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Monoribbed-Functionalized Macrobicyclic Iron(Ⅱ) Complexes Decorated with Terminal Reactive and Vector Groups: Synthetic Strategy, Chemical Transformations and Structural Characterization

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Chinese Journal of Chemistry 2022年第17期40卷 2089-2105页

作者： ilya P.Limarev Genrikh E.Zelinskii Svetlana A.Belova Pavel V.Dorovatovskii Anna V.Vologzhanina Ekaterina G.Lebed Yan Z.Voloshin Nesmeyanov Institute of Organoelement Compounds of the Russian Academy of Sciences 28 Vavilova stMoscow119991 Russia Kurnakov Institute of General and Inorganic Chemistry of the Russian Academy of Sciences 31 Leninsky prMoscow119991 Russia National Research Center Kurchatov Institute 1 Kurchatova plMoscow123098 Russia

General and straightforward synthetic strategy towards the iron(Ⅱ)clathrochelates with functionalizing substituents in their apical capping and one of the three chelate ribbed fragments was *** hexachloroclathrochelate precursors were prepared by the direct template condensation of dichloroglyoxime with a suitable boronic acid on the Fe^(2+) ion as a matrix and underwent a stepwise nucleophilic substitution with S_(2)-,N_(2)- or O_(2)-bis-nucleophiles,forming the alicyclic or aromatic N_(2)-,S_(2)-or O_(2)-six-membered *** on the reaction conditions and precursor-to-dinucleophile molar ratios,iron(Ⅱ)clathrochelates with one(S,O and N),two(S,O and N)or three(S and O)X_(2)-six-membered ribbed substituent(s)were *** reactivity substantially decreases in a row:Cl_(6)-Cage>Cl_(4)X_(2)-Cage(where X=S,O or,especially,N)>Cl_(2)X_(4)-Cage(where X=S or O).The reactive monoribbed-functionalized clathrochelates underwent further chemical transformations giving the target macrobicyclic complexes with terminal vector *** follows from the single crystal XRD data,their FeN_(6)-coordination polyhedra possess the geometry intermediate between a trigonal prism and a trigonal antiprism(φ=21.3°—25.20°).Fe-N distances vary from 1.887(6)to 1.933(8)Å.Their 3D-molecules,the hydrophobic–hydrophilic balance in which can be tuned using a ribbed functionalization,form in the crystals the intermolecular specific halogen bonds and/or hydrophobic interactions.

关键词： Macrocyclic compounds Clathrochelates Iron complexes Ligand reactivity Targetdelivery

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A STUDY OF STRUCTURE AND PROPERTY CHANGES OF BIODEGRADABLE POLYGLYCOLIDE AND POLY(GLYCOLIDE-co-LACTIDE)FIBERS DURING PROCESSING AND IN VITRO DEGRADATION

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Chinese Journal of Polymer Science 2003年第2期21卷 159-167页

作者： Bruce X.Fu Benjamin S.Hsiao Gavin Chen Jack Zhou Susan Lin Jenny Yuan ilya Koyfman Dennis D Jamiolkowski Edward Dormier Department of Chemistry State University of New York at Stony Brook Stony BrookNY 11794-3400 USA Ethicon Worldwide A Johnson & Johnson Company P. O. Box 151 Somerville. New Jersey 08876-0151 USA

Structure and properties of bioabsorbable polyglycolide (PGA) and poly(glycolide-co-lactide) (PGA-co-PLA)fibers were investigated during several industrial processing stages and in vitro degradation by means of wide-angle X-raydiffraction (WAXD), dynamic mechanical analysis (DMA) and mechanical property tests. In the orientation stage, the PGAfibers were found to have higher degrees of crystallinity than corresponding PGA-co-PLA samples produced under similarconditions. In the hot-stretching and post-annealing stages, after fibers were braided, PGA samples were found to gain morecrystallinity and higher T_g than PGA-co-PLA samples. The higher crystallinity in PGA fibers resulted in a slower rate ofdegradation. DMA results showed that a great deal of internal stress that was built during orientation and hot-stretchingstages was released in the post-annealing stage for a1l PGA and PGA-co-PLA samples. During earlier stages of in vitrodegradation, both PGA and PGA-co-PLA samples exhibited the typical cleavage-induced crystallization mechanism. Theheat shrinkage in the glass transition area was found to disappear after 6-8 days of degradation for all PGA and PGA-co-PLAsamples, indicating the amorphous portions of the polymers lost orientation after a short period in the buffer solution, mostlikely due to relaxation of the cleaved chains.

