suggest that the newly produced anti-CHIKV-E2 mAb,19-1,could he used for CHIKV diagnostic approaches.

关键词： Chikungunya virus(CHIKV) Envelope 2 Monoclonal antibody Diagnosis• Sensitivity Specificity

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Fermented rice bran prevents atopic dermatitis in DNCB-treated NC/Nga mice

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The Journal of Biomedical Research 2016年第4期30卷 334-343页

作者： Evelyn Saba Chun hee lee Da Hye Jeong Kija lee Tae-Hwan Kim Seong-Soo Roh Seung-Hyung Kim Man hee Rhee Department of Veterinary Medicine College of Veterinary MedicineKyungpook National UniversityDaegu 41566Korea Enzyme LAPA Co. Cheonan 31164 Korea College of Korean Medicine Daegu Haany University Daegu 42158Korea Institute of Traditional Medicine&Bioscience Daejeon University Daejeon 34520 Korea

The fermentation of natural plants has a favorable effect on the functional and biological activities of living systems. These include anti-oxidative, anti-inflammatory, and anti-platelet aggregation activities. This is attributed to the chemical conversion of the parent plants to functional constituents, which show more potent biological activity. In our study, rice bran along with oriental medicinal plants （Angelicae gigantis, Cnidium officinale, Artemisia princeps, and Camellia sinensis） was fermented by Lactobacillus rhamnosus and Pichia deserticola （FRBE）. We evaluated the effects of oral administration of FRBE on atopic dermatitis in 1-chloro-2,4-dinitrobenzene （DNCB）-treated NC/Nga mice. FRBE significantly ameliorated the macroscopic and microscopic appearance of skin lesions in DNCB-induced atopic dermatitis and reduced levels of serum immunoglobulin E and the differential white blood cell count. In addition, it reduced skin thickness compared to that of atopic dermatitis-affected skin. FRBE treatment also reduced mast cell incorporation in skin lesions of atopic dermatitis. The total cell number in dorsal skin tissue and the axillary lymph node increased following DNCB application, and this was normalized by FRBE treatment. Moreover, it decreased the levels ofCD8＋ helper T cells and Gr-1 ＋/CD1 lb＋ B cells in peripheral blood mononuclear cells and skin lesions in DNCB-induced atopic dermatitis. Using real-time polymerase chain reaction analysis, we demonstrated that FRBE significantly inhibited mRNA expression of cytokines （e.g., interleukin-5 and interleukin-13） and cyclooxygenase-2 in AD skin lesions. These results suggest that FRBE could be a valuable herbal remedy for the treatment of atopic dermatitis.

关键词： fermentation rice bran gas chromatography Lactobacillus rhamnosus Pichia deserticola

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Bronchobiliary fistula after ramucirumab treatment for advanced gastric cancer: A case report

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World Journal of Clinical Cases 2019年第19期7卷 3039-3046页

作者： Hong-Beum Kim Yong Sub Na hee-Jeong lee Sang-Gon Park Department of Premedical Course Chosun University School of MedicineDong-guGwangju 501-717South Korea Department of Internal Medicine PulomonologyChosun University HospitalDong-guGwangju 501-717South Korea Department of Internal Medicine Hemato-oncologyChosun University HospitalDong-guGwangju 501-717South Korea

BACKGROUND Bronchobiliary fistula(BBF)is a rare disease characterized by an abnormal connection between the biliary system and *** causes of BBF include trauma and infections,and more recent causes include malignancies and certain cancer *** is an antivascular endothelial growth factor receptor 2 monoclonal antibody,currently used as a second-line treatment for gastric *** SUMMARY A 43-year-old man visited our hospital with the complaint of *** was diagnosed with inoperable advanced gastric cancer owing to invasion of the hepatic hilum by the *** percutaneous transhepatic biliary drainage(PTBD)and stent placement,capecitabine and oxaliplatin were administered as first-line palliative *** tumor progressed,and paclitaxel and ramucirumab were administered as second-line ***,on the first day of the second cycle,the patient suddenly developed dyspnea and *** was diagnosed on the basis of the presence of bilious sputum and the results of computed tomography,and PTBD was *** This is the first report of BBF after administration of the new antiangiogenic agent ramucirumab.

