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Random lasing detection of structural transformation and compositions in silk fibroin scaffolds

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Nano Research 2019年第2期12卷 289-297页

作者： SungYeun Yang Soocheol Kim Hyeln shin Seung Ho Choi Young L. Kim Chulmin Joo WonHyoung Ryu Department of Mechanical Engineering Yonsei University Yonsei-ro 50 Seodaemun-gu Seoul 03722 Republic of Korea Weldon School of Biomedical Engineering Purdue University West Lafayette Indiana 47907 USA Present address: Center of Bio Microsystems Korea Institute of Science and Technology (KIST) Hwarang-ro Seongbuk-gu Seoul 02792 Republic of Korea School of Electrical Engineering University of Ulsan Daehak-ro Nam-gu Ulsan 44610 Republic of Korea

In tissue engineering, microstructure and material composition of tissue scaffolds have major influences on the proliferation and differentiation of cells in the scaffolds. However, once tissue scaffolds implanted, it is extremely difficult to monitor the change of their microstructure and compositions during tissue regeneration. Here, we report how random lasing can be utilized to non-invasively monitor the structure and composition of scaffolds. We hypothesize that morphological and compositional change of silk fibroin (SF) scaffolds can be conveniently detected based on random lasing responses. Engineered SF scaffolds with hydroxyapatite (HAP) nanoparticles and controlled pore alignment were fabricated, and their random lasing responses were analyzed depending on the concentration of HAP nanoparticles and the degree of,:internal pore alignment. We also examined the real-time random lasing responses of porous SF scaffolds by applying a compressive force to' the scaffolds. Introduction of HAP nanoparticles lowered the lasing thresholds and narrowed the random lasing (RL) width dramatically, which :is likely due to the increase in heterogeneity in both refractive index and physical arrangement within the SF and HAP composites. The strong dependency of RL response on pore alignment was also measured and validated by numerical calculation with the finite element method (FEM).Finally, real-time monitoring of RL on compressed scaffolds demonstrated the possibility of using RL as a monitoring tool for structural change of SF scaffolds in vivo.

关键词： random lasing silk fibroin porous scaffolds aligned pore structure electrospinning hydroxyapatite

Effect of Temperature on Structural and Magnetic Properties of Laser Ablated Iron Oxide Deposited on Si（100）

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Chinese Physics Letters 2009年第11期26卷 211-214页

作者： Shahid M. Ramay Saadat A. Siddiqi M. Sabieh Anwar S. C. shin Centre for Solid State Physics University of Punjab Lahore-54590 Pakistan School of Science and Engineering Lahore University of Management Sciences (LUMS) Opposite Sector U D.H.A Lahore 54972 Pakistan Department of Physics KAIST 373-1 Guseong-dong Yuseong-gu Daejeon 305-701 Republic of Korea

We fabricate Fe3O4 thin films on Si（100） substrates at different temperatures using pulsed laser deposition, and study the effect of annealing and deposition temperature on the structural and magnetic properties of Fe3O4 thin films. Subsequently, the films are characterized by x-ray diffraction （XRD）, scanning electron microscopy （SEM） and vibrating sample magnetometery （VSM）. The XRD results of these films confirm the presence of the Fe3O4 phase and show room-temperature ferromagnetism, as observed with VSM. We demonstrate the optimized deposition and annealing conditions for an enhanced magnetization of 854 emu/cm3 that is very high when compared to the bulk sample.

关键词： Condensed matter: electrical magnetic and optical Surfaces interfaces and thin films Condensed matter: structural mechanical & thermal

Bulk-Si photonics technology for DRAM interface[Invited]

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Photonics Research 2014年第3期2卷 S0025-S0033页

作者： Hyunil Byun Jinkwon Bok Kwansik Cho Keunyeong Cho Hanmei Choi Jinyong Choi Sanghun Choi Sangdeuk Han Seokyong Hong Seokhun Hyun TJJeong Ho-Chul Ji In-Sung Joe Beomseok Kim Donghyun Kim Junghye Kim Jeong-Kyoum Kim Kiho Kim Seong-gu Kim Duanhua Kong Bongjin Kuh Hyuckjoon Kwon Beomsuk Lee Hocheol Lee Kwanghyun Lee shinyoung Lee Kyoungwon Na Jeongsik Nam Amir Nejadmalayeri Yongsang Park Sunil Parmar Junghyung Pyo Dongjae shin Joonghan shin Yong-hwack shin Sung-Dong Suh Honggoo Yoon Yoondong Park Junghwan Choi Kyoung-Ho Ha Gitae Jeong Samsung Electronics 1 SamsungjeonjaroHwasungshiGyoung-gido445-330South Korea

We present photonics technology based on a bulk-Si substrate for cost-sensitive dynamic random-access memory(DRAM)optical interface *** summarize the progress on passive and active photonic devices using a local-crystallized Si waveguide fabricated by solid phase epitaxy or laser-induced epitaxial growth on bulk-Si *** process of integration of a photonic integrated circuit(IC)with an electronic IC is demonstrated using a 65 nm DRAM periphery process on 300 mm wafers to prove the possibility of seamless integration with various complementary metal-oxide-semiconductor *** the bulk-Si photonic devices,we show the feasibility of high-speed multidrop interface:the Mach–Zehnder interferometer modulators and commercial photodetectors are used to demonstrate four-drop link operation at 10 Gb∕s,and the transceiver chips with photonic die and electronic die work for the DDR3 DRAM interface at 1.6 Gb∕s under a 1∶4 multidrop configuration.

