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5-year efficacy of all surface laser ablation with cross-linking(ASLA-XTRA)for the treatment of myopia

Eye and Vision 2020年第1期7卷 294-299页

作者： Ioannis M.Aslanides Farhad Hafezi Shihao Chen Hatch Mukherjee Vasileios Selimis ilias maragkos Nanji Lu George Kymionis Emmetropia Mediterranean Eye Institute Plateia Eleftherias 44Heraklion71201 CreteGreece Eye Hospital Wenzhou Medical UniversityWenzhouChina Center for Applied Biotechnology and Molecular Medicine University of ZurichDietikon/ZurichSwitzerland ELZA Institute Dietikon/ZurichSwitzerland USC Roski Eye Institute University of Southern CaliforniaCaliforniaLos AngelesUSA Faculty of Medicine University of GenevaGenevaSwitzerland Essex County Hospital EssexUK Athens Medical School University of AthensAthensGreece Faculty of Biology and Medicine Jules Gonin Eye HospitalUniversity of LausanneLausanneSwitzerland

Background:The purpose of our study is to examine the long(5-year)efficacy of the all surface laser ablation(ASLA)combined with accelerated cross-linking(CXL)for the treatment of myopia without the use of mitomycin-C(MMC).Methods:This retrospective study consisted of 202 eyes of 118 myopic(SD:2.41,range:−1.50 to−12.75 D)patients(44 males,74 females).Mean age was 28.50 years(SD:6.45,range:18 to 51 years)that underwent ASLA with accelerated CXL for the treatment of their ***:The patients underwent routine postoperative assessment on the 1st,3rd,7th day and in the 1st,3rd,6th and 12th month,30th month(±6 months),4th and 5th *** mean spherical equivalent(SEq)refractive error changed from−6.41±2.41 D preoperatively to−0.02±0.53 D at 5 years *** haze score was 0.18,0.25 and 0.28 at 1,3 and 6 months *** 12 months after the treatment,no eyes had significant corneal haze and in all the following postoperative time intervals the haze traces were ***:ASLA combined with accelerated CXL(ASLA-XTRA)appears to be safe,efficacious and offering very good refractive *** potential additional benefits of this modality are the stabilizing effect of the refraction and its sterilization effect on the treated cornea without the potential side effects of MMC.

关键词： Refractive surgery Transepithelial PRK ASLA Cross-linking CXL ASLA-XTRA

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Endogenous versus exogenous cell replacement for Parkinson’s disease: where are we at and where are we going?

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Neural Regeneration Research 2022年第12期17卷 2637-2642页

作者： Theodora Mourtzi ilias Kazanis Laboratory of Developmental Biology Department of BiologyUniversity of PatrasPatrasGreece

Parkinson’s disease is the second most common neurodegenerative disease and has currently no effective treatment,one that would be able to stop or reverse the loss of dopaminergic neurons in the substantia nigra pars *** addition,Parkinson’s disease diagnosis is typically done when a significant percentage of the dopaminergic neurons is already *** neurodegenerative disorders,some therapeutic strategies could be effective only at inhibiting further degeneration;on the other hand,cell replacement therapies aim at replacing lost neurons,an approach that would be ideal for the treatment of Parkinson’s *** cell replacement therapies have been tested since the 1970s in the field of Parkinson’s disease;however,there are still significant limitations prohibiting a successful clinical *** the first fetal midbrain intrastriatal graft to the most recent conversion of astrocytes into dopaminergic neurons,we have gained equally,significant insights and questions still looking for an *** review aims to summarize the main milestones in cell replacement approaches against Parkinson’s *** focusing on achievements and failures,as well as on the additional research steps needed,we aim to provide perspective on how future cell replacement therapies treats Parkinson’s disease.

关键词： endogenous neurodegenerative disease neurogenesis neurotrophic factors Parkinson’s disease stem cells transdifferentiation transplantations

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District heating system operation in power systems with high share of wind power

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Journal of Modern Power Systems and Clean Energy 2017年第6期5卷 850-862页

作者： ilias DIMOULKAS Mikael AMELIN Fabian LEVIHN School of Electrical Engineering Electric Power and Energy SystemsKTH Royal Institute of TechnologyStockholmSweden Fortum Va¨rme StockholmSweden School of Industrial Engineering and Management Industrial Economics and ManagementKTH Royal Institute of TechnologyStockholmSweden

The integration of continuously varying and not easily predictable wind power generation is affecting the stability of the power system and leads to increasing demand for balancing *** this study,a short-term operation model of a district heating system is proposed to optimally schedule the production of both heat and power in a system with high wind power *** application of the model in a case study system shows the increased flexibility offered by the coordination of power generation,consumption and heat storage units which are available in district heating systems.

