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Sex,but not age and bone mass index positively impact on the development of osteochondral micro-defects and the accompanying cellular alterations during osteoarthritis progression

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Chronic Diseases and Translational Medicine 2022年第1期8卷 41-50页

作者： Angelos Kaspiris efstathios Chronopoulos elias Vasiliadis Lubna Khaldi Dimitra Melissaridou ilias D.Iliopoulos Olga D.Sawidou Laboratory of Molecular Pharmacology Division for Orthopaedic ResearchSchool of Health SciencesUniversity of PatrasPatrasGreece Second Department of Orthopaedic Surgery School of MedicineNational and Kapodistrian University of Athens"Konstantopoulio"General HospitalAthensGreece Third Department of Orthopaedic Surgery "KAT"General Hospital and Medical SchoolUniversity of AthensAthensGreece Department of Pathology "Agios Savvas"Athens Cancer Hospital-NHSAthensGreece First Department of Orthopaedic Surgery School of MedicineNational and Kapodistrian University of Athens"ATTIKON"University General HospitalAthensGreece Department of Orthopaedic Surgery "Rion"University Hospital and Medical SchoolSchool of Health SciencesUniversity of PatrasPatrasGreece

Background:Osteoarthritis(ΟΑ)is characterized by cartilage breakdown and subchondral ***-fractures of the calcified tissues have been,also,detected,but their exact role has not been elucidated *** study was to examine the frequency of cracks during OA progression and to correlate them with the underlying cellular modifications and matrix metalloproteinase-2(MMP-2)expression using histological/immunohistological ***:Overall,20 patients and 3 controls(9 specimens per patient),aged 60-89 years,diagnosed with hip/knee OA were *** development of cracks was examined in 138 sections,whereas the expression of MMP-2 was examined in 69 additional ***:Based on Mankin score,three groups of OA severity were analyzed:Group I(mild)was constituted of sections with score 1-5 while Groups II(moderate)and III(severe)with score 6-7 and greater or equal to 8,*** characteristics did not reveal any association between the number of microdefects and age or body mass index(BMI).Cartilage micro-cracks were increased during moderate and severe OA,while bone cracks were increased during mild and severe *** knee OA,cartilage cracks were not correlated with Mankin score,whereas in hip OA they appeared association with severity *** cracks were positively correlated with matrix apoptotic osteocytes and osteoblastic cells,but not with ***-2 immunostaining was increasing by OA severity in the osteochondral ***,MMP-2 was expressed on the microcracks’wall mainly in Group ***:Our data displayed that bone cracks during primary OA stages,represent an early adaptative mechanism aiming to maintain cartilage *** of bone defects and concomitant increase of apoptotic osteocytes activated an abnormal remodeling due to osteoblastic activity,in which MMP-2 played a pivotal role,leading to subchondral sclerosis promoting further osteochondral deformities.

关键词： demographic characteristics matrix metalloproteinase-2 micro-cracks osteoarthritis

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Hysterosalpingography Profile of Utero-Tubal Lesions in Female Infertility in Mopti (Mali, West Africa)

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Open Journal of Medical Imaging 2022年第2期12卷 67-72页

作者： Souleymane Sanogo Mamadou N’Diaye Alassane Kouma Nana Dembélé Issa Cissé Ouncoumba Diarra ilias Guindo Mahamadou Diallo Medical Imaging Department Sominé Dolo Hospital Mopti Mali Medical Imaging Department Mother-Child Luxembourg University Hospital Center Bamako Mali Army Medical Imaging Center Central Directorate of Armed Forces Services Bamako Mali Medical Imaging Department Municipal III Reference Health Center Bamako Mali Medical Imaging Department The University Hospital Center of Kati Bamako Mali Medical Imaging Department The University Hospital Center Gabriel Touré Bamako Mali

