The new K_V3.4 inhibitor BDS-I[1–8] as a potential pharmacological opportunity in Alzheimer’s disease therapy
The new K_V3.4 inhibitor BDS-I[1–8] as a potential pharmacological opportunity in Alzheimer’s disease therapy作者机构：Division of Pharmacology Department of NeuroscienceReproductive and Dentistry Sciences School of Medicine Federico II University of Naples
出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)
年 卷 期：2020年第15卷第7期
页 面：1255-1256页
核心收录：
基 金：supported by the following grants:ProgettoAteneo Federico II to AP PON03PE_00146_1 by MIUR POR Campania FESR 2007-2013 MOVIE(B25C1300024007) POR Campania FESR 2007-2013 FARMABIONET(B25C1300023007) ProgrammaOperativo Nazionale(PON_01602 and PON03PE_00146_1)from MIUR
主 题：inhibitor BDS-I[1-8] BDS Alzheimer
摘 要：Alzheimer s disease(AD)is the most common neurodegenerative disorder and the first cause of dementia in the elderly,with no treatment able to prevent or to block disease *** is characterized by memory impairment and cognitive dysfunction,followed in the late phases of the disease by severe neurodegeneration and neuronal *** amyloid-β(Aβ)peptide,generated upon the processing of the amyloid precursor protein,is considered the main initiator of AD ***,Aβpeptides,which aggregate and accumulate to form extracellular plaques and intraneuronal deposits.
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