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MuTaTo<sup>&copy</sup>—A Novel Concept for Curing Cancer

Journal of Cancer Therapy 2020年第2期11卷 55-73页

作者： ilan morad Hanan Itzhaki Accelerated Evolution Biotechnologies (AEBi) Ltd. Nes-Ziona Israel

One of the main reasons for developing cancer drug-resistance is the ability of cancer cells to adopt mutations that help them fight the treatments. Cancer cells are very mutagenic. This makes the population of cancer cells in any tumor, or any other cancer cells that come from a distinct origin (one parent cell) highly variable. In some cases, there are already drug-resistant cancer cells at the beginning of the treatment. In other cases, they emerge during the treatment. Treating cancer patients with drugs, or other treatments that attack only one cancer-target would therefore be prone to bad prognosis. In addition, these kinds of treatments would also attack (to a lower degree) non-cancer cells that contain the same targets as the cancer cells. This would lead to adverse effects. Combination therapies, or bispecific drugs could partly solve these problems, but not completely. To address this and other problems, a novel concept for curing cancer, MuTaTo©, was developed. MuTaTo is a personalized medicine concept. The main principal of it is using multiple targeting peptides connected together with a toxin. The main advantage of MuTaTo is that it would lower the probability of the targeted cancer cells to develop drug-resistance due to mutations they possess, and at the same time would lower adverse effects due to avidity effect. Each cancer patient would receive a specific MuTaTo drug perfectly suited to his cancer, based on the expression profile of receptors on the outer membrane of his cancer cells. MuTaTo construct production is easy and rapid. Therefore, the production cost would not be as expensive as with other biological drugs, or other sophisticated cancer treatments. In this article several experiments were performed to show the efficacy of different MuTaTo constructs, and the sustainability of the principals of this concept. The results showed that multi-targeting was better than mono targeting, and that MuTaTo was efficient as a mono treatment in vi

关键词： MuTaTo Multiple Targeting Avidity Effect Toxin Curing Cancer

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Neutral and metallic *** and semiconducting surface layer in acceptor doped CeO_(2)

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International Journal of Minerals,Metallurgy and Materials 2024年第4期31卷 795-802页

作者： ilan Riess Physics Department Technion IITHaifa 3200003Israel

The monomolecular surface layer of acceptor doped CeO_(2) may become neutral and metallic or charged and *** is revealed in the theoretical analysis of the oxygen pressure dependence of the surface defects concentration in acceptor doped ceria with two different dopant types and operated under different oxygen *** published experimental data for highly reduced Sm0.2Ce0.8O1.9-x(SDC)containing a fixed valence dopant Sm3+are very different from those published for Pr0.1Ce0.9O_(2)-x(PCO) with the variable valence dopant Pr4+/Pr3+being reduced under milder *** theoretical analysis of these experimental results fits very well the experimental results of SDC and *** leads to the following predictions:the highly reduced surface of SDC is metallic and neutral,the metallic surface electron density of state is gs=0.9×10^(38)J-1·m^(-2)(1.4×1015eV^(-1)·cm^(-2)),the electron effective mass is meff,s=3.3me,and the phase diagram of the reduced surface has theα(fcc)structure as in the *** PCO a double layer is predicted to be formed between the surface and the bulk with the surface being negatively charged and *** surface of PCO maintains high Pr^(3+) defect concentration as well as relative high oxygen vacancy concentration at oxygen pressures higher than in the *** reasons for the difference between a metallic and semiconducting surface layer of acceptor doped CeO_(2) are reviewed,as well as the key theoretical considerations applied in coping with this *** that we make use of the experimental data and theoretical analysis available for acceptor doped ceria.

关键词： CeO_(2) surface defects metallic surface oxide reduction Sm doped CeO_(2) Pr doped CeO_(2)

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Enhanced Chimp Optimization Algorithm Using Attack Defense Strategy and Golden Update Mechanism for Robust COVID-19 Medical Image Segmentation

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Journal of Bionic Engineering 2024年第4期21卷 2086-2109页

作者： Amir Hamza morad Grimes Abdelkrim Boukabou Samira Dib Non Testing Destructive Laboratory Faculty of TechnologyUniversity of Jijel18000JijelAlgeria Laboratory of Renewable Energy Faculty of TechnologyUniversity of Jijel18000JijelAlgeria