Introduction: Infertility is the inability to achieve pregnancy after 12 months of regular, unprotected sexual intercourse by a couple of childbearing age. It is a real public health problem because of its high prevalence in both developed and developing countries. Female infertility occupies a prominent place in reproductive health in Africa such as in our country Mali. The objective of this work was to determine the hysterosalpingography profile of utero-tubal lesions in the etiological research of female infertility in Mopti. Materials and Method: This was a cross-sectional descriptive study covering a period of one year from January 2019 to December 2019 in the radiology department of Sominé Dolo Hospital in Mopti. The variables analyzed were patient age and hysterosalpingography results. The hysterosalpingography examination was performed 3 or 4 days after menstruation on a remote-controlled table under fluoroscopic control. Data analysis was done with the aid of SPSS version 22 and excel 2016 software. Results: During the study period, 9012 patients were seen in the imaging department, including 115 patients, or 1.3% for infertility assessment. The 25 - 29 age group was the most represented with 34 patients or 29.6%. The mean was 30.39 ± 6.96 years with extremes of 17 and 46 years. Tubal abnormalities represented 45 cases or 39.1%. Hydrosalpinx was the most prevalent with 26 cases or 36.6%. Conclusion: Tubal lesions were the most observed, especially hydrosalpinx following. Hysterosalpingography remains the first choice in the radiological assessment of female infertility in our context.

关键词： Infertility Hysterosalpingography Hydrosalpinx Mopti Hospital

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Hydrologic Modeling Using SWAT and GIS, Application to Subwatershed Bab-Merzouka (Sebou, Morocco)

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Journal of Geographic Information System 2016年第1期8卷 20-27页

作者： Yassine Bouslihim ilias Kacimi Hassane Brirhet Mourad Khatati Aicha Rochdi Namira el Amrani Pazza Abdelhalim Miftah Zainab Yaslo Research Team in environmental Geosciences Faculty of Science and Technology Hassan 1 University Settat Morocco Faculty of Sciences Mohamed V University Rabat Morocco Faculty of Science and Technology Sidi Mohamed Ben Abdellah University Fes Morocco Research Team eRGO Faculty of Science Abdelmalek Essaadi University Tetouan Morocco

Water management in morocco faces significant challenges in both levels, quality and quantity, in order to address these challenges and to secure the rational and efficient management of water resources, it is necessary to try to understand the different issues involved in the water cycle works! The large number of hydrological studies and techniques used at the Sebou watershed are limited to water quality, and the use of the simpler empirical models, that, do not permit to take into consideration all the factors affecting flow and cycle of water. In the purpose of using the hydrological model SWAT to study the hydrological functioning of the Sebou watershed (Morocco) which faces many problems regarding the management of its water resources like all the other watersheds in our country, this study focuses on the creation, organization and generation of input data (soil, soil occupation, climate…) using a GIS (ARCGIS) then, the configuration and calibration of the model and after that, the evaluation of the results. The main reason behind this work is to measure the adaptability of this model to the selected area in order to generalize the model to the whole Sebou watershed. The results are satisfying;they show that this model can represent the overall hydrological regime of the pilot basin Bab-Merzouka. This model can open up new perspectives regarding the effects of climate change, and the changes caused by humans on water resources, in terms of both quantity and quality.

关键词： Hydrological Functioning SWAT GIS Sebou (Morocco)

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Unusual Head Trauma: About Three Observations at the Chu Pr Bocar Sidy Sall (BSS) of Kati

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Open Journal of Medical Imaging 2023年第3期13卷 57-62页

作者： Coulibaly Salia ilias Guindo Traore Ousmane Diarra Issa Traore Youssouf Sanogo Souleymane Diarra Ouncoumba Diarra Hawa Sidibe Siaka Medical Imaging Department Pr BSS University Hospital of Kati Mali Medical Imaging Department Kati University Hospital Kati Mali Department of Traumatology Neurosurgery Unit Pr BSS University Hospital of Kati Mali

Introduction: Penetrating head injuries are often due to human-to-human violence, mainly by firearms, those by stab are rare. CT is the exam of choice in the assessment of emergency lesions. We report three observations, all victims of knife assault during the brawl in order to clarify the contribution of DTM in the care. Observations: 1) Mr. I S, 21-year-old, student, was admitted with the hillside implanted in the skull. There were traces of blood on his face and clothes. There was no neurological deficit on examination. The CT scan performed showed the knife penetrating the vault of the skull at the left parietal level, up to 5 cm in the cerebral parenchyma with a minimal subdural and intracerebral hematoma;2) Mr. S C, 43-year-old, farmer, admitted with a large left fronto-temporo-parietal wound, bleeding and right hemiplegia. The CT scan performed showed a frontal linear fracture (with fronto-ethmoid hemosinus) and left temporoparietal with a parietal intraparenchymal hematoma and homolateral frontoparietal subdural hematoma;3) Mr. S B: 40 years old, driver, admitted with a parietal wound. The CT scan performed objectified a left parietal cortical hematoma in relation to a metallic foreign body (3000 HU) corresponding to the distal end of the knife penetrating the vault of the skull. They all underwent emergency surgery and received antibiotics and preventive serotherapy. The postoperative follow-up was simple, the follow-ups are without neurological sequelae. Conclusion: Head trauma by knife is rare, it results from inter-human violence. The lesion diagnosis is computed tomography. The prognosis depends on the severity.