关键词： Ramucirumab Liver Bronchobiliary fistula Advanced gastric cancer Case report

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Anti-inflammatory effects of traditional mixed extract of medicinal herbs(MEMH)on monosodium urate crystal-induced gouty arthritis

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Chinese Journal of Natural Medicines 2017年第8期15卷 561-575页

作者： Ju-Suk Nam Supriya Jagga Ashish Ranjan Sharma Joon-hee lee Jong Bong Park Jun-Sub Jung Sang-Soo lee Institute For Skeletal Aging&Orthopedic Surgery Hallym University-Chuncheon Sacred Heart HospitalChuncheonGangwon-do24252Republic of Korea Institute of Natural Medicine College of MedicineHallym UniversityChucheonGangwon-do 24252Republic of Korea Hana Oriental Clinic ChucnheonGangwon-do 24433Republic of Korea

Korean oriental medicine prescription is widely used for the treatment of gouty diseases. In the present study, we investigated anti-inflammatory effects of modified Korean herbal formulation, mixed extract of medicinal herbs(MEMH), and its modulatory effects on inflammatory mediators associated with gouty arthritis. Both in vitro and in vivo studies were carried out to assess the anti-inflammatory efficacy of MEMH on monosodium urate(MSU) crystals-induced gouty inflammation. MSU crystals stimulated human chondrosarcoma cell line, SW1353, and human primary chondrocytes were treated with MEMH in vitro. The expression levels of pro-inflammatory mediators and metalloproteases were analyzed. The effect of MEMH on NFκB signaling pathway in SW1353 cells was examined. Effect of MEMH on the mR NA expression level of pro-inflammatory mediators and chemotactic factor from human monocytic cell line, THP-1, was also analyzed. The probable role of MEMH in the differentiation process of osteoblast like cells, SaO S-2, after MSU treatment was also observed. To investigate the effects of MEMH in vivo, MSU crystals-induced ankle arthritic model was established. Histopathological changes in affected joints and plasma levels of pro-inflammatory mediators(IL-1β and TNFα) were recorded. MEMH inhibited NFκB signaling pathway and COX-2 protein expression in chondrocytes. MSU-induced mR NA expressions of pro-inflammatory mediators and chemotactic cytokines were suppressed by MEMH. In MSU crystals-induced ankle arthritic mouse model, administration of MEMH relieved inflammatory symptoms and decreased the plasma levels of IL-1β and TNFα. The results indicated that MEMH can effectively inhibit the expression of inflammatory mediators in gouty arthritis, demonstrating its potential for treating gouty arthritis.

关键词： Gout Monosodium urate crystals Inflammation Chondrocyte Oriental medicine

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Handheld endomicroscope using a fiber-optic harmonograph enables real-time and in vivo confocal imaging of living cell morphology and capillary perfusion

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Microsystems & Nanoengineering 2020年第1期6卷 449-459页

作者： Kyungmin Hwang Yeong-Hyeon Seo Daniel YKim Jinhyo Ahn Soyoung lee Kyung hee Han Koun-hee lee Sangyong Jon Pilhan Kim Kate EYu Hyungsin Kim Shin-Hyuk Kang Ki-Hun Jeong Department of Bio and Brain Engineering KAIST and KAIST Institute of Health Science and TechnologyDaejeon 34141Republic of Korea Graduate School of Nanoscience and Technology KAIST and KAIST Institute of Health Science and TechnologyDaejeon 34141Republic of Korea Department of Biological Sciences KAIST and KAIST Institute for the BioCenturyDaejeon 34141Republic of Korea Hyunjoo In-Tech Seoul 08390Republic of Korea VPIX Medical IncDeajeon 34141Republic of Korea Graduate School of Medical Science and Engineering Daejeon 34141Republic of Korea Department of Neurosurgery Korea University Anam HospitalKorea University MedicineSeoul 02842Korea

Confocal laser endomicroscopy provides high potential for noninvasive and in vivo optical biopsy at the cellular ***,we report a fully packaged handheld confocal endomicroscopic system for real-time,high-resolution,and in vivo cellular imaging using a Lissajous scanning fiber-optic *** endomicroscopic system features an endomicroscopic probe with a fiber-optic harmonograph,a confocal microscope unit,and an image signal *** fiber-optic harmonograph contains a single mode fiber coupled with a quadrupole piezoelectric tube,which resonantly scans both axes at~1 kHz to obtain a Lissajous *** fiber-optic harmonograph was fully packaged into an endomicroscopic probe with an objective *** endomicroscopic probe was hygienically packaged for waterproofing and disinfection of medical instruments within a 2.6-mm outer diameter stainless tube capable of being inserted through the working channel of a clinical *** probe was further combined with the confocal microscope unit for indocyanine green imaging and the image signal processor for high frame rate and high density Lissajous *** signal processing unit delivers driving signals for probe actuation and reconstructs confocal images using the auto phase matching process of Lissajous fiber *** confocal endomicroscopic system was used to successfully obtain human in vitro fluorescent images and real-time ex vivo and in vivo fluorescent images of the living cell morphology and capillary perfusion inside a single mouse.

