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Modification of tenascin-R expression following unilateral labyrinthectomy in rats indicates its possible role in neural plasticity of the vestibular neural circuit

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Neural Regeneration Research 2015年第9期10卷 1463-1470页

作者： Botond Gaal Einar ?rn Jóhannesson Amit Dattani Agnes Magyar ildikó Wéber Clara Matesz Department of Anatomy Histology and Embryology Faculty of Medicine and Faculty of Dentistry University of Debrecen Department of Pediatric Surgery Faculty of Medicine Clinical Center University of Debrecen MTA-DE Neuroscience Research Group University of Debrecen

We have previously found that unilateral labyrinthectomy is accompanied by modification of hyaluronan and chondroitin sulfate proteoglycan staining in the lateral vestibular nucleus of rats and the time course of subsequent reorganization of extracellular matrix assembly correlates to the restoration of impaired vestibular function. The tenascin-R has repelling effect on pathfinding during axonal growth/regrowth, and thus inhibits neural circuit repair. By using immunohistochemical method, we studied the modification of tenascin-R expression in the superior, medial, lateral, and descending vestibular nuclei of the rat following unilateral labyrin- thectomy. On postoperative day 1, tenascin-R reaction in the perineuronal nets disappeared on the side of labyrinthectomy in the superior, lateral, medial, and rostral part of the descending vestibular nuclei. On survival day 3, the staining intensity of tenascin-R reaction in perineuronal nets recovered on the operated side of the medial vestibular nucleus, whereas it was restored by the time of postoperative day 7 in the superior, lateral and rostral part of the descending vestib- ular nuclei. The staining intensity of tenascin-R reaction remained unchanged in the caudal part of the descending vestibular nucleus bilaterally. Regional differences in the modification of tena- scin-R expression presented here may be associated with different roles of individual vestibular nuclei in the compensatory processes. The decreased expression of the tenascin-R may suggest the extracellular facilitation of plastic modifications in the vestibular neural circuit after lesion of the labyrinthine receptors.

关键词： nerve regeneration extracellular matrix brainstem vestibular system vestibular lesion vestibular compensation perineuronal net neural plasticity neural regeneration

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Behavior of ductile steel X-braced RC frames in seismic zones

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Earthquake Engineering and Engineering Vibration 2019年第4期18卷 845-869页

作者： Eber Alberto Godínez-domínguez Arturo Tena-Colunga Facultad de Ingeniería Universidad Autónoma de Chiapas Tuxtla Gutiérrez 29050 Mexico Departamento de Materiales Universidad Autónoma Metropolitana México City 02200 Mexico

A satisfactory ductile performance of moment-resisting reinforced concrete concentric braced frame structures (RC-MRCBFs) is not warranted by only following the provisions proposed in Mexico’s Federal District Code (MFDC-04). The nonlinear behavior of low to medium rise ductile RC-MRCBFs using steel X-bracing susceptible to buckling is evaluated in this study. The height of the studied structures ranges from 4 to 20 stories and they were located for design in the lakebed zone of Mexico City. The design of RC-MRCBFs was carried out considering variable contribution of the two main lines of defense of the dual system (RC columns and steel braces). In order to observe the principal elements responsible for dissipating the earthquake input energy, yielding mappings for diff erent load-steps were obtained using both nonlinear static and dynamic analyses. Some design parameters currently proposed in MFDC-04 as global ductility capacities, overstrength reduction factors and story drifts corresponding to diff erent limit states were assessed as a function of both the considered shear strength and slenderness ratios for the studied RC-MRCBFs using pushover analyses. Additionally, envelopes of response maxima of dynamic parameters were obtained from the story and global hysteresis curves. Finally, a brief discussion regarding residual drifts, residual drift ratios, mappings of residual deformations in steel braces and residual rotations in RC beams and columns is presented. From the analysis of the obtained results, it is concluded that when a suitable design criterion is considered, good structural behavior of RC-MRCBFs with steel-X bracing can be obtained. It is also observed that the shear strength balance has an impact in the height-wise distribution of residual drifts, and an important “shake-down” eff ect is obtained for all cases. There is a need to improve design parameters currently proposed in MFDC to promote an adequate seismic performance of RC-MRCBFs.