关键词： Head Trauma Stabbing CT CHU Kati

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Laser trimming of the operating wavelength of silicon nitride racetrack resonators

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Photonics Research 2020年第5期8卷 677-683页

作者： GReTA De PAOLI SeNTA L.JANTZeN THALIA DOMINGUeZ BUCIO ilias SKANDALOS CHRISTOPHeR HOLMeS PeTeR G.R.SMITH MILAN M.MILOSeVIC FReDeRIC Y.GARDeS Department of Information engineering Universitàdegli Studi di PadovaVia Giovanni Gradenigo 635131 PadovaItaly Optoelectronics Research Centre University of SouthamptonSouthampton S0171BJUK

We demonstrate the possibility of post-fabrication trimming of the response of nitrogen-rich silicon nitride racetrack resonators by using an ultraviolet *** results revealed the possibility to efficiently tune the operating wavelength of fabricated racetrack resonators to any point within the full free spectral *** process is much faster than similar,previously presented methods(in the order of seconds,compared to hours).This technique can also be applied to accurately trim the optical performance of any other silicon photonic device based on nitrogen-rich silicon nitride.

关键词： trimming track faster

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Ultrasound of the Siren Syndrome (Sirenomelia) in the District of Bamako Apropos of a Case

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Open Journal of Medical Imaging 2022年第3期12卷 165-170页

作者： Ouncoumba Diarra Ousmane Traore ilias Guindo Mamadou Dembele Souleymane Traore Alassane Kouma Issa Cisse Mahamadou Diallo Siaka Sidibe Adama Diama Keita Radiology Department of the Reference Health Center of the CIII Commune of Bamako Bamako Mali Radiology Department of the Medical Clinic “Marie Curie” Bamako Mali Radiology Department of the KATI Hospital Center Bamako Mali Radiology Department of the Medical Clinic “FeRTILIA-DIAFOUNOU” Bamako Mali Radiology Department of the “Luxembourg” Mother-Child Hospital Center Bamako Mali Radiology Department of the “Gabriel TOURe” Hospital Center Bamako Mali Radiology Department CHU Point G Bamako Mali

Sirenomelia is a rare fetal malformation with more or less complete fusion of both lower limbs consistently associated with bilateral renal abnormalities. The positive diagnosis can be made antenatally by ultrasound during the first trimester of pregnancy but often before the 22 weeks of amenorrhea. The objective was to think about the possible diagnosis by ultrasound in front of the urinary anomalies and the ologiamnios during the morphological study of the second trimester of pregnancy. We report a case of sirenomelia in a 25-year-old lady as part of the routine prenatal assessment suspected and confirmed during the morphological ultrasound of the second trimester of pregnancy and confirmed after the termination of pregnancy in Mali in the Health Center of Reference of commune III of the district of Bamako. The morphological ultrasound made it possible to diagnose the malformation of the urinary tract, the amniotic fluid and to make the therapeutic decision of medical termination of pregnancy at the end of confirming the siren syndrome.

关键词： Sirenomalia Ultrasound Fetal Malformation Mali

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enhanced recovery after surgery in liver transplantation:Challenges and feasibility

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World Journal of Transplantation 2022年第7期12卷 195-203页

作者： Georgios Katsanos Konstantina-eleni Karakasi Nikolaos Antoniadis Stella Vasileiadou Athanasios Kofinas Antonios Morsi-Yeroyannis evangelia Michailidou Ioannis Goulis emmanouil Sinakos Olga Giouleme ilias Marios Oikonomou George evlavis Georgios Tsakiris eleni Massa eleni Mouloudi Georgios Tsoulfas Department of Transplantation Medical SchoolAristotle University of ThessalonikiHippokration General HospitalThessaloniki 54642Greece Intensive Care Unit National Health SystemHippokration General HospitalThessaloniki 54642Greece Fourth Department of Internal Medicine Hippokration General HospitalMedical School of Aristotle UniversityThessaloniki 54642Greece Second Propaedeutic Department of Internal Medicine Hippokratio General HospitalAristotle University ThessalonikiThessaloniki 54642Greece Nursing Department National Health SystemDepartment of TransplantationHippokration General HospitalThessaloniki 54642Greece

