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Scaling and design of high-energy laser plasma electron acceleration

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High Power Laser Science and Engineering 2015年第1期3卷 81-91页

作者： Kazuhisa Nakajima Hyung taek Kim tae moon Jeong Chang Hee Nam Center for Relativistic Laser Science Institute for Basic Science (IBS)

Recently there has been great progress in laser-driven plasma-based accelerators by exploiting high-power lasers,where electron beams can be accelerated to multi-GeV energy in a centimeter-scale plasma due to the laser wakefield acceleration mechanism. While, to date, worldwide research on laser plasma accelerators has been focused on the creation of compact particle and radiation sources for basic sciences, medical and industrial applications, there is great interest in applications for high-energy physics and astrophysics, exploring unprecedented high-energy frontier phenomena. In this context, we present an overview of experimental achievements in laser plasma acceleration from the perspective of the production of GeV-level electron beams, and deduce the scaling formulas capable of predicting experimental results self-consistently, taking into account the propagation of a relativistic laser pulse through plasma and the accelerating field reduction due to beam loading. Finally, we present design examples for 10-GeV-level laser plasma acceleration, which is expected in near-term experiments by means of petawatt-class lasers.

关键词： electron beam loading GeV-level electron beam acceleration laser plasma(wakefield) accelerators petawatt-class lasers propagation of relativistic laser pulses in plasma

Impact of statin intensity on adverse cardiac and cerebrovascular events in older adult patients with myocardial infarction

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Journal of Geriatric Cardiology 2021年第8期18卷 609-622页

作者： in tae moon Si-Hyuck Kang Wonjae Lee Youngjin Cho Jin Joo Park Yeonyee EYoon Il-Young Oh Chang-Hwan Yoon Jung-Won Suh tae-Jin Youn In-Ho Chae Dong-Ju Choi Young-Seok Cho Uijeongbu Eulji Medical Center Eulji University School of MedicineUijeongbuSouth Korea Seoul National University Bundang Hospital SeongnamSouth Korea Department of Cardiology Incheon Sejong HospitalIncheonSouth Korea

BACKGROUND There is insufficient evidence regarding the effect of high-intensity statin therapy in older *** study aimed to investigate the effects of high-intensity statin treatment on the clinical outcomes in older adults with myocardial infarc-tion(MI).METHODS Consecutive patients with MI aged at least 75 years were analyzed *** primary endpoint was major adverse cardiac and cerebrovascular events(MACCE),defined as a composite of all-cause death,MI,rehospitalization due to un-stable angina,repeat revascularization,and ischemic *** high-intensity group was compared to the low-to-moderate in-tensity group in the propensity score-matched *** Average age of total 546 patients was 81 *** them,84%of patients underwent percutaneous coronary *** unadjusted seven-year MACCE rate differed by statin intensity(high-intensity statin group:38%,moderate-intensity statin group:42%,low-intensity statin group:56%,and no-statin group:61%,P=0.004).However,among these groups,many baseline characteristics were significantly *** the 74 propensity score-matched pairs,which lacked any significant differences in all baseline characteristics,the high-intensity group had a significantly lower rate of MACCE than the low-to-moderate intensity group(37%vs.53%,P=0.047).Follow-up low-density lipoprotein cholesterol levels were significantly lower in the high-intensity group than that in the low-to-moderate intensity group(69.4±16.0 mg/dL vs.77.9±25.9 mg/dL,P=0.026).CONCLUSIONS In older adult patients with MI,the use of high-intensity statin caused significantly less occurrence of MACCE in comparison to that in low-to-moderate intensity for up to seven years of follow-up.

关键词： patients cardiac intensity

Meta-Analysis of the Expansion in the Field of Structural Biology of ABC Transporters

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BioDesign Research 2022年第1期2022卷 124-135页

作者： Soomi Kim Teena Bajaj Cole Chabon Eric Tablante Tatyana Kulchinskaya tae Seok moon Ruchika Bajaj Stem Cell Technology Certificate Program City College of San FranciscoUSA Biotechnology Certificate Program City College of San FranciscoUSA Comparative Biochemistry Program University of California BerkeleyUSA Department of Energy Environmental and Chemical EngineeringWashington University in St.LouisUSA Department of Bioengineering and Therapeutics Sciences University of California San FranciscoUSA

