Romo1 regulates cell cycle and proliferation in human glioblastoma
作者单位：Department of NeurosurgeryKorea UniversityCollege of MedicineSeoulKorea Graduate School of Medicine and Brain Korea 21 Program for Biomedical ScienceKorea UniversityCollege of MedicineSeoulKorea
会议名称：《中国抗癌协会神经肿瘤专业委员会第八届学术会议》
会议日期：2011年
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
摘 要：Purpose An imbalance in ROS production may contributes to cancer development and *** study was designed to identify ROS modulator 1（Romo1） expression in human glioblastoma and to determine its effect on cell cycle and *** Romo1 expression was examined in human glioblastoma,and determined by various condition including oxidative stress,*** using Romo1 plasmid and siRNA,we determined ROS production,cell cycle and *** Compared to normal cells,Romo1 was increased in glioblastoma tissue and various *** stress（H2O2） decreased Romo1 expression,whereas TMZ and serum starvation didn’***1 was localized in the cytoplasm and ROS was increased in Romo1-induced U87 gliblastoma *** Romo1 siRNA transfection,cell cycle arrest（G1 phase） was found in flowcytometry *** addition,cell proliferation was *** We found that Romo1 is increased in glioblastoma and may regulate cell cycle and proliferation by ROS ***1 can be a new therapeutic target for glioblastoma progression.