关键词： RC braced-frames seismic design nonlinear dynamic analyses steel-X bracing overstrength collapse mechanism story drifts residual drifts

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Fully integrated and broadband Si-rich silicon nitride wavelength converter based on Bragg scattering intermodal four-wave mixing

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Photonics Research 2024年第3期12卷 I0001-I0010页

作者： VALERIO VITALI THALÍA domÍNGUEZ BUCIO HAO LIU JOSÉMANUEL LUQUE GONZÁLEZ FRANCISCO JURADO-ROMERO ALEJANDRO ORTEGA-MOÑUX GLENN CHURCHILL JAMES C.GATES JAMES HILLIER NIKOLAOS KALFAGIANNIS DANIELE MELATI JENS H.SCHMID ILARIA CRISTIANI PAVEL CHEBEN J.GONZALO WANGÜEMERT-PÉREZ ÑIGO MOLINA-FERNÁNDEZ FREDERIC GARDES COSIMO LACAVA PERIKLIS PETROPOULOS Optoelectronics Research Centre University of SouthamptonSouthampton SO171BJUK Electrical Computer and Biomedical Engineering DepartmentUniversity of PaviaPavia 27100Italy Telecommunication Research Institute(TELMA) Universidad de MálagaCEI Andalucı´a TECHE.T.S.I.Telecomunicación29010 MálagaSpain School of Science and Technology Nottingham Trent UniversityNottingham NG118NSUK Department of Electrical Engineering Eindhoven University of TechnologyEindhoven 5600 MBThe Netherlands Department of Materials Science and Engineering University of IoanninaIoannina 45110Greece Centre de Nanosciences et de Nanotechnologies UniversitéParis-SaclayCNRS91120 PalaiseauFrance Advanced Electronics and Photonics Research Center National Research Council CanadaOttawaOntario K1A 0R6Canada

Intermodal four-wave mixing(FWM)processes have recently attracted significant interest for all-optical signal processing applications thanks to the possibility to control the propagation properties of waves exciting distinct spatial modes of the same *** allows,in principle,to place signals in different spectral regions and satisfy the phase matching condition over considerably larger bandwidths compared to intramodal ***,the demonstrations reported so far have shown a limited bandwidth and suffered from the lack of on-chip components designed for broadband manipulation of different *** demonstrate here a silicon-rich silicon nitride wavelength converter based on Bragg scattering intermodal FWM,which integrates mode conversion,multiplexing and de-multiplexing functionalities *** system enables wavelength conversion between pump waves and a signal located in different telecommunication bands(separated by 60 nm)with a 3 dB bandwidth exceeding 70 nm,which represents,to our knowledge,the widest bandwidth ever achieved in an intermodal FWM-based system.

关键词： scattering pump modal

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Novel human immunomodulatory T cell receptors and their double-edged potential in autoimmunity,cardiovascular disease and cancer

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Cellular & Molecular Immunology 2021年第4期18卷 919-935页

作者： Pilar Martin Rafael Blanco-dom fnguez Raquel Sanchez-Diaz Vascular Pathophysiology Area Centro Nacional de Investigaciones Cardiovasculares(CNIC)MadridSpain CIBERCV MadridSpain

In the last decade,approaches based on T cells and their immunomodulatory receptors have emerged as a solid improvement in treatments for various types of ***,the roles of these molecules in the therapeutic context of autoimmune and cardiovascular diseases are still relatively ***,we review the best known and most com m only used immunomodulatory T cell receptors in clinical practice(PD-1 and CTLA-4),along with the rest of the receptors with known functions in animal models,which have great potential as modulators in human pathologies in the medium *** ong these other receptors is the receptor CD69,which has recently been described to be expressed in mouse and human T cells in autoimmune and cardiovascular diseases and ***,inhibition of these receptors individually or in combination by drugs or monoclonal antibodies generates a loss of immunological tolerance and can trigger multiple autoimmune disorders in different organs and immune-related adverse *** the coming decades,knowledge on the functions of different immunomodulatory receptors will be pivotal for the development of new and better therapies with less harmful side *** this review,we discuss the roles of these receptors in the control of immunity from a perspective focused on therapeutic potential in not only cancer but also autoimmune diseases,such as systemic lupus erythematosus,autoimmune diabetes and rheumatoid arthritis,and cardiovascular diseases,such as atherosclerosis,acute myocardial infarction,and myocarditis.

