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Multifaceted superoxide dismutase 1 expression in amyotrophic lateral sclerosis patients:a rare occurrence?

Neural Regeneration Research 2025年第1期20卷 130-138页

作者： ilaria Martinelli Jessica Mandrioli Andrea Ghezzi Elisabetta Zucchi Giulia Gianferrari Cecilia Simonini Francesco Cavallieri Franco Valzania Department of Neurosciences Azienda Ospedaliero Universitaria di ModenaModenaItaly Clinical and Experimental Medicine Ph.D.Program University of Modena and Reggio EmiliaModenaItaly Department of Biomedical Metabolic and Neural SciencesUniversity of Modena and Reggio EmiliaModenaItaly Neurology Unit Neuromotor&Rehabilitation DepartmentAzienda USL-IRCCS di Reggio EmiliaReggio EmiliaItaly

Amyotrophic lateral sclerosis(ALS)is a neuromuscular condition resulting from the progressive degeneration of motor neurons in the cortex,brainstem,and spinal *** the typical clinical phenotype of ALS involves both upper and lower motor neurons,human and animal studies over the years have highlighted the potential spread to other motor and non-motor regions,expanding the phenotype of *** superoxide dismutase 1(SOD1)mutations represent a minority of ALS cases,the SOD1 gene remains a milestone in ALS research as it represents the first genetic target for personalized *** numerous single case reports or case series exhibiting extramotor symptoms in patients with ALS mutations in SOD1(SOD1-ALS),no studies have comprehensively explored the full spectrum of extramotor neurological manifestations in this *** this narrative review,we analyze and discuss the available literature on extrapyramidal and non-motor features during *** multifaceted expression of SOD1 could deepen our understanding of the pathogenic mechanisms,pointing towards a multidisciplinary approach for affected patients in light of new therapeutic strategies for SOD1-ALS.

关键词： amyotrophic lateral sclerosis(ALS) autonomic extramotor genotype-phenotype multisystem involvement Parkinson’s disease sensory SOD1 superoxide dismutase 1 urinary vocal cord palsy

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Psycho-gastroenterological profile of an Italian population of children with disorders of gut-brain interaction:A case-control study

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World Journal of Clinical Pediatrics 2025年第1期14卷 69-77页

作者： Valentina Giorgio ilaria Venezia Licia Pensabene Elisa Blasi Donato Rigante Paolo Mariotti Giuseppe Stella Gaia Margiotta Giovanna Quatrale Giuseppe Marano Marianna Mazza Antonio Gasbarrini Eleonora Gaetani Pediatric Unit Department of WomenChildren and Public Health SciencesFondazione Policlinico Universitario“A.Gemelli”IRCCSUniversitàCattolica del Sacro CuoreRome 00168Italy Child Neuropsychiatry Unit ASST Santi Paolo e CarloSan Paolo HospitalMilan 20142Italy Child Neuropsychiatry Unit Department of WomenChildren and Public Health SciencesFondazione Policlinico Universitario“A.Gemelli”IRCCSUniversitàCattolica del Sacro CuoreRome 00168Italy Department of Medical and Surgical Sciences Pediatric UnitUniversity Magna GraeciaCatanzaro 88100Italy Unit of Psychiatry Fondazione Policlinico Universitario“A.Gemelli”IRCCSRome 00168Italy Department of Neurosciences UniversitàCattolica del Sacro CuoreRome 00168Italy Department of Internal Medicine and Gastroenterology Fondazione Policlinico Universitario"A.Gemelli"IRCCSRome 00168Italy Department of Medical and Surgical Sciences Fondazione Policlinico Universitario"A.Gemelli"IRCCSUniversitàCattolica del Sacro CuoreRome 00168Italy

BACKGROUND Disorders of gut-brain interaction(DGBI)are common,but knowledge about their physiopathology is still poor,nor valid tools have been used to evaluate them in *** To develop a psycho-gastroenterological questionnaire(PGQ)to assess the psycho-gastroenterological profile and social characteristics of a pediatric population with and without *** One hundred and nineteen Italian children(age 11-18)were included:28 outpatient patients with DGBI(Rome IV criteria)and 91 healthy *** filled the PGQ,faces pain scale revised(FPS-R),Bristol stool chart,ga-strointestinal symptoms rating scale,state-trait anxiety inventory,Toronto alexithymia scale 20,perceived self-efficacy in the management of negative emotions and expression of positive emotions(APEN-G,APEP-G),irritable bowel syndrome-quality of life questionnaire,school performances,tobacco use,early life events,degree of *** Compared to controls,patients had more medical examinations(35%of them went to the doctor more than five times),a higher school performance(23%vs 13%,P<0.05),didn’t use tobacco(never vs 16%,P<0.05),had early life events(28%vs 1%P<0.05)and a higher percentage of pain classified as 4 in the FPS-R during the examination(14%vs 7%,P<0.05).CONCLUSION Pediatric outpatients with DGBI had a higher prevalence of early life events,a lower quality of life,more medical examinations rising health care costs,lower anxiety levels.

