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Significance of ipsilateral breast tumor recurrence after breast conserving treatment: role of surgical removal

Chinese Journal of Cancer Research 2013年第1期25卷 22-31页

作者： Romano Demicheli ilaria Ardoino Federico Ambrogi Roberto Agresti Elia Biganzoli Scientific Directorate IRCCS National Cancer Institute Medical Statistics and Biometry University of Milan Breast Surgery IRCCS National Cancer Institute Medical Statistics and Biometry IRCCS National Cancer Institute

Objective： To analyze the pattern over time （dynamics） of further recurrence and death after ipsilateral breast tumor recurrence （IBTR） in breast cancer patients undergoing breast conserving treatment （BCT）. Methods： A total of 338 evaluable patients experiencing IBTR were extracted from a database of 3,293 patients undergoing BCT. The hazard rates for recurrence and mortality throughout 10 years of follow-up after IBTR were assessed and were compared to the analogous estimates associated to the primary treatment. Results： In a time frame with the time origin at the surgical treatment for IBTR, the hazard rate for further recurrence displays a bimodal pattern （peaks at the second and at the sixth year）. Patients receiving mastectomy for IBTR reveal recurrence and mortality dynamics similar to that of node positive （N＋） patients receiving mastectomy as primary surgery, apart from the first two-three years, when IBTR patients do worse. If the patients with time to IBTR longer than 2.5 years are considered, differences disappear. Conclusions： The recurrence and mortality dynamics following IBTR surgical removal is similar to the corresponding dynamics following primary tumor removal. In particular, patients with time to IBTR in excess of 2.5 years behave like N＋ patients following primary tumor removal. Findings may be suitably explained by assuming that the surgical manoeuvre required by IBTR treatment is able to activate a sudden growing phase for tumor foci most of which, as suggested by the systemic model of breast cancer, would have reached the clinical level according to their own dynamics.

关键词： Breast cancer IBTR recurrence dynamics effects of surgery conservative surgery tumor homeostasis

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Synthesis and Characterization of Iron-Rich Glass Ceramic Materials：A Model for Steel Industry Waste Reuse

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Journal of Materials Science & Technology 2016年第11期32卷 1105-1110页

作者： Riccardo Carlini ilaria Alfieri Gilda Zanicchi Francesco Soggia Enos Gombia Andrea Lorenzi Department of Chemistry and Industrial Chemistry University of GenoaVia Dodecaneso 3116146 GenovaItaly Department of Chemistry University of ParmaParco area delle Scienze 17/a43124 ParmaItaly IMEM-CNR Parco Area delle Sdenze 37/a43124 ParmaItaly

Wastes deriving from steel industry, containing large amounts of iron oxides and heavy metals, when collected in landfills are subjected to atmospheric agents, with consequent release of toxic substances in the soil and groundwater. The reuse of these wastes as raw materials for the production of advanced materials is a viable way both to overcome the environmental impact and to reduce the disposal costs,proposing new technologically advanced materials. This work aims to simulate these interesting glassceramics by using glass cullet coming from recycled municipal waste and high amount of iron（III） oxide（from 25 wt% to 50 wt%）, the prevalent component of steel waste. The oxide was mixed with glass cullet and vitrified. The samples composition and the microstructure were investigated by scanning electron microscopy（SEM）, and X-ray diffraction（XRD） was used to evaluate the nature of the crystalline *** chemical stability of the materials, in terms of ionic release into saline solution, was assessed. The electrical behavior of the samples was also investigated by varying the iron ions content and controlling the crystallization process. It is possible to obtain chemically stable materials with a nearly semiconducting behavior.