关键词： Immunomodulatory receptors Autoimmune diseases T cells Immunotherapy

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Nutritional Supplement Ocoxin® Combined with Gemcitabine-Based Chemotherapy in Patients with Advanced Pancreatic Adenocarcinoma

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Open Journal of Gastroenterology 2024年第8期14卷 267-287页

作者： Mayté Lima-Pérez Jorge Luis Soriano-García Masiel González-Meisozo Jorge Luis Soriano-Lorenzo Vilma Fleites-Calvo Dunia Morales-Morgado Carlos domínguez-Álvarez Iván Ramón-Concepción Raidel Rodríguez-Barrios Alicia Tarinas-Reyes Ivis Mendoza-Hernández Rolando Uranga-Piña Clinical Oncology Department Ameijeiras Hospital Havana Cuba Clinical Pathology Department Ameijeiras Hospital Havana Cuba Clinical Section National Coordinating Centre for Clinical Trials Havana Cuba Biostatistics Section National Coordinating Centre for Clinical Trials Havana Cuba

Background: the quality of life (QoL) of patients with pancreatic ductal adenocarcinoma (PDAC), with its limited survival, can be affected by chemotherapy-induced toxicity. The main objective was to evaluate the effect of introducing ocoxin oral solution (OOS) in combination with standard therapy on quality of life. Methods: Thirty patients were enrolled in an exploratory, prospective, single-centre clinical trial in the oncology department of “Hermanos Ameijeiras” University Hospital in Havana, Cuba. Quality of life was measured using the EORTC QLQ-C30 questionnaire and toxicity was assessed using the NCI-CTC-AE classification version 5.0. Results: There was stability in the scores over time for overall QoL and the functional scale criteria, while in terms of symptoms, fatigue, pain and loss of appetite were reduced. No grade 3 - 4 adverse events (AEs) were recorded, and only 14.9% of toxicities were classified as grade 2, and these were considered to be unrelated to OOS. Biochemical and nutritional parameters were normalised at 12 months compared to the baseline values. Conclusions: This clinical study is the first report of the use of OOS in patients with advanced pancreatic cancer, and demonstrates that it is able to maintain optimal quality of life with reduced severity of toxicity during and after combination treatment with gemcitabine-based chemotherapy.

关键词： EORTC QLQ-C30 Ocoxin Chemotherapy Pancreatic Cancer Quality of Life

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Building geometry data from online maps for accurate thermal simulations of districts

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建筑模拟(英文) 2023年第9期16卷 1659-1674页

作者： Laura Romero Rodríguez JoséSánchez Ramos ServandoÁlvarez domínguez Grupo Termotecnia.Departamento de Máquinas y Motores Térmicos University of CádizPuerto RealCádizSpain Grupo Termotecnia.Departamento de Ingenieria Energética University of SevilleSevilleSpain

Current approaches for simulating the energy performance of buildings on a large scale are limited by numerous assumptions and simplifications,which can lead to inaccurate *** new tools and procedures are emerging to improve accuracy,there remains a need for more user-friendly *** study proposes a new tool based on online maps to create the geometry of districts in a simple *** tool also enables an automatic evaluation of all buildings through dynamic hourly simulations,using a building simulation software and allowing to consider different weather *** illustrate the procedure,a district at risk of energy poverty in Seville(Spain)is modeled,where hourly temperature data for a whole year are available to demonstrate the need for building *** tool is used to evaluate the energy demands of the district under several retrofitting alternatives,and free-floating simulations are also performed to evaluate the improvement of thermal comfort without air-conditioning *** aim is not to discuss the actual values for this particular case,but rather to identify the correct direction for large-scale studies,so as to make them more easily ***,it may be concluded that the results provided by comprehensive tools,such as the one proposed in this study,enable easy yet accurate evaluations of buildings on a large scale with significant time savings,as well as the identification of locations where retrofitting interventions would have the greatest impact.

关键词： buildings districts energy demand efficiency GIS urban scale

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AN IMPLEMENTATION OF THE COLLOCATION METHOD FOR INITIAL VALUE PROBLEMS

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International Journal of Modeling, Simulation, and Scientific Computing 2013年第2期4卷 142-154页

作者： RAFAEL G.CAMPOS FRANCISCO dom´INGUEZ MOTA Facultad de Ciencias Fısico-Matematicas Universidad Michoacana 58060 MoreliaMich.Mexico

An implementation of the standard collocation method based on polynomial interpolation is presented in a matrix framework in this *** underlying differentiation matrix can be partitioned to yield a superconvergent implicit multistep-like method to solve the initial value problem *** first-and second-order versions of this method are L-stable.