Medical image segmentation is a powerful and evolving technology in medical *** fact,it has been identified as a very effective tool to support and accompany doctors in their fight against the spread of the coronavirus(COVID-19).Various techniques have been utilized for COVID-19 image segmentation,including Multilevel Thresholding(MLT)-based meta-heuristics,which are considered crucial in addressing this ***,despite their importance,meta-heuristics have significant ***,the imbalance between exploration and exploitation,as well as premature convergence,can cause the optimization process to become stuck in local optima,resulting in unsatisfactory segmentation *** this paper,an enhanced War Strategy Chimp Optimization Algorithm(WSChOA)is proposed to address MLT *** strategies are incorporated into the traditional Chimp Optimization *** update mechanism that provides diversity in the ***,the attack and defense strategies are incorporated to improve the search space leading to avoiding local *** experimental results were conducted by comparing WSChoA with recent and well-known algorithms using various evaluation metrics such as Feature Similarity Index(FSIM),Structural Similarity Index(SSIM),Peak signal-to-Noise Ratio(PSNR),Standard deviation(STD),Freidman Test(FT),and Wilcoxon Sign Rank Test(WSRT).The results obtained by WSChoA surpassed those of other optimization techniques in terms of robustness and accuracy,indicating that it is a powerful tool for image segmentation.

关键词： Image processing Segmentation Optimization Chimp Golden update mechanism Attack-defense strategy COVID-19

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Video Summarization Approach Based on Binary Robust Invariant Scalable Keypoints and Bisecting K-Means

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Computers, Materials & Continua 2024年第3期78卷 3565-3583页

作者： Sameh Zarif Eman morad Khalid Amin Abdullah Alharbi Wail S.Elkilani Shouze Tang Department of Information Technology Faculty of Computers and InformationMenoufia UniversityMenoufia32511Egypt Department of Artificial Intelligence Faculty of Artificial IntelligenceEgyptian Russian UniversityBader11829Egypt Department of Computer Science Community CollegeKing Saud UniversityRiyadh11362Saudi Arabia College of Applied Computer Science King Saud UniversityAl-Muzahmiya19676Saudi Arabia School of Communication and Information Engineering Chongqing University of Posts and TelecommunicationsChongqing400065China

Due to the exponential growth of video data,aided by rapid advancements in multimedia *** became difficult for the user to obtain information from a large video *** process of providing an abstract of the entire video that includes the most representative frames is known as static video *** method resulted in rapid exploration,indexing,and retrieval of massive video *** propose a framework for static video summary based on a Binary Robust Invariant Scalable Keypoint(BRISK)and bisecting K-means clustering *** current method effectively recognizes relevant frames using BRISK by extracting keypoints and the descriptors from video *** video frames’BRISK features are clustered using a bisecting K-means,and the keyframe is determined by selecting the frame that is most near the cluster *** applying any clustering parameters,the appropriate clusters number is determined using the silhouette *** were carried out on a publicly available open video project(OVP)dataset that contained videos of different *** proposed method’s effectiveness is compared to existing methods using a variety of evaluation metrics,and the proposed method achieves a trade-off between computational cost and quality.

关键词： BRISK bisecting K-mean video summarization keyframe extraction shot detection

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The germline genetics of mild-to-moderate penetrance:An intriguing role of PRAME in multiple carcinogenesis

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Genes & Diseases 2024年第3期11卷 7-10页

作者： Diaddin Hamdan Van Tai Nguyen Justine Paris Christophe Leboeuf morad El Bouchtaoui Marc Espie Anne Janin Geraldine Falgarone Melanie Di Benedetto Guithem Bousquet Universite de Paris Cite INSERMUMR_S942MASCOTParis F-75006France Hopital La Porte Verte Versailles F-78004France National Cancer Hospital Cancer Research and Clinical Trials CenterHaNoi100000VietNam AP-HP-Hopital Saint Louis Centre de Maladies du SeinParisF-75010France Universite Sorbonne Paris Nord Bobigny F-93000France AP-HP-Hopital Avicenne Unite de Medecine AmbulatoireBobigny F-93000France

Germline genetics of high penetrance such as BRCA genes,mutations might be sufficient for carcinogenesis,but this only explains fewer than 10%of *** assume that most cancers are the result of germline mutations of low to moderate penetrance,combined with acquired mutations due to external carcinogenic *** their accumulation over time,aging is associated with an increased risk of multiple cancer development in a given *** decades,germline genetics have been based on familial linkage studies enabling most high-penetrance genes to be *** recently,population-wide studies have led to the identification of considerable numbers of polymorphisms associated with cancer ***,most of them are of unknown functional value,thus limiting their translational application.