关键词： Glass-ceramics Electrical properties Leaching tests Iron rich waste Vitrification

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Chemical and minero-petrographical changes on granulite rocks affected by weathering processes

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Frontiers of Earth Science 2019年第2期13卷 247-261页

作者： Carmine APOLLARO Francesco PERRI Emilia LE PERA ilaria FUOCO Teresa CRITELLI DiBEST University of Calabria1-87036 Arcavacata di Rende (CS)Italy

The purpose of this work is to study the weathering processes of the granulite rocks of the Serre Massif (southern Calabria,Italy) using a multidisciplinary approach based on field studies,geochemical modeling,and minero?petrographical *** granulite rocks are plagioclase-rich with minor amphibole,clinopyroxene,orthopyroxene,biotite,and garnet and their texture are *** reaction path modeling was performed to simulate the evolution of groundwaters upon interaction with local granulite by means of the software package EQ3/6,version *** were performed in kinetic (time) mode under a closed system at a constant temperature of 11.5℃,(which reproduces the average temperature of local area) and fixing the fugacity of CO2 at 10-2.34 bar (mean value).During the most advanced stage of weathering the main mineralogical changes are: partial destruction and transformation of biotite and plagioclase associated with neoformation of ferruginous products and secondary clay minerals producing a change in the origin rock *** secondary solid phases observed during the geochemical modeling (kaolinite,vermiculite and ferrihydrite) are similar to those found in this natural ***,the soil-like material mainly characterized by mostly sand to gravel grain-size fractions is the final result of the weathering processes.

关键词： Serre Massif granulitic rocks mineralogy petrography weathering profile reaction path-modeling

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A Controller-Based Architecture for Information Centric Network Construction and Topology management

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China Communications 2018年第7期15卷 131-145页

作者： Zeinab Zali Massoud Reza Hashemi ilaria Cianci Alfredo Grieco Gennaro Boggia Department of Electrical and Computer Engineering Isfahan University of Technology DEI Dep.of Electrical and Information Engineering

Information-Centric Networking(ICN) has recently emerged as a result of the increased demand to access contents regardless of their location in the network services. This new approach facilitates content distribution as a service of the network with lower delay and higher security in comparison with the current IP network. Applying ICN in current IP infrastructure leads to major complexities. One approach to deploy ICN with less complexity is to integrate ICN with Software Defined Networking(SDN). The SDN controller manages the content distribution, caching, and routing based on the users' requests. In this paper, we extend these context by addressing the ICN topology management problem over the SDN network to achieve an improved user experience as well as network performance. In particular, a centralized controller is designed to construct and manage the ICN overlay. Experimental results indicate that this adopted topology management strategy achieves high performance, in terms of low failure in interest satisfaction and reduced download time compared to a plain ICN.

关键词：网络建设管理问题控制器拓扑学体系结构中央信息网络服务

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High-intensity Interval Training for the Management of Nonalcoholic Steatohepatitis: Participant Experiences and Perspectives

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Journal of Clinical and Translational Hepatology 2023年第5期11卷 1050-1060页

作者： Shelley E.Keating ilaria Croci Matthew P.Wallen Emily R.Cox Jeff S.Coombes Nicola W.Burton Graeme A.Macdonald Ingrid J.Hickman Centre for Research on Exercise Physical Activity and HealthSchool of Human Movement and Nutrition SciencesThe University of QueenslandBrisbaneAustralia K.G.Jebsen Center of Exercise in Medicine Norwegian University of Science and Technology Department of Circulation and Medical ImagingFaculty of MedicineTrondheimNorway Department of Sport Exercise and HealthUniversity of BaselBaselSwitzerland Caring Futures Institute College of Nursing and Health SciencesFlinders UniversityAdelaideAustralia Institute of Health and Wellbeing Federation UniversityMount HelenAustralia School of Environmental and Life Sciences University of NewcastleOurimbahAustralia School of Applied Psychology Griffith UniversityMt GravattAustralia Menzies Health Institute Griffith UniversityGold CoastAustralia Centre for Mental Health Griffith UniversityBrisbaneAustralia Department of Gastroenterology and Hepatology Princess Alexandra HospitalBrisbaneAustralia Faculty of Medicine The University of QueenslandBrisbaneAustralia Department of Nutrition and Dietetics Princess Alexandra HospitalBrisbaneAustralia