关键词： IVP ODE collocation differentiation matrix interpolation superconvergence stability

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Diagnostic challenges in alcohol use disorder and alcoholic liver disease

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World Journal of Gastroenterology 2014年第25期20卷 8024-8032页

作者： Luisa Vonghia Peter Michielsen Geert dom Sven Francque Department of Gastroenterology and Hepatology University Hospital Antwerp Wilrijkstraat 10 2650 Edegem Belgium Department of Basic Medical Sciences Neuroscience and Sensory OrgansUniversity of BariPoliclinicoPiazza Giulio Cesare70100 BariItaly Collaborative Antwerp Psychiatric Research Institute (CAPRI) Antwerp University Universiteitsplein 12610 Antwerp Belgium

Alcohol use disorders represent a heterogeneous spectrum of clinical manifestations that have been defined by the Diagnostic and Statistical Manual of Mental Disorders-5. Excessive alcohol intake can lead to damage of various organs, including the liver. Alcoholic liver disease includes different injuries ranging from steatosis to cirrhosis and implicates a diagnostic assessment of the liver disease and of its possible complications. There is growing interest in the possible different tools for assessing previous alcohol consumption and for establishing the severity of liver injury, especially by noninvasive methods.

关键词： Alcoholic liver disease Alcohol use disorder Diagnosis Diagnostic and Statistical Manual of Mental Disorders-5 Screening tests Markers of previous alcohol consumption Non-invasive fibrosis assessment

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Metabolomic Fingerprinting of Blood Samples by Direct Infusion Mass Spectrometry:Application in Alzheimer’s Disease Research

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Journal of Analysis and Testing 2017年第3期1卷 83-91页

作者： Rau´l Gonza´lez-domı´nguez Department of Chemistry Faculty of Experimental SciencesUniversity of Huelva21007 HuelvaSpain

Metabolomics is largely employed in numerous biomedical research fields,such as the study of the underlying pathology of diseases,discovery of diagnostic biomarkers,or drug ***,the main challenge is to obtain comprehensive and unbiased metabolomic profiles due to the huge complexity,heterogeneity,and dynamism of the *** this end,mass spectrometry represents a very interesting analytical platform,since the complexity of metabolome may be overcome through the use of different orthogonal separation techniques,including liquid chromatography,gas chromatography,and capillary ***,direct mass spectrometry analysis has been postulated as a complementary choice to hyphenated *** technique exhibits several advantages such as the ability for high-throughput screening,fast analysis,and wide metabolomic coverage,since there is not exclusion of compounds due to the separation *** present work explores the utility of metabolomics based on direct infusion mass spectrometry for analyzing blood *** most important analytical concerns to be considered are discussed,including sample handling,comprehensive fingerprinting,as well as subsequent identification of metabolites,and global characterization of metabolomic *** conclude,a brief review on the application of these metabolomic platforms in Alzheimer’s disease research is also provided.

关键词： Metabolomics Direct infusion mass spectrometry Alzheimer’s disease Blood

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The immune hunger games:the effects of fasting on monocytes

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Cellular & Molecular Immunology 2023年第10期20卷 1098-1100页

作者： Jorge domínguez-Andrés Holger Reinecke Yahya Sohrabi Department of Internal Medicine and Radboud Center for Infectious Diseases Radboud University Nijmegen Medical Centre6500HBNijmegenthe Netherlands Department of Cardiology I-Coronary and Peripheral Vascular Disease Heart FailureUniversity Hospital MünsterWestfälische Wilhelms-UniversitätMünsterGermany Institutes of Molecular Genetics of the Czech Academy of Sciences PragueCzech Republic Department of Medical Genetics Third Faculty of MedicineCharles UniversityPragueCzech Republic

Currently,different types of fasting are becoming increasingly popular for their potential health benefits,particularly in improving cardiometabolic ***,how these practices affect immune function is not well *** a recent study published in Immunity,Janssen et *** into the complex relationship among fasting,refeeding,and the immune *** fasting caused monocyte homing in bone marrow(BM),refeeding escalated monocyte counts in the circulation but altered immune responses to bacterial infection[1].

关键词： becoming fasting she

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