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双磷酸改性血管支架作为基因载体的研究

国际生物医学工程杂志 2012年第1期35卷 3-7,I0001页

作者：王勇俞玫张琳华马桂蕾 ilia fishbein Ivan S. Alferiev Robert J. Levy 宋存先中国医学科学院北京协和医学院生物医学工程研究所天津300192 PA 19104 USA Division of Cardiology The Children＇s Hospital of Philadelphia

目的将基因通过化学偶联和特异性免疫结合在双磷酸氨基酯改性的316L不锈钢冠状动脉支架上，评价支架改性和负载质粒DNA的效果。方法金属支架首先利用双磷酸氨基酯改性引入氨基活性基团，化学偶联抗DNA抗体，然后免疫偶联质粒DNA，得到... 详细信息

目的将基因通过化学偶联和特异性免疫结合在双磷酸氨基酯改性的316L不锈钢冠状动脉支架上，评价支架改性和负载质粒DNA的效果。方法金属支架首先利用双磷酸氨基酯改性引入氨基活性基团，化学偶联抗DNA抗体，然后免疫偶联质粒DNA，得到血管支架上负载抗体和基因的模型。结果利用x射线光电子能谱（xPs）和原子力显微镜（AFM）等分析确定了支架表面磷酸氨基的存在，同位素标记验证了改性后支架表面结合的抗体具有很好的稳定性和结合容量。结论双磷酸氨基改性的血管支架表层富含可反应氨基，可以作为新型反应界面，与生物活性分子进行偶联反应。

关键词：支架双磷酸酯质粒DNA 基因载体

Hetero-integrated high-peak-optical-power laser source (940 nm) for time-of-flight sensors

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Chinese Optics Letters 2024年第7期22卷 81-85页

作者： Sergey Olegovich Slipchenko Aleksandr Aleksandrovich Podoskin ilia Vasil'evich Shushkanov Marina Gennad'evna Rastegaeva Artem Eduardovich Rizaev Matvey Igorevich Kondratov Artem Evgen'evich Grishin Nikita Aleksandrovich Pikhtin Timur Anatol'evich Bagaev Maxim Anatol'evich Ladugin Aleksandr Anatol'evich Marmalyuk Vladimir Aleksandrovich Simakov Ioffe Institut Russian Academy of SciencesSt.Petersburg 194021Russia Open Joint-Stock Company M.F.Stel’makh Polyus Research Institute Moscow 117342Russia RUDN University Moscow 117198Russia

The generation of high-power laser pulses using a compact hetero-integrated assembly based on a semiconductor laser with a dual-element composite 2μm×100μm aperture and a compact heterothyristor switch is *** achieved peak optical power was 33 W with a pulse duration of 3 ns at a thyristor operating voltage of 55 *** leading edge of the laser pulse turn-on was 50 ps to a power level of 24.7 W,and the turn-on delay between the elements of the composite aperture was 160 ps.

关键词： hetero-integrated assembly semiconductor lasers thyristor switches LIDAR gain-switching mode laser heterostructure

What can we learn from the history of aging research?

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History & Philosophy of Medicine 2024年第2期6卷 4-5页

作者： ilia Stambler Department of Science Technology and SocietyBar-Ilan UniversityRamat Gan 5290002Israel

There is currently a massive movement advocating for the enhancement of biomedical research on aging,sometimes referred to as“longevity advocacy”or“longevity activism”[1].The principal argument of the longevity advocacy movement is that the therapies developed by biomedical research of aging should enable us to directly intervene in the aging process and thus prevent multiple aging-related diseases,thereby extending healthy longevity.

关键词： thereby aging argument

Tensor products of coherent configurations

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Frontiers of Mathematics in China 2022年第5期17卷 829-852页

作者： Gang CHEN ilia PONOMARENKO School of Mathematics and Statistics Central China Normal UniversityWuhan 430079China Steklov Institute of Mathematics at St.Petersburg Russia Sobolev Institute of Mathematics NovosibirskRussia

A Cartesian decomposition of a coherent configuration✗is defined as a special set of its parabolics that form a Cartesian decomposition of the underlying *** turns out that every tensor decomposition of✗comes from a certain Cartesian *** is proved that if the coherent configuration✗is thick,then there is a unique maximal Cartesian decomposition of✗;i.e.,there is exactly one internal tensor decomposition of✗into indecomposable *** particular,this implies an analog of the Krull–Schmidt theorem for the thick coherent configurations.A polynomial-time algorithm for finding the maximal Cartesian decomposition of a thick coherent configuration is constructed.

关键词： Coherent configuration Cartesian decomposition Krull-Schmidt theorem

A fractal concentrator of direct and indirect sunlight

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Clean Energy 2020年第4期4卷 305-315页

作者： ilia Katardjiev Department of Electrical Engineering Uppsala UniversityUppsala 75121Sweden

A novel concept for concentrating both direct and indirect sunlight employing a combination of waveguiding and refractive optics is *** specifically,it is based on both the individual and the collective focusing effects of an array of refractive optical elements of specific *** analytical framework and design principles regarding the geometry of the optical elements taking into account Fresnel reflection and refraction are *** principle of operation along with loss mechanisms and acceptance angles are discussed in ***-tracing simulations of a light concentrator designed accordingly indicate transmittance>90%with acceptance angles of≤65°at 3 suns for moderate refractive *** is further numerically demonstrated that the new approach allows the utilization of the dominant fraction of the solar radiation by harvesting the waste heat in addition to photovoltaic conversion with an operating energy efficiency for diffuse light>70%.