Background and Aims:High-intensity interval training(HIIT)is a therapeutic option for people with nonalcoholic steatohepatitis(NASH).However,the perspectives and experiences of HIIT for people with NASH are unknown,limiting translation of *** explored the experiences and perspectives of both professionally supervised and self-directed HIIT in people with NASH and evaluated participant-reported knowledge,barriers,and enablers to commencing and sustaining ***:Twelve participants with NASH underwent 12 weeks of supervised HIIT(3 days/week,4×4 minutes at 85–95%maximal heart rate,interspersed with 3 minutes active recovery),followed by 12-weeks of selfdirected(unsupervised)***-on-one,semistructured participant interviews were conducted by exercise staff prior to HIIT and following both supervised and self-directed HIIT to explore prior knowledge,barriers,enablers,and outcomes at each *** were audio-recorded,transcribed,coded,and thematically analyzed by two independent ***:Four dominant themes were identified:(1)no awareness of/experience with HIIT and ambivalence about exercise capabilities;(2)multiple medical and social barriers to commencing and continuing HIIT;(3)exercise specialist support was a highly valued enabler,and(4)HIIT was enjoyed and provided holistic ***:People with NASH may lack knowledge of and confidence for HIIT,and experience multiple complex barriers to commencing and continuing *** specialist support is a key enabler to sustained *** factors need to be addressed in future clinical programs to augment the uptake and long-term sustainability of HIIT by people with NASH so they can experience the range of related benefits.

关键词： Nonalcoholic fatty liver disease NAFLD Exercise Lifestyle Qualitative Patient-reported outcomes

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Production performance and plasma metabolite concentrations of broiler chickens fed low crude protein diets differing in Thr and Gly

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Animal Nutrition 2021年第2期7卷 472-480页

作者： Laura Star Sophie Tesseraud Marije van Tol ilaria Minussi Etienne Corrent William Lambert Schothorst Feed Research Meerkoetenweg 268218 NA Lelystadthe Netherlands INRAE BOAUniversitéde Tours37380 NouzillyFrance Orffa Additives B.V. Vierlinghstraat 514251 LC Werkendamthe Netherlands Ajinomoto Animal Nutrition Europe 32 rue Guersant75017 ParisFrance

The aim of the study was to test the interaction between Thr and Gly in low crude protein(CP)diets in 7 to 28 d broilers on production performance and plasma metabolites.A total of 2,040 broilers were allocated to 17 treatments.A positive control(PC)diet(20.5%CP)was formulated to be adequate in dietary Thr and Gly.A negative control(NC)diet(18.5%CP,deficient in Thr and Gly)was supplemented with crystalline L-Thr and Gly to obtain a 4 Thr×4 Gly *** Thr was tested at an apparent faecal digestibility(AFD)Thr-to-Lys ratio,which was 55%,58%,61%or 64%,and dietary Gly was tested at an AFD(Gly+Ser)-to-Lys ratio,which was 135%,142%,149%or 156%.Plasma samples were collected at 28 *** low CP diet,formulated at 64%Thr and 156%Gly,resulted in a higher body weight gain(BWG)(P<0.01)and similar feed conversion ratio(FCR)as the high CP treatment(PC).FCR was improved(P<0.001)by L-Thr *** response to dietary Thr was significant for feed intake(FI),BWG and FCR(P<0.01).A near-significant interaction for Thr×Gly was observed for FI and BWG(Plinear=0.091 and P=0.074,respectively).Gly did not affect production *** interaction between Thr×Gly on plasma free AA level was observed(P<0.05).Free AA concentration in plasma linearly decreased with increase in AFD Thr-to-Lys ratio,and increased with increase in AFD(Gly+Ser)-to-Lys *** uric acid concentration was higher in PC than in all of the other diets,and plasma triglyceride concentration was decreased by L-Thr supplementation,but not by *** conclusion,Gly was not limiting for growth at low dietary CP level unless Thr was deficient,showing that adequate amounts of Thr in broiler diets can overcome marginal supply of Gly and Ser and allow reduction of dietary CP from 20.5%to 18.5%for broilers from 7 to 28 d of age.

