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Inhibition of pacemaker activity in interstitial cells of Cajal by LPS via NF-κB and MAP kinase

World Journal of Gastroenterology 2013年第8期19卷 1210-1218页

作者： Dong Chuan Zuo Seok Choi Pawan Kumar Shahi Man Yoo Kim Chan Guk Park Young Dae Kim Jun Lee in yeoup chang Insuk So Jae Yeoul Jun Department of Physiology College of MedicineChosun UniversityGwangju 501-759South Korea Department of Internal Medicine College of MedicineChosun UniversityGwangju 501-759South Korea Department of Anatomy College of MedicineChosun UniversityGwangju 501-759South Korea Department of Physiology and Biophysics College of MedicineSeoul National UniversitySeoul 56-1South Korea

AIM:To investigate lipopolysaccharide(LPS) related signal transduction in interstitial cells of Cajal(ICCs) from mouse small ***:For this study,primary culture of ICCs was prepared from the small intestine of the *** was treated to the cells prior to measurement of the membrane currents by using whole-cell patch clamp *** was used to examine the expression of the proteins in ***:LPS suppressed the pacemaker currents of ICCs and this could be blocked by AH6809,a prostaglandin E2-EP2 receptor antagonist or NG-Nitro-Larginine Methyl Ester,an inhibitor of nitric oxide(NO) ***-like receptor 4,inducible NO synthase or cyclooxygenase-2 immunoreactivity by specific antibodies was detected on ***(antioxidant agent) had no action on LPS-induced action in *** actions were blocked by nuclear factor kB(NF-kB) inhibitor,actinomycin D(a gene transcription inhibitor),PD 98059(a p42/44 mitogen-activated protein kinases inhibitor) or SB 203580 [a p38 mitogen-activated protein kinases(MAPK) inhibitor].SB 203580 also blocked the prostaglandin E2-induced action on pacemaker currents in ICCs but not ***:LPS inhibit the pacemaker currents in ICCs via prostaglandin E2-and NO-dependent mechanism through toll-like receptor 4 and suggest that MAPK and NF-kB are implicated in these actions.

关键词： Interstitial cells of Cajal Lipopolysaccharide Mitogen-activated protein kinases Nuclear factor kB Small intestine

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