关键词： Disorders of gut-brain interaction Functional gastrointestinal disorders Psycho-gastroenterological profile Gut-brain axis Rome IV criteria Pediatric patients

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Disentangling brain PrP^(C)proteoforms and their roles in physiology and disease

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Neural Regeneration Research 2024年第5期19卷 963-965页

作者： ilaria Vanni Nonno Romolo Department of Food Safety Nutrition and Veterinary Public HealthIstituto Superiore di SanitàRomeItaly

The cellular prion protein(PrPC),a cell surface glycoprotein of 209 amino acids,has been considerably studied over the decades mainly due to its critical involvement in transmissible spongiform encephalopathies,or prion ***,it is the misfolding and aggregation of PrPC into pathological assemblies-named PrPSc-that constitute prions,the agents causing these unusual neurodegenerative diseases affecting humans and animals(Prusiner,1982).Furthermore,increasing evidence support its relevance also in other neurodegenerative diseases(NDDs),such as Alzheimer’s and Parkinson’s diseases(Corbett et al.,2020).

关键词： diseases involvement glycoprotein

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Asymptotic Formulae for Multivariate Kantorovich Type Generalized Sampling Series

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Acta Mathematica Sinica,English Series 2011年第7期27卷 1247-1258页

作者： Carlo BARDARO ilaria MANTELLINI Dipartimento di Matematica e Informatica Universitd di Perugia Via Vanvitelli 1 06123 Perugia Italy

In this paper an asymptotic formula of Voronovskaja type for a multivariate extension of the Kantorovich generalized sampling series is given. Moreover a quantitative version in terms of some moduli of smoothness is established. Finally some particular examples of kernels are discussed, as the Bochner-Riesz kernel and the multivariate splines.

关键词： Voronovskaja-type formula moments multivariate Kantorovich generalized sampling series Peetre K-functional

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Spinterface:A new platform for spintronics

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Nano Materials Science 2019年第3期1卷 149-155页

作者： ilaria Bergenti Valentin Dediu Institute of Nanostructured Materials ISMN National Research Council CNR40129BolognaItaly CNR-ISMN Bologna Via P.Gobetti 10140129BolognaItaly

Since its discovery in early 2000’s Molecular Spintronics has developed in an established and fructuous research field,achieving a number of outstanding results and unveiling unusual spintronic *** the most mysterious device element,the interface,in molecular spintronics has on contrary received and enormous attention and even gained a special nickname–the *** on significant efforts of many research groups worldwide it has been established its critical role in defining the main functionalities of molecular spintronic *** the spinterface was found to control the properties of the both components constituting the interface,not only those of the molecular layer but surprisingly also those of the magnetic *** paper aims to overview the most striking spinterface properties and to highlight the possibilities to promote new device paradigms based on interfacial modulation.

关键词： Molecular spintronics Ferromagnetism Spin polarization Hybridization organic semiconductors

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The new K_V3.4 inhibitor BDS-I[1–8] as a potential pharmacological opportunity in Alzheimer’s disease therapy

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Neural Regeneration Research 2020年第7期15卷 1255-1256页

作者： ilaria Piccialli Roselia Ciccone Anna Pannaccione Division of Pharmacology Department of NeuroscienceReproductive and Dentistry Sciences School of Medicine Federico II University of Naples

Alzheimer's disease(AD)is the most common neurodegenerative disorder and the first cause of dementia in the elderly,with no treatment able to prevent or to block disease *** is characterized by memory impairment and cognitive dysfunction,followed in the late phases of the disease by severe neurodegeneration and neuronal *** amyloid-β(Aβ)peptide,generated upon the processing of the amyloid precursor protein,is considered the main initiator of AD ***,Aβpeptides,which aggregate and accumulate to form extracellular plaques and intraneuronal deposits.

关键词： inhibitor BDS-I[1-8] BDS Alzheimer

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Isoenergetic-practical and semi-purified diets for protein requirement determination in Hermetia illucens larvae:consequences on life history traits

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Journal of Animal Science and Biotechnology 2022年第3期13卷 897-906页

作者： Sara Bellezza Oddon ilaria Biasato Laura Gasco Department of Agricultural Forest and Food SciencesUniversity of TurinLargo P.Braccini 210095 GrugliascoTOItaly