关键词： District heating systems Combined heat and power(CHP) Flexible power system operation Heat storage

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A reassessment of the diversity of green toads(Bufotes)in the circum-Aegean region

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Integrative Zoology 2021年第3期16卷 420-428页

作者： Christophe DUFRESNES Nikolas MPROBONAS ilias STRACHINIS LASER College of Biology and the EnvironmentNanjing Forestry UniversityNanjingPeople’s Republic of China Filoti NaxosGreece Department of Genetics Development and Molecular BiologySchool of BiologyFaculty of Natural SciencesAristotle University of ThessalonikiThessalonikiGreece

The dynamic biogeography of glacial refugia may cause complex patterns of genetic admixture between parapatric taxa,which in turn can mislead their systematics,diversity,and *** investigated this issue for green toads(Bufotes)inhabiting the circum-Aegean region,a biodiversity hotspot of the Eastern Mediterranean.A previous phylogeographic study based on mitochondrial and microsatellite loci identified the hybrid zone between the European(viridis)and Anatolian(sitibundus)lineages of *** all over the Balkan Peninsula,but subsequent range-wide genomic analyses(>1000 SNPs)located this transition in Turkey,a thousand kilometers *** order to clarify the diversity and taxonomy of the circum-Aegean populations,we reconciled these conflicting findings by integrating previous data with pure sitibundus *** results confirmed that the viridis/sitibundus hybrid zone extends in Western Anatolia,but that southeastern European populations feature cytonuclear discordances and a high and structured microsatellite *** remarkable situation may stem from a massive geographic displacement of the hybrid zone during the last glacial fluctuations,an underappreciated yet seemingly common feature among the herpetofauna of the *** study thus contributes to the rising view that mitochondrial DNA can be a poor predictor of current phylogeographic structure,hence the need for genomic data,especially for narrowly distributed ***,the analyses unambiguously support the distinction of a micro-endemic clade of green toads unique to some Cyclades islands,for which we provide a formal taxonomic description.

关键词： Cyclades hybrid zone Naxos phylogeography speciation

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Are pregnancy-associated hypertensive disorders so sweet?

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World Journal of Clinical Cases 2022年第28期10卷 10384-10386页

作者： Costas Thomopoulos Ioannis ilias Department of Cardiology Elena Venizelou General and Maternity HospitalAthens GR-11521Greece Department of Endocrinology Elena Venizelou General and Maternity HospitalAthens GR-11521Greece

Worldwide,one in seven pregnancies is complicated by some form of diabetes,with a rising ***,hypertension is one of the main causes of morbidity and mortality for both the pregnant woman and the fetus and also contributes to premature *** a cohort study of pregnant women with diabetes,which was recently published in this journal,at least 84.5% of the subjects had *** rate of hypertension might be among the highest reported thus *** the medical literature,approximately 20% of women with diabetes during pregnancy have various pregnancy-associated hypertensive ***/ethnic differences,apparently,were not implicated in this elevated rate of hypertension:Although black and Hispanic women have a twofold higher rate of hypertension in pregnancy compared to white women,75% of the subjects in the study in question were ***,the impressive finding delivered by this large study,merits additional clarifications.

关键词： Pregnancy Hypertension Pre-eclampsia Diabetes Gestational diabetes Human

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Liver function in transgender persons:Challenges in the COVID-19 era

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World Journal of Clinical Cases 2023年第2期11卷 299-307页

作者： Charalampos Milionis Ioannis ilias Eftychia Koukkou Department of Endocrinology Diabetes and MetabolismElena Venizelou HospitalAthens GR-11521Greece

Transgender persons constitute a non-negligible percentage of the general *** gender-transitioning in trans persons is mainly achieved with hormonal cross-sex therapy and sex reassignment surgeries that aim to align bodily appearance with gender *** treatment acts via suppressing the secretion of the endogenous sex hormones and replacing them with the hormones of the desired *** administration of testosterone is the typical masculinizing treatment in trans men,whilst trans women are routinely treated with estradiol agents in combination with anti-androgens or gonadotrophinreleasing hormone agonists if testes are *** androgenic steroids,estradiol agents,and anti-androgens have been implicated in a series of hepatotoxic ***,liver integrity is a major concern with the long-term administration of cross-sex *** tissue is susceptible to coronavirus disease 19(COVID-19)through various pathophysiological *** consideration should be paid to minimize the risk of hepatic damage from the potential cumulative effect of COVID-19 and gender-affirming treatment in transgender *** care is significant,with continuous laboratory monitoring,clinical observation and,if needed,specific treatment,especially in severe cases of infection and in persons with additional liver *** pandemic can be an opportunity to provide equal access to care for all and increase the resilience of the transgender population.