关键词： interferometer waveguide interface

Romo1 regulates cell cycle and proliferation in human glioblastoma

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Romo1 regulates cell cycle and proliferation in human gliobl...

Paclitaxel and curcumin co-bound albumin nanoparticles having antitumor potential to pancreatic cancer

中国抗癌协会神经肿瘤专业委员会第八届学术会议

作者： shin-Hyuk Kang Mi Ok Yu Kyung-Jae Park Young-Do Yoo Yong-gu Chung Department of Neurosurgery Korea UniversityCollege of MedicineSeoulKorea Graduate School of Medicine and Brain Korea 21 Program for Biomedical Science Korea UniversityCollege of MedicineSeoulKorea

Purpose An imbalance in ROS production may contributes to cancer development and *** study was designed to identify ROS modulator 1（Romo1） expression in human glioblastoma and to determine its effect on cell cycle and *** Romo1 expression was examined in human glioblastoma,and determined by various condition including oxidative stress,*** using Romo1 plasmid and siRNA,we determined ROS production,cell cycle and *** Compared to normal cells,Romo1 was increased in glioblastoma tissue and various *** stress（H2O2） decreased Romo1 expression,whereas TMZ and serum starvation didn’***1 was localized in the cytoplasm and ROS was increased in Romo1-induced U87 gliblastoma *** Romo1 siRNA transfection,cell cycle arrest（G1 phase） was found in flowcytometry *** addition,cell proliferation was *** We found that Romo1 is increased in glioblastoma and may regulate cell cycle and proliferation by ROS ***1 can be a new therapeutic target for glioblastoma progression.

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来源： cnki会议评论

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Asian Journal of Pharmaceutical Sciences 2016年第6期11卷 708-714页

作者： Bomi Kim Changkyu Lee Eun Seong Lee Beom Soo shin Yu Seok Youn School of Pharmacy Sungkyunkwan University2066 Seobu-roJangan-guSuwonGyeonggi-do 16419Republic of Korea Division of Biotechnology The Catholic University of Korea43-1 Yeokgok 2-dongWonmi-guBucheon-siGyeonggi-do 14662Republic of Korea College of Pharmacy Catholic University of Daegu330 Geumrak 1-riHayang EupGyeongsan siGyeongbuk 38430Republic of Korea

Albumin nanoparticles are considered to be an effective way to load water-insoluble anticancer drugs and target tumors via the gp60-mediated pathway. Herein, we fabricated an albumin nanoparticle formulation for co-loading paclitaxel(PTX) and curcumin(CCM), both of which have prominent anticancer efficacy, via nanoparticle albumin-bound(NabTM) technology using high-pressure homogenization. The PTX/CCM co-bound albumin nanoparticles(PTX/CCM Alb-NPs) had a slightly greater particle size of ~250 nm than that of plain PTX AlbNPs and CCM Alb-NPs(~234 and ~134 nm, respectively), with spherical surface morphology and stable size maintenance. However, the zeta potential of PTX/CCM Alb-NPs(ca.-30 mV)was not significantly different from that of PTX or CCM Alb-NPs. The loaded PTX and CCM were released gradually from the PTX/CCM Alb-NPs over ~24 h(97.7 ± 1.7% and 76.2 ± 0.5%,respectively). Furthermore, PTX/CCM Alb-NPs appeared to be efficiently internalized into Mia Paca-2 cells and exhibited a 71% increased IC50 versus PTX Alb-NPs in terms of cytotoxicity to Mia Paca-2 cells. These results suggest that PTX/CCM Alb-NPs are a new potential anticancer agent for combination therapy.