关键词： carcinogenesis BRCA linkage

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Spectrum of COVID-19 induced liver injury:A review report

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World Journal of Hepatology 2024年第4期16卷 517-536页

作者： Lokjan Singh Anil Kumar Maya Rai Bibek Basnet Nishant Rai Pukar Khanal Kok-Song Lai Wan-Hee Cheng Ahmed morad Asaad Shamshul Ansari Department of Microbiology Karnali Academy of Health ScienceTeaching HospitalJumla 21200KarnaliNepal Health Sciences Asian College of Advance StudiesPurbanchal UniversitySatdobato 24122LalitpurNepal Department of Biotechnology Graphic Era(Deemed to be University)Dehradun 248002UttarakhandIndia Department of Pharmacology&Toxicology KLE College of PharmacyBelagaviKLE Academy of Higher Education and ResearchBelagavi 590010KarnatakaIndia Division of Health Sciences Abu Dhabi Women's CollegeHigher Colleges of TechnologyAbu Dhabi 41012United Arab Emirates Health and Life Sciences INTI International UniversityNilai 71800Malaysia Department of Microbiology College of MedicineZagazig UniversityZagazig 44519Egypt

The coronavirus disease 2019(COVID-19)pandemic has caused changes in the global health system,causing significant setbacks in healthcare systems *** pandemic has also shown resilience,flexibility,and creativity in reacting to the *** severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection targets most of the respiratory tract,resulting in a severe sickness called acute respiratory distress syndrome that may be fatal in some *** the lung is the primary organ targeted by COVID-19 viruses,the clinical aspect of the disease is varied and ranges from asymptomatic to respiratory ***,due to an unorganized immune response and several affected mechanisms,the liver may also experience liver cell injury,ischemic liver dysfunction,and drug-induced liver injury,which can result in respiratory failure because of the immune system’s disordered response and other compromised processes that can end in multisystem organ *** with liver cirrhosis or those who have impaired immune systems may be more likely than other groups to experience worse results from the SARS-CoV-2 *** thus intend to examine the pathogenesis,current therapy,and consequences of liver damage concerning COVID-19.

关键词： Autoimmune liver disease COVID-19 Clinical manifestation of liver Drug-induced liver injury SARS-CoV-2

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Harnessing innovation to help meet the needs of elders:field testing an electronic tool to streamline geriatric assessments across healthcare settings

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Family Medicine and Community Health 2024年第2期12卷 1-11页

作者： Limor Adler Zorian Radomyslsky Miri Mizrahi Reuveni Eduardo Schejter ilan Yehoshua Yakov Segal Sara Kivity Etti Naimi Mor Saban Maccabi Healthcare Services Tel AvivIsrael Department of Health system management Ariel UniversityArielIsrael Medical&Health Sciences Tel Aviv UniversityTel AvivIsrael

Background As populations age globally,effectively managing geriatric health poses challenges for primary *** geriatric assessments(CGAs)aim to address these challenges through multidisciplinary screening and coordinated care ***,most CGA tools and workflows have not been optimised for routine primary care *** This study aimed to evaluate the impact of a computerised CGA tool,called the Golden Age Visit,implemented in primary care in *** This study employed a quasiexperimental mixed-methods design to evaluate outcomes associated with the Golden Age electronic health assessment *** analysis used electronic medical records data from Maccabi Healthcare Services,the second largest health management organisation(HMO)in *** aged 75 and older were included in analyses from January 2017 to December 2019 and January 2021 to December *** patients,data were also collected on controls who did not participate in the Golden Age Visit programme during the same time period,to allow for comparison of *** physicians,qualitative data were collected via surveys and interviews with primary care physicians who used the Golden Age Visit SMARTEST e-assessment *** A total of 9022 community-dwelling adults aged 75 and older were included in the study:1421 patients received a Golden Age Visit CGA(intervention group),and 7601 patients did not receive the assessment(control group).After CGAs,diagnosis rates increased significantly for neuropsychiatric conditions and *** to physiotherapy,occupational therapy,dietetics and geriatric outpatient clinics also rose ***,no differences were found in rates of hip fracture or relocation to long-term care between *** among physicians(n=151)found high satisfaction with the *** Implementation of a large-scale primary care CGA programme was associated with improved diagnosis and management of geriatr

关键词： diagnosis routine Golden

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Hypolipidemic activity of Tamarix articulata Vahl. in diabetic rats

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Journal of Integrative Medicine 2017年第6期15卷 476-482页

作者： morad hebi mohamed eddouks faculty of sciences and techniques errachidia moulay ismail universityBoutalamine52000 Errachidia Morocco