关键词： fiber processor confocal

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Surface-modified Ag@Ru-P25 for photocatalytic CO_(2) conversion with high selectivity over CH_(4) formation at the solid–gas interface

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Carbon Energy 2024年第1期6卷 182-196页

作者： Chaitanya B.Hiragond Sohag Biswas Niket SPowar Junho lee Eunhee Gong Hwapyong Kim Hong Soo Kim Jin-Woo Jung Chang-hee Cho Bryan M.Wong Su-Il In Department of Energy Science&Engineering Daegu Gyeongbuk Institute of Science and Technology(DGIST)DaeguRepublic of Korea Department of Chemical&Environmental Engineering Materials Science&Engineering ProgramDepartment of ChemistryDepartment of Physics&AstronomyUniversity of California-RiversideRiversideCaliforniaUSA Department of Physics and Chemistry Daegu Gyeongbuk Institute of Science and Technology(DGIST)DaeguRepublic of Korea NiceScience Corporation DaeguRepublic of Korea

Systematic optimization of the photocatalyst and investigation of the role of each component is important to maximizing catalytic activity and comprehending the photocatalytic conversion of CO_(2) reduction to solar fuels.A surface-modified Ag@Ru-P25 photocatalyst with H_(2)O_(2) treatment was designed in this study to convert CO_(2) and H_(2)O vapor into highly selective *** doping followed by Ag nanoparticles(NPs)cocatalyst deposition on P25(TiO_(2))enhances visible light absorption and charge separation,whereas H_(2)O_(2) treatment modifies the surface of the photocatalyst with hydroxyl(–OH)groups and promotes CO_(2) ***-resonance transmission electron microscopy,X-ray photoelectron spectroscopy,X-ray absorption near-edge structure,and extended X-ray absorption fine structure techniques were used to analyze the surface and chemical composition of the photocatalyst,while thermogravimetric analysis,CO_(2) adsorption isotherm,and temperature programmed desorption study were performed to examine the significance of H_(2)O_(2) treatment in increasing CO_(2) reduction *** optimized Ag1.0@Ru1.0-P25 photocatalyst performed excellent CO_(2) reduction activity into CO,CH4,and C2H6 with a~95%selectivity of CH4,where the activity was~135 times higher than that of pristine TiO_(2)(P25).For the first time,this work explored the effect of H_(2)O_(2) treatment on the photocatalyst that dramatically increases CO_(2) reduction activity.

关键词： gas-phase CO_(2) reduction H_(2)O_(2) treatment plasmonic nanoparticles solar fuel photocatalyst surface modification

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Impact of statin usage patterns on outcomes after percutaneous coronary in-tervention in acute myocardial infarction：Korea Working Group on Myocar-dial Infarction registry （KorMI） study

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Journal of Geriatric Cardiology 2014年第2期11卷 93-99页

作者： Chan-hee lee Sang-hee lee Jong-Seon Park Young-Jo Kim Kee-Sik Kim Shung-Chull Chae Hyo-Soo Kim Dong-Ju Choi Myeong-Chan Cho Seung-Woon Rha Myung-Ho Jeong Department of Cardiology Yeungnam University Hospital 170 Hyeonchung-ro Nam-gu Daegu 705-717 South Korea Department of Internal Medicine Daegu Catholic University Hospital 33 Duryugongwon-ro 17-gil Nam-gu Daegu 705-718 South Korea Department of Internal Medicine Kyungpook National University Hospital 130 Dongdeok-ro Jung-gu Daegu 700-721 South Korea Department of Internal Medicine Seoul National University Hospital 101 Daehak-ro Jongno-gu Seoul 110-744 South Korea Department of Internal Medicine Seoul National University Bundang Hospital 82 Gumi-ro 173-gil Bundang-gu Seongnam 463-707 South Korea Department of Internal Medicine Chungbuk National University Hospital 776 1sunhwan-ro Heungdeok-gu Cheongju 361-711 South Korea Department of Internal Medicine Korea University Guro Hospital 148 Gurodong-ro Guro-gu Seoul 152-703 South Korea Department of Internal Medicine Chonnam National University Hospital 42 Jebong-ro Dong-gu Gwangju 501-757 South Korea