ABC transporters are molecular machines which power the solute transport using ATP *** structural biology of ABC transporters has been exploding for the last few years,and this study explores timelines and trends for various attributes such as structural tools,resolution,fold,sources,and group *** study also evidences the significance of mammalian expression systems,advancements in structural biology tools,and the developing interest of group leaders across the world in the remarkably progressing *** field started in 2002 and bloomed in 2016,and COVID years were really productive to the ***,the study explores 337 structures of 58 unique ABC transporters deposited in the PDB database from which P-glycoprotein has the largest number of ***,62%of total structures are determined at the resolution of 3-4Åand 53%of structures belong to fold IV *** progressive advancements in the field,the field is shifting from prokaryotic to eukaryotic sources and X-ray crystallography to cryoelectron *** the nutshell,this study uniquely provides the detailed snapshot of the field of structural biology of ABC transporters with real-time data.

关键词： uniquely really shifting

Chuna Therapy for Musculoskeletal Pain:A Systematic Review of Randomized Clinical Trials in Korean Literature

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Chinese Journal of Integrative Medicine 2013年第3期19卷 228-232页

作者： tae-Woong moon tae-Young Choi tae-Yong Park Myeong Soo Lee Brain Disease Research Center Korea Institute of Oriental Medicine

Objective： To evaluate the effectiveness of Chuna for the treatment of musculoskeletal pain as reported in Korean literature. Methods： We conducted an electronic literature search using seven Korean databases and manually searched six traditional Korean medicine journals. Risk of bias was assessed with the Cochrane criteria. Results： Six randomized controlled trials （RCTs） were included in the study. Compared with standard care, three RCTs suggested favorable effects of Chuna on neck pain due to a hypolordotic cervical spine, low back pain caused by traffic accidents, and low back pain. In contrast, compared with standard care, three RCTs failed to show positive effects on temporomandibular joint disorder, mandibular movement, and neck pain caused by traffic accidents. Conclusions： Currently, the evidence of the effectiveness of Chuna for the treatment of musculoskeletal pain is not convincing. Further rigorously designed trials are warranted to determine its effectiveness.

关键词： Chuna musculoskeletal pain systematic review Korean literature

Glycyrrhizin attenuates HMGB1-induced hepatocyte apoptosis by inhibiting the p38-dependent mitochondrial pathway

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World Journal of Gastroenterology 2012年第7期18卷 679-684页

作者： Geum-Youn Gwak tae Gun moon Dong Ho Lee Byung Chul Yoo Department of Medicine Samsung Medical CenterSugnkyunkwan University School of Medicine50 Irwon-DongGangnam-Gu135-710 SeoulSouth Korea

AIM： To examine how High-mobility group box I （HMGB1） regulates hepatocyte apoptosis and, furthermore, to determine whether glycyrrhizin （GL）, a known HMGB1 inhibitor, prevents HMGBl-induced hepatocyte apoptosis.

关键词： High-mobility group box 1 Hepatocyte Apoptosis Glycyrrhizin p38 Mitochondria

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从焦虑到行动

科学新闻 2024年第4期 62-63页

作者： tae Seok moon 倪伟波美国圣路易斯华盛顿大学

“tae Seok，你知道该怎么做——让大家安静下来，并把他赶出去。”“他”是我最好的研究生之一，在5年内发表了4篇论文，从美国寄钱给在非洲的家人。但当他在走廊接一个公司的面试电话时，与一位教授发生了冲突。鉴于他的肤色，教授以...

“tae Seok，你知道该怎么做——让大家安静下来，并把他赶出去。”“他”是我最好的研究生之一，在5年内发表了4篇论文，从美国寄钱给在非洲的家人。但当他在走廊接一个公司的面试电话时，与一位教授发生了冲突。鉴于他的肤色，教授以为他不是学生，于是报了警，警察把他带走了。除了受到侮辱之外，我的学生还因此失去了他梦寐以求的工作。他向学校反歧视办公室投诉——现在学校领导让我解决这件事。我很愤怒，但无能为力。我的终身职位马上就要接受评估了，我觉得没有能力反击。

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Nonlinearity of traveling-wave photodetector according to incident optical power

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Cutting force signal pattern recognition using hybrid neural network in end milling