BACKGROUND enhanced recovery after surgery(eRAS)started a revolution that changed age-old surgical stereotypical practices regarding the overall management of the surgical *** the last decade,eRAS has gained significant acceptance in the community of general surgery,in addition to several other surgical specialties,as the evidence of its advantages continues to *** of the last remaining fields,given its significant complexity and intricate nature,is liver transplantation(LT).AIM To investigate the existing efforts at implementing eRAS in *** We conducted a systematic review of the existing studies that evaluate eRAS in orthotopic LT,with a multimodal approach and focusing on measurable clinical primary endpoints,namely length of hospital *** All studies demonstrated a considerable decrease in length of hospital stay,with no readmission or negative impact of the eRAS protocol applied to the postoperative *** eRAS is a well-validated multimodal approach for almost all types of surgical procedures,and its future in selected LT patients seems promising,as the preliminary results advocate for the safety and efficacy of eRAS in the field of LT.

关键词： enhanced recovery enhanced recovery after surgery Recovery Liver transplantation Liver

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epidemio-Clinical and Uretrocystographic Profile of Pathologies of the Lower Urinary Tract at the Chu Pr Bss of Kati

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Open Journal of Medical Imaging 2023年第1期13卷 40-48页

作者： ilias Guindo Souleymane Sanogo Alassane Kouma Dramane Bagayoko Issa Diarra Mamadou N’diaye Ouncoumba Diarra Amadou Kassogue Salia Coulibaly Adama Diaman Keita Medical Imaging Department Kati University Hospital Kati Mali Department of Radiology Luxembourg Mother-Child Hospital Bamako Mali Radiology Department Bamako Infirmary Bamako Mali Medical Imaging Service CS Ref of Commune III Bamako Mali Department of Urology University Hospital of Kati Kati Mali Department of Radiology and Nuclear Medicine Point “G” University Hospital Bamako Mali

Introduction: Pathologies of the lower urinary tract are common in urology composed of various conditions, responsible for urinary disorders. Despite the new methods, exploration in Africa is mainly based on retrograde urethrocystography (UCR). The main objective was to determine the importance of UCR in the diagnosis of pathologies of the lower urinary tract. Materials and Methods: This was a retrospective and descriptive study covering a period of 5 years (July 2016-June 2021). It involved all patients admitted to the ward for retrograde urethrocystography during the period. A remote-controlled table of the Ge PReSTILIX 1600× type was used for the examinations. Results: At the end of our study we collected 100 cases of pathologies of the lower urinary tract out of a total of 112 RCUs performed or 89.28%. Pathologies of the lower urinary tract accounted for 78% of the UCRs in the department. The age group of (61 - 70) was the most affected with extremes from 1 year to 101 years. Non-specific urination disorders were the most common indications (43%), followed by acute urine retention (18%). Acquired urethral pathology was the most common (89%), followed by bladder neck disease 5% and posterior urethral valve with 4%, Bladder struggle was the most common associated sign (54%) with post-urination residue in 97% of patients. Conclusion: Pathologies of the lower urinary tract are relatively common in our region, dominated by urethral narrowings. Retrograde urethrocystography remains the reference examination in our control for the diagnosis of obstructive pathologies of the lower urinary tract while specifying the seat of the obstacle.

关键词： Pathologies of the Lower Urinary Tract UCR CHU Kati

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The epidemiological, Clinical and Radiological (echography, Mammography) Characteristics of Breast Pathologies at the Diagnostic Imaging Center (C.I.D) “Teriya” in Bamako

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Open Journal of Medical Imaging 2023年第1期13卷 30-39页