关键词： Transgender persons Drug induced liver injury COVID-19

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Polycystic ovary syndrome: Pathways and mechanisms for possible increased susceptibility to COVID-19

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World Journal of Clinical Cases 2021年第12期9卷 2711-2720页

作者： Ioannis ilias Spyridon Goulas Lina Zabuliene Department of Endocrinology Elena Venizelou HospitalAthens GR-11521Greece Department of Gastroenterology Unit Elena Venizelou HospitalAthens GR-11521Greece Institute of Clinical Medicine Faculty of MedicineVilnius UniversityVilnius LT-03101Lithuania

In 75%of women with polycystic ovary syndrome(PCOS),insulin action is *** obesity,visceral adipose tissue becomes dysfunctional:Chronic inflammation is favored over storage,contributing to the development of metabolic ***,metabolic syndrome(MetSy)and non-alcoholic fatty liver disease(NAFLD)apparently share common pathogenic factors;these include abdominal adiposity,excess body weight and insulin *** in the gut microbiome have been noted in women with PCOS compared to controls;these may lead to deterioration of the intestinal barrier,increased gut mucosal permeability and immune system activation,hyperinsulinemia and glucose intolerance,which hamper normal ovarian function and follicular development(all being hallmarks of PCOS).It has been proposed that PCOS may entail higher susceptibility to coronavirus disease 2019(COVID-19)via its associated comorbidities(NAFLD,obesity,MetSy and alterations in the gut microbiome).Studies have found an association between acute respiratory distress syndrome(seen in severe cases of COVID-19)and the intestinal ***,apparently,severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)can gain entry to the gastrointestinal tract via locally-expressed angiotensin converting enzyme type 2 *** body weight is associated with more severe COVID-19 and increased *** robust links between SARS-CoV-2 infection and PCOS/NAFLD/gut microbiome/metabolic consequences are yet to be confirmed,it seems that strategies for adapting the intestinal microbiome could help reduce the severity of COVID-19 in women with PCOS with or without NAFLD,MetSy or obesity.

关键词： Adipose tissue Obesity Polycystic ovaries SARS-CoV-2 COVID-19 Human

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COVID-19 and hyperglycemia/diabetes

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World Journal of Diabetes 2021年第5期12卷 642-650页

作者： Konstantinos Michalakis Ioannis ilias Private Practice Athens GR-11521Greece Department of Endocrinology Diabetes and MetabolismElena Venizelou HospitalAthens GR-11521Greece

In early studies regarding coronavirus disease 2019(COVID-19),type 2 diabetes mellitus was considered to contribute substantially to the disease’s inflammatory ***,even hyperglycemia,regardless of insulin resistance or diabetes mellitus,was found to be additionally *** studies have shown inflammation of the pancreaticβcells in COVID-19,even leading to new onset diabetes *** hereby summarize core literature on glycemia and COVID-19,and present implicated pathways and mechanisms.

关键词： COVID-19 Humans SARS-CoV-2 Risk factors Glucose Inflammation Diabetes

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Adipose-derived regenerative therapies for the treatment of knee osteoarthritis

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World Journal of Stem Cells 2024年第4期16卷 324-333页

作者： ilias E Epanomeritakis Wasim S Khan Division of Trauma and Orthopaedic Surgery Addenbrooke’s HospitalCambridge University Hospitals NHS Foundation TrustCambridge CB20QQUnited Kingdom Division of Trauma and Orthopaedic Surgery Department of SurgeryUniversity of CambridgeCambridge CB20QQUnited Kingdom

Knee osteoarthritis is a degenerative condition with a significant disease burden and no disease-modifying *** treatment ultimately requires joint *** capable of regenerating cartilage could significantly reduce financial and clinical *** regenerative potential of mesenchymal stromal cells(MSCs)has been extensively studied in the context of knee *** has yielded promising results in human studies,and is likely a product of immunomodulatory and chondroprotective biomolecules produced by MSCs in response to ***-derived MSCs(ASCs)are becoming increasingly popular owing to their relative ease of isolation and high proliferative *** vascular fraction(SVF)and micro-fragmented adipose tissue(MFAT)are produced by the enzymatic and mechanical disruption of adipose tissue,*** avoids expansion of isolated ASCs ex vivo and their composition of heterogeneous cell populations,including immune cells,may potentiate the reparative function of *** this editorial,we comment on a multicenter randomized trial regarding the efficacy of MFAT in treating knee *** discuss the study’s findings in the context of emerging evidence regarding adipose-derived regenerative *** underlying mechanism of action of ASCs is proposed while drawing important distinctions between the properties of isolated ASCs,SVF,and MFAT.

关键词： Knee osteoarthritis Mesenchymal stromal cells Adipose tissue Stromal vascular fraction Micro-fragmented adipose tissue Regeneration

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Non-alcoholic fatty liver disease,diabetes medications and blood pressure

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World Journal of Diabetes 2021年第10期12卷 1809-1811页

作者： Ioannis ilias Costas Thomopoulos Department of Endocrinology Diabetes and MetabolismElena Venizelou HospitalAthens 11521Greece Department of Cardiology Elena Venizelou HospitalAthens 11521Greece

New glucose-lowering agents reduce liver enzyme levels and blood pressure(BP).Whether this finding can be extended to non-alcoholic fatty liver disease(NAFLD)patients,in whom a bidirectional association of NAFLD measu... 详细信息

关键词： Antidiabetic drugs Blood pressure reduction Non-alcoholic fatty liver disease Sodium glucose cotransporter 2 Alanine aminotransferase Aspartate aminotransferase

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