Photonics Asia 2004;Optics and Lasers

作者： Yon-tae moon Young-Seol Yun Seong-Hae Ok Young-Wan Choi Seok Lee Lab.of Optoelecrtonics and Optical Communications School of Electrical and Electronics Engineering Chung-Ang University 221 Heukseok-Dong Dongjak-Gu Seoul 156-756 Korea Lab.of Optoelecrtonics and Optical Communications School of Electrical and Electronics Engineering Chung-Ang University 221 Heukseok-Dong Dongjak-Gu Seoul 156-756 Korea Lab.of Optoelecrtonics and Optical Communications School of Electrical and Electronics Engineering Chung-Ang University 221 Heukseok-Dong Dongjak-Gu Seoul 156-756 Korea Lab.of Optoelecrtonics and Optical Communications School of Electrical and Electronics Engineering Chung-Ang University 221 Heukseok-Dong Dongjak-Gu Seoul 156-756 Korea Photonics Research Center Korea Institute of Science and Technology 39-1 Hawolgok-Dong Seongbuk-Gu Seoul 136-791 Korea

At low light intensities (linear regime), the absorption coefficient is independent of the light intensity; however, at sufficiently high intensities, the absorption becomes a nonlinear function. In

关键词： TWPD, nonlinearity, absorption coefficient, saturation absorption,SFDR

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中国有色金属学会会刊：英文版 2009年第B09期19卷 209-214页

作者： Song-tae SEONG Ko-tae JO Young-moon LEE Research and Development Department Gyeongbuk Hybrid Technology Institute School of Mechanical Engineering Yeongnam University School of Mechanical Engineering Kyungpo ok National University

Under certain cutting conditions in end milling, the signs of cutting forces change from positive to negative during a revolution of the tool. The change of force direction causes the cutting dynamics to be unstable which results in chatter vibration. Therefore, cutting force signal monitoring and classification are needed to determine the optimal cutting conditions and to improve the efficiency of cut. Artificial neural networks are powerful tools for solving highly complex and nonlinear problems. It can be divided into supervised and unsupervised learning machines based on the availability of a teacher. Hybrid neural network was introduced with both of functions of multilayer perceptron (MLP) trained with the back-propagation algorithm for monitoring and detecting abnormal state, and self organizing feature map (SOFM) for treating huge datum such as image processing and pattern recognition, for predicting and classifying cutting force signal patterns simultaneously. The validity of the results is verified with cutting experiments and simulation tests.

关键词：切削力信号混合神经网络模式识别铣床人工神经网络切削条件信号监测监督学习

An effective evolutionary algorithm for the multiple container packing problem

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Progress in Natural Science:Materials International 2008年第3期18卷 337-344页

作者： Sang-moon Soak Sang-Wook Lee Gi-tae Yeo moon-Gu Jeon Information Systems Examination Team Korean Intellectual Property Office (KIPO) Gov. Complex Daejeon Building 4 920 Dunsandong Seogu Daejeon Republic of Korea School of Information and Mechatronics Gwangju Institute of Science and Technology 261 Cheomdan-gwagiro Buk-gu Gwanju Republic of Korea College of Humanities and Social Sciences Woosuk University 490 Hujung-Ri Samrye-Eup Wanju-Gun Jeollabuk-Do Republic of Korea School of Information and Mechatronics Gwangju Institute of Science and Technology 261 Cheomdan-gwagiro Buk-gu Gwanju Republic of Korea c

This paper focuses on a new optimization problem, which is called ''The Multiple Container Packing Problem (MCPP)" and proposes a new evolutionary approach for it. The proposed evolutionary approach uses ''Adaptive Link Adjustment Evolutionary Algorithm (ALA-EA)" as a basic framework and it incorporates a heuristic local improvement approach into ALA-EA. The first step of the local search algorithm is to raise empty space through the exchange among the packed items and then to improve the fitness value through packing unpacked items into the raised empty space. The second step is to exchange the packed items and the unpacked items one another toward improving the fitness value. The proposed algorithm is compared to the previous evolutionary approaches at the bench- mark instances (with the same container capacity) and the modifled benchmark instances (with different container capacity) and that the algorithm is proved to be superior to the previous evolutionary approaches in the solution quality.

关键词： ALA-EA Evolutionary algorithm Heuristic The multiple container packing problem