作者： ilias Guindo Souleymane Sanogo Mamadou N’diaye Mody Abdoulaye Camara Adama Dao Youssouf Goita Amadou Sow Mohamed Malinke Salia Coulibaly Mahamadou Diallo Medical Imaging Department CHU Pr BSS of Kati Kati Mali Medical Imaging Department CHU Gabriel Touré Bamako Mali Medical Imaging Department Luxembourg Mother-Child Hospital Bamako Mali Imaging Service Bamako Infirmary Central Directorate of Armed Forces Health Services (DCSSA) Bamako Mali Medical Imaging Department Mali Hospital Bamako Mali TeRIYA Diagnostic Imaging Center Bamako Mali

Breast pathology is varied, bringing together tumor and non-tumor lesions. Objective: To study the contribution of the ultrasound-mammography pair in the diagnosis of breast pathologies. Materials and Method: This was a retrospective descriptive study, carried out over a period of 3 years (from January 2018 to December 2020) at the Diagnostic Imaging Center (C.I.D) “TeRIYA” in BAMAKO. It concerned all patients who came for a mammogram/ultrasound examination of the breast. All women admitted for mammogram or breast ultrasound who were diagnosed with a breast injury during the study period were included. Incomplete records and radiological checks were not included. The variables analyzed were age, sex, clinical data, and ultrasound and mammography aspects. The devices used are: a Voluson 730 PRO ultrasound machine and a G 600T type mammography machine. Results: At the end of our study, we collected 254 breast pathologies on a number of 382 women, i.e. a frequency of 66.49%. The average age of our patients was 41 years old. The dominant clinical data were mastodynia (41.88%) and mammary nodule (21.70%). On imaging (mammo-ultrasound) the lesions predominated on the left in 36% of cases, bilateral in 28% of cases and in the upper-outer quadrants in 31.5% of cases. Tumor pathologies represented 66.54% of which 45.27% were benign mainly composed of fibro-adenoma (20.88%) and cyst (18.50%), 11.8% of suspected cases and 9.45% of cancers. Non-tumor pathologies represented 33.46%, mainly mastitis (16.14%), galactophoric dilations (11.02%) and abscesses (5.51%). These pathologies were classified in 50.3% in ACR2, 17.75% in ACR3 and 4, and in 14.20% in ACR5. Lymphadenopathy was present in 73.21% of cases.

关键词： Breast Pathologies Ultrasound-Mammography Pair Diagnostic Imaging Center Bamako

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Rare Antenatal Fetal Malformations of the Anterior Abdominal Wall in Mali: About a Case

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Open Journal of Medical Imaging 2022年第4期12卷 208-214页

作者： Ousmane Traore Ouncoumba Diarra Mamadou N’Diaye Souleymane Sanogo ilias Guindo Abdoulaye Kone Hamady Sissoko Mahamadou Diallo Siaka Sidibe Adama Diaman Keita Radiology Department of the Medical Clinic “Marie Curie” Bamako Mali Department of Radiology Center Hospital-University “Le Point G” Bamako Mali Radiology Department Commune III Reference Health Center of Bamako Bamako Mali Radiology Department of the Military Camp of Bamako Bamako Mali Department of Radiology Center Hospital-University “Le Luxembourg” Bamako Mali Radiology Department Center Hospital-University de Kati Bamako Mali Radiology Department of the Medical Clinic “Pasteur” Bamako Mali Department of Radiology Center Hospital-University “Gabriel Toure” Bamako Mali

Abdominal wall malformations correspond to a wide spectrum of congenital anomalies that are due to a defect in the closure of the anterior abdominal wall and can be fatal. We report the case of laparoschisis associated with a poly malformation syndrome in the same fetus at the reference health center of commune III of the district of Bamako. The objective is to clarify the interest of antenatal ultrasound in the diagnosis and prognosis of these malformations. It was a 19-year-old prim gravid woman received as part of the prenatal check-up. Antenatal ultrasound had allowed the diagnosis of malformation of the anterior abdominal wall of the gastroschisis type associated with abnormalities of the neural tube, the urogenital system and the bone skeleton. The antenatal diagnosis of the malformations had motivated the realization of a therapeutic termination of pregnancy at 19 weeks of amenorrhea and 3 days by triggering and vaginal delivery, allowing the confirmation of the diagnosis of gastroschisis and the poly malformation syndrome which is extremely rare. Antenatal ultrasound remains an ideal means of imaging for monitoring pregnancy and had made it possible to make the prognosis and antenatal diagnosis of multiple malformations in association, and to indicate better therapeutic decision-making.

关键词： Malformation Fetus Antenatal Ultrasound Laparoschisis

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