关键词： Polyglycolide Poly(glycolide-co-lactide) Bioabsorbable Fiber processing in vitro Degradation

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Enhanced nonlinear instabilities in photonic circuits with exceptional point degeneracies

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Photonics Research 2020年第5期8卷 737-744页

作者： SUWUN SUWUNNARAT RODION KONONCHUK ANDREY CHABANOV ilya VITEBSKIY NICHOLAOS I.LIMBEROPOULOS TSAMPIKOS KOTTOS Department of Physics Wesleyan UniversityConnecticut 06459USA Department of Physics and Astronomy University of Texas at San AntonioSan AntonioTexas 78249USA Air Force Research Laboratory Sensors DirectorateWright-Patterson Air Force BaseOhio 45433USA

We propose a conceptual design of optical power limiters with abrupt limiting action and enhanced powerhandling capabilities that is based on exceptional point degeneracies(EPDs).The photonic circuit consists of two coupled cavities with differential Q *** of the cavities includes a Kerr-like nonlinear *** underlying mechanism that triggers an abrupt transmittance suppression relies on the interplay between a nonlinear instability and an abrupt destruction of EPDs due to a resonance detuning occurring when the incident power exceeds a critical *** proposal opens up possibilities for the use of EPDs in optical power switching,Q switching,routing,and so on.

关键词： material. value. exceptional

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小毛足鼠繁殖活动的季节变化(英文)

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动物学报 2005年第1期51卷 1-6页

作者： Natalia Yu FEOKTISTOVA ilya G. MESCHERSKY Severtsov Institute of Ecology and Evolution Russian Academy of SciencesLeninskii pr.33Moscow 119071RussiaSevertsov Institute of Ecology and EvolutionRussian Academy of SciencesLeninskii pr.33Moscow 119071Russia

有关小毛足鼠 (Phodopusroborovskii)冬季活动和季节性繁殖模式的资料很少。九年来 ,我们在自然温度和光照条件下维持了一个实验室种群。这些自然条件说明其繁殖活动与野生条件下的很一致。甚至在零下 4 0度的冬季 ,罗氏仓鼠都不休眠。... 详细信息

有关小毛足鼠 (Phodopusroborovskii)冬季活动和季节性繁殖模式的资料很少。九年来 ,我们在自然温度和光照条件下维持了一个实验室种群。这些自然条件说明其繁殖活动与野生条件下的很一致。甚至在零下 4 0度的冬季 ,罗氏仓鼠都不休眠。第一个繁殖高峰 (每 10对鼠繁殖 2 4窝 ,每窝平均 3 5只幼鼠 )在 4月份 ,第二个繁殖高峰 (每 10对鼠繁殖 2 9- 2 6窝 ,每窝平均 3 9- 3 6只幼鼠 )在 6 - 7月份。在秋季和初冬 ,繁殖强度降低到每 10对鼠产 0 1- 0 4窝 ,但繁殖并不完全终止。全年内 ,所有成年雄鼠可见下降的睾丸 ,雌鼠可见开放的阴道口。雄鼠的血液睾酮浓度在夏季最高 ,秋季和初冬降低。但是 ,独居鼠在最短的光周期和寒冷季节保持高的睾酮浓度。春季 ,睾酮平均水平显著升高。

关键词：小毛足鼠繁殖季节

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A pilot survey on antimicrobial activity and diversity of soil-derived actinobacteria from different depths in Gudzhirganskoe saline lake in Eastern Siberia

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Journal of Oceanology and Limnology 2023年第4期41卷 1307-1320页

作者： Qin YANG Puyu GUO Elena Y.ABIDUEVA Elena V.LAVRENTYEVA Irina M.LISEVICH ilya A.OSTERMAN Petr V.SERGIEV Shaowei LIU Chunmei XUE Chenghang SUN Department of Microbial Chemistry Institute of Medicinal BiotechnologyChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100050China Beijing Key Laboratory of Antimicrobial Agents Institute of Medicinal BiotechnologyChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100050China College of Life Sciences Jiamusi UniversityJiamusi 154000China Institute of General and Experimental Biology Siberian BranchRussian Academy of SciencesUlan-Ude 670047Russia Center of Life Sciences Skolkovo Institute of Science and TechnologyMoscow 101135Russia Department of Chemistry A.N.Belozersky Institute of Physico-Chemical BiologyLomonosov Moscow State UniversityMoscow 101135Russia

