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Open Journal of Composite Materials 2019年第4期9卷 338-354页

作者： y. imai K. Nishitani G. Fortin A. Ohtani H. Hamada Department of Advanced Fibro-Science Kyoto Institute of Technology Kyoto Japan

This article presents an experimental study that clarifies the relationship between the initial fracture stress and fatigue limit of glass fiber reinforced unsaturated polyester resin specimens with a laminated structure taken from a pultruded square pipe. Quasi-static bending and tension tests are performed with acoustic emission (AE) measurements to identifying the occurrence of initial fracture during testing. AE and observation results have clarified the occurrence of initial fracture was detected by maximum acoustic energy values and corresponding fiber breakage in the unidirectional (UD) bundles. Moreover, the ratio of initial fracture stress to ultimate strength is 32% in bending and 26% in tension, when comparing stress and strains on the tension side of the UD layer. These values are in good agreement with each other and with the measured tensile fatigue limit when the cyclic stress is at 25% of the tensile strength. Initial fracture stress obtained by static tests is close values to the fatigue limit which will greatly contribute to the prediction of the fatigue limit.

关键词： Initial Fracture Fatigue Limit Acoustic Emission Testing Tensile Testing Bending Testing

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巨大冠状动脉瘤破裂致死1例

世界核心医学期刊文摘（儿科学分册） 2006年第6期2卷 22-23页

作者： imai y. Sunagawa K. Ayusawa M. 王经纬 Department of Pediatrics Ninon University School of Medicine 30-1Oyaguchi-kamicho Itabashi Tokyo 173-8610 Japan

A 5-year-old Japanese boy died because of a ruptured left coronary artery aneurysm (CAA). He was diagnosed as having Kawasaki disease (KD) on the 5th day from onset, with all of the principal signs. On the 7th day of illness, bilateral CAAs were already found via echocardiography, and he was treated with intravenous (IV) gamma globulin and oral ASA. However, the fever persisted and the CAA progressed rapidly. Echocardiography on the 12th illness day showed a giant (18-mm) left anterior descending (LAD) artery aneurysm. Oral propranolol and nifedipine were administered, in conjunction with warfarinaspirin anti-coagulation therapy. On the 13th day of illness, cardiac arrest developed abruptly, and, despite cardiopulmonary resuscitation (CPR), the patient remained unresponsive and died one hour later. The final pathological diagnosis was a ruptured LAD artery aneurysm and cardiac tamponade. Microscopic investigation of the ruptured vascular wall revealed marked neutrophilic infiltration, with fewer macrophages and lymphocytes. CAA ruptures are a very rare, but fatal, complication of KD. Based on a review of previous reports on CAA ruptures, we consider it useful to distinguish aneurysms which rapidly dilate and continue to expand beyond a diameter of 10 mm with ongoing vasculitis (these CAAs can be termed “super-giant”) from the more common giant CAAs limited to a diameter of 8 or 9 mm, because a decision must be made as to whether to start intensive care or to intervene surgically, in order to ensure the survival of patients with such a potentially critical complication.

关键词：动脉瘤破裂冠状动脉瘤巨大中性粒细胞浸润心动描记病理诊断抗凝血治疗显微镜检查主要症状 γ球蛋白

Cortical hem signaling center: functions, development, and potential implications for evolution and brain disorders

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Neural Regeneration Research 2025年第4期20卷 1079-1080页

作者： Victor V.Chizhikov Igor y.Iskusnykh Department of Anatomy and Neurobiology University of Tennessee Health Science CenterMemphisTNUSA

Development of the telencephalon relies upon several signaling centers-localized cellular populations that supply secreted factors to pattern the cortical *** such signaling center is the cortical hem,which arises during embryonic development at the telencephalic dorsal midline,adjacent to the choroid plexus and hippocampal primordium(Figure 1A).While the cortical hem has also been described in reptiles and birds,most of our knowledge about the developmental roles of the cortical hem is derived from the analysis in *** cortical hem produces several types of secreted molecules,including wingless-related integration site(Wnt)and bone morphogenetic(Bmp)*** cortical hem is particularly important for the development of the hippocampus,which is involved in learning and memory,and the neocortex,which is the most complex brain region that mediates multiple types of behavior and higher cognitive functions(Mangale et al.,2008;Dal-Valle-Anton and Borrell,2022).

关键词： epithelium Figure center

Exercise preconditioning alleviates ischemia-induced memory deficits by increasing circulating adiponectin

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Neural Regeneration Research 2025年第5期20卷 1445-1454页

作者： Meifeng Zheng Borui Zhang Sonata S y yau Kwok-Fai So Li Zhang Haining Ou Department of Rehabilitation Medicine Guangzhou Medical UniversityGuangzhouGuangdong ProvinceChina Department of Rehabilitation Medicine The Fifth Clinical College of Guangzhou Medical UniversityGuangzhouGuangdong ProvinceChina Key Laboratory of CNS Regeneration(Ministry of Education) Guangdong-Hong Kong-Macao Institute of CNS RegenerationJinan UniversityGuangzhouGuangdong ProvinceChina Department of Rehabilitation Sciences The Hong Kong Polytechnic UniversityHong Kong Special Administrative RegionChina State Key Laboratory of Brain and Cognitive Science Li Ka Shing Faculty of MedicineThe University of Hong KongHong Kong Special Administrative RegionChina Center for Exercise and Brain Science School of PsychologyShanghai University of SportShanghaiChina Neuroscience and Neurorehabilitation Institute University of Health and Rehabilitation SciencesQingdaoShandong ProvinceChina