OBJECTIVE： Tamarix articulata Vahl. （Tamaricaceae） is a medicinal plant commonly used in Morocco for the treatment of diabetes mellitus and cardiovascular diseases. The objective of this study was to evaluate the hypolipidemic activity of aqueous extract of T. articulata in normal and streptozotocin （STZ）-induced diabetic rats. Phytochemical analysis as well as determination of polyphenol and flavonoid contents in the aqueous extract of T. articulata was performed. METHODS： The effects of oral administration of aqueous extract of T. articulata （5 mg/kg） on the plasma total cholesterol, triglyceride and high-density lipoprotein cholesterol （HDL-c） concentrations were measured in both normal and STZ-induced diabetic rats. Total phenolic content of the aqueous extract was determined by Folin-Ciocalteu method. In addition, determination of flavonoid content was performed using colorimetric AICI3 method. RESULTS： A single oral administration in diabetic rats induced a significant increase in the HDL-c concentration after 6 h of treatment with T. articulata （5 mg/kg）. The results also demonstrated that the aqueous extract of T. articulata produced a significant decrease of serum total cholesterol after repeated oral administration in diabetic rats （P 〈 0.01）. The total polyphenol and flavonoid contents of T. articulata aqueous extract were equal to 102.50 mg of gallic acid equivalent per gram of extract and 54.83 mg of quercetin equivalent per gram of extract, respectively. CONCLUSION： According to preliminary phytochemical screening of the aerial part of T. articulata, severa classes of chemicals have been found, such as polyphenols, flavonoids, tannins, cyanidins （flavones, catechols）, mucilage, sesquiterpenes, terpenoids and carbohydrates. In conclusion, T. articulata exhibits a hypolipidemic effect in diabetic rats and its beneficial role as hypolipidemic agent should be evaluated in clinical studies.

关键词： hypolipidemic streptozotocin total cholesterol triglycerides flavonoids

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Taking Time, Sharing Spaces: Adaptive Risk Governance Processes in Rural Japan

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International Journal of Disaster Risk Science 2018年第4期9卷 464-471页

作者： ilan Chabay Institute for Advanced Sustainability Studies (IASS) 14467 PotsdamGermany

Rural and peri-urban communities in Japan, as well as in many other regions of the world, face risks of discrete event natural phenomena, including earthquakes,floods, and landslides. They also face persistent disruptive stress due to risks that remain active over long durations,such as the loss of community capacities due to an aging population. This article describes my observations of and subsequent reflections on adaptive risk governance and community resilience building processes in two areas of western and southern Japan—Chizu in Tottori Prefecture and towns near Kumamoto City in Kumamoto *** aspects of adaptive risk governance from this limited set of observations stood out:(1) the importance of establishing a durable, patient process,(2) initiated and facilitated by a trusted figure, in(3) a space or venue accessible and open to the community, and(4) augmented by boundary objects that facilitate role playing, iteration,and ownership by the community of solutions generated in these dialogues.

关键词： Boundary objects Case Station-Field Campuses(CASiFiCA) Community resilience Knowledge Learning and Societal Change Alliance(KLASICA) Japan Risk governance Yonmenkaigi System Method(YSM)

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Leaky gut and the liver: A role for bacterial translocation in nonalcoholic steatohepatitis

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World Journal of Gastroenterology 2012年第21期18卷 2609-2618页

作者： Yaron ilan Gastroenterology and Liver Units Department of Medicine Hadassah Hebrew University Medical CenterJerusalem 91120 Israel

Gut flora and bacterial translocation (BT) play important roles in the pathogenesis of chronic liver disease, including cirrhosis and its complications. Intestinal bacterial overgrowth and increased bacterial translocation of gut flora from the intestinal lumen predispose patients to bacterial infections, major complications and also play a role in the pathogenesis of chronic liver disorders. Levels of bacterial lipopolysaccharide, a component of gram-negative bacteria, are increased in the portal and/or systemic circulation in several types of chronic liver disease. Impaired gut epithelial integrity due to alterations in tight junction proteins may be the pathological mechanism underlying bacterial translocation. Preclinical and clinical studies over the last decade have suggested a role for BT in the pathogenesis of nonalcoholic steatohepatitis (NASH). Bacterial overgrowth, immune dysfunction, alteration of the luminal factors, and altered intestinal permeability are all involved in the pathogenesis of NASH and its complications. A better understanding of the cell-specific recognition and intracellular signaling events involved in sensing gut-derived microbes will help in the development of means to achieve an optimal balance in the gut-liver axis and ameliorate liver diseases. These may suggest new targets for potential therapeutic interventions for the treatment of NASH. Here, we review some of the mechanisms connecting BT and NASH and potential therapeutic developments.

关键词： Nonalcoholic steatohepatitis Bacterial translocation Insulin resistance Leaky gut Lipopolysaccharide

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