关键词： Broiler Threonine Glycine Low protein Performance Plasma metabolite

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COVID-19 in normal,diseased and transplanted liver

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World Journal of Gastroenterology 2021年第20期27卷 2576-2585页

作者： Alessandro Signorello ilaria Lenci Martina Milana Giuseppe Grassi Leonardo Baiocchi Hepatology Unit Department of MedicineUniversity of Tor VergataRome 00133Italy

Starting from December 2019 the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)has extended in the entire world giving origin to a *** the respiratory system is the main apparatus involved by the infection,several other organs may suffer coronavirus disease 2019(COVID-19)-related *** human tissues expressing angiotensin-converting enzyme 2(ACE2)are all possible targets of viral *** fact myocarditis,meningo-encephalitis,acute kidney injury and other complications have been described with regard to SARS-CoV-2 *** liver has a central role in the body homeostasis contributing to detoxification,catabolism and also synthesis of important factor such as plasma ***2 is significantly expressed just by cholangiocytes within the liver,however transaminases are increased in more than one third of COVID-19 patients,at hospital *** reasons for liver impairment in the course of this infection are not completely clear at present and multiple factors such as:Direct viral effect,release of cytokines,ischemic damage,use of hepatotoxic drugs,sepsis,and others,may contribute to *** COVID-19 seems to elicit just a transient alteration of liver function tests in subjects with normal hepatic function,of concern,more severe sequelae are frequently observed in patients with a reduced hepatic *** this review we report data regarding SARS-CoV-2 infection in subjects with normal or diseased *** addition the risks of COVID-19 in immunosuppressed patients(either transplanted or suffering for autoimmune liver diseases)are also described.

关键词： COVID-19 Liver Non-alcoholic fatty-liver-disease Cirrhosis Liver transplant Angiotensin-converting enzyme 2

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Association between non-alcoholic fatty liver disease and obstructive sleep apnea

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World Journal of Gastroenterology 2020年第20期26卷 2669-2681页

作者： ilaria Umbro Valerio Fabiani Mario Fabiani Francesco Angelico Maria Del Ben Department of Anatomical HistologicalForensic Medicine and Orthopedic SciencesSapienza University of RomeRome 00161Italy Department of Neurosciences Mental Health and Sensory OrgansSapienza University of RomeRome 00123Italy Department of Sense Organs Sapienza University of RomeRome 00161Italy Department of Public Health and Infectious Diseases Sapienza University of RomeRome 00161Italy Department of Clinical InternalAnesthetic and Cardiovascular SciencesSapienza University of RomeRome 00161Italy

BACKGROUND Non-alcoholic fatty liver disease(NAFLD)is an emerging liver disease and currently the most common cause of incidental abnormal liver *** pathogenesis of NAFLD is multifactorial and many mechanisms that cause fatty liver infiltration,inflammation,oxidative stress and progressive fibrosis have been *** sleep apnea(OSA)may be linked with the pathogenesis and the severity of *** To study the association between NAFLD and OSA considering also the efficacy of continuous positive airway pressure(CPAP)*** A Pub Med search was conducted using the terms"non-alcoholic fatty liver disease AND(obstructive sleep apnea OR obstructive sleep disorders OR sleep apnea)".Research was limited to title/abstract of articles published in English in the last 5 years;animal and child studies,case reports,commentaries,letters,editorials and meeting abstracts were not *** were extracted on a standardized data collection table which included:First author,publication year,country,study design,number of patients involved,diagnosis and severity of OSA,diagnosis of NAFLD,patient characteristics,results of the *** total,132 articles were initially retrieved on Pub Med search and 77 in the last five *** removal of irrelevant studies,13 articles were included in the qualitative *** was a total of 2753 participants across all the studies with a mean age between 42 and 58 *** proportion of males ranged from21%to 87.9%and the mean body mass index ranged from 24.0 to 49.9 kg/*** results of this review showed an increased prevalence of NAFLD in patients with diagnosis of OSA,even in the absence of coexisting comorbidities such as obesity or metabolic ***,the severity of NAFLD is associated with the increase in OSA *** CPAP treatment,although not always decisive,may stabilize or slow NAFLD progression with benefits on metabolic and cardiovascular *** In