Cerebral ischemia is a major health risk that requires preventive approaches in addition to drug *** exercise enhances neurogenesis and synaptogenesis,and has been widely used for functional rehabilitation after *** this study,we determined whether exercise training before disease onset can alleviate the severity of cerebral *** also examined the role of exercise-induced circulating factors in these *** mice were subjected to 14 days of treadmill exercise training before surgery for middle cerebral artery *** found that this exercise pre-conditioning strategy effectively attenuated brain infarct area,inhibited gliogenesis,protected synaptic proteins,and improved novel object and spatial memory *** analysis showed that circulating adiponectin plays a critical role in these preventive effects of *** activation of adiponectin receptors by Adipo Ron mimicked the effects of exercise,while inhibiting receptor activation abolished the exercise *** summary,our results suggest a crucial role of circulating adiponectin in the effects of exercise pre-conditioning in protecting against cerebral ischemia and supporting the health benefits of exercise.

关键词： adiponectin cerebral ischemia exercise pre-conditioning hippocampus memory function middle cerebral artery occlusion prefrontal cortex synaptic proteins treadmill exercise

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夜间血压与慢性肾脏病发生相关

中华高血压杂志 2013年第12期21卷 1199-1199页

作者： Kanno A Kikuya M Asayama K Satoh M Inoue R Hosaka M Metoki H Obara T Hoshi H Totsune K Sato T Taguma y Sato H imai y Ohkubo T

已知动态血压与靶器官损害相关。然而，动态血压对慢性肾脏病（chronickidneydisease，CKD）发生的预测意义如何尚未证实。方法：纳入日本一般人群中基线无CKD者843名，检测其基线动态血压，及随后CKD[-定义为体检时蛋白尿阳性或估算的... 详细信息

已知动态血压与靶器官损害相关。然而，动态血压对慢性肾脏病（chronickidneydisease，CKD）发生的预测意义如何尚未证实。方法：纳入日本一般人群中基线无CKD者843名，检测其基线动态血压，及随后CKD[-定义为体检时蛋白尿阳性或估算的肾小球滤过率（estimatedglomerularfiltrationrate，eGFR）≤60mL／（min·1．73m2）]的发生率。应用Cox比例风险回归模型对性别、年龄、体质量指数、习惯性吸烟、习惯性饮酒、糖尿病、高胆固醇血症、心血管疾病史、抗高血压药物、基线eGFR、随访次数和基线检查的年份进行调整后，分析基线动态血压和CKD发生的关系。

关键词：慢性肾脏病夜间血压 Cox比例风险回归模型体质量指数动态血压肾小球滤过率高胆固醇血症抗高血压药物

Gene therapy for spinal muscular atrophy:perspectives on the possibility of optimizing SMN1 delivery to correct all neurological and systemic perturbations

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Neural Regeneration Research 2025年第7期20卷 2011-2012页

作者： Sharon J.Brown Rafael J.yáñez-Muñoz Heidi R.Fuller School of Pharmacy and Bioengineering Keele UniversityKeeleUK Wolfson Center for Inherited Neuromuscular Disease TORCH BuildingRJAH Orthopaedic HospitalOswestryUK *** Center of Gene and Cell TherapyDepartment of Biological SciencesSchool of Life Sciences and the EnvironmentRoyal Holloway University of LondonEghamUK

Spinal muscular atrophy(SMA)is a genetic condition that results in selective lower motor neuron loss with concomitant muscle weakness and *** genetic cause of SMA was understood in 1995 when loss or impairment of the survival motor neuron 1(SMN1)gene was identified as the main contributing factor(Lefebvre et al.,1995).This,in combination with the discovery that humans have a“back-up”gene,SMN2,which can produce low levels(approximately 10%)of the full-length functional SMN protein,has led to the generation of SMA-specific gene *** was traditionally classified according to age of symptom onset and developmental milestones achieved,with life expectancy and severity varying between ***,SMN2 copy number is used as a proxy for the prediction of disease severity,with higher SMN2 copy number typically being associated with reduced severity of SMA,although this relationship is not absolute:some individuals with low SMN2 copy number have less severe SMA phenotypes and vice ***,the etiology of SMA is further complicated by other factors,such as non-typical nucleotide variants and SMN2-independent modifiers of disease severity.

关键词： atrophy traditionally absolute

正常血压人群中动态血压与家庭高血压风险的相关性:Ohasama研究

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中华高血压杂志(中英文) 2023年第10期31卷 1000-1000页

作者： Nakayama S Satoh M Metoki H Murakami T Tatsumi y Asayama K Hara A Hirose T Tsubota-Utsugi M Kikuya M Mori T Hozawa A imai y Ohkubo T 刘青练桂丽

研究者评估正常血压人群中动态血压与家庭高血压风险之间的关系,并研究增加动态血压是否可以改进先前Ohasama研究中建立的家庭高血压风险10年预测模型。方法:在该前瞻性研究中,研究者对没有家庭和动态高血压的日本大阪一般人群的410名...

