Noises and Signal-to-Noise Ratio of Nanosize EIS and ISFET Biosensors

作     者：Lusine Gasparyan Ilya Mazo Vahan Simonyan Ferdinand Gasparyan 

作者机构：DNA-HIVE LLC 15313 Diamond Cove Terrace Rockville USA Yerevan State University Yerevan Armenia Argentis LLC Gaithersburg USA 

出 版 物：《Open Journal of Biophysics》 (生物物理学期刊（英文）)

年 卷 期：2020年第10卷第1期

页      面：1-12页

学科分类：080903[工学-微电子学与固体电子学] 0809[工学-电子科学与技术（可授工学、理学学位）] 08[工学] 080501[工学-材料物理与化学] 0805[工学-材料科学与工程（可授工学、理学学位）] 080502[工学-材料学] 

主　　题：Biosensor Noise Sensitivity Signal-to-Noise Ratio 

摘      要：The results of comparative theoretical analyzes of the behavior of internal low-frequency noises, signal-to-noise ratio and sensitivity to DNA molecules for EIS and ISFET based nanosize biosensors are presented. It is shown that EIS biosensor is more sensitive to the presence of DNA molecules in aqueous solution than ISFET sensor. Internal electrical noises level decreases with the increase of concentration of DNA molecules in aqueous solution. In the frequency range 10−3 - 103 Hz noises level for EIS sensor about in three orders is higher than for ISFET sensor. In the other hand, signal-to-noise ratio for capacitive EIS biosensor is much higher than for ISFET sensor.