To explore pharmaceutical actinobacteria from salty environments in Siberia,8 soil samples were collected from different depths of Gudzhirganskoe saline lake,the Republic of Buryatia,***,635 actinobacterial strains affiliated with 21 genera in 12 families of 7 orders were obtained by culture-dependent *** predominant genus was Streptomyces(74.5%),followed by Microbacterium(4.9%),Agromyces(3.5%),Nocardiopsis(3.0%),and Kitasatospora(2.5%).Seven strains showed relatively low 16 S rRNA similarities(<98.65%)with validly described ***-seven strains were selected as representatives to evaluate their antimicrobial activities and underlying mechanisms by paper-disk diffusion method and a double fluorescent protein reporter system(pDualrep 2),*** sp.S 6 b 3-1 was highlighted due to its strong inhibitory activities against Gram-positive bacteria and underlying antibacterial mechanism by inducing the SOS response in the reporter ***-1,(R)-6-[1-(benzoyloxy)ethyl]-phenazine-1-carboxylic acid,an analogue of saphenamycin was finally isolated from the culture broth of Streptomyces *** study preliminarily explored the actinobacterial diversity of soil samples collected in the highly alkaline and saline lake Gudzhirganskoe by culture-dependent approach and their capacity to produce antibiotics for the first time,which revealed that it deserves to make more efforts to discover new actinobacterial species and potential new antibiotics from the saline lake in Eastern Siberia.

关键词： Gudzhirganskoe saline lake actinobacteria diversity antimicrobial activities phenazine antibiotic

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COMPARATIVE TREATMENT OF ACNE VULGARIS USING PALOMAR LUX APPLIQU´E TECHNIQUE AND DIRECT INTRALESIONAL INJECTION

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Journal of Innovative Optical Health Sciences 2009年第3期2卷 279-287页

作者： ELINA A.GENINA ALEXEY N.BASHKATOV VALERY V.TUCHIN GEORGY V.SIMONENKO VERA N.SHERSTNEVA ilya V.YAROSLAVSKY GREGORY B.ALTSHULER Department of Optics and Biophotonics Saratov State University 83 Astrakhanskaya str. Saratov 410012Russia Saratov State Medical University 112 B.Kazachya str. Saratov 410012Russia Palomar Medical Technologies Inc. 82 Cambridge St.Burlington 01803MAUSA

Intralesional injection of triamcinolone(TMC)preparations is an effective therapy for cystic acne ***,invasive delivery techniques limit the use of this modality to a relatively narrow class of *** permeability can be enhanced through creating a lattice of microzones(islets)of light-induced limited thermal damage in the upper layers of *** this paper,we directly compared safety and efficacy of delivering TMC acetonide with this novel technique versus conventional intralesional injection for treatment of inflammatory acne lesions.A combination of an intense pulsed light system and a specially designed appliqu´e with a pattern of absorbing centers has been used to create the lattice of islets of damage(LID).Quantitative analysis has included estimation of the following parameters:redness,diameter,and height of acne *** photography has been used to document dynamics of lesion development at successive visits(two hours,24 hours and one week post-treatment).Seven subjects have participated in the *** difference in lesion dynamics between the treatment and control groups was observed at two-hours *** 24-hours/one-week follow-ups,TMC-injected and TMC-LID-delivered groups have demonstrated 82%/93%and 80%/89%improvement in height of lesions in comparison to control(60%/68%).Delivery of TMC with the newly proposed LID technique is at least as effective as intralesional injection for treating inflammatory acne *** of skin permeability using LID approach is a promising technique for accelerating delivery of various compounds to their target areas in the skin.

关键词： Acne vulgaris drug delivery skin permeability enhancement.