关键词： Continuous positive air pressure Non-alcoholic fatty liver disease Nonalcoholic steatohepatitis Obstructive sleep apnea Obstructive sleep disorders Sleep apnea

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The clinical challenges of homologous recombination proficiency in ovarian cancer: from intrinsic resistance to new treatment opportunities

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Cancer Drug Resistance 2023年第3期6卷 499-516页

作者： Teresa Zielli Intidhar Labidi-Galy Maria Del Grande Cristiana Sessa ilaria Colombo Service of Medical Oncology Oncology Institute of Southern Switzerland(IOSI)EOCBellinzona 6500Switzerland Department of Oncology Geneva University HospitalsGeneva 1205Switzerland Department of Medicine Center of Translational Research in Onco-HematologyGeneva 1205Switzerland

Ovarian cancer is the most lethal gynecologic cancer. Optimal cytoreductive surgery followed by platinum-based chemotherapy with or without bevacizumab is the conventional therapeutic strategy. Since 2016, the pharmacological treatment of epithelial ovarian cancer has significantly changed following the introduction of the poly (ADP-ribose) polymerase inhibitors (PARPi). BRCA1/2 mutations and homologous recombination deficiency (HRD) have been established as predictive biomarkers of the benefit from platinum-based chemotherapy and PARPi. While in the absence of HRD (the so-called homologous recombination proficiency, HRp), patients derive minimal benefit from PARPi, the use of the antiangiogenic agent bevacizumab in first line did not result in different efficacy according to the presence of homologous recombination repair (HRR) genes mutations. No clinical trials have currently compared PARPi and bevacizumab as maintenance therapy in the HRp population. Different strategies are under investigation to overcome primary and acquired resistance to PARPi and to increase the sensitivity of HRp tumors to these agents. These tumors are characterized by frequent amplifications of Cyclin E and MYC, resulting in high replication stress. Different agents targeting DNA replication stress, such as ATR, WEE1 and CHK1 inhibitors, are currently being explored in preclinical models and clinical trials and have shown promising preliminary signs of activity. In this review, we will summarize the available evidence on the activity of PARPi in HRp tumors and the ongoing research to develop new treatment options in this hard-to-treat population.

关键词： PARP inhibitors homologous recombination proficiency ovarian cancer PARP inhibitor resistance replication stress

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Liver transplantation for hepatocellular carcinoma: Where do we stand?

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World Journal of Gastroenterology 2019年第21期25卷 2591-2602页

作者： Francesco Santopaolo ilaria Lenci Martina Milana Tommaso Maria Manzia Leonardo Baiocchi Hepatology Unit Department of MedicinePoliclinico Universitario Tor VergataRome 00133Italy Transplant Surgery Unit Department of SurgeryPoliclinico Universitario Tor VergataRome 00133Italy

Hepatocellular carcinoma represents an important cause of morbidity and mortality worldwide. It is the sixth most common cancer and the fourth leading cause of cancer death. Liver transplantation is a key tool for the treatment of this disease in human therefore hepatocellular carcinoma is increasing as primary indication for grafting. Although liver transplantation represents an outstanding therapy for hepatocellular carcinoma, due to organ shortage, the careful selection and management of patients who may have a major survival benefit after grafting remains a fundamental question. In fact, only some stages of the disease seem amenable of this therapeutic option, stimulating the debate on the appropriate criteria to select candidates. In this review we focused on current criteria to select patients with hepatocellular carcinoma for liver transplantation as well as on the strategies (bridging) to avoid disease progression and exclusion from grafting during the stay on wait list. The treatments used to bring patients within acceptable criteria (down-staging), when their tumor burden exceeds the standard criteria for transplant, are also reported. Finally, we examined tumor reappearance following liver transplantation. This occurrence is estimated to be approximately 8%-20% in different studies. The possible approaches to prevent this outcome after transplant are reported with the corresponding results.

关键词： Hepatocellular carcinoma Liver transplantation Bridging Down-staging Milan Criteria

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