研究者评估正常血压人群中动态血压与家庭高血压风险之间的关系,并研究增加动态血压是否可以改进先前Ohasama研究中建立的家庭高血压风险10年预测模型。方法:在该前瞻性研究中,研究者对没有家庭和动态高血压的日本大阪一般人群的410名参与者(女性占83.2%,年龄53.6岁)进行随访。采用Cox模型评估家庭高血压[家庭血压≥135/85 mmHg(1 mmHg=0.133 k Pa)或开始降压治疗]和模型改进的风险比(HR)。结果:在平均14.2年的随访期内,发生225例家庭高血压事件。

关键词：

根据血压等级确定脑卒中和冠状动脉粥样硬化性心脏病死亡的终生风险:日本EPOCH(观察队列的心血管预防证据)研究

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中华高血压杂志 2019年第4期27卷 379-379页

作者：陈嘉睿(译) 练桂丽(审校) Satoh M Ohkubo T Asayama K Murakami y Sugiyama D yamada M Saitoh S Sakata K Irie F Sairenchi T Ishikawa S Kiyama M Ohnishi H Miura K imai y Ueshima H Okamura T EPOCH-JAPAN research group EPOCH-JAPAN research group

在亚洲人群中.很少研究关注根据血压分类确定脑卒中和冠状动脉粥样硬化性心脏病(coronary heartdisease,CHD)的终生风险。该研究旨在用一个包含个体参与者数据的荟萃分析大数据库来评估它。该荟萃分析纳入来源于13个队列的107 737名日本... 详细信息

在亚洲人群中.很少研究关注根据血压分类确定脑卒中和冠状动脉粥样硬化性心脏病(coronary heartdisease,CHD)的终生风险。该研究旨在用一个包含个体参与者数据的荟萃分析大数据库来评估它。该荟萃分析纳入来源于13个队列的107 737名日本人(男性占42.4%,平均年龄55.1岁)。在平均(15.2±5.3)年(1 559 136人年)的随访期.1922人死于脑卒中,913人死于CHDO研究者在调整其他死亡危险因素后估计风险。

关键词：冠状动脉粥样硬化性心脏病死亡危险因素血压分类脑卒中日本人风险队列心血管

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初产妇和经产妇妊娠期间的诊室和家庭血压

中华高血压杂志 2013年第6期21卷 598-598页

作者： Ishikuro M Obara T Metoki H Ohkubo T yamamoto M Akutsu K Sakurai K Iwama N Katagiri M yagihashi K yaegashi N Mori S Suzuki M Kuriyama S imai y 罗冬梅叶鹏

妊娠高血压可导致分娩时产生严重的并发症，如脑卒中、早产或低出生体质量。初产妇被认为是妊娠高血压的一个危险因素。产次与妊娠期间家庭血压相关性仍不明确。方法：入选初产妇和经产妇共575名，评估妊娠高血压和先兆子痫的发病率。... 详细信息

妊娠高血压可导致分娩时产生严重的并发症，如脑卒中、早产或低出生体质量。初产妇被认为是妊娠高血压的一个危险因素。产次与妊娠期间家庭血压相关性仍不明确。方法：入选初产妇和经产妇共575名，评估妊娠高血压和先兆子痫的发病率。收集在一家日本产科医院接受产前检查的530名正常血压孕妇的家庭和诊室血压值。诊室血压为产前检查2次测量的血压平均值，参与者妊娠期间每日清晨在家自测血压。

关键词：妊娠高血压妊娠期间初产妇家庭诊室低出生体质量产前检查危险因素

家庭血压测量和动态血压测量确诊的不完全白大衣性高血压或隐蔽性高血压的长期脑卒中风险

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中华高血压杂志 2015年第10期23卷 999-999页

作者： Satoh M Asayama K Kikuya M Inoue R Metoki H Hosaka M Tsubota-Utsugi M Obara T Ishiguro A Murakami K Matsuda A yasui D Murakami T Mano N imai y Ohkubo T 赵狄练桂丽

白大衣性高血压（white-coathypertension，WCH）的预后意义存在争论，且家庭自测血压与24h动态血压监测的不同结果使得wCH确诊困难。本研究探讨采用不同的诊室外血压测量方法诊断的不完全性或完全性WCH以及隐蔽性高血压（maskedhyper—... 详细信息

白大衣性高血压（white-coathypertension，WCH）的预后意义存在争论，且家庭自测血压与24h动态血压监测的不同结果使得wCH确诊困难。本研究探讨采用不同的诊室外血压测量方法诊断的不完全性或完全性WCH以及隐蔽性高血压（maskedhyper—tension，MH）是否存在不同的长期脑卒中风险。

关键词：白大衣性高血压动态血压测量脑卒中隐蔽性风险确诊家庭 24h动态血压监测