关键词： Albumin Nanoparticles Paclitaxel Curcumin NabTM technology Anti-cancer agent

Justifying benzoselenadiazole acceptor core as organic semiconductor for stable bulk-heterojunction organic solar cells at ambient temperature

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Journal of Materiomics 2021年第5期7卷 1112-1121页

作者： Abdullah M.Shaheer Akhtar Eun-Bi Kim Hyung-Shik shin Sadia Ameen Advanced Materials and Devices Laboratory Department of Bio-Convergence ScienceJeongeup CampusJeonbuk National University56212Republic of Korea New&Renewable Energy Material Development Center(NewREC) Jeonbuk National UniversityRepublic of Korea Energy Materials&Surface Science Laboratory Solar Energy Research CenterSchool of Chemical EngineeringJeonbuk National University54896Republic of Korea Korea Basic Science Institute(KBSI) 169-148 Gwahak-roYuseong-guDaejon34133Republic of Korea

This work describes the utilization of D-A-D type organic semiconductor,4,4’-(benzo[c][1,2,5]selenadiazole-4,7-diyl)bis(N,N-diphenylaniline),denoted as Se-2TPA,containing benzoselenadiazole(BSe)as acceptor core and end-capped with triphenylamine(TPA)donor units as donor materials in solar ***,the attachment of TPA donor moiety in BSe acceptor unit enlarged the conjugated system by extending the p-bonding which effectively tuned the optical and electrochemical properties of *** bulk heterojunction organic solar cell(BHJ-OSCs)with configuration of ITO/cp-TiO_(2)/Se-2TPA:PC61BM/Au showed power conversion efficiency(PCE)of~4.12% with short circuit current(Jsc)value of~11.28 mA/cm^(2),open circuit voltage(Voc)of~0.775 V and fill factor(FF)of~*** significantly increased from~4.12% to~5.29% when 1,8-diiodooctane(DIO)was added as an additive in Se-2TPA:PC61BM blend which associated with less phase separation and improved the charge *** fabricated BHJ-OSCs processed with 3%DIO,ITO/cp-TiO_(2)/Se-2TPA:PC61BM/Au configuration displayed a long-term stability under air condition at an ambient temperature by maintaining~80% PCE for the duration of 30 *** advantages of easy synthesis,low cost and promising cell performance supported Se-2TPA as successful organic semiconductor for BHJ-OSCs.

关键词： Benzoselenadiazole Thin film Organic semiconductor Stability Organic solar cells

Enhanced biometric encryption algorithm for private key protection in BioPKI system

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Journal of Central South University 2014年第11期21卷 4286-4290页

作者： Cheol-Joo Chae Kwang-Nam Choi Kiseok Choi Jae-Soo Kim Yong Ju shin Korea Institute of Science and Technology Information 245 DaehangnoYuseong-gu Daejeon Korea

Protection of private key is the most critical part in public key infrastructure(PKI) system since it depends on the confidentiality of private key. Thread of password detection has been known as the vulnerability in this PKI system. Recently, studies have been conducted on Bio PKI system that uses the biometric information of users in order to replace the password type of private key protection in PKI system. However, Bio PKI system also has vulnerability in that biometric information used for protection of private key cannot be reused once it is stolen or lost. So, we propose the method to protect the private key using FIDSEQi which binds sequence to biometric information. The proposed method enhances reusability of biometric information and presents higher attack complexity than the method of authentication by cross matching single biometric information.

关键词：生物特征信息 PKI系统密钥保护私钥加密算法 Bio 公共密钥基础设施 PKI体系

LiNbO_3 Self-Aligned Ridge Waveguide with Dielectric Side Buffers

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光学学报 2003年第S1期23卷 211-212页

作者： Young-Bo Cho Hyung-Gi Jung Sang-Yung shin Dept. EECS Korea Advanced Institute of Science and Technology 373-1 Kusong-dong Yusong-gu Dae jeon. Republic of KoreaDept. EECS Korea Advanced Institute of Science and Technology 373-1 Kusong-dong Yusong-gu Dae jeon. Republic of KoreaDept. EECS Korea Advanced Institute of Science and Technology 373-1 Kusong-dong Yusong-gu Dae jeon. Republic of Korea

A simple fabrication method of self-aligned ridge waveguides with dielectric side buffers is demonstrated on +Z-cut LiNbO3. The ridge waveguide is fabricated by a combination of the annealed proton exchange process an... 详细信息

关键词： with of it In is LiNbO3 Self-Aligned Ridge Waveguide with Dielectric Side Buffers have Cr for been APE length

Memory-centric neuromorphic computing for unstructured data processing

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Nano Research 2021年第9期14卷 3126-3142页

作者： Sang Hyun Sung Tae Jin Kim Hera shin Hoon Namkung Tae Hong Im Hee Seung Wang Keon Jae Lee Department of Materials Science and Engineering Korea Advanced Institute of Science and Technology(KAIST)291 Daehak-roYuseong-guDaejeon 34141Republic of Korea

The unstructured data such as visual information,natural language,and human behaviors opens up a wide array of opportunities in the field of artificial intelligence(Al).The memory-centric neuromorphic computing(MNC)has been proposed for the efficient processing of unstructured data,bypassing the von Neumann bottleneck of current computing *** development of MNC would provide massively parallel processing of unstructured data,realizing the cognitive Al in edge and wearable *** this review,recent advances in memory-centric neuromorphic devices are discussed in terms of emerging nonvolatile memories,volatile switches,synaptic plasticity,neuronal models,and memristive neural network.

关键词： neuromorphic computing memory-centric memristor artificial synapses artificial neurons memristive neural network