关键词： concentrator diffuse light non-imaging optics solar harvesting

Pediatric-type follicular lymphoma in a Crohn’s disease patient receiving anti-α4β7-integrin therapy:A case report

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World Journal of Gastroenterology 2023年第43期29卷 5865-5871页

作者： Keval Yerigeri ilia Buhtoiarov Internal Medicine-Pediatrics Case Western Reserve University/MetroHealthClevelandOH 44109United States Pediatric Hematology/Oncology and Bone Marrow Transplantation Cleveland Clinic Children’sClevelandOH 44106United States

BACKGROUND Patients with autoimmune conditions receiving immunosuppressants are at risk of non-Hodgkin lymphomas(NHL).Vedolizumab(anti-α4β7-integrin antibody),a treatment-of-choice for Crohn’s disease(CD),reduces inflammatory lymphocyte trafficking into the intestinal *** effect is believed to be confined to the *** SUMMARY We report the case of a CD patient on vedolizumab for five years who developed pediatric-type follicular ***-up prior to therapy revealed a reduction in circulating T-lymphocytes and their suppressed response to ***,cyclophosphamide,vincristine,and prednisone chemoimmunotherapy resulted in durable lymphoma remission,and vedolizumab treatment was *** the patient’s T-lymphocyte population and immunoglobulin production recovered,the T-lymphocyte mitogen response remained *** This patient’s NHL may be linked to receiving anti-α4β7 *** research could be beneficial to determine if proactive surveillance for NHL and other systemic diseases is indicated in patients on vedolizumab.

关键词： Pediatric-type follicular lymphoma Crohn’s disease Vedolizumab Immunosuppression Non-Hodgkin lymphoma Case report

Low-power emerging memristive designs towards secure hardware systems for applications in internet of things

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Nano Materials Science 2021年第2期3卷 186-204页

作者： Nan Du Heidemarie Schmidt ilia Polian Department Nano Device Technology Fraunhofer Institute for Electronic Nano SystemsTechnologie-Campus 309126ChemnitzGermany Faculty of Electrical Engineering and Information Technology Chemnitz University of Technology(TU Chemnitz)Straße der Nationen 6209126ChemnitzGermany Department of Quantum Detection Leibniz Institute of Photonic Technology(IPHT)Albert-Einstein-Str.907745JenaGermany Institute for Solid State Physics Friedrich Schiller University JenaFürstengraben 107743JenaGermany Institute of Computer Engineering and Computer Architecture(ITI) University of StuttgartPfaffenwaldring 4770569StuttgartGermany

Emerging memristive devices offer enormous advantages for applications such as non-volatile memories and inmemory computing(IMC),but there is a rising interest in using memristive technologies for security applications in the era of internet of things(IoT).In this review article,for achieving secure hardware systems in IoT,lowpower design techniques based on emerging memristive technology for hardware security primitives/systems are *** reviewing the state-of-the-art in three highlighted memristive application areas,*** non-volatile memory,memristive reconfigurable logic computing and memristive artificial intelligent computing,their application-level impacts on the novel implementations of secret key generation,crypto functions and machine learning attacks are explored,*** the low-power security applications in IoT,it is essential to understand how to best realize cryptographic circuitry using memristive circuitries,and to assess the implications of memristive crypto implementations on security and to develop novel computing paradigms that will enhance their *** review article aims to help researchers to explore security solutions,to analyze new possible threats and to develop corresponding protections for the secure hardware systems based on low-cost memristive circuit designs.

关键词： Memristive technology Nanoelectronic device Low-power consumption Miniaturization Nonvolatility Reconfigurability In memory computing Artificial intelligence Hardware security primitives Machine learning-related attacks and defenses

GRAFTED STYRENE-DIVINYLBENZENE COPOLYMERS CONTAINING BENZALDEHYDES AND THEIR WITTIG REACTIONS WITH VARIOUS PHOSPHONIUM SALTS

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Chinese Journal of Polymer Science 2005年第6期23卷 651-656页

作者： Adriana Popa Gheorghe ilia Aurelia Pascariu Smaranda Iliescu Nicoleta Plesu Institute of Chemistry Romanian Academy Bd.Mihai Viteazul 24 R-300223 TimisoaraRomania

A chloromethylated styrene-divinylbenzene copolymer support system functionalized with 4-benzaldehyde and 2-benzaldehyde was prepared. The degree of functionalization with aldehyde groups is well suited for the subsequent use of the products as Wittig reagents. The polymer bound aldehyde was reacted with Wittig reagents to give olefin groups grafted on styrene-divinylbenzene copolymers. The reactions were carded out in phase transfer catalysis conditions. A simple procedure for the calculation of the degree of functionalization and the statistical modeling of the structural repetitive unit of the copolymer are reported.

关键词： Chloromethylated styrene-divinylbenzene copolymer 4-Benzaldehyde 2-Benzaldehyde Phase-transfer catalysis Wittig reaction

Fifty years of capital markets research in accounting:Achievements so far and opportunities ahead

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China Journal of Accounting Research 2020年第3期13卷 237-249页

作者： ilia D.Dichev Goizueta Business School Emory UniversityUSA

This paper reviews the literature on capital markets research in accounting over the last 50 *** than trying to be comprehensive,the review focuses on selected areas,and strives to be *** first major takeaway is that the literature has made great progress,especially on the technical *** second takeaway is that great opportunities remain,especially in using Big Data,looking more closely into the accrual process,and in issues related to standard setting.

关键词： capital looking market