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DNA Sequencing Modified Method through Effective Regulation of Its Translocation Speed in Aqueous Solution

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Open Journal of Biophysics 2020年第2期10卷 96-112页

作者： Lusine Gasparyan ilya Mazo Ferdinand Gasparyan Vahan Simonyan Yerevan State University Yerevan Armenia DNA-HIVE LLC 15313 Diamond Cove Terrace Rockville MD USA Argentis LLC Gaithersburg MD USA

Solid-state nanopore DNA sequencing modified method is developed. Method is based on the tunnel current investigation through the nanogap made on lateral gold electrodes in the form of nanowires or nanoribbons. The movement of DNA in aqueous solution is regulated by the potential applied to reference electrode. The potential applied to the lateral metal electrodes helps to the creation of the molecular junctions. They consist of the nucleosides passing through the pores. Taking into account that DNA moves under gravity, electrophoretic and drag forces, the analytic expression for the DNA translocation speed is calculated and analyzed. The conditions for decreasing the DNA translocation speed or increasing the nucleosides reading time are received. It is shown that one can control value of the DNA molecules bases reading time and the frequency of the bases passes by the choice of magnitude of the potential applied to reference electrode. Our results, therefore potentially suggest a realistic, inherently design-specific, high-throughput nanopore DNA sequencing device/cell as a de-novo alternative to the existing methods.

关键词： DNA Sequencing DNA Speed Forces Reading Time

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Noises and Signal-to-Noise Ratio of Nanosize EIS and ISFET Biosensors

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Open Journal of Biophysics 2020年第1期10卷 1-12页

作者： Lusine Gasparyan ilya Mazo Vahan Simonyan Ferdinand Gasparyan DNA-HIVE LLC 15313 Diamond Cove Terrace Rockville USA Yerevan State University Yerevan Armenia Argentis LLC Gaithersburg USA

The results of comparative theoretical analyzes of the behavior of internal low-frequency noises, signal-to-noise ratio and sensitivity to DNA molecules for EIS and ISFET based nanosize biosensors are presented. It is shown that EIS biosensor is more sensitive to the presence of DNA molecules in aqueous solution than ISFET sensor. Internal electrical noises level decreases with the increase of concentration of DNA molecules in aqueous solution. In the frequency range 10−3 - 103 Hz noises level for EIS sensor about in three orders is higher than for ISFET sensor. In the other hand, signal-to-noise ratio for capacitive EIS biosensor is much higher than for ISFET sensor.

关键词： Biosensor Noise Sensitivity Signal-to-Noise Ratio

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DNA Sequencing: Current State and Prospects of Development

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Open Journal of Biophysics 2019年第3期9卷 169-197页

作者： Lusine Gasparyan ilya Mazo Vahan Simonyan Ferdinand Gasparyan Argentys Informatics LLC Gaithersburg MD USA Yerevan State University Yerevan Armenia The Department of Biochemistry & Molecular Medicine The School of Medicine and Health Sciences The George Washington University Washington DC USA

In this review, we collected and classified the stages of development of DNA sequencing methods and described its peculiarities. We pay attention mostly on solid-stead nanopore sequencing methods. Detailed discussion of the peculiarity and feasibility of the electrical methods of DNA sequencing is discussed. The detail analyses of the literature data, some critical considerations and the potential ways of optimization of DNA nanopore sequencing were presented.

关键词： DNA Sequencing ISFET Sensor EIS Sensor Solid-Stead Nanopore

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ISFET Based DNA Sensor: Current-Voltage Characteristic and Sensitivity to DNA Molecules

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Open Journal of Biophysics 2019年第4期9卷 239-253页

作者： Lusine Gasparyan ilya Mazo Vahan Simonyan Ferdinand Gasparyan Argentis LLC Gaithersburg MD USA Yerevan State University Yerevan Armenia The Department of Biochemistry & Molecular Medicine The George Washington University Washington DC USA

Dependency of both source-drain current and current sensitivity of nanosize ISFET biosensor vs. concentration of DNA molecules in aqueous solution theoretically is investigated. In calculations it is carried out effects concerning charge carriers distribution in current channel and concerning carriers’ mobility behavior in high electrical fields in the channel. The influence of DNA molecules on the work of ISFET biosensors is manifested by a change in the magnitude of the gate surface charge. Starting with fairly low concentrations of DNA, ISFET sensors respond to the presence of DNA molecules in an aqueous solution which is manifested by modulation of channel conductance and therefore the source-drain current changes of the field-effect transistor. It is shown that the current sensitivity with respect to concentration of DNA molecules linearly depends on the source-drain voltage and reaches high values.

关键词： DNA ISFET Sensitivity Nanosize Current Channel

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