在心肌的梗塞(STEMI ) 是的尖锐圣片断举起以后的 statin 使用的 BackgroundThe 利益然而，很好证实预定 statin 管理的影响没被阐明。这研究的目的在经皮的冠的干预(一种总线标准) 以后集中了于早临床的结果学习包括了的心肌的梗塞登记... 详细信息

在心肌的梗塞(STEMI ) 是的尖锐圣片断举起以后的 statin 使用的 BackgroundThe 利益然而，很好证实预定 statin 管理的影响没被阐明。这研究的目的在经皮的冠的干预(一种总线标准) 以后集中了于早临床的结果学习包括了的心肌的梗塞登记(KorMI ) 上的朝鲜工作组的 .MethodsThis 分析 3,584 个 STEMI 病人(吝啬的年龄， 63 ±；13 年；男性， 2,684， 74.9%) 从 2008 年 1 月经历一种总线标准到 2009 年 6 月。主要不利心脏的事件的率(向：所有原因死亡，周期性的 MI，和目标损害 revascularization ) 在根据 statin 治疗预定组织的病人之中被比较：我，在期间并且在住院以后(n = 2,653， 74%) ；II，仅仅在住院期间(n = 309， 8.6%) ；III，仅仅在分泌物以后(n = 157， 4.4%) ；并且 IV，没有 statin 治疗(n = 465， 13%) 。吝啬的后续持续时间是 234 ±；statin 的 113 个 *** 因素在住院期间使用包括的优先的 statin 使用，多重 diseased 容器，在心肌的梗塞流动等级 III 的最后的 thrombolysis，和低密度的脂蛋白胆固醇水平。在 6 月的后续，组 III 和 IV 有最高的向率(2.3% ， 3.9% ， 5.1% ，和 4.9% 为组 I-IV，分别地 P = 0.004 ) 。在为 confounders 调整以后，组 II-IV 比组有更高的向风险我[危险比率(HR ) ：3.20， 95% 信心间隔(95%CI ) ：1.31-7.86， P = 0.011；HR：3.84， 95%CI：1.47-10.02， P = 0.006；并且 HR：3.17， 95%CI：1.59-6.40， P = 0.001；分别地] 基于国家注册表数据库， .ConclusionsThis 学习早显示出早、连续的 statin 治疗 improvs 在在真实世界的临床的实践的一种总线标准以后的 STEMI 病人的结果。

关键词：急性心肌梗死他汀类药物冠状动脉注册表韩国拨号 MACE 低密度脂蛋白

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Evaluation of Unified Model Microphysics in High-resolution NWP Simulations Using Polarimetric Radar Observations

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Advances in Atmospheric Sciences 2018年第7期35卷 771-784页

作者： Marcus JOHNSON Youngsun JUNG Daniel DAWSON Timothy SUPINIE Ming XUE Jongsook PARK Yong-hee lee Center for Analysis and Prediction of Storms (CAPS) University of Oklahoma Norman OK 73072 USA School of Meteorology University of Oklahoma Norman OK 73072 USA Purdue University West Lafayette IN 47907 USA Korea Meteorological Administration Seoul 07062 Korea

The UK Met Office Unified Model（UM） is employed by many weather forecasting agencies around the globe. This model is designed to run across spatial and time scales and known to produce skillful predictions for large-scale weather systems. However, the model has only recently begun running operationally at horizontal grid spacings of ～1.5 km [e.g.,at the UK Met Office and the Korea Meteorological Administration（KMA）]. As its microphysics scheme was originally designed and tuned for large-scale precipitation systems, we investigate the performance of UM microphysics to determine potential inherent biases or weaknesses. Two rainfall cases from the KMA forecasting system are considered in this study： a Changma（quasi-stationary） front, and Typhoon Sanba（2012）. The UM output is compared to polarimetric radar observations in terms of simulated polarimetric radar variables. Results show that the UM generally underpredicts median reflectivity in stratiform rain, producing high reflectivity cores and precipitation gaps between them. This is partially due to the diagnostic rain intercept parameter formulation used in the one-moment microphysics scheme. Model drop size is generally both underand overpredicted compared to observations. UM frozen hydrometeors favor generic ice（crystals and snow） rather than graupel, which is reasonable for Changma and typhoon cases. The model performed best with the typhoon case in terms of simulated precipitation coverage.

关键词： Unified Model microphysics polarimetric radar radar simulator numerical weather prediction

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