Background:Black soldier fly(BSF)is one of the most promising species for the intensive breeding of insects given its adaptability and its efficiency in the conversion of *** maximize the production and use waste as substrates,it is essential to determine the larvae nutritional *** study aims to evaluate the effects of5 practical,semi-purified and isoenergetic diets(PSPID)with increasing protein levels(10%,CP10;14%,CP14;16%,CP16;19%,CP19)on BSF life history traits.A total of 2000 six-day-old larvae were weighed and divided into groups of 100(4 replicates/treatment[PSPID and Gainesville diet(GA)used as environmental control]).In larva-prepupa stage,sampling was carried out on 30 individuals/replicate,while in prepupa-adult stage on ***:In the whole larval stage,the CP16 treatment performed better when compared to the other ***18 days old,the CP14 treatment showed a higher weight than the CP19(P<0.01),while the CP10 and CP16weights were *** the contrary,the CP10 prepupae weight was higher than the CP19(P<0.01).The CP10 and CP14 pupae performed better in terms of weight when compared to the others(P<0.01).The dietary treatments did not affect the adult *** sex significantly influenced both the exuvia weight,which was the greatest in females(P<0.001),and the fly lifespan,longest in males(P<0.05).Fly lifespan was also influenced by the interaction between treatment and sex,with the CP19 females showing a longer life than the others(P<0.05).Conclusions:In conclusion,the optimal protein level considering the whole larval stage is 16%on dry matter(DM).At 18 days old,looking at the size intended for the meal production,it can be considered 14%on *** result obtained on adult emergence in PSPID may not be attributable to the protein *** researches on macronutrients requirements determination have to be conducted to evaluate the substrates composition effects on BSF life history traits.

关键词： Hermetia illucens Life history traits Nutritional requirements Semi-purified

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Advances in Space Medicine Applied to Pandemics on Earth

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Space(Science & Technology) 2021年第1期2021卷 271-273页

作者： ilaria Cinelli Thais Russomano Aerospace Human Factors Association Aerospace Medical AssociationUSA InnovaSpace Ltd&Centre for Human and Applied Physiological Sciences School of Basic&Medical BiosciencesFaculty of Life Sciences and MedicineKing’s College LondonUK

Preparation and planning are critical when facing an epidemic or *** solutions must be incorporated in addition to existing guidelines in the case of a fast-spreading *** in space health have been driven by the need to preserve human health in an austere environment,in which medical assistance or resupply from the ground is not *** paper speculates on the similarities between human spaceflight and epidemics,extended to pandemics,identifying implementable solutions for immediate use by healthcare personnel and healthcare *** believe aerospace medical research can be seen as a resource to improve terrestrial medical care and the management of patients on Earth.

关键词： preserve incorporated addition

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Bone metastases:When and how lung cancer interacts with bone

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World Journal of Clinical Oncology 2014年第2期5卷 149-155页

作者： ilaria Roato CeRMS AO Città della Salute e della Scienza di Torino Department of Medical Science University of Turin

Bone metastasis is a common and debilitating consequence of lung cancer:30%-40% of patients with nonsmall cell lung cancer develop bone metastases during the course of their disease. Lung cancer cells find a favorable soil in the bone microenvironment due to factors released by the bone matrix, the immune system cells, and the same cancer cells. Many aspects of the cross-talk among lung tumor cells, the immune system,and bone cells are not clear, but this review aims to summarize the recent findings in this field, with particular attention to studies conducted to identify biomarkers for early detection of lung cancer bone metastases.

关键词： Lung cancer Bone metastases Osteoclast T cell Bone microenvironment

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Assessment of lead pollution in topsoils of a southern Italy area: Analysis of urban and peri-urban environment

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Journal of Environmental Sciences 2015年第7期27卷 179-187页

作者： ilaria Guagliardi Domenico Cicchella Rosanna De Rosa Gabriele Buttafuoco Department of Biology Ecology and Earth Sciences University of Calabria Department of Science and Technology University of Sannio National Research Council of Italy Institute for Agricultural and Forest Systems in the Mediterranean (ISAFOM)

Exposure to lead（Pb） may affect adversely human health. Mapping soil Pb contents is essential to obtain a quantitative estimate of potential risk of Pb contamination. The main aim of this paper was to determine the soil Pb concentrations in the urban and peri-urban area of Cosenza-Rende to map their spatial distribution and assess the probability that soil Pb concentration exceeds a critical threshold that might cause concern for human *** were collected at 149 locations from residual and non-residual topsoil in gardens,parks, flower-beds, and agricultural fields. Fine earth fraction of soil samples was analyzed by X-ray Fluorescence spectrometry. Stochastic images generated by the sequential Gaussian simulation were jointly combined to calculate the probability of exceeding the critical threshold that could be used to delineate the potentially risky areas. Results showed areas in which Pb concentration values were higher to the Italian regulatory values. These polluted areas were quite large and likely, they could create a significant health risk for human beings and vegetation in the near future. The results demonstrated that the proposed approach can be used to study soil contamination to produce geochemical maps,and identify hot-spot areas for soil Pb concentration.

关键词： Urban and peri-urban soils Geochemistry Lead Soil